Philip Tarr
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View article: Untargeted Metabolite Profile Associations With Body Mass Index, Waist–Hip Ratio, and Antiretroviral Therapy in >1300 People With HIV: The Swiss HIV Cohort Study
Untargeted Metabolite Profile Associations With Body Mass Index, Waist–Hip Ratio, and Antiretroviral Therapy in >1300 People With HIV: The Swiss HIV Cohort Study Open
Background How obesity and antiretroviral therapy (ART) are associated with specific metabolite profiles in people with HIV (PWH) is not well described. Methods In Swiss HIV Cohort Study participants, applying multiple linear regression, w…
View article: Population pharmacokinetics of bictegravir in real-world people with HIV
Population pharmacokinetics of bictegravir in real-world people with HIV Open
Objectives Bictegravir is an integrase strand transfer inhibitor widely prescribed due to its good efficacy and safety profile. Its pharmacokinetic (PK) profile has not been described in real-world settings yet. This study aimed to charact…
View article: Leukocyte count and new‐onset diabetes mellitus in people with <scp>HIV</scp>: A longitudinal study
Leukocyte count and new‐onset diabetes mellitus in people with <span>HIV</span>: A longitudinal study Open
Objectives The risk of diabetes mellitus (DM) is increased in people with HIV. Chronic inflammation contributes to DM risk. High leukocytes are associated with DM in the general population, but in people with HIV, evidence of a leukocyte–D…
View article: Low Trauma Fractures in People With HIV: Longitudinal Time Trends in the Swiss HIV Cohort Study, 2009–2022
Low Trauma Fractures in People With HIV: Longitudinal Time Trends in the Swiss HIV Cohort Study, 2009–2022 Open
Background People with human immunodeficiency virus (HIV) are at increased risk of low trauma fractures (LTFs). Published data on LTF incidence trends over time have not been uniform. This study sought to analyze LTF time trends in the Swi…
View article: Types of Myocardial Infarction in People With HIV in Switzerland
Types of Myocardial Infarction in People With HIV in Switzerland Open
Background Of myocardial infarctions (MIs) recorded in 2 large human immunodeficiency virus (HIV) observational studies from North America, approximately half were classified as type 2. In the REPRIEVE clinical trial of pitavastatin versus…
View article: HIV-1 Low-Level Viremia Predicts Viral Failure in Participants on Antiretroviral Therapy in the Swiss HIV Cohort Study
HIV-1 Low-Level Viremia Predicts Viral Failure in Participants on Antiretroviral Therapy in the Swiss HIV Cohort Study Open
Background Most individuals receiving combination antiretroviral therapy (ART) have human immunodeficiency virus (HIV) plasma viral loads below the limit of detection. However, episodes of low-level viremia (LLV) are observed in subsets of…
View article: Gender Disparities in Statin Prescriptions in People With HIV With Low/Moderate to High Cardiovascular Risk
Gender Disparities in Statin Prescriptions in People With HIV With Low/Moderate to High Cardiovascular Risk Open
The REPRIEVE trial suggests that primary cardiovascular disease (CVD) prevention could be considered among people with HIV at low CVD risk. We found cisgender women with low/moderate and high CVD risk are less likely to receive statins tha…
View article: La coqueluche et l’importance de la vaccination
La coqueluche et l’importance de la vaccination Open
View article: Integrase Strand Transfer Inhibitor–Related Changes in Body Mass Index and Risk of Diabetes: A Prospective Study From the RESPOND Cohort Consortium
Integrase Strand Transfer Inhibitor–Related Changes in Body Mass Index and Risk of Diabetes: A Prospective Study From the RESPOND Cohort Consortium Open
Background With integrase strand transfer inhibitor (INSTI) use associated with increased body mass index (BMI) and BMI increases associated with higher diabetes mellitus (DM) risk, we explored the relationships between INSTI/non-INSTI reg…
View article: External Validation of Serologic Scores for the Detection of Liver Steatosis Among People With HIV
External Validation of Serologic Scores for the Detection of Liver Steatosis Among People With HIV Open
Background Fatty liver index (FLI) and hepatic steatosis index (HSI) are serologic scores used to detect liver steatosis. However, their diagnostic performance in people with HIV (PWH) remains unclear. We performed an external validation o…
View article: Antibody and T-Cell Response to Bivalent Booster SARS-CoV-2 Vaccines in People With Compromised Immune Function: COVERALL-3 Study
Antibody and T-Cell Response to Bivalent Booster SARS-CoV-2 Vaccines in People With Compromised Immune Function: COVERALL-3 Study Open
Background Bivalent messenger RNA (mRNA) vaccines, designed to combat emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, incorporate ancestral strains and a new variant. Our study assessed the immune response i…
View article: Circulating HBV RNA and Hepatitis B Core–Related Antigen Trajectories in Persons With HIV/HBV Coinfection and Hepatitis B Surface Antigen Loss During Tenofovir Therapy
Circulating HBV RNA and Hepatitis B Core–Related Antigen Trajectories in Persons With HIV/HBV Coinfection and Hepatitis B Surface Antigen Loss During Tenofovir Therapy Open
Background We evaluated long-term trajectories of circulating hepatitis B virus (HBV) RNA and hepatitis B core–related antigen (HBcrAg) in persons with and without hepatitis B surface antigen (HBsAg) loss during tenofovir therapy in the Sw…
View article: Weight, Anthropometric and Metabolic Changes After Discontinuing Antiretroviral Therapy Containing Tenofovir Alafenamide (TAF) in People With Human Immunodeficiency Virus (HIV)
Weight, Anthropometric and Metabolic Changes After Discontinuing Antiretroviral Therapy Containing Tenofovir Alafenamide (TAF) in People With Human Immunodeficiency Virus (HIV) Open
