Philipp Boder
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View article: Early renal response to long-term salt loading: mitochondrial dysfunction, ER stress, and uromodulin accumulation in the kidney medulla
Early renal response to long-term salt loading: mitochondrial dysfunction, ER stress, and uromodulin accumulation in the kidney medulla Open
This study reveals that even in normotensive Wistar Kyoto rats, mild long-term salt loading induces early renal stress without overt kidney damage or hypertension. Novel findings include reduced uromodulin (UMOD) excretion and altered intr…
View article: #2062 Protein interactome and trafficking of uromodulin in HEK and MDCK cell model
#2062 Protein interactome and trafficking of uromodulin in HEK and MDCK cell model Open
Background and Aims Uromodulin (UMOD) is a kidney-specific glycoprotein and the most abundant urinary protein in healthy individuals. Genome-wide association studies have shown an association between UMOD variants, kidney diseases, and hyp…
View article: P19 Protein interactome and trafficking of uromodulin in HEK and MDCK cell model
P19 Protein interactome and trafficking of uromodulin in HEK and MDCK cell model Open
Uromodulin (UMOD) is a kidney-specific glycoprotein and the most abundant urinary protein in healthy individuals. Genome-wide association studies have shown an association between UMOD variants, kidney diseases, and hypertension. UMOD exh…
View article: Skin-specific mechanisms of body fluid regulation in hypertension
Skin-specific mechanisms of body fluid regulation in hypertension Open
Increasing evidence suggests excess skin Na+ accumulation in hypertension; however, the role of skin-specific mechanisms of local Na+/water regulation remains unclear. We investigated the association between measures of sweat and trans-epi…
View article: Role of Uromodulin in Salt-Sensitive Hypertension
Role of Uromodulin in Salt-Sensitive Hypertension Open
The exclusive expression of uromodulin in the kidneys has made it an intriguing protein in kidney and cardiovascular research. Genome-wide association studies discovered variants of uromodulin that are associated with chronic kidney diseas…
View article: Salt loading decreases urinary excretion and increases intracellular accumulation of uromodulin in stroke-prone spontaneously hypertensive rats
Salt loading decreases urinary excretion and increases intracellular accumulation of uromodulin in stroke-prone spontaneously hypertensive rats Open
Uromodulin (UMOD) is the most abundant renal protein secreted into urine by the thick ascending limb (TAL) epithelial cells of the loop of Henle. Genetic studies have demonstrated an association between UMOD risk variants and hypertension.…
View article: Mechanistic interactions of uromodulin with the thick ascending limb: perspectives in physiology and hypertension
Mechanistic interactions of uromodulin with the thick ascending limb: perspectives in physiology and hypertension Open
Hypertension is a significant risk factor for cardiovascular disease and mortality worldwide. The kidney is a major regulator of blood pressure and electrolyte homeostasis, with monogenic disorders indicating a link between abnormal ion tr…