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View article: Machine Perfusion in an Ageing Population - Results From a German, National Survey Among Transplant Centers
Machine Perfusion in an Ageing Population - Results From a German, National Survey Among Transplant Centers Open
Machine perfusion (MP) is rapidly emerging as an alternative to static cold storage in transplantation, providing notable benefits in graft preservation and repair. To better understand the current landscape of machine perfusion in Germany…
View article: Outcomes of Kidney Transplants from Donors after Circulatory Death with Acute Kidney Injury: A Systematic Review
Outcomes of Kidney Transplants from Donors after Circulatory Death with Acute Kidney Injury: A Systematic Review Open
Background Kidney transplantation offers superior survival to dialysis, but donor organ shortage limits access. Utilizing kidneys from donation after circulatory death (DCD) donors with acute kidney injury (AKI) could expand the donor pool…
View article: Hypothermic oxygenated perfusion (HOPE) against cancer recurrence after liver transplantation for hepatocellular carcinoma—study protocol for an international multicenter randomized controlled trial (HOPE4Cancer)
Hypothermic oxygenated perfusion (HOPE) against cancer recurrence after liver transplantation for hepatocellular carcinoma—study protocol for an international multicenter randomized controlled trial (HOPE4Cancer) Open
Background A frequent and increasing indication for liver transplantation (LT) is hepatocellular carcinoma (HCC). However, despite strict selection criteria, HCC recurrence after LT occurs in a relevant proportion of patients and is associ…
View article: Technological Advances in Pre-Operative Planning
Technological Advances in Pre-Operative Planning Open
Surgery remains a healthcare intervention with significant risks for patients. Novel technologies can now enhance the peri-operative workflow, with artificial intelligence (AI) and extended reality (XR) to assist with pre-operative plannin…
View article: Technological Advances in Pre-Operative Planning
Technological Advances in Pre-Operative Planning Open
Surgery remains a healthcare intervention with significant risks for patients. Novel technologies can now enhance the peri-operative workflow, with artificial intelligence (AI) and extended reality (XR) to assist with pre-operative plannin…
View article: Correction to: The role of resection in hepatocellular carcinoma BCLC stage B: A multi-institutional patient-level meta-analysis and systematic review
Correction to: The role of resection in hepatocellular carcinoma BCLC stage B: A multi-institutional patient-level meta-analysis and systematic review Open
Correction to: Langenbeck’s Archives of Surgery (2024) 409:277. https://doi.org/10.1007/s00423-024-03466-x. This article unfortunately contained a mistake. The author name ‘Mathew Vithayathil’ was incorrectly written as ‘Vithayathil Mathew…
View article: Full robotic versus open ALPPS: a bi-institutional comparison of perioperative outcomes
Full robotic versus open ALPPS: a bi-institutional comparison of perioperative outcomes Open
Background In primarily unresectable liver tumors, ALPPS ( Associating Liver Partition and Portal Vein Ligation for Staged hepatectomy ) may offer curative two-stage hepatectomy trough a fast and extensive hypertrophy. However, concerns ha…
View article: Full Robotic Versus Open ALPPS: A Bi-Institutional Comparison of Perioperative Outcomes
Full Robotic Versus Open ALPPS: A Bi-Institutional Comparison of Perioperative Outcomes Open
Background In primarily unresectable liver tumors, ALPPS (Associating Liver Partition and Portal Vein Ligation for Staged hepatectomy) may offer curative two stage hepatectomy trough a fast and extensive hypertrophy. However, concerns have…
View article: Long-Term Ex Situ Normothermic Kidney Perfusion
Long-Term Ex Situ Normothermic Kidney Perfusion Open
Background Marginal grafts are increasingly considered for transplantation due to the widening gap of available donor grafts and waiting recipients. Graft assessment and repair prior to implantation are therefore essential to minimize the …
View article: New trends in surgery for colorectal liver metastasis
New trends in surgery for colorectal liver metastasis Open
By presenting the most up‐to‐date findings and incorporating the latest evidence, this article seeks to present a comprehensive guide for navigating the complexities inherent in the management of colorectal liver metastasis. It aims to ser…
View article: Outcomes of Kidney Perfusion Techniques in Transplantation from Deceased Donors: A Systematic Review and Meta-Analysis
Outcomes of Kidney Perfusion Techniques in Transplantation from Deceased Donors: A Systematic Review and Meta-Analysis Open
The high demand for organs in kidney transplantation and the expansion of the donor pool have led to the widespread implementation of machine perfusion technologies. In this study, we aim to provide an up-to-date systematic review of the d…
View article: Current Evidence and Future Perspectives to Implement Continuous and End-Ischemic Use of Normothermic and Oxygenated Hypothermic Machine Perfusion in Clinical Practice
Current Evidence and Future Perspectives to Implement Continuous and End-Ischemic Use of Normothermic and Oxygenated Hypothermic Machine Perfusion in Clinical Practice Open
The use of high-risk renal grafts for transplantation requires the optimization of pretransplant assessment and preservation reconditioning strategies to decrease the organ discard rate and to improve short- and long-term clinical outcomes…