Background Antiretroviral therapy (ART)-related weight gain is of particular concern in people with HIV (PWH). Although weight gain was observed among PWH receiving tenofovir alafenamide (TAF), little is known about the potential reversibi…
View article: Vaccination des nourrissons et des jeunes enfants contre la varicelle
Vaccination des nourrissons et des jeunes enfants contre la varicelle Open
View article: Varizellen-Impfung der Säuglinge und Kleinkinder
Varizellen-Impfung der Säuglinge und Kleinkinder Open
Einleitung Bis Ende 2022 war das Konzept des Bundesamt für Gesundheit (BAG) und der Eidgenössische Kommission für Impffragen (EKIF), dass Kinder die Varizellen (Wilde bzw.Spitze Blattern, Windpocken) «natürlich» als Kinderkrankheit durchma…
View article: HPV-Impfung
HPV-Impfung Open
View article: Vaccination contre les HPV
Vaccination contre les HPV Open
View article: Diagnosis and Therapy of Community-Acquired Pneumonia in the Emergency Department: A Retrospective Observational Study and Medical Audit
Diagnosis and Therapy of Community-Acquired Pneumonia in the Emergency Department: A Retrospective Observational Study and Medical Audit Open
Background: Despite advances in therapy, community-acquired pneumonia (CAP) is still associated with significant morbidity and mortality. Several studies conducted in different countries have reported suboptimal adherence to the guidelines…
View article: Deciphering Factors Linked With Reduced Severe Acute Respiratory Syndrome Coronavirus 2 Susceptibility in the Swiss HIV Cohort Study
Deciphering Factors Linked With Reduced Severe Acute Respiratory Syndrome Coronavirus 2 Susceptibility in the Swiss HIV Cohort Study Open
Background Factors influencing susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain to be resolved. Using data from the Swiss HIV Cohort Study on 6270 people with human immunodeficiency virus (HIV) and sero…
View article: Time Trends in Causes of Death in People With HIV: Insights From the Swiss HIV Cohort Study
Time Trends in Causes of Death in People With HIV: Insights From the Swiss HIV Cohort Study Open
Background Advancements in access to antiretroviral therapy (ART) and human immunodeficiency virus (HIV) care have led to a decline in AIDS-related deaths among people with HIV (PWH) in Switzerland. However, data on the ongoing changes in …
View article: Update Humanes Papillomavirus 2024 – Teil 1
Update Humanes Papillomavirus 2024 – Teil 1 Open
View article: Mise à jour sur les papillomavirus humains 2024 - 1ère partie
Mise à jour sur les papillomavirus humains 2024 - 1ère partie Open
View article: Real-world trough concentrations and effectiveness of long-acting cabotegravir and rilpivirine: a multicenter prospective observational study in Switzerland
Real-world trough concentrations and effectiveness of long-acting cabotegravir and rilpivirine: a multicenter prospective observational study in Switzerland Open
This work was funded by the Swiss National Science Foundation, grant number N◦ 324730_192449. This study received no support from pharmaceutical industries. This study was performed within the framework of the Swiss HIV Cohort S…
View article: Brief Report: Decreased Physical Activity and Prolonged Sitting Time Are Associated With Liver Steatosis in People With HIV
Brief Report: Decreased Physical Activity and Prolonged Sitting Time Are Associated With Liver Steatosis in People With HIV Open
Background: Physical activity (PA) regulates intrahepatic storage of fat and reduces the risk of liver steatosis. Given our limited understanding of the pathogenesis of metabolic complications in people with HIV (PWH), it remains unclear w…
View article: Zona et vaccination contre le zona
Zona et vaccination contre le zona Open
© * Études contrôlées contre placebo réalisées par le fabricant du vaccin et ayant conduit à l'autorisation des autorités: [6] observées pendant 3,2 ans après la vaccination, [80] observées pendant 3,7 ans après la vaccination.
View article: Antibody Response After the Third SARS-CoV-2 Vaccine in Solid Organ Transplant Recipients and People Living With HIV (COVERALL-2)
Antibody Response After the Third SARS-CoV-2 Vaccine in Solid Organ Transplant Recipients and People Living With HIV (COVERALL-2) Open
Background After basic immunization with 2 mRNA SARS-CoV-2 vaccine doses, only a small proportion of patients who are severely immunocompromised generate a sufficient antibody response. Hence, we assessed the additional benefit of a third …
View article: Zoster und Zoster-Impfung
Zoster und Zoster-Impfung Open
View article: Incidence of sexually transmitted infections and association with behavioural factors: Time‐to‐event analysis of a large pre‐exposure prophylaxis (<scp>PrEP</scp>) cohort
Incidence of sexually transmitted infections and association with behavioural factors: Time‐to‐event analysis of a large pre‐exposure prophylaxis (<span>PrEP</span>) cohort Open
Objectives Our objective was to obtain long‐term data on the incidence of sexually transmitted infections (STIs) and their association with behavioural factors after widespread pre‐exposure prophylaxis (PrEP) implementation. Methods This w…
View article: Impfungen bei Immunsuppression
Impfungen bei Immunsuppression Open
Personen mit einem geschwächten Immunsystem möchten wir besonders gut vor durch Impfung verhinderbaren Infektionen schützen. Die Impfverträglichkeit sollte nicht anders sein als in der Allgemeinbevölkerung, aber Lebendimpfstoffe sind aus S…
View article: Vaccination en cas d'immunosuppression
Vaccination en cas d'immunosuppression Open
Nous souhaitons protéger en particulier les personnes dont le système immunitaire est affaibli contre les infections évitables par la vaccination. La tolérance aux vaccins ne devrait pas être différente de celle de la population générale, …