Philipp Jent
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View article: β-Lactam vs Non–β-Lactam Antimicrobial Prophylaxis and Surgical Site Infection
β-Lactam vs Non–β-Lactam Antimicrobial Prophylaxis and Surgical Site Infection Open
Importance β-lactam–based surgical antimicrobial prophylaxis (SAP) is the standard for most surgical procedures. Alternatively, and mostly due to allergies, non–β-lactam–based prophylaxis is used. The association between the use of non–β-l…
View article: Adherence to national recommendations for the control of multidrug-resistant microorganisms in Swiss acute care hospitals – an updated national survey
Adherence to national recommendations for the control of multidrug-resistant microorganisms in Swiss acute care hospitals – an updated national survey Open
Summary Background Screening patients at risk of multidrug-resistant organism (MDRO) carriage is a cornerstone of infection prevention and control to identify carriers and prevent transmission. In 2021, the Swiss Centre for Infection Preve…
View article: Absences, Symptoms and Respiratory Viruses in a Swiss School: Longitudinal Study With Serial Saliva Sampling
Absences, Symptoms and Respiratory Viruses in a Swiss School: Longitudinal Study With Serial Saliva Sampling Open
Background Viral respiratory infections contribute to sick days in school children. We monitored respiratory infections, absences, and symptoms in a Swiss school. Methods Serial saliva sampling (three per week) and daily recording of absen…
View article: The relative contribution of close-proximity contacts, shared classroom exposure and indoor air quality to respiratory virus transmission in schools.
The relative contribution of close-proximity contacts, shared classroom exposure and indoor air quality to respiratory virus transmission in schools. Open
Close-proximity interactions are considered a key risk factor for respiratory virus transmission, but their importance relative to shared space and air quality remains unclear. We conducted a six-week longitudinal study in a Swiss secondar…
View article: Infection Control Measures in the Classroom During and in the Aftermath of the COVID‐19 Pandemic: A Multidimensional Analysis of Secondary Student Well‐Being and Emotions
Infection Control Measures in the Classroom During and in the Aftermath of the COVID‐19 Pandemic: A Multidimensional Analysis of Secondary Student Well‐Being and Emotions Open
Background In our research, we investigated student state and habitual well‐being in school during and in the aftermath of the COVID‐19 pandemic (after schools reopened) and analyzed their associations to measures in schools aimed at preve…
View article: Introducing a New Polymerase Chain Reaction Panel–Based Cerebrospinal Fluid Evaluation for Encephalitis and Meningitis: Does It Influence Empiric Treatment Duration, Length of Hospital Stay, and Pathogen-Specific Diagnoses?
Introducing a New Polymerase Chain Reaction Panel–Based Cerebrospinal Fluid Evaluation for Encephalitis and Meningitis: Does It Influence Empiric Treatment Duration, Length of Hospital Stay, and Pathogen-Specific Diagnoses? Open
We analyzed the impact of a diagnostic meningitis/encephalitis polymerase chain reaction panel. Introducing the test resulted in no significantly shortened empiric antibiotic streptococcal/meningococcal treatment (−1 day [95% confidence in…
View article: In-hospital Outcomes of Healthcare-associated Coronavirus Disease 2019 (Omicron) Versus Healthcare-associated Influenza: A Retrospective, Nationwide Cohort Study in Switzerland
In-hospital Outcomes of Healthcare-associated Coronavirus Disease 2019 (Omicron) Versus Healthcare-associated Influenza: A Retrospective, Nationwide Cohort Study in Switzerland Open
Background As coronavirus disease 2019 (COVID-19) is integrated into existing infectious disease control programs, it is important to understand the comparative clinical impact of COVID-19 and other respiratory diseases. Methods We conduct…
View article: Guidelines for the Prevention, Diagnosis, and Management of Urinary Tract Infections in Pediatrics and Adults
Guidelines for the Prevention, Diagnosis, and Management of Urinary Tract Infections in Pediatrics and Adults Open
Importance Traditional approaches to practice guidelines frequently result in dissociation between strength of recommendation and quality of evidence. Objective To create a clinical guideline for the diagnosis and management of urinary tra…
View article: Overview and evaluation of a nationwide hospital-based surveillance system for Influenza and COVID-19 in Switzerland (CH-SUR): 2018-2023
Overview and evaluation of a nationwide hospital-based surveillance system for Influenza and COVID-19 in Switzerland (CH-SUR): 2018-2023 Open
Background In 2018, a hospital-based surveillance system for influenza (CH-SUR) was established in six tertiary care hospitals in Switzerland. From March 2020 onwards, this surveillance system was expanded to include more institutions, as …
View article: Swiss COVID-19 hospital surveillance: an in-depth analysis of the factors associated with hospital readmission dynamics in community-acquired COVID-19 cases
Swiss COVID-19 hospital surveillance: an in-depth analysis of the factors associated with hospital readmission dynamics in community-acquired COVID-19 cases Open
BACKGROUND: The COVID-19 pandemic has placed unprecedented pressure on hospitals worldwide. In such a context of tension in healthcare systems, efficiently allocating hospital resources is a crucial aspect of crisis management. The aim of …
View article: Association of institutional masking policies with healthcare-associated SARS-CoV-2 infections in Swiss acute care hospitals during the BA.4/5 wave (CH-SUR study): a retrospective observational study
Association of institutional masking policies with healthcare-associated SARS-CoV-2 infections in Swiss acute care hospitals during the BA.4/5 wave (CH-SUR study): a retrospective observational study Open
View article: Povidone Iodine vs Chlorhexidine Gluconate in Alcohol for Preoperative Skin Antisepsis
Povidone Iodine vs Chlorhexidine Gluconate in Alcohol for Preoperative Skin Antisepsis Open
Importance Preoperative skin antisepsis is an established procedure to prevent surgical site infections (SSIs). The choice of antiseptic agent, povidone iodine or chlorhexidine gluconate, remains debated. Objective To determine whether pov…
View article: Do all Emergency Room Patients With Influenza-like Symptoms Need Blood Cultures? A Retrospective Cohort Study of 2 Annual Influenza Seasons
Do all Emergency Room Patients With Influenza-like Symptoms Need Blood Cultures? A Retrospective Cohort Study of 2 Annual Influenza Seasons Open
In this retrospective cohort study, we evaluated risk factors for bacteremia in emergency department patients presenting with influenza-like symptoms during influenza epidemic seasons. In patients without fever, chronic heart or chronic li…
View article: Surveillance of catheter-associated bloodstream infections: development and validation of a fully automated algorithm
Surveillance of catheter-associated bloodstream infections: development and validation of a fully automated algorithm Open
View article: Air Cleaners and Respiratory Infections in Schools: A Modeling Study Based on Epidemiologic, Environmental, and Molecular Data
Air Cleaners and Respiratory Infections in Schools: A Modeling Study Based on Epidemiologic, Environmental, and Molecular Data Open
Background Using a multiple-measurement approach, we examined the real-world effectiveness of portable HEPA air filtration devices (air cleaners) in a school setting. Methods We collected data over 7 weeks during winter 2022/2023 in 2 Swis…
View article: Molecular detection of SARS-CoV-2 and other respiratory viruses in saliva and classroom air: a two winters tale
Molecular detection of SARS-CoV-2 and other respiratory viruses in saliva and classroom air: a two winters tale Open
View article: Air cleaners and respiratory infections in schools: A modeling study using epidemiological, environmental, and molecular data
Air cleaners and respiratory infections in schools: A modeling study using epidemiological, environmental, and molecular data Open
Background Using a multiple-measurement approach, we examined the real-world effectiveness of portable HEPA-air filtration devices (air cleaners) in a school setting. Methods We collected environmental (CO 2 , particle concentrations), epi…
View article: Association between the introduction of a national targeted intervention program and the incidence of surgical site infections in Swiss acute care hospitals
Association between the introduction of a national targeted intervention program and the incidence of surgical site infections in Swiss acute care hospitals Open
Background In Switzerland, the national surgical site infection (SSI) surveillance program showed a modest decrease in SSI rates for different procedures over the last decade. The study aimed to determine whether a multimodal, targeted int…
View article: Determination of the Diagnostic Performance of Laboratory Tests in the Absence of a Perfect Reference Standard: The Case of SARS-CoV-2 Tests
Determination of the Diagnostic Performance of Laboratory Tests in the Absence of a Perfect Reference Standard: The Case of SARS-CoV-2 Tests Open
Background: Currently, assessing the diagnostic performance of new laboratory tests assumes a perfect reference standard, which is rarely the case. Wrong classifications of the true disease status will inevitably lead to biased estimates o…
View article: Predictive performance of automated surveillance algorithms for intravascular catheter bloodstream infections: a systematic review and meta-analysis
Predictive performance of automated surveillance algorithms for intravascular catheter bloodstream infections: a systematic review and meta-analysis Open
