Philipp A. Lang
YOU?
Author Swipe
View article: Bile acid receptor Tgr5 prevents macrophage hyperinflammation during bacterial sepsis through metabolic and epigenetic silencing
Bile acid receptor Tgr5 prevents macrophage hyperinflammation during bacterial sepsis through metabolic and epigenetic silencing Open
Summary: Tgr5 is a membrane-bound bile acid receptor that negatively regulates immune cells, although the molecular mechanisms behind this observation remain elusive. Here we report that Tgr5 is upregulated in macrophages during stimulatio…
View article: Optimized arenaviruses with tumor-tropic mutations promote safe anti-tumor efficacy via sustainable immune modulatory properties
Optimized arenaviruses with tumor-tropic mutations promote safe anti-tumor efficacy via sustainable immune modulatory properties Open
The non-cytopathic arenavirus lymphocytic choriomeningitis virus (LCMV) induces strong anti-tumor responses. To generate an optimized arenavirus for tumor therapy, we passage LCMV in human or murine tumor cells. Occurring mutations shift t…
View article: Effects of Helicobacter pylori infection on T cell activation markers and regulatory T cells in people with and without HIV infection in Central Ethiopia
Effects of Helicobacter pylori infection on T cell activation markers and regulatory T cells in people with and without HIV infection in Central Ethiopia Open
Background: Helicobacter pylori (H. pylori) is known to modulate host immunity and sustain chronic inflammation, yet most data come from HIV-negative populations. In people living with HIV, whose T cell compartments are already dysregulate…
View article: Controlling mitochondrial membrane architecture via MIC60 determines viral replication to promote anti-viral immunity
Controlling mitochondrial membrane architecture via MIC60 determines viral replication to promote anti-viral immunity Open
Virus-infected cells often exhibit dramatic cellular changes accompanied by altered mitochondrial function. The contribution of factors shaping the inner mitochondrial membrane (IMM) and cristae architecture to viral replication is insuffi…
View article: Myoglobin expression improves T-cell metabolism and antitumor effector function
Myoglