Philipp Homan
YOU?
Author Swipe
View article: Dualistic Thinking and Beliefs About the Treatability of Mental Illnesses Among Medical Students: Development and Validation of a New Questionnaire
Dualistic Thinking and Beliefs About the Treatability of Mental Illnesses Among Medical Students: Development and Validation of a New Questionnaire Open
Background: Dualistic thinking, the belief that mind and body are two separate entities, has long been assumed to influence how future physicians perceive the treatability of mental disorders and to contribute to stigma against people with…
View article: TRUSTING: An International Multicenter Observational Study of Speech-Based Relapse Prediction in Psychosis Using Explainable AI
TRUSTING: An International Multicenter Observational Study of Speech-Based Relapse Prediction in Psychosis Using Explainable AI Open
Introduction The course of psychotic disorders typically involves relapses. Early warning signs vary between individuals and are difficult to detect in clinical practice, especially in outpatient settings. Speech provides a quantitative cl…
View article: Altered white matter microstructure of language pathways and semantic cognition deficiencies in early psychosis
Altered white matter microstructure of language pathways and semantic cognition deficiencies in early psychosis Open
View article: Integrating HiTOP and Computational Psychiatry for a New Era of Clinical Science
Integrating HiTOP and Computational Psychiatry for a New Era of Clinical Science Open
For decades, advancements in understanding and treating mental illness have been hindered by a categorical psychiatric nosology that fails to describe and explain how symptoms emerge and relate to one another. In response, two separate ini…
View article: Detecting and Preventing Harmful Behaviors in AI Companions: Development and Evaluation of the SHIELD Supervisory System
Detecting and Preventing Harmful Behaviors in AI Companions: Development and Evaluation of the SHIELD Supervisory System Open
AI companions powered by large language models (LLMs) are increasingly integrated into users' daily lives, offering emotional support and companionship. While existing safety systems focus on overt harms, they rarely address early-stage pr…
View article: Detecting and Preventing Harmful Behaviors in AI Companions: Development and Evaluation of the SHIELD Supervisory System
Detecting and Preventing Harmful Behaviors in AI Companions: Development and Evaluation of the SHIELD Supervisory System Open
AI companions powered by large language models (LLMs) are increasingly integrated into users' daily lives, offering emotional support and companionship. While existing safety systems focus on overt harms, they rarely address early-stage pr…
View article: What is the retest reliability of computationally extractable speech and language markers?
What is the retest reliability of computationally extractable speech and language markers? Open
Speech is a signal rich in information about cognitive and affective states, which can be of high clinical utility for detecting and monitoring mental health conditions. Numerous studies have employed natural language processing (NLP) and …
View article: Crisis versus extended care: bimodal distribution of length of stay in psychiatric inpatients
Crisis versus extended care: bimodal distribution of length of stay in psychiatric inpatients Open
Our findings reveal that psychiatric hospitalization durations follow a bimodal rather than simply right-skewed distribution, suggesting two distinct patient populations requiring fundamentally different treatment approaches. This pattern …
View article: Goal-Directed Control in Schizophrenia: Loss-Biased Engagement of the Anterior Cingulate Relates to Negative-Symptom Outcomes
Goal-Directed Control in Schizophrenia: Loss-Biased Engagement of the Anterior Cingulate Relates to Negative-Symptom Outcomes Open
Background and Hypothesis Individuals with schizophrenia spectrum disorders (SSD) often show diminished reward pursuit, whereas loss avoidance is relatively preserved. The neural mechanisms of this dissociation and its relation to negative…
View article: Orbitofrontal Thickness and Network Associations as Transdiagnostic Signature of Amotivation Along the Bipolar-Schizophrenia Spectrum
Orbitofrontal Thickness and Network Associations as Transdiagnostic Signature of Amotivation Along the Bipolar-Schizophrenia Spectrum Open
Background and Hypothesis Negative symptoms of schizophrenia (SCZ), particularly amotivation, are prominent across both SCZ and bipolar disorder (BD). While orbitofrontal cortex (OFC) alterations have been implicated in the development of …
View article: The Global Economic Burden of Schizophrenia: An Umbrella Review of Systematic Reviews and Meta-Analyses
The Global Economic Burden of Schizophrenia: An Umbrella Review of Systematic Reviews and Meta-Analyses Open
Background Existing studies on the economic impact of schizophrenia are fragmented and vary in methodology, hindering an ample understanding of the total economic burden. Aims To quantify the global economic burden of schizophrenia by synt…
View article: The value of mental science: we publish what matters
The value of mental science: we publish what matters Open
Summary Recent changes to US research funding are having far-reaching consequences that imperil the integrity of science and the provision of care to vulnerable populations. Resisting these changes, the BJPsych Portfolio reaffirms its comm…
View article: Mapping the trajectory of psychotic symptoms and their interaction with antipsychotic treatment: a longitudinal network intervention study
Mapping the trajectory of psychotic symptoms and their interaction with antipsychotic treatment: a longitudinal network intervention study Open
Antipsychotic efficacy in schizophrenia spectrum disorders (SSD) is commonly evaluated using static measures that fail to capture the dynamic evolution of symptoms and the unfolding impact of treatment over time. Network Intervention Analy…
View article: Lexical meaning is lower-dimensional in psychosis: the intrinsic geometry of the semantic space
Lexical meaning is lower-dimensional in psychosis: the intrinsic geometry of the semantic space Open
Diverse language models (LMs), including large language models (LLMs) based on deep neural networks have come to provide an unprecedented opportunity for mapping out the semantic spaces navigated in speech and their distortions in mental d…
View article: Altered white matter microstructure of language pathways and semantic cognition deficiencies in early psychosis
Altered white matter microstructure of language pathways and semantic cognition deficiencies in early psychosis Open
Background Semantic language dysfunction is a hallmark of early psychosis, yet the underlying brain structural correlates are largely unexplored. In particular, it is unclear whether core deficits arise from disruptions to semantic represe…
View article: Optimizing PTSD Diagnosis: A Mathematical Approach to Simplifying Complexity to Six Symptoms Without Compromising Diagnostic Accuracy
Optimizing PTSD Diagnosis: A Mathematical Approach to Simplifying Complexity to Six Symptoms Without Compromising Diagnostic Accuracy Open
Diagnostic criteria for posttraumatic stress disorder (PTSD) in the Diagnostic and Statistical Manual of Mental Disorders (DSM) have evolved substantially since their introduction, now encompassing 20 symptoms across four clusters. This co…
View article: Subgrouping suicidal ideations: an ecological momentary assessment study in psychiatric inpatients
Subgrouping suicidal ideations: an ecological momentary assessment study in psychiatric inpatients Open
10DL12_183251.
View article: Genetic susceptibility to schizophrenia through neuroinflammatory pathways associated with retinal thinness
Genetic susceptibility to schizophrenia through neuroinflammatory pathways associated with retinal thinness Open
View article: A single composite index of semantic behavior tracks symptoms of psychosis over time
A single composite index of semantic behavior tracks symptoms of psychosis over time Open
Semantic variables automatically extracted from spontaneous speech characterize anomalous semantic associations generated by groups with schizophrenia spectrum disorders (SSD). However, with the use of different language models and numerou…
View article: Assessing and alleviating state anxiety in large language models
Assessing and alleviating state anxiety in large language models Open
The use of Large Language Models (LLMs) in mental health highlights the need to understand their responses to emotional content. Previous research shows that emotion-inducing prompts can elevate "anxiety" in LLMs, affecting behavior and am…
View article: An exploratory network analysis to investigate schizotypy’s structure using the ‘Multidimensional Schizotypy Scale’ and ‘Oxford-Liverpool Inventory’ in a healthy cohort
An exploratory network analysis to investigate schizotypy’s structure using the ‘Multidimensional Schizotypy Scale’ and ‘Oxford-Liverpool Inventory’ in a healthy cohort Open
View article: Uncertainty Modeling in Multimodal Speech Analysis Across the Psychosis Spectrum
Uncertainty Modeling in Multimodal Speech Analysis Across the Psychosis Spectrum Open
Capturing subtle speech disruptions across the psychosis spectrum is challenging because of the inherent variability in speech patterns. This variability reflects individual differences and the fluctuating nature of symptoms in both clinic…
View article: Motivational Interviewing in Patients with Acute Psychosis: A Feasibility Study
Motivational Interviewing in Patients with Acute Psychosis: A Feasibility Study Open
Background and Hypothesis Psychotic disorders are among the top causes of disability worldwide. Guidelines emphasize the need for psychotherapeutic approaches in the acute phase of this illness. Motivational interviewing (MI) is highly sui…
View article: Brief Interventions and Contacts after Suicide Attempt: A Meta-Analysis
Brief Interventions and Contacts after Suicide Attempt: A Meta-Analysis Open
View article: Brief interventions and contacts after suicide attempt: A meta-analysis
Brief interventions and contacts after suicide attempt: A meta-analysis Open
Following a suicide attempt, only a third of people receive outpatient treatment. This highlights the need to rethink our approach to treatment, to include the consideration of low-threshold brief interventions and contacts. Therefore, in …
View article: Approximating the semantic space: word embedding techniques in psychiatric speech analysis
Approximating the semantic space: word embedding techniques in psychiatric speech analysis Open
View article: Parsing heterogeneity in global and local white matter integrity at different stages across the psychosis continuum
Parsing heterogeneity in global and local white matter integrity at different stages across the psychosis continuum Open
Psychosis progresses along a continuum. While heterogeneity is evident across the continuum, it remains unknown whether this is also reflected in white matter (WM) heterogeneity and whether parsing WM heterogeneity may reveal subgroups wit…
View article: Genetic analysis of retinal cell types reveals synaptic pathology in schizophrenia
Genetic analysis of retinal cell types reveals synaptic pathology in schizophrenia Open
Importance: As an accessible part of the central nervous system, the retina provides a unique window to study pathophysiological mechanisms of brain disorders in humans. Imaging and electrophysiological studies have revealed retinal altera…
View article: Orbitofrontal thickness and network associations as transdiagnostic signature of negative symptoms along the bipolar-schizophrenia spectrum
Orbitofrontal thickness and network associations as transdiagnostic signature of negative symptoms along the bipolar-schizophrenia spectrum Open
Negative symptoms are core features of schizophrenia (SCZ) and also prevalent in bipolar disorder (BD). While orbitofrontal cortex (OFC) alterations have been implicated in the development of negative symptoms, their contributions across d…
View article: Beyond Increasing Sample Sizes: Optimizing Effect Sizes in Neuroimaging Research on Individual Differences
Beyond Increasing Sample Sizes: Optimizing Effect Sizes in Neuroimaging Research on Individual Differences Open
Linking neurobiology to relatively stable individual differences in cognition, emotion, motivation, and behavior can require large sample sizes to yield replicable results. Given the nature of between-person research, sample sizes at least…