Philipp Eisele
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View article: Multimodal Quantitative MRI Atlas of the Human Brain in Healthy Young Adults
Multimodal Quantitative MRI Atlas of the Human Brain in Healthy Young Adults Open
Background and Purpose Quantitative MRI provides insights into (patho‐) physiological processes of the brain macro‐ and microstructure. In this study, we applied a multimodal MRI approach to determine quantitative values of the brain in he…
View article: Cell type mapping reveals tissue niches and interactions in subcortical multiple sclerosis lesions
Cell type mapping reveals tissue niches and interactions in subcortical multiple sclerosis lesions Open
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system. Inflammation is gradually compartmentalized and restricted to specific tissue niches such as the lesion rim. However, the precise cell type compositio…
View article: H3K27M neoepitope vaccination in diffuse midline glioma induces B and T cell responses across diverse HLA loci of a recovered patient
H3K27M neoepitope vaccination in diffuse midline glioma induces B and T cell responses across diverse HLA loci of a recovered patient Open
H3K27M, a driver mutation with T and B cell neoepitope characteristics, defines an aggressive subtype of diffuse glioma with poor survival. We functionally dissect the immune response of one patient treated with an H3K27M peptide vaccine w…
View article: A generalizable deep voxel-guided morphometry algorithm for the detection of subtle lesion dynamics in multiple sclerosis
A generalizable deep voxel-guided morphometry algorithm for the detection of subtle lesion dynamics in multiple sclerosis Open
Introduction Multiple sclerosis (MS) is a chronic neurological disorder characterized by the progressive loss of myelin and axonal structures in the central nervous system. Accurate detection and monitoring of MS-related changes in brain s…
View article: Myeloid cell iron uptake pathways and paramagnetic rim formation in multiple sclerosis
Myeloid cell iron uptake pathways and paramagnetic rim formation in multiple sclerosis Open
In multiple sclerosis (MS), sustained inflammatory activity can be visualized by iron-sensitive magnetic resonance imaging (MRI) at the edges of chronic lesions. These paramagnetic rim lesions (PRLs) are associated with clinical worsening,…
View article: PL01.4.A LATE BREAKING ABSTRACT: A LONG PEPTIDE VACCINE TARGETING THE CLONAL DRIVER MUTATION H3K27M IN ADULT PATIENTS WITH DIFFUSE MIDLINE GLIOMA
PL01.4.A LATE BREAKING ABSTRACT: A LONG PEPTIDE VACCINE TARGETING THE CLONAL DRIVER MUTATION H3K27M IN ADULT PATIENTS WITH DIFFUSE MIDLINE GLIOMA Open
BACKGROUND Clonal and mutually exclusive substitution of lysine 27 to methionine in histone H3-3A (H3K27M) defines an aggressive subtype of diffuse glioma. These diffuse midline gliomas (DMG) are aggressive, incurable primary brain tumors …
View article: Cerebrospinal fluid–related tissue damage in multiple sclerosis patients with iron rim lesions
Cerebrospinal fluid–related tissue damage in multiple sclerosis patients with iron rim lesions Open
Background: In multiple sclerosis (MS), iron rim lesions (IRLs) are associated with pronounced tissue damage, higher disease severity and have been suggested as an imaging marker of chronic active inflammation behind the blood–brain barrie…
View article: Multiple sclerosis iron rim lesions are linked to impaired cervical spinal cord integrity using the T1/T2‐weighted ratio
Multiple sclerosis iron rim lesions are linked to impaired cervical spinal cord integrity using the T1/T2‐weighted ratio Open
Background and Purpose In multiple sclerosis (MS), iron rim lesions (IRLs) are characterized by pronounced tissue matrix damage. The T1/T2‐weighted (T1/T2w) ratio represents a postprocessing MRI approach to investigate tissue integrity, bu…
View article: Concurrent gliomas in patients with multiple sclerosis
Concurrent gliomas in patients with multiple sclerosis Open
Background Concurrent malignant brain tumors in patients with multiple sclerosis (MS) constitute a rare but paradigmatic phenomenon for studying neuroimmunological mechanisms from both molecular and clinical perspectives. Methods A multice…