View article: Guidelines for Diagnosis and Management of Infective Endocarditis in Adults
Guidelines for Diagnosis and Management of Infective Endocarditis in Adults Open
Importance Practice guidelines often provide recommendations in which the strength of the recommendation is dissociated from the quality of the evidence. Objective To create a clinical guideline for the diagnosis and management of adult ba…
View article: Timing of Cefuroxime Surgical Antimicrobial Prophylaxis and Its Association With Surgical Site Infections
Timing of Cefuroxime Surgical Antimicrobial Prophylaxis and Its Association With Surgical Site Infections Open
Importance World Health Organization guidelines recommend administering surgical antimicrobial prophylaxis (SAP), including cefuroxime, within 120 minutes prior to incision. However, data from clinical settings supporting this long interva…
View article: SARS-CoV-2 transmission with and without mask wearing or air cleaners in schools in Switzerland: A modeling study of epidemiological, environmental, and molecular data
SARS-CoV-2 transmission with and without mask wearing or air cleaners in schools in Switzerland: A modeling study of epidemiological, environmental, and molecular data Open
Background Growing evidence suggests an important contribution of airborne transmission to the overall spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), in particular via smaller particles called aerosols. However, th…
View article: Influence of environmental temperature and heatwaves on surgical site infection after hip and knee arthroplasty: a nationwide study
Influence of environmental temperature and heatwaves on surgical site infection after hip and knee arthroplasty: a nationwide study Open
SSI rates after hip and knee replacement appear to increase with higher environmental temperature. To establish whether, and to what extent, heatwaves increase the risk of SSI, studies involving geographical areas with larger variability i…
View article: Hospital Outcomes of Community-Acquired SARS-CoV-2 Omicron Variant Infection Compared With Influenza Infection in Switzerland
Hospital Outcomes of Community-Acquired SARS-CoV-2 Omicron Variant Infection Compared With Influenza Infection in Switzerland Open
Importance With the ongoing COVID-19 pandemic, it is crucial to assess the current burden of disease of community-acquired SARS-CoV-2 Omicron variant in hospitalized patients to tailor appropriate public health policies. Comparisons with b…
View article: Nosocomial outbreak of vancomycin-resistant Enterococcus faecium (VRE) ST796, Switzerland, 2017 to 2020
Nosocomial outbreak of vancomycin-resistant Enterococcus faecium (VRE) ST796, Switzerland, 2017 to 2020 Open
A large clonal outbreak caused by vancomycin-resistant Enterococcus faecium (VRE) affected the Bern University Hospital group from the end of December 2017 until July 2020. We describe the characteristics of the outbreak and the bundle of …
View article: Antibiotics for Preventing Recurrent Urinary Tract Infection: Systematic Review and Meta-analysis
Antibiotics for Preventing Recurrent Urinary Tract Infection: Systematic Review and Meta-analysis Open
Recurrent urinary tract infections are a common health problem. The only comprehensive synthesis on antibiotic prophylaxis in the last 15 years has been a guideline-embedded meta-analysis. We conducted a systematic review and meta-analysis…
View article: Effects and utility of an online forward triage tool during the SARS-CoV-2 pandemic: a mixed method study and patient perspectives, Switzerland
Effects and utility of an online forward triage tool during the SARS-CoV-2 pandemic: a mixed method study and patient perspectives, Switzerland Open
Objective To assess the effects (quantitatively) and the utility (qualitatively) of a COVID-19 online forward triage tool (OFTT) in a pandemic context. Design A mixed method sequential explanatory study was employed. Quantitative data of a…
View article: Use of Novel Strategies to Develop Guidelines for Management of Pyogenic Osteomyelitis in Adults
Use of Novel Strategies to Develop Guidelines for Management of Pyogenic Osteomyelitis in Adults Open
The WikiGuidelines approach offers a novel methodology for clinical guideline development that precludes recommendations based on low-quality data or opinion. The primary limitation is the need for more rigorous clinical investigations, en…
View article: Focusing on the follow-up for detecting surgical site infections after total joint arthroplasty and cardiac surgery: A cohort study from the Swiss national surveillance system, 2009–2018
Focusing on the follow-up for detecting surgical site infections after total joint arthroplasty and cardiac surgery: A cohort study from the Swiss national surveillance system, 2009–2018 Open
Focusing on the follow-up for detecting surgical site infections after total joint arthroplasty and cardiac surgery: A cohort study from the Swiss national surveillance system, 2009–2018 - Volume 43 Issue 12