Philipp Holzner
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View article: Lateral-dock single-port robotic-assisted extended totally extraperitoneal plasty (eTEP)-Sublay-Herniotomy-Procedure– presentation of a novel technique for robotic-assisted ventral hernia surgery (with video)
Lateral-dock single-port robotic-assisted extended totally extraperitoneal plasty (eTEP)-Sublay-Herniotomy-Procedure– presentation of a novel technique for robotic-assisted ventral hernia surgery (with video) Open
Introduction Robotic-assisted minimally-invasive extended totally extraperitoneal plasty (eTEP)-sublay-herniotomy is one of the most promising novel techniques for the management of ventral hernia. While several techniques for multiport-ro…
View article: Mesh-Augmented Ventral Hernia Repair Despite Iatrogenic <i>Staphylococcus aureus</i>-Peritonitis Due to Progressive Pneumoperitoneum: A Case Report
Mesh-Augmented Ventral Hernia Repair Despite Iatrogenic <i>Staphylococcus aureus</i>-Peritonitis Due to Progressive Pneumoperitoneum: A Case Report Open
The presented case demonstrates the possibilities in complex ventral hernia repair to achieve a satisfying outcome for the patients. Even in cases with infectious complications, a single-stage procedure might be performed safely and a comp…
View article: Impact of ALDH1A1 Expression in Intrahepatic Cholangiocellular Carcinoma
Impact of ALDH1A1 Expression in Intrahepatic Cholangiocellular Carcinoma Open
Background: Intrahepatic cholangiocarcinoma (iCC) is a rare malignant liver tumor with limited therapeutic advancements. Despite its increasing global incidence knowledge of treatment options remains stagnant, leading to poor five-year pat…
View article: AI-Assisted High-Throughput Tissue Microarray Workflow
AI-Assisted High-Throughput Tissue Microarray Workflow Open
Immunohistochemical (IHC) studies of formalin-fixed paraffin-embedded (FFPE) samples are a gold standard in oncology for tumor characterization, and the identification of prognostic and predictive markers. However, despite the abundance of…
View article: Long-Term Outcome After Resection of Hepatic and Pulmonary Metastases in Multivisceral Colorectal Cancer
Long-Term Outcome After Resection of Hepatic and Pulmonary Metastases in Multivisceral Colorectal Cancer Open
Background/Objectives: Colorectal cancer (CRC) with hepatic (CRLM) and pulmonary metastases (CRLU) presents a significant clinical challenge, leading to poor prognosis. Surgical resection of these metastases remains controversial because o…
View article: MCAM is a prognostic biomarker in patients with liver cirrhosis and HCC
MCAM is a prognostic biomarker in patients with liver cirrhosis and HCC Open
Background: Despite the rising prevalence of liver cirrhosis and HCC worldwide, reliable prognostic blood biomarkers are lacking. Melanoma cell adhesion molecule (MCAM) is a cell adhesion protein, and its cleavage by metalloproteinases, kn…
View article: Percutaneous transcatheter aspiration of pulmonary embolism leading to diagnosis of hepatocellular carcinoma tumor embolus and change in systemic chemotherapy
Percutaneous transcatheter aspiration of pulmonary embolism leading to diagnosis of hepatocellular carcinoma tumor embolus and change in systemic chemotherapy Open
The management of metastatic hepatocellular carcinoma (HCC) is complex, particularly when complicated by pulmonary embolism. In these cases, atezolizumab-bevacizumab therapy is contraindicated due to an elevated risk of thromboembolic even…
View article: Non-antigen-specific Immunoadsorption Is a Risk Factor for Severe Postoperative Infections in ABO-Incompatible Kidney Transplant Recipients
Non-antigen-specific Immunoadsorption Is a Risk Factor for Severe Postoperative Infections in ABO-Incompatible Kidney Transplant Recipients Open
ABO-incompatible (ABOi) living kidney transplantation (KTx) is an established procedure to address the demand for kidney transplants with outcomes comparable to ABO-compatible KTx. Desensitization involves the use of immunoadsorption (IA) …
View article: Single-cell deconvolution reveals high lineage- and location-dependent heterogeneity in mesenchymal multivisceral stage 4 colorectal cancer
Single-cell deconvolution reveals high lineage- and location-dependent heterogeneity in mesenchymal multivisceral stage 4 colorectal cancer Open
Metastasized colorectal cancer (CRC) is associated with a poor prognosis and rapid disease progression. Besides hepatic metastasis, peritoneal carcinomatosis is the major cause of death in Union for International Cancer Control (UICC) stag…
View article: Senescent Tumor Cells in the Peritoneal Carcinomatosis Drive Immunosenescence in the Tumor Microenvironment
Senescent Tumor Cells in the Peritoneal Carcinomatosis Drive Immunosenescence in the Tumor Microenvironment Open
More than half of all patients with colorectal cancer (CRC) develop distant metastasis and, depending on the local stage of the primary tumor, up to 48% of patients present peritoneal carcinomatosis (PC). PC is often considered as a widesp…
View article: Comparison of hyperthermic intraperitoneal chemotherapy regimens for treatment of peritoneal-metastasized colorectal cancer
Comparison of hyperthermic intraperitoneal chemotherapy regimens for treatment of peritoneal-metastasized colorectal cancer Open
In this single-institution retrospective review of patients undergoing CRS with either oxaliplatin or MMC HIPEC, overall survival was not different, though oxaliplatin was associated with a higher postoperative complication rate, indicatin…
View article: Outcome after hepatic resection for isolated non-colorectal, non-neuroendocrine liver metastases in 100 patients – the role of the embryologic origin of the primary tumor
Outcome after hepatic resection for isolated non-colorectal, non-neuroendocrine liver metastases in 100 patients – the role of the embryologic origin of the primary tumor Open
Overall outcome after HR of NCNNE LM results in acceptable long-term outcome. Although individual decision-making today mostly relies on clinical experience for this type of disease, risk factors derived from the embryologic origin of the …