Philip S.J. Weston
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View article: Accelerated long-term forgetting as a predictor of clinical onset in presymptomatic autosomal dominant Alzheimer’s disease
Accelerated long-term forgetting as a predictor of clinical onset in presymptomatic autosomal dominant Alzheimer’s disease Open
Background In Alzheimer’s disease (AD), sensitive measures of cognitive decline prior to overt symptoms are urgently needed. Accelerated long-term forgetting (ALF), where new information is retained normally over conventional testing inter…
View article: Connectivity as a universal predictor of tau progression in atypical Alzheimer’s disease
Connectivity as a universal predictor of tau progression in atypical Alzheimer’s disease Open
The link between regional tau load and clinical manifestation of Alzheimer’s disease (AD) highlights the importance of characterizing spatial tau distribution across disease variants. In typical (memory-predominant) AD, the spatial progres…
View article: The association between grey matter microstructural MRI biomarkers, mid‐life blood pressure, and late‐life Alzheimer’s disease pathology
The association between grey matter microstructural MRI biomarkers, mid‐life blood pressure, and late‐life Alzheimer’s disease pathology Open
Background With an aging population, it is essential to identify subtle features of brain pathology – both neurodegenerative and vascular – at an early stage, which may predict risk of future decline. We used diffusion MRI (dMRI) to assess…
View article: Connectivity as a universal predictor of tau spreading in typical and atypical Alzheimer’s disease
Connectivity as a universal predictor of tau spreading in typical and atypical Alzheimer’s disease Open
Background There is a strong link between tau and progression of Alzheimer’s disease (AD), necessitating an understanding of tau spreading mechanisms. Prior research, predominantly in typical AD, suggested that tau propagates from epicente…
View article: The association between focal prefrontal cortical atrophy and accelerated long‐term forgetting in presymptomatic autosomal dominant Alzheimer’s disease
The association between focal prefrontal cortical atrophy and accelerated long‐term forgetting in presymptomatic autosomal dominant Alzheimer’s disease Open
Background Accelerated long‐term forgetting (ALF) is a form of episodic memory impairment where information is retained normally over 30‐60 minutes but lost at an accelerated rate over subsequent days to weeks, and is a very early – perhap…
View article: Connectivity as a universal predictor of tau spreading in typical and atypical Alzheimer’s disease
Connectivity as a universal predictor of tau spreading in typical and atypical Alzheimer’s disease Open
Background There is a strong link between tau and progression of Alzheimer’s disease (AD), necessitating an understanding of tau spreading mechanisms. Prior research, predominantly in typical AD, suggested that tau propagates from epicente…
View article: T1/T2 weighted ratio mapping to assess intracortical myelination in autosomal dominant Alzheimer's disease
T1/T2 weighted ratio mapping to assess intracortical myelination in autosomal dominant Alzheimer's disease Open
Background Identifying early pathological changes in Alzheimer’s Disease (AD), and accounting for variability in progression between individuals, is crucial for timely and effective intervention. While Amyloid‐b, tau, and neuronal loss are…
View article: Associations between accelerated forgetting, amyloid deposition and brain atrophy in older adults
Associations between accelerated forgetting, amyloid deposition and brain atrophy in older adults Open
Accelerated long-term forgetting (ALF) is the phenomenon whereby material is retained normally over short intervals (e.g. minutes) but forgotten abnormally rapidly over longer periods (days or weeks). ALF might be an early marker of cognit…
View article: MK‐6240 tau‐PET in an Aβ‐enriched sample from the 1946 British birth cohort
MK‐6240 tau‐PET in an Aβ‐enriched sample from the 1946 British birth cohort Open
Background We investigated imaging biomarkers of Aß and neurodegeneration in relation to tau‐PET Braak stage in a preclinical birth cohort. Method Cognitively normal individuals enrolled in Insight 46, the neuroimaging sub‐study of the MRC…
View article: The association between microstructural MRI biomarkers and sequential amyloid and tau‐related cortical changes in asymptomatic elderly individuals
The association between microstructural MRI biomarkers and sequential amyloid and tau‐related cortical changes in asymptomatic elderly individuals Open
