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View article: Association of Inflammation-Based Ratios with Endothelial Dysfunction Markers and Clinical Parameters in Limited Cutaneous Systemic Sclerosis
Association of Inflammation-Based Ratios with Endothelial Dysfunction Markers and Clinical Parameters in Limited Cutaneous Systemic Sclerosis Open
Background: Limited cutaneous systemic sclerosis (lcSSc) is an autoimmune disease with a wide range of different biomarkers, while inflammation-based ratios have been less extensively investigated. This study aimed to evaluate the associat…
View article: Correlation and Risk Assessment of Inflammation-Based Parameters on Cardiovascular Parameters and Clinical Events in Giant Cell Arteritis: A Retrospective Study
Correlation and Risk Assessment of Inflammation-Based Parameters on Cardiovascular Parameters and Clinical Events in Giant Cell Arteritis: A Retrospective Study Open
This study investigated associations of inflammation-based biomarkers with endothelial dysfunction and lipids and their predictive value for clinical outcome parameters in patients with giant cell arteritis (GCA). A total of 138 patients w…
View article: Evaluation of the utility of cardiac biomarkers for risk stratification in patients with lower extremity artery disease: A retrospective study
Evaluation of the utility of cardiac biomarkers for risk stratification in patients with lower extremity artery disease: A retrospective study Open
Critical limb threatening ischemia (CLTI) is associated with a one-year mortality rate of up to 25% making prompt diagnosis essentially. This study aims to investigate if cardiac biomarkers may serve as an effective tool for risk stratific…
View article: Lipoprotein (a) is not associated with thrombus burden derived from CT pulmonary angiography in patients with acute pulmonary embolism
Lipoprotein (a) is not associated with thrombus burden derived from CT pulmonary angiography in patients with acute pulmonary embolism Open
Lipoprotein (a) [Lp(a)] is suspected to have antifibrinolytic effects, however, its relevance for the severity of venous thromboembolic events remains unclear. We studied the association of Lp(a) levels with thrombus load in pulmonary embo…
View article: Successful long-term systemic sclerosis treatment by high-frequent low-dose B cell-depleting therapy
Successful long-term systemic sclerosis treatment by high-frequent low-dose B cell-depleting therapy Open
SSc was effectively and safely treated with low-dose RTX quarterly. RCTs are warranted to validate the advantage of continuous B cell depletion by quarterly low-dose RTX administration compared to other treatment intervals.
View article: Association of clinical, imaging and laboratory parameters with adverse effects of glucocorticoid therapy in patients with giant cell arteritis
Association of clinical, imaging and laboratory parameters with adverse effects of glucocorticoid therapy in patients with giant cell arteritis Open
Background Giant cell arteritis (GCA) is characterized by inflammation of large and medium vessels. First-line therapy for the treatment of GCA are glucocorticoids, which are effective while potential adverse effects should be considered, …
View article: Pseudo-halo sign in temporal pseudoaneurysm
Pseudo-halo sign in temporal pseudoaneurysm Open
A 40-year-old man presented with tenderness and swelling of the right frontotemporal region existing for about three years after bumping his right temple against a table's edge, but his complaints have increased in the last weeks.No furthe…
View article: Cardiovascular diseases and their associations with lipid parameters and endothelial dysfunction in giant cell arteritis
Cardiovascular diseases and their associations with lipid parameters and endothelial dysfunction in giant cell arteritis Open
Objectives Evaluation of endothelial dysfunction, lipid metabolism, prevalence and development of cardiovascular diseases in patients with giant cell arteritis (GCA). Methods 138 GCA patients and 100 controls were evaluated for prevalent c…
View article: Association of amino acids and parameters of bone metabolism with endothelial dysfunction and vasculopathic changes in limited systemic sclerosis
Association of amino acids and parameters of bone metabolism with endothelial dysfunction and vasculopathic changes in limited systemic sclerosis Open
Objectives Pathways contributing to endothelial dysfunction in patients with limited cutaneous systemic sclerosis (lcSSc) are largely unknown. The aim of this study was to investigate potential associations of amino acids and parameters of…
View article: Periodontal disease and its association to endothelial dysfunction and clinical changes in limited systemic sclerosis: A case–control study
Periodontal disease and its association to endothelial dysfunction and clinical changes in limited systemic sclerosis: A case–control study Open
Objectives Periodontal disease occurs frequently in patients with limited cutaneous systemic sclerosis (lcSSc) while data about underlying pathways contributing to periodontal changes are scarce. The aim of this study was to evaluate perio…
View article: Association of immunological parameters with aortic dilatation in giant cell arteritis: a cross-sectional study
Association of immunological parameters with aortic dilatation in giant cell arteritis: a cross-sectional study Open
Aortic dilatation (AD) occurs in up to 30% of patients with giant cell arteritis (GCA). Reliable biomarkers for AD development, however, are still absent. The aim of this exploratory study was to evaluate whether immunological parameters a…
View article: Bilateral Necrotizing Polymicrobial Thrombophlebitis
Bilateral Necrotizing Polymicrobial Thrombophlebitis Open
A 32-year-old male was presented to the emergency department because of ulcers, eschars, and multiple reddish nodules on both arms for five days, which developed after scratching both arms owing to severe pruritus.The patient's medical his…
