Philipp Houben
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View article: Impact of parenchymal transection techniques on intraoperative blood loss during liver resection in a porcine model of elevated central venous pressure: A comparative study
Impact of parenchymal transection techniques on intraoperative blood loss during liver resection in a porcine model of elevated central venous pressure: A comparative study Open
This pilot study demonstrates superior outcomes for HS and ST techniques in high-CVP liver resections. Insights from this large animal model provide a basis for investigating optimal transection techniques for chronically elevated CVP, bri…
View article: Effect of Donor Cigarette Smoking in Kidney Transplantation: Re-Evaluation of Long-Term Outcomes
Effect of Donor Cigarette Smoking in Kidney Transplantation: Re-Evaluation of Long-Term Outcomes Open
Cigarette smoking is a common risk factor associated with negative long-term outcomes in kidney transplant recipients. However, whether donor smoking decreases graft longevity or negatively impacts recipient survival after kidney transplan…
View article: Donor Proteinuria and Allograft Function in Kidney Transplantation: Short- and Long-Term Results From a Retrospective Cohort Study
Donor Proteinuria and Allograft Function in Kidney Transplantation: Short- and Long-Term Results From a Retrospective Cohort Study Open
Donor proteinuria (DP) is a common but rarely evaluated aspect of today’s kidney transplant allocation process. While proteinuria after kidney transplantation is a risk factor for impaired graft function and survival, the long-term effects…
View article: Graft-versus-host disease following liver transplantation: A systematic review of literature
Graft-versus-host disease following liver transplantation: A systematic review of literature Open
Background: Graft-versus-host disease following liver transplantation is a serious and usually fatal complication. Data identifying the risk factors and specifying the diagnosis and treatment options of the disease are scarce and contentio…
View article: Extracellular vesicles as potential biomarkers for diagnosis and recurrence detection of hepatocellular carcinoma: A pilot study
Extracellular vesicles as potential biomarkers for diagnosis and recurrence detection of hepatocellular carcinoma: A pilot study Open
Hepatocellular carcinoma (HCC) is the most common primary malignant liver tumor and a leading cause of cancer-related deaths worldwide. However, current diagnostic tools are often invasive and technically limited. Extracellular vesicles (E…
View article: Hyperspectral Imaging for Viability Assessment of Human Liver Allografts During Normothermic Machine Perfusion
Hyperspectral Imaging for Viability Assessment of Human Liver Allografts During Normothermic Machine Perfusion Open
Background. Normothermic machine perfusion (NMP) is nowadays frequently utilized in liver transplantation. Despite commonly accepted viability assessment criteria, such as perfusate lactate and perfusate pH, there is a lack of predictive o…
View article: Dynamic Parameters of Hypothermic Machine Perfusion—An Image of Initial Graft Function in Adult Kidney Transplantation?
Dynamic Parameters of Hypothermic Machine Perfusion—An Image of Initial Graft Function in Adult Kidney Transplantation? Open
Kidney allografts are subjected to ischemia reperfusion injury during the process of transplantation. Hypothermic machine perfusion (HMP) of deceased donor kidneys from organ procurement until transplantation is associated with a superior …
View article: Ex situ arterial reconstruction prior normothermic machine perfusion of liver grafts
Ex situ arterial reconstruction prior normothermic machine perfusion of liver grafts Open
Purpose Atypical variants of the hepatic artery are common and pose a technical challenge for normothermic machine perfusion (NMP). The transplant surgeon has three options when confronted with hepatic arterial variation in a liver graft t…
View article: How Old Is Old? An Age-Stratified Analysis of Elderly Liver Donors above 65
How Old Is Old? An Age-Stratified Analysis of Elderly Liver Donors above 65 Open
In liver transplantation, older donor age is a well-known risk factor for dismal outcomes, especially due to the high susceptibility of older grafts to ischemia-reperfusion injury. However, whether the factors correlating with impaired gra…
View article: Hyperspectral imaging for quantitative assessment of hepatic steatosis in human liver allografts
Hyperspectral imaging for quantitative assessment of hepatic steatosis in human liver allografts Open
Introduction In liver transplantation (LT), steatosis is commonly judged to be a risk factor for graft dysfunction, and quantitative assessment of hepatic steatosis remains crucial. Liver biopsy as the gold standard for evaluation of hepat…
View article: Hyperspectral Imaging for Assessment of Initial Graft Function in Human Kidney Transplantation
Hyperspectral Imaging for Assessment of Initial Graft Function in Human Kidney Transplantation Open
The aim of our study was to evaluate hyperspectral imaging (HSI) as a rapid, non-ionizing technique for the assessment of organ quality and the prediction of delayed graft function (DGF) in kidney transplantation after static cold storage …
View article: Abstracts DGCH
Abstracts DGCH Open
Background:Surgical innovation has centered on instrumentation, visualization, robotics and intraoperative diagnostics and could successfully improve patients outcome.Surgeons themselves have not been in the focus of innovation, although t…
View article: Rare Malignant Indications for Liver Transplantation: A Collaborative Transplant Study Report
Rare Malignant Indications for Liver Transplantation: A Collaborative Transplant Study Report Open
Introduction: Hepatocellular carcinoma (HCC) is by far the leading malignant indication for liver transplantation (LT). Few other malignancies, including cholangiocellular carcinoma (CCC), metastases from neuroendocrine tumors (NET), and s…
View article: Short- and Long-Term Outcomes of Different Reperfusion Sequences in Liver Transplantation
Short- and Long-Term Outcomes of Different Reperfusion Sequences in Liver Transplantation Open
BACKGROUND Although most centers perform primary portal vein reperfusion (PV) in orthotopic liver transplantation (OLT) for historical reasons, there is so far no sound evidence as to whether this technique is superior. The present study e…
View article: A prospective, randomized, single-blind, multicentre, phase III study on organ preservation with Custodiol-N solution compared with Custodiol® solution in organ transplantation (kidney, liver and pancreas)
A prospective, randomized, single-blind, multicentre, phase III study on organ preservation with Custodiol-N solution compared with Custodiol® solution in organ transplantation (kidney, liver and pancreas) Open
Background Organ preservation before transplantation is still a challenge. Both the University of Wisconsin and Bretschneider’s histidine-tryptophan-ketoglutarate (HTK; Custodiol®) solution are standard for liver, kidney and pancreas prese…
View article: Randomized controlled trial on Pringle Maneuver to reduce blood loss during stapler hepatectomy - PriMal StHep
Randomized controlled trial on Pringle Maneuver to reduce blood loss during stapler hepatectomy - PriMal StHep Open
The PriMaL StHep trial has been prospectively registered to the German Clinical Trial Registry (WHO ID: DRKS00010427 ) on April 21st. 2016.
View article: SEALIVE: the use of technical vessel-sealing devices for recipient hepatectomy in liver transplantation: study protocol for a randomized controlled trial
SEALIVE: the use of technical vessel-sealing devices for recipient hepatectomy in liver transplantation: study protocol for a randomized controlled trial Open
ClinicalTrials.gov, NCT 03323242 . Registered on October 26, 2017.
View article: Evaluation of Graft Effluent High Mobility Group Box-1 (HMGB-1) for Prediction of Outcome After Liver Transplantation
Evaluation of Graft Effluent High Mobility Group Box-1 (HMGB-1) for Prediction of Outcome After Liver Transplantation Open
BACKGROUND Pre-transplant assessment of the graft for liver transplantation is crucial. Based on experimental data, this study was designed to assess both nuclear high mobility group box-1 (HMGB-1) protein and arginine-specific proteolytic…