Philipp Koldewey
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View article: Discovery of Novel Allosteric EGFR L858R Inhibitors for the Treatment of Non-Small-Cell Lung Cancer as a Single Agent or in Combination with Osimertinib
Discovery of Novel Allosteric EGFR L858R Inhibitors for the Treatment of Non-Small-Cell Lung Cancer as a Single Agent or in Combination with Osimertinib Open
Addressing resistance to third-generation EGFR TKIs such as osimertinib via the EGFRC797S mutation remains a highly unmet need in EGFR-driven non-small-cell lung cancer (NSCLC). Herein, we present the discovery of the allosteric EGFR inhib…
View article: Elaborating a coiled‐coil‐assembled octahedral protein cage with additional protein domains
Elaborating a coiled‐coil‐assembled octahedral protein cage with additional protein domains Open
De novo design of protein nano‐cages has potential applications in medicine, synthetic biology, and materials science. We recently developed a modular, symmetry‐based strategy for protein assembly in which short, coiled‐coil sequences medi…
View article: Front Cover: Symmetry‐Directed Self‐Assembly of a Tetrahedral Protein Cage Mediated by de Novo‐Designed Coiled Coils (ChemBioChem 19/2017)
Front Cover: Symmetry‐Directed Self‐Assembly of a Tetrahedral Protein Cage Mediated by de Novo‐Designed Coiled Coils (ChemBioChem 19/2017) Open
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View article: Symmetry‐Directed Self‐Assembly of a Tetrahedral Protein Cage Mediated by de Novo‐Designed Coiled Coils
Symmetry‐Directed Self‐Assembly of a Tetrahedral Protein Cage Mediated by de Novo‐Designed Coiled Coils Open
The organization of proteins into new hierarchical forms is an important challenge in synthetic biology. However, engineering new interactions between protein subunits is technically challenging and typically requires extensive redesign of…
View article: Chaperone-client interactions: Non-specificity engenders multifunctionality
Chaperone-client interactions: Non-specificity engenders multifunctionality Open
Here, we provide an overview of the different mechanisms whereby three different chaperones, Spy, Hsp70, and Hsp60, interact with folding proteins, and we discuss how these chaperones may guide the folding process. Available evidence sugge…
View article: Correction: Corrigendum: Determining crystal structures through crowdsourcing and coursework
Correction: Corrigendum: Determining crystal structures through crowdsourcing and coursework Open
Nature Communications 7: Article number:12549 (2016); Published 16 September 2016; Updated 25 October 2016 The original version of this Article contained an error in the spelling of a member of the University of Michigan students Consortiu…
View article: Detection of the pH-dependent Activity of <em>Escherichia coli</em> Chaperone HdeB <em>In Vitro</em> and <em>In Vivo</em>
Detection of the pH-dependent Activity of <em>Escherichia coli</em> Chaperone HdeB <em>In Vitro</em> and <em>In Vivo</em> Open
Bacteria are frequently exposed to environmental changes, such as alterations in pH, temperature, redox status, light exposure or mechanical force. Many of these conditions cause protein unfolding in the cell and have detrimental impact on…
View article: Flexible, symmetry-directed approach to assembling protein cages
Flexible, symmetry-directed approach to assembling protein cages Open
Significance The ability to organize biological molecules into new hierarchical forms represents an important goal in synthetic biology. However, designing new quaternary interactions between protein subunits has proved technically challen…
View article: Mechanistic and structural characterization of the molecular chaperone Spy
Mechanistic and structural characterization of the molecular chaperone Spy Open
Understanding how chaperones work is an important question in basic biology, given their function as guardians of protein folding and homeostasis. In this thesis, the molecular chaperone Spy of E. coli was used to study kinetic, thermodyna…