View article: SUPPLEMENTARY FIGURES: Antihypoxic Effects of Myo-Inositol Trispyrophosphate on Vasculature and Therapy of Colorectal Liver Metastasis from Antihypoxic Potentiation of Standard Therapy for Experimental Colorectal Liver Metastasis through Myo-Inositol Trispyrophosphate
SUPPLEMENTARY FIGURES: Antihypoxic Effects of Myo-Inositol Trispyrophosphate on Vasculature and Therapy of Colorectal Liver Metastasis from Antihypoxic Potentiation of Standard Therapy for Experimental Colorectal Liver Metastasis through Myo-Inositol Trispyrophosphate Open
Supplementary Figure 1. ITPP increases O2 dissociation from hemoglobin. Supplementary Figure 2. Impact of ITPP on tumor burden, hypoxia and survival in the CT- 26/BALB model. Supplementary Figure 3. Impact of ITPP on metabolic and immune p…
View article: SUPPLEMENTS: Antihypoxic Effects of Myo-Inositol Trispyrophosphate on Vasculature and Therapy of Colorectal Liver Metastasis from Antihypoxic Potentiation of Standard Therapy for Experimental Colorectal Liver Metastasis through Myo-Inositol Trispyrophosphate
SUPPLEMENTS: Antihypoxic Effects of Myo-Inositol Trispyrophosphate on Vasculature and Therapy of Colorectal Liver Metastasis from Antihypoxic Potentiation of Standard Therapy for Experimental Colorectal Liver Metastasis through Myo-Inositol Trispyrophosphate Open
Supplementary Methods and Figure Legends
View article: Data from Antihypoxic Potentiation of Standard Therapy for Experimental Colorectal Liver Metastasis through Myo-Inositol Trispyrophosphate
Data from Antihypoxic Potentiation of Standard Therapy for Experimental Colorectal Liver Metastasis through Myo-Inositol Trispyrophosphate Open
Purpose: Tumor hypoxia activates hypoxia-inducible factors (Hifs), which induce a range of malignant changes including vascular abnormalities. Here, we determine whether inhibition of the hypoxic tumor response through myo-inositol trispyr…
View article: SUPPLEMENTARY FIGURES: Antihypoxic Effects of Myo-Inositol Trispyrophosphate on Vasculature and Therapy of Colorectal Liver Metastasis from Antihypoxic Potentiation of Standard Therapy for Experimental Colorectal Liver Metastasis through Myo-Inositol Trispyrophosphate
SUPPLEMENTARY FIGURES: Antihypoxic Effects of Myo-Inositol Trispyrophosphate on Vasculature and Therapy of Colorectal Liver Metastasis from Antihypoxic Potentiation of Standard Therapy for Experimental Colorectal Liver Metastasis through Myo-Inositol Trispyrophosphate Open
Supplementary Figure 1. ITPP increases O2 dissociation from hemoglobin. Supplementary Figure 2. Impact of ITPP on tumor burden, hypoxia and survival in the CT- 26/BALB model. Supplementary Figure 3. Impact of ITPP on metabolic and immune p…
View article: SUPPLEMENTS: Antihypoxic Effects of Myo-Inositol Trispyrophosphate on Vasculature and Therapy of Colorectal Liver Metastasis from Antihypoxic Potentiation of Standard Therapy for Experimental Colorectal Liver Metastasis through Myo-Inositol Trispyrophosphate
SUPPLEMENTS: Antihypoxic Effects of Myo-Inositol Trispyrophosphate on Vasculature and Therapy of Colorectal Liver Metastasis from Antihypoxic Potentiation of Standard Therapy for Experimental Colorectal Liver Metastasis through Myo-Inositol Trispyrophosphate Open
Supplementary Methods and Figure Legends
View article: Data from Antihypoxic Potentiation of Standard Therapy for Experimental Colorectal Liver Metastasis through Myo-Inositol Trispyrophosphate
Data from Antihypoxic Potentiation of Standard Therapy for Experimental Colorectal Liver Metastasis through Myo-Inositol Trispyrophosphate Open
Purpose: Tumor hypoxia activates hypoxia-inducible factors (Hifs), which induce a range of malignant changes including vascular abnormalities. Here, we determine whether inhibition of the hypoxic tumor response through myo-inositol trispyr…
View article: Real-time assessment of kidney allografts during HOPE using flavin mononucleotide (FMN) — a preclinical study
Real-time assessment of kidney allografts during HOPE using flavin mononucleotide (FMN) — a preclinical study Open
Introduction The gap between available donor grafts and patients on the waiting lists is constantly growing. This leads to an increased utilization of high-risk and therefore more vulnerable kidney grafts. The use of high-risk organs requi…
View article: Low‐dose aspirin confers protection against acute cellular allograft rejection after primary liver transplantation
Low‐dose aspirin confers protection against acute cellular allograft rejection after primary liver transplantation Open
This study investigated the effect of low‐dose aspirin in primary adult liver transplantation (LT) on acute cellular rejection (ACR) as well as arterial patency rates. The use of low‐dose aspirin after LT is practiced by many transplant ce…
View article: Liver resection and ablation for squamous cell carcinoma liver metastases.
Liver resection and ablation for squamous cell carcinoma liver metastases. Open
BACKGROUND: Limited evidence exists to guide the management of patients with liver metastases from squamous cell carcinoma (SCC). The aim of this retrospective multicentre cohort study was to describe patterns of disease recurrence after l…
View article: Long-Term Effects of Pedicle Clamping during Major Hepatectomy for Colorectal Liver Metastases
Long-Term Effects of Pedicle Clamping during Major Hepatectomy for Colorectal Liver Metastases Open
The use of the Pringle maneuver (PM) varies widely among surgical departments. Its use depends on the operator and type of liver resection. The aim of this study was to determine the impact of the PM on patient outcomes when undergoing maj…