Background In Alzheimer’s disease, early amyloid‐β and tau deposition may have differential downstream effects on synaptic function and neuronal loss in a stage‐dependent manner. Amyloid‐related synaptic changes are thought to precede tau …
View article: MK‐6240 tau‐PET in an Aβ‐enriched sample from the 1946 British birth cohort
MK‐6240 tau‐PET in an Aβ‐enriched sample from the 1946 British birth cohort Open
Background We investigated imaging biomarkers of Aβ and neurodegeneration in relation to tau‐PET Braak stage in a preclinical birth cohort. Method Cognitively normal individuals enrolled in Insight 46, the neuroimaging sub‐study of the MRC…
View article: Advanced measures of cortical microstructural change and associations with cognitive and blood‐based biomarkers in autosomal dominant Alzheimer’s disease
Advanced measures of cortical microstructural change and associations with cognitive and blood‐based biomarkers in autosomal dominant Alzheimer’s disease Open
Background In Alzheimer’s disease (AD), dysfunction and loss of cortical neurons occurs prior to symptom onset. Diffusion tensor imaging, measuring mean diffusivity (MD), provides a metric of microscopic change but lacks specificity for di…
View article: Associations between accelerated long‐term forgetting of Complex Figure Drawing, cerebral amyloid deposition, brain atrophy and serum neurofilament light in 73‐year‐olds
Associations between accelerated long‐term forgetting of Complex Figure Drawing, cerebral amyloid deposition, brain atrophy and serum neurofilament light in 73‐year‐olds Open
Background Accelerated Long‐term Forgetting (ALF) is the phenomenon whereby material is retained normally over short intervals (minutes or hours) but forgotten abnormally rapidly over longer periods (days or weeks). ALF may be an early mar…
View article: Advanced measures of cortical microstructural change and associations with cognitive and blood‐based biomarkers in autosomal dominant Alzheimer’s disease
Advanced measures of cortical microstructural change and associations with cognitive and blood‐based biomarkers in autosomal dominant Alzheimer’s disease Open
Background In Alzheimer’s disease (AD), dysfunction and loss of cortical neurons occurs prior to symptom onset. Diffusion tensor imaging, measuring mean diffusivity (MD), provides a metric of microscopic change but lacks specificity for di…
View article: Atypical presentations of autosomal dominant familial Alzheimer’s disease: insights into genetic, neuropathological and clinical heterogeneity
Atypical presentations of autosomal dominant familial Alzheimer’s disease: insights into genetic, neuropathological and clinical heterogeneity Open
Background Autosomal dominant familial Alzheimer’s disease (ADAD), caused by APP, PSEN1 and PSEN2 mutations, is clinically and pathologically similar to sporadic AD, with both typically presenting with memory impairment. However as in spor…
View article: Tau accumulation in autosomal dominant Alzheimer’s disease: a longitudinal [18F]flortaucipir study
Tau accumulation in autosomal dominant Alzheimer’s disease: a longitudinal [18F]flortaucipir study Open
View article: Cortical tau is associated with microstructural imaging biomarkers of neurite density and dendritic complexity in Alzheimer's disease
Cortical tau is associated with microstructural imaging biomarkers of neurite density and dendritic complexity in Alzheimer's disease Open
Introduction In Alzheimer's disease (AD), hyperphosphorylated tau is closely associated with focal neurodegeneration, but the mechanism remains uncertain. Methods We quantified cortical microstructure using neurite orientation dispersion a…
View article: The PSEN1 E280G mutation leads to increased amyloid-β43 production in induced pluripotent stem cell neurons and deposition in brain tissue
The PSEN1 E280G mutation leads to increased amyloid-β43 production in induced pluripotent stem cell neurons and deposition in brain tissue Open
Mutations in the presenilin 1 gene, PSEN1, which cause familial Alzheimer’s disease alter the processing of amyloid precursor protein, leading to the generation of various amyloid-β peptide species. These species differ in their potential …
View article: Plasma GFAP in presymptomatic and symptomatic familial Alzheimer’s disease: a longitudinal cohort study
Plasma GFAP in presymptomatic and symptomatic familial Alzheimer’s disease: a longitudinal cohort study Open
View article: Visual short-term memory impairments in presymptomatic familial Alzheimer's disease: A longitudinal observational study
