Philipp E. Hartrampf
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View article: SSTR-directed peptide receptor radionuclide therapy for recurrent meningiomas: analysis of safety, efficacy and prognostic factors
SSTR-directed peptide receptor radionuclide therapy for recurrent meningiomas: analysis of safety, efficacy and prognostic factors Open
Purpose This study evaluates safety and efficacy of peptide receptor radionuclide therapy (PRRT) as a stand-alone treatment for recurrent meningiomas and investigates the prognostic value of laboratory markers and quantitative PET paramete…
View article: Combined [18F]Fluorodeoxyglucose PET and [123I]Iodometomidate-SPECT for diagnostic evaluation of indeterminate adrenal neoplasias—the cross-sectional diagnostic test accuracy study FAMIAN
Combined [18F]Fluorodeoxyglucose PET and [123I]Iodometomidate-SPECT for diagnostic evaluation of indeterminate adrenal neoplasias—the cross-sectional diagnostic test accuracy study FAMIAN Open
German Research Foundation and EU-FP7.
View article: Detection of Local Prostate Cancer Recurrence from PET/CT Scans Using Deep Learning
Detection of Local Prostate Cancer Recurrence from PET/CT Scans Using Deep Learning Open
Background: Prostate cancer (PC) is a leading cause of cancer-related deaths in men worldwide. PSMA-directed positron emission tomography (PET) has shown promising results in detecting recurrent PC and metastasis, improving the accuracy of…
View article: PSMA PET/CT in biochemical recurrence of prostate cancer with PSA levels ≤ 0.2 ng/mL: a German multicenter analysis of conventional PSMA tracers, including [68Ga]Ga-PSMA-11, [68Ga]Ga-PSMA I&T, and [18F]PSMA-1007
PSMA PET/CT in biochemical recurrence of prostate cancer with PSA levels ≤ 0.2 ng/mL: a German multicenter analysis of conventional PSMA tracers, including [68Ga]Ga-PSMA-11, [68Ga]Ga-PSMA I&T, and [18F]PSMA-1007 Open
View article: 131I SPECT/CT provides prognostic information in patients with differentiated thyroid cancer
131I SPECT/CT provides prognostic information in patients with differentiated thyroid cancer Open
View article: Detection of Local Prostate Cancer Recurrence from PET/CT Scans Using Deep Learning
Detection of Local Prostate Cancer Recurrence from PET/CT Scans Using Deep Learning Open
Prostate cancer (PC) is a leading cause of cancer-related deaths in men worldwide. PSMA-directed positron emission tomography (PET) has shown promising results in detecting recurrent PC and metastasis. We developed a deep-learning model to…
View article: Somatostatin Receptor-Directed Theranostics in Esthesioneuroblastoma
Somatostatin Receptor-Directed Theranostics in Esthesioneuroblastoma Open
Background: We aim to report on somatostatin receptor (SSTR)-targeted molecular imaging and therapy in patients with advanced esthesioneuroblastoma (ENB). Patients and Methods: Five patients with ENB [Kadish stage D in 5/5 (100%); Hyams gr…
View article: C-X-C motif chemokine receptor 4-directed PET signal in the arterial tree is not consistently linked to calcified plaque burden and cardiovascular risk
C-X-C motif chemokine receptor 4-directed PET signal in the arterial tree is not consistently linked to calcified plaque burden and cardiovascular risk Open
Purpose: To establish the extent, distribution and frequency of in-vivo vessel wall [68Ga]Ga-PentixaFor uptake and to determine its relationship with calcified atherosclerotic plaque burden (CAP) and cardiovascular risk f…
View article: [<sup>18</sup>F]FDG and [<sup>68</sup>Ga]Ga-FAPI-04–Directed Imaging for Outcome Prediction in Patients with High-Grade Neuroendocrine Neoplasms
[<sup>18</sup>F]FDG and [<sup>68</sup>Ga]Ga-FAPI-04–Directed Imaging for Outcome Prediction in Patients with High-Grade Neuroendocrine Neoplasms Open
We aimed to quantitatively investigate the prognostic value of PET-based biomarkers on [18F]FDG and [68Ga]Ga-fibroblast activation protein inhibitor (FAPI)-04 PET/CT in patients with highly aggressive neuroendocrine n…
