Philipp Demling
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View article: Polyphosphate Accumulation Is Determined by Zinc and Inositol in <i>Saccharomyces cerevisiae</i>
Polyphosphate Accumulation Is Determined by Zinc and Inositol in <i>Saccharomyces cerevisiae</i> Open
Polyphosphate (polyP) is an intriguing polymer with diverse biological and industrial applications. Chemical polyP production is energy‐intensive and limited in chain length at large‐scale production. Alternatively, biological production o…
View article: Coming to Terms: The Mechanisms of Overplus and Luxury Phosphorus Uptake for Polyphosphate Storage in Microalgae and Yeast
Coming to Terms: The Mechanisms of Overplus and Luxury Phosphorus Uptake for Polyphosphate Storage in Microalgae and Yeast Open
Polyphosphate (polyP) synthesis is ubiquitous in organisms, including microorganisms such as microalgae and yeasts, playing a crucial role in phosphorus (P) metabolism (e.g., storage) and in other vital functions. Two mechanisms are broadl…
View article: Coming to terms: The mechanisms of overplus and luxury phosphorus uptake for polyphosphate storage in microalgae and yeast
Coming to terms: The mechanisms of overplus and luxury phosphorus uptake for polyphosphate storage in microalgae and yeast Open
View article: Window of sustainable bioprocess operation: towards merging environmental sustainability assessment and process operation at early-stage bioprocess development
Window of sustainable bioprocess operation: towards merging environmental sustainability assessment and process operation at early-stage bioprocess development Open
View article: Acetol biosynthesis enables NADPH balance during nitrogen limitation in engineered Escherichia coli
Acetol biosynthesis enables NADPH balance during nitrogen limitation in engineered Escherichia coli Open
View article: Biotechnological polyphosphate as an opportunity to contribute to the circularization of the phosphate economy
Biotechnological polyphosphate as an opportunity to contribute to the circularization of the phosphate economy Open
Polyphosphates, chains of polymerized phosphate subunits, are used as food additives for various applications such as conservation, water retention, and pH buffering. Currently, the value chain of phosphates is linear, based on mining foss…
View article: Foam control in biotechnological processes—challenges and opportunities
Foam control in biotechnological processes—challenges and opportunities Open
Foam formation is a massive challenge in submerged aerated bioprocesses, e.g., in beer fermentation. While the use of antifoam may easily overcome foaming at laboratory scale, it is often an unattractive solution since the challenge remain…
View article: Novel multiphase loop reactor with improved aeration prevents excessive foaming in Rhamnolipid production by Pseudomonas putida
Novel multiphase loop reactor with improved aeration prevents excessive foaming in Rhamnolipid production by Pseudomonas putida Open
Rhamnolipids are biosurfactants that tend to cause strong foaming, making microbial production in an aerated stirred tank fermenter challenging. The continuous removal of rhamnolipids from the cultivation broth via in situ liquid-liquid ex…
View article: Novel multiphase loop reactor with improved aeration enables foam-free rhamnolipid production by Pseudomonas putida
Novel multiphase loop reactor with improved aeration enables foam-free rhamnolipid production by Pseudomonas putida Open
The novel multiphase loop reactor is a modified airlift reactor with an internal loop enabling continuous in situ liquid-liquid extraction. In this study, the reactor is applied for a microbial production of biosurfactants. The obligate ae…
View article: <i>Pseudomonas putida</i> KT2440 endures temporary oxygen limitations
<i>Pseudomonas putida</i> KT2440 endures temporary oxygen limitations Open
The obligate aerobic nature of Pseudomonas putida , one of the most prominent whole‐cell biocatalysts emerging for industrial bioprocesses, questions its ability to be cultivated in large‐scale bioreactors, which exhibit zones of low disso…
View article: Bioprocess intensification in a novel multiphase loop reactor
Bioprocess intensification in a novel multiphase loop reactor Open
View article: Microfluidic Irreversible Electroporation—A Versatile Tool to Extract Intracellular Contents of Bacteria and Yeast
Microfluidic Irreversible Electroporation—A Versatile Tool to Extract Intracellular Contents of Bacteria and Yeast Open
Exploring the dynamic behavior of cellular metabolism requires a standard laboratory method that guarantees rapid sampling and extraction of the cellular content. We propose a versatile sampling technique applicable to cells with different…
View article: Microfluidic Irreversible Electroporation – A Versatile Tool to Extract Intracellular Contents of Bacteria and Yeast
Microfluidic Irreversible Electroporation – A Versatile Tool to Extract Intracellular Contents of Bacteria and Yeast Open
Exploring the dynamic behavior of cellular metabolism requires a standard laboratory method that guarantees rapid sampling and extraction of the cellular content. We propose a versatile sampling technique applicable to cells with different…
View article: Restoration of biofuel production levels and increased tolerance under ionic liquid stress is enabled by a mutation in the essential Escherichia coli gene cydC
Restoration of biofuel production levels and increased tolerance under ionic liquid stress is enabled by a mutation in the essential Escherichia coli gene cydC Open
View article: Development of a Modular Biosensor System for Rapid Pathogen Detection
Development of a Modular Biosensor System for Rapid Pathogen Detection Open
Progress in the field of pathogen detection relies on at least one of the following three qualities: selectivity, speed, and cost-effectiveness. Here, we demonstrate a proof of concept for an optical biosensing system for the detection of …
View article: MOESM3 of Restoration of biofuel production levels and increased tolerance under ionic liquid stress is enabled by a mutation in the essential Escherichia coli gene cydC
MOESM3 of Restoration of biofuel production levels and increased tolerance under ionic liquid stress is enabled by a mutation in the essential Escherichia coli gene cydC Open
Additional file 3. Shotgun proteomics raw data for cydC-D86G and control strains.
View article: MOESM4 of Restoration of biofuel production levels and increased tolerance under ionic liquid stress is enabled by a mutation in the essential Escherichia coli gene cydC
MOESM4 of Restoration of biofuel production levels and increased tolerance under ionic liquid stress is enabled by a mutation in the essential Escherichia coli gene cydC Open
Additional file 4. Targeted MRM proteomics raw data for cydC-D86G and control strains.
View article: MOESM2 of Restoration of biofuel production levels and increased tolerance under ionic liquid stress is enabled by a mutation in the essential Escherichia coli gene cydC
MOESM2 of Restoration of biofuel production levels and increased tolerance under ionic liquid stress is enabled by a mutation in the essential Escherichia coli gene cydC Open
Additional file 2. Phylogenetic analysis of cydC and cydB genomic co-occurrence in bacterial genomes.