Visual short-term memory impairments in presymptomatic familial Alzheimer's disease: A longitudinal observational study Open
View article: Transitioning from cerebrospinal fluid to blood tests to facilitate diagnosis and disease monitoring in Alzheimer's disease
Transitioning from cerebrospinal fluid to blood tests to facilitate diagnosis and disease monitoring in Alzheimer's disease Open
Alzheimer’s disease (AD) is increasingly prevalent worldwide, and disease‐modifying treatments may soon be at hand; hence, now, more than ever, there is a need to develop techniques that allow earlier and more secure diagnosis. Current bio…
View article: Plasma amyloid-β ratios in autosomal dominant Alzheimer’s disease: the influence of genotype
Plasma amyloid-β ratios in autosomal dominant Alzheimer’s disease: the influence of genotype Open
In vitro studies of autosomal dominant Alzheimer’s disease implicate longer amyloid-β peptides in disease pathogenesis; however, less is known about the behaviour of these mutations in vivo. In this cross-sectional cohort study, we used li…
View article: Visuomotor integration deficits are common to familial and sporadic preclinical Alzheimer’s disease
Visuomotor integration deficits are common to familial and sporadic preclinical Alzheimer’s disease Open
We investigated whether subtle visuomotor deficits were detectable in familial and sporadic preclinical Alzheimer’s disease. A circle-tracing task—with direct and indirect visual feedback, and dual-task subtraction—was completed by 31 indi…
View article: Plasma phospho‐tau in familial Alzheimer’s disease
Plasma phospho‐tau in familial Alzheimer’s disease Open
Background Blood biomarkers have the potential to advance clinical care and accelerate the development of disease‐modifying treatments. P‐tau181 is a promising blood biomarker, with levels increasing in Alzheimer’s disease (AD) dementia (d…
View article: Visual short-term memory impairments in presymptomatic familial Alzheimer’s disease: A longitudinal observational study
Visual short-term memory impairments in presymptomatic familial Alzheimer’s disease: A longitudinal observational study Open
Visual short-term memory (VSTM) deficits including VSTM binding have been associated with Alzheimer’s disease (AD) from preclinical to dementia stages, cross-sectionally. Yet, longitudinal investigations are lacking. The objective of this …
View article: Quantitative detection and staging of presymptomatic cognitive decline in familial Alzheimer’s disease: a retrospective cohort analysis
Quantitative detection and staging of presymptomatic cognitive decline in familial Alzheimer’s disease: a retrospective cohort analysis Open
Background Understanding the earliest manifestations of Alzheimer’s disease (AD) is key to realising disease-modifying treatments. Advances in neuroimaging and fluid biomarkers have improved our ability to identify AD pathology in vivo. Th…
View article: Measuring cortical mean diffusivity to assess early microstructural cortical change in presymptomatic familial Alzheimer’s disease
Measuring cortical mean diffusivity to assess early microstructural cortical change in presymptomatic familial Alzheimer’s disease Open
Background There is increasing interest in improving understanding of the timing and nature of early neurodegeneration in Alzheimer’s disease (AD) and developing methods to measure this in vivo. Autosomal dominant familial Alzheimer’s dise…
View article: Visual Short-term Memory Impairments in Presymptomatic Familial Alzheimer’s Disease: a Longitudinal Observational Study
Visual Short-term Memory Impairments in Presymptomatic Familial Alzheimer’s Disease: a Longitudinal Observational Study Open
Background: Cross-sectional studies in presymptomatic familial Alzheimer’s disease (FAD), have associated binding deficits with preclinical AD. How impairments in visual-short term memory (VSTM) relate to longitudinal change and proximity …
View article: Plasma phospho-tau181 in presymptomatic and symptomatic familial Alzheimer’s disease: a longitudinal cohort study
Plasma phospho-tau181 in presymptomatic and symptomatic familial Alzheimer’s disease: a longitudinal cohort study Open
View article: Longitudinal (<sup>18</sup>F)AV-1451 PET imaging in a patient with frontotemporal dementia due to a Q351R MAPT mutation
Longitudinal (<sup>18</sup>F)AV-1451 PET imaging in a patient with frontotemporal dementia due to a Q351R MAPT mutation Open
Mutations in the microtubule associated protein tau ( MAPT ) gene are a common cause of inherited frontotemporal dementia (FTD) and result in the deposition of pathological tau protein in the brain.1 Tau positron emission tomography (PET) …