View article: Predictive value of C-X-C motif chemokine receptor 4-directed molecular imaging in patients with advanced adrenocortical carcinoma
Predictive value of C-X-C motif chemokine receptor 4-directed molecular imaging in patients with advanced adrenocortical carcinoma Open
View article: Modelling the In Vivo and Ex Vivo DNA Damage Response after Internal Irradiation of Blood from Patients with Thyroid Cancer
Modelling the In Vivo and Ex Vivo DNA Damage Response after Internal Irradiation of Blood from Patients with Thyroid Cancer Open
This work reports on a model that describes patient-specific absorbed dose-dependent DNA damage response in peripheral blood mononuclear cells of thyroid cancer patients during radioiodine therapy and compares the results with the ex vivo …
View article: Prognostic role of quantitative [18F]FDG PET/CT parameters in adrenocortical carcinoma
Prognostic role of quantitative [18F]FDG PET/CT parameters in adrenocortical carcinoma Open
View article: Volumetric Parameters Derived from CXCR4-Directed PET/CT Predict Outcome in Patients with Gastrointestinal Neuroendocrine Carcinomas
Volumetric Parameters Derived from CXCR4-Directed PET/CT Predict Outcome in Patients with Gastrointestinal Neuroendocrine Carcinomas Open
View article: Combined [18f]Fluorodeoxyglucose Pet and [123i]Iodometomidate-SPECT for Diagnostic Evaluation of Indeterminate Adrenal Neoplasias – The Prospective Cross-Sectional Diagnostic Test Accuracy Study FAMIAN
Combined [18f]Fluorodeoxyglucose Pet and [123i]Iodometomidate-SPECT for Diagnostic Evaluation of Indeterminate Adrenal Neoplasias – The Prospective Cross-Sectional Diagnostic Test Accuracy Study FAMIAN Open
View article: Radiopharmaceuticals for Treatment of Adrenocortical Carcinoma
Radiopharmaceuticals for Treatment of Adrenocortical Carcinoma Open
Adrenocortical carcinoma (ACC) represents a rare tumor entity with limited treatment options and usually rapid tumor progression in case of metastatic disease. As further treatment options are needed and ACC metastases are sensitive to ext…
View article: CXCR4-directed PET/CT with [68 Ga]Ga-pentixafor in solid tumors—a comprehensive analysis of imaging findings and comparison with histopathology
CXCR4-directed PET/CT with [68 Ga]Ga-pentixafor in solid tumors—a comprehensive analysis of imaging findings and comparison with histopathology Open
Background C-X-C motif chemokine receptor 4 (CXCR4) is overexpressed in various solid cancers and can be targeted by CXCR4-directed molecular imaging. We aimed to characterize the in-vivo CXCR4 expression in patients affected with solid tu…
View article: Chemokine receptor–targeted PET/CT provides superior diagnostic performance in newly diagnosed marginal zone lymphoma patients: a head-to-head comparison with [18F]FDG
Chemokine receptor–targeted PET/CT provides superior diagnostic performance in newly diagnosed marginal zone lymphoma patients: a head-to-head comparison with [18F]FDG Open
View article: Complete loss of E-cadherin expression in a rare case of metastatic malignant meningioma: a case report
Complete loss of E-cadherin expression in a rare case of metastatic malignant meningioma: a case report Open
Background Hematogenous tumor spread of malignant meningiomas occurs very rarely but is associated with very poor prognosis. Case presentation We report an unusual case of a patient with a malignant meningioma who developed multiple metast…
View article: Comparison of PET/CT-based eligibility according to VISION and TheraP trial criteria in end-stage prostate cancer patients undergoing radioligand therapy
Comparison of PET/CT-based eligibility according to VISION and TheraP trial criteria in end-stage prostate cancer patients undergoing radioligand therapy Open
View article: Long-Term Nephrotoxicity of<sup>177</sup>Lu-PSMA Radioligand Therapy
Long-Term Nephrotoxicity of<sup>177</sup>Lu-PSMA Radioligand Therapy Open
β-emitting 177Lu targeting prostate-specific membrane antigen (PSMA) is an approved treatment option for metastatic castration-resistant prostate cancer. Data on its long-term nephrotoxicity are sparse. This study aimed to retro…
View article: Chemokine Receptor PET/CT Provides Relevant Staging and Management Changes in Marginal Zone Lymphoma
Chemokine Receptor PET/CT Provides Relevant Staging and Management Changes in Marginal Zone Lymphoma Open
Because of gastral and extranodal manifestations, guideline-compatible diagnostic work-up of marginal zone lymphoma is challenging. We aimed to determine the diagnostic performance of C-X-C motif chemokine receptor 4 (CXCR4)-directed PET/C…
View article: Somatostatin Receptor–Directed PET/CT Can Differentiate Between Different Subtypes of Head and Neck Paragangliomas
Somatostatin Receptor–Directed PET/CT Can Differentiate Between Different Subtypes of Head and Neck Paragangliomas Open
Background Given their neuroendocrine origin, head and neck paragangliomas (HNPGLs) can be imaged with somatostatin receptor (SSTR)–directed PET/CT. We aimed to determine whether the in vivo PET signal can differentiate between varying HNP…
View article: PSMA-PET improves deep learning-based automated CT kidney segmentation
PSMA-PET improves deep learning-based automated CT kidney segmentation Open
This study shows that deep-learning based kidney segmentation can be significantly improved through the addition of a PET-based pre-segmentation. The presented method was shown to be especially beneficial for kidneys with cysts or kidneys …
View article: Early biochemical and radiographic response after one cycle of [177Lu]Lu-PSMA I&T radioligand therapy in metastatic castration-resistant prostate cancer patients
Early biochemical and radiographic response after one cycle of [177Lu]Lu-PSMA I&T radioligand therapy in metastatic castration-resistant prostate cancer patients Open
Purpose The aim of this study was to investigate very early radiographic PSMA PET response after one cycle of [ 177 Lu]Lu-PSMA I&T radioligand therapy (RLT) of metastatic castration-resistant prostate cancer (mCRPC) and to assess its role …
View article: Prostate-specific Membrane Antigen Reporting and Data System Version 2.0
Prostate-specific Membrane Antigen Reporting and Data System Version 2.0 Open
View article: CXCR4-Directed Imaging and Endoradiotherapy in Desmoplastic Small Round Cell Tumors
CXCR4-Directed Imaging and Endoradiotherapy in Desmoplastic Small Round Cell Tumors Open
Desmoplastic small round cell tumor (DSRCT) is a rare, radiosensitive, yet difficult-to-treat sarcoma subtype affecting predominantly male adolescents. Extensive intraperitoneal seeding is common and requires multimodal management. With no…
View article: Elevated Body Mass Index Is Associated with Improved Overall Survival in Castration-Resistant Prostate Cancer Patients Undergoing Prostate-Specific Membrane Antigen–Directed Radioligand Therapy
Elevated Body Mass Index Is Associated with Improved Overall Survival in Castration-Resistant Prostate Cancer Patients Undergoing Prostate-Specific Membrane Antigen–Directed Radioligand Therapy Open
In patients with prostate cancer scheduled for systemic treatment, being overweight is linked to prolonged overall survival (OS), whereas sarcopenia is associated with shorter OS. We investigated fat-related and body composition parameters…
View article: Lymphoma-Sink Effect in Marginal Zone Lymphoma Based on CXCR4-Targeted Molecular Imaging
Lymphoma-Sink Effect in Marginal Zone Lymphoma Based on CXCR4-Targeted Molecular Imaging Open
View article: SUVmean on baseline [18F]PSMA-1007 PET and clinical parameters are associated with survival in prostate cancer patients scheduled for [177Lu]Lu-PSMA I&T
SUVmean on baseline [18F]PSMA-1007 PET and clinical parameters are associated with survival in prostate cancer patients scheduled for [177Lu]Lu-PSMA I&T Open
View article: Molecular imaging of arterial fibroblast activation protein: association with calcified plaque burden and cardiovascular risk factors
Molecular imaging of arterial fibroblast activation protein: association with calcified plaque burden and cardiovascular risk factors Open