Philipp Beumers
YOU?
Author Swipe
View article: Distinct reduction in relative microglial glucose uptake compared to astrocytes and neurons upon isolation from the brain environment
Distinct reduction in relative microglial glucose uptake compared to astrocytes and neurons upon isolation from the brain environment Open
Introduction Microglial energy metabolism has gained attention for the treatment of neurodegenerative diseases. In vitro methods provide important insights; however, it remains unclear whether the metabolism of highly motile microglia is p…
View article: Astroglial glucose uptake determines brain FDG-PET alterations and metabolic connectivity during healthy aging in mice
Astroglial glucose uptake determines brain FDG-PET alterations and metabolic connectivity during healthy aging in mice Open
Trajectories of astroglial glucose uptake drive brain FDG-PET alterations and metabolic connectivity during aging.
View article: Deciphering sources of PET signals in the tumor microenvironment of glioblastoma at cellular resolution
Deciphering sources of PET signals in the tumor microenvironment of glioblastoma at cellular resolution Open
Various cellular sources hamper interpretation of positron emission tomography (PET) biomarkers in the tumor microenvironment (TME). We developed an approach of immunomagnetic cell sorting after in vivo radiotracer injection (scRadiotracin…
View article: Deciphering sources of PET signals in the tumor microenvironment of glioblastoma at cellular resolution
Deciphering sources of PET signals in the tumor microenvironment of glioblastoma at cellular resolution Open
Various cellular sources hamper interpretation of positron-emission-tomography (PET) biomarkers in the tumor microenvironment (TME). We developed immunomagnetic cell sorting after in vivo radiotracer injection (scRadiotracing) in combinati…
A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models Open
Loss-of-function variants of TREM2 are associated with increased risk of Alzheimer’s disease (AD), suggesting that activation of this innate immune receptor may be a useful therapeutic strategy. Here we describe a high-affinity human TREM2…
View article: NIMG-51. 18KDA TRANSLOCATOR PROTEIN (TSPO) DECLINES IN TUMOR AND IMMUNE CELLS DURING PROGRESSION OF EXPERIMENTAL GLIOBLASTOMA
NIMG-51. 18KDA TRANSLOCATOR PROTEIN (TSPO) DECLINES IN TUMOR AND IMMUNE CELLS DURING PROGRESSION OF EXPERIMENTAL GLIOBLASTOMA Open
Glioblastoma combines a lack of immunogenicity with a highly immunosuppressive tumor microenvironment (TME), including both tumor and immune cells. However, biomarkers that allow monitoring of the immune phenotype are still lacking. Hence,…
Single-Cell Radiotracer Allocation via Immunomagnetic Sorting to Disentangle PET Signals at Cellular Resolution Open
With great interest, our independent groups of scientists located in Korea and Germany recognized the use of a very similar methodologic approach to quantify the uptake of radioactive glucose (18F-FDG) at the cellular level. The focus of o…