View article: Lipoprotein(a) and Pulmonary Embolism Severity-A Retrospective Data Analysis
Lipoprotein(a) and Pulmonary Embolism Severity-A Retrospective Data Analysis Open
Aim We aimed to investigate a correlation between PE severity and Lp(a) levels. Methods We performed a retrospective data analysis from our medical records of PE patients admitted to the University Hospital Graz, Austria. Patients with an …
View article: Endovascular Thrombolysis in Hypothenar Hammer Syndrome: A Systematic Review
Endovascular Thrombolysis in Hypothenar Hammer Syndrome: A Systematic Review Open
Objectives: Hypothenar hammer syndrome (HHS) is a rare vascular disease caused by blunt trauma of the hypothenar region. The optimal therapeutic strategy remains debatably since no large comparative studies are available yet. We want to ev…
View article: Red urine and a red herring – diagnosing rare diseases in the light of the COVID-19 pandemic
Red urine and a red herring – diagnosing rare diseases in the light of the COVID-19 pandemic Open
Background The COVID-19 pandemic has occupied the time and resources of health care professionals for more than 1 year. The risk of missed diagnoses has been discussed in the medical literature, mainly for common diseases such as cancer an…
View article: Evaluation of Endothelial Dysfunction and Inflammatory Vasculopathy After SARS-CoV-2 Infection—A Cross-Sectional Study
Evaluation of Endothelial Dysfunction and Inflammatory Vasculopathy After SARS-CoV-2 Infection—A Cross-Sectional Study Open
Background: Rising data suggest that COVID-19 affects vascular endothelium while the underlying mechanisms promoting COVID-19-associated endothelial dysfunction and inflammatory vasculopathy are largely unknown. The aim was to evaluate the…
View article: Lower Lean Mass Is Associated with Greater Arterial Stiffness in Patients with Lower Extremity Artery Disease
Lower Lean Mass Is Associated with Greater Arterial Stiffness in Patients with Lower Extremity Artery Disease Open
Background: Arterial stiffness is independently associated with lower extremity artery disease (LEAD). Although obesity is already known as an independent cardiovascular risk factor, it was found that, paradoxically, in patients diagnosed …
View article: Evaluation of endothelial dysfunction and clinical events in patients with early-stage vasculopathy in limited systemic sclerosis
Evaluation of endothelial dysfunction and clinical events in patients with early-stage vasculopathy in limited systemic sclerosis Open
Selected parameters of endothelial dysfunction contribute to clinical events in lcSSc patients with early-stage vasculopathy and endothelial dysfunction seems to be primarily present in microvasculature, while its impact on macrovascular c…
View article: Images of the month 3: Transient perivascular inflammation of the carotid artery syndrome
Images of the month 3: Transient perivascular inflammation of the carotid artery syndrome Open
A 44-year-old man presented to the emergency department with a painful, palpable mass in the area of the right carotid triangle lasting for 1 week. He was otherwise healthy without any trauma or further otorhinolaryngological symptoms. Oth…
View article: Rituximab as a Treatment Option after Autologous Hematopoietic Stem Cell Transplantation in a Patient with Systemic Sclerosis
Rituximab as a Treatment Option after Autologous Hematopoietic Stem Cell Transplantation in a Patient with Systemic Sclerosis Open
Systemic sclerosis (SSc) is an intractable autoimmune disease characterized by vasculopathy and organ fibrosis. Autologous hematopoietic stem cell transplantation (AHSCT) should be considered for the treatment of selected patients with rap…
View article: Case Report: Changes of Vascular Reactivity and Arterial Stiffness in a Patient With Covid-19 Infection
Case Report: Changes of Vascular Reactivity and Arterial Stiffness in a Patient With Covid-19 Infection Open
Covid-19 infection may be associated with a higher incidence developing cardiovascular complications, however, the underlying mechanisms contributing to cardiovascular complications are largely unknown, while endothelial cell damage may be…
View article: Effect of short‐interval rituximab and high‐dose corticosteroids on kidney function in systemic sclerosis: Long‐term experience of a single centre
Effect of short‐interval rituximab and high‐dose corticosteroids on kidney function in systemic sclerosis: Long‐term experience of a single centre Open
Introduction Scleroderma renal crisis (SRC) is a rare but one of the most recognised complications of systemic sclerosis (SSc). Corticosteroid (CS) use has been considered as a major risk factor for SRC. Several studies reported the effica…
View article: Prevalence and prognostic factors for aortic dilatation in giant cell arteritis – a longitudinal study
Prevalence and prognostic factors for aortic dilatation in giant cell arteritis – a longitudinal study Open
Thoracic but not abdominal ADs occur more commonly in GCA patients, however, the subsequent risk for aortic repair, rupture or dissection is low. Changes of T-cell subsets, presence of polymyalgia rheumatica and increased carotid IMT at di…
View article: Paraneoplastic acral vascular syndrome
Paraneoplastic acral vascular syndrome Open
An 85-year-old man with a history of recurrent non–small cell lung adenocarcinoma presented to the clinic with a 2-week history of painful cyanosis and necrosis of his fingers ([Figure 1][1]), along with weight loss, dry cough and dyspnea.…
View article: Significant increase in the incidence of high-risk pulmonary embolism during the COVID-19 shutdown: the pandemic response causes serious collateral consequences
Significant increase in the incidence of high-risk pulmonary embolism during the COVID-19 shutdown: the pandemic response causes serious collateral consequences Open
Background Strict stay-at-home rules, along with fear of coronavirus infection, have kept many patients from timely seeking medical attention during the novel coronavirus disease (COVID-19) pandemic. This situation may have led to an incre…