View article: Impact of disease-modifying therapies on evolving tissue damage in iron rim multiple sclerosis lesions
Impact of disease-modifying therapies on evolving tissue damage in iron rim multiple sclerosis lesions Open
We investigated the impact of disease-modifying therapies (DMTs) on the evolving tissue damage in iron rim multiple sclerosis lesions using a novel post-processing magnetic resonance imaging (MRI) approach, the T1/T2 ratio. In this study, …
View article: Association of iron rim lesions with brain and cervical cord volume in relapsing multiple sclerosis
Association of iron rim lesions with brain and cervical cord volume in relapsing multiple sclerosis Open
Objectives In multiple sclerosis (MS), iron rim lesions (IRLs) are indicators of chronic low-grade inflammation and ongoing tissue destruction. The aim of this study was to assess the relationship of IRLs with clinical measures and magneti…
View article: Characterization of chronic active multiple sclerosis lesions with sodium (<sup>23</sup>Na) magnetic resonance imaging—preliminary observations
Characterization of chronic active multiple sclerosis lesions with sodium (<sup>23</sup>Na) magnetic resonance imaging—preliminary observations Open
Background and purpose There has been an increasing interest in chronic active multiple sclerosis (MS) lesions as a new magnetic resonance imaging (MRI) marker of disease progression. Chronic active lesions are characterized by progressive…
View article: MRI topography of lesions related to internuclear ophthalmoplegia in patients with multiple sclerosis or ischemic stroke
MRI topography of lesions related to internuclear ophthalmoplegia in patients with multiple sclerosis or ischemic stroke Open
Background and Purpose Internuclear ophthalmoplegia is a dysfunction of conjugate eye movements, caused by lesions affecting the medial longitudinal fasciculus (MLF). Multiple sclerosis (MS) and ischemic stroke represent the most common pa…
View article: Susceptibility‐Weighted 3T MRI of the Swallow Tail Sign in Multiple Sclerosis: A Case Control Study
Susceptibility‐Weighted 3T MRI of the Swallow Tail Sign in Multiple Sclerosis: A Case Control Study Open
BACKGROUND AND PURPOSE The swallow tail sign describes the physiological appearance of nigrosome‐1 within the substantia nigra on high‐resolution transverse susceptibility‐weighted imaging (SWI). Previous studies demonstrated its absence i…
View article: Nivolumab for treatment of progressive multifocal leukoencephalopathy in Sézary syndrome
Nivolumab for treatment of progressive multifocal leukoencephalopathy in Sézary syndrome Open
Progressive multifocal leukoencephalopathy (PML) is a rare but severe opportunistic central nervous system infection caused by John Cunningham (JC) polyomavirus (JCPyV) in immunosuppressed patients. Immune checkpoint blockade stimulates im…
View article: Shedding light on the clinical recognition process of transient global amnesia
Shedding light on the clinical recognition process of transient global amnesia Open
Background and purpose Diagnostic uncertainty is common in the emergency evaluation of neurological conditions such as acute confusional states, particularly for non‐neurologists. We aimed to investigate the clinical recognition process of…
View article: <p>Comparing Expert and Non-Expert Assessment of Patients Presenting with Neurological Symptoms to the Emergency Department: A Retrospective Observational Study</p>
Comparing Expert and Non-Expert Assessment of Patients Presenting with Neurological Symptoms to the Emergency Department: A Retrospective Observational Study Open
The ESI may not take specific aspects of neurological emergency (eg, time-sensitivity) sufficiently into account. Refinements of existing systems or supplementation with dedicated neurological triage tools based on neurological expertise a…
View article: Comparing Expert and Non-Expert Assessment of Patients Presenting with Neurological Symptoms to the Emergency Department: A Retrospective Observational Study
Comparing Expert and Non-Expert Assessment of Patients Presenting with Neurological Symptoms to the Emergency Department: A Retrospective Observational Study Open
Carolin Hoyer,1 Patrick Stein,1 Anne Ebert,1 Hans-Werner Rausch,1 Simon Nagel,2 Philipp Eisele,1 Angelika Alonso,1 Michael Platten,1 Kristina Szabo1 1Department of Neurology, UniversitätsMedizin Mannheim, Heidelberg University, Mannheim, G…
View article: Quantitative Signal Intensity in Fluid-Attenuated Inversion Recovery and Treatment Effect in the WAKE-UP Trial
Quantitative Signal Intensity in Fluid-Attenuated Inversion Recovery and Treatment Effect in the WAKE-UP Trial Open
Background and Purpose— Relative signal intensity of acute ischemic stroke lesions in fluid-attenuated inversion recovery (fluid-attenuated inversion recovery relative signal intensity [FLAIR-rSI]) magnetic resonance imaging is associated …
View article: Characterization of Contrast-Enhancing and Non-contrast-enhancing Multiple Sclerosis Lesions Using Susceptibility-Weighted Imaging
Characterization of Contrast-Enhancing and Non-contrast-enhancing Multiple Sclerosis Lesions Using Susceptibility-Weighted Imaging Open
Susceptibility-weighted magnetic resonance imaging (MRI) (SWI) offers additional information on conventional MRI contrasts. Central veins can be identified within lesions, and recently, it has been suggested that multiple sclerosis (MS) le…
View article: Spatiotemporal evolution of venous narrowing in acute MS lesions
Spatiotemporal evolution of venous narrowing in acute MS lesions Open
Our findings contribute to the increasing database of plaque development and evolution. The smaller diameter of intralesional veins on SWI at the time of blood-brain barrier breakdown may reflect morphologic changes because of perivascular…
View article: Early structural changes of the heart after experimental polytrauma and hemorrhagic shock
Early structural changes of the heart after experimental polytrauma and hemorrhagic shock Open
Evidence is emerging that systemic inflammation after trauma drives structural and functional impairment of cardiomyocytes and leads to cardiac dysfunction, thus worsening the outcome of polytrauma patients. This study investigates the str…
View article: Idarucizumab as Antidote to Intracerebral Hemorrhage under Treatment with Dabigatran
Idarucizumab as Antidote to Intracerebral Hemorrhage under Treatment with Dabigatran Open
Background and Purpose: Non-vitamin K anticoagulants (NOAC) such as dabigatran have become important therapeutic options for the prevention of stroke. Until recently, there were only nonspecific agents to reverse their anticoagulant effect…
View article: Lack of increased signal intensity in the dentate nucleus after repeated administration of a macrocyclic contrast agent in multiple sclerosis
Lack of increased signal intensity in the dentate nucleus after repeated administration of a macrocyclic contrast agent in multiple sclerosis Open
Recently, several studies reported increased signal intensity (SI) in the dentate nucleus (DN) after repeated application of gadolinium-based contrast agents (GBCAs), suggesting a deposition of gadolinium in this location. Patients with re…
View article: Susceptibility-weighted MRI signs of compensatory mechanism in nonconvulsive status epilepticus
Susceptibility-weighted MRI signs of compensatory mechanism in nonconvulsive status epilepticus Open
A 22-year-old woman was diagnosed with CSF antibody-confirmed NMDA receptor encephalitis after repeated generalized seizures. Initial MRI and EEG were unremarkable (figure). She developed acoustic hallucinations and nonconvulsive status ep…
View article: Individual Assessment of Brain Tissue Changes in MS and the Effect of Focal Lesions on Short-Term Focal Atrophy Development in MS: A Voxel-Guided Morphometry Study
Individual Assessment of Brain Tissue Changes in MS and the Effect of Focal Lesions on Short-Term Focal Atrophy Development in MS: A Voxel-Guided Morphometry Study Open
We performed voxel-guided morphometry (VGM) investigating the mechanisms of brain atrophy in multiple sclerosis (MS) related to focal lesions. VGM maps detect regional brain changes when comparing 2 time points on high resolution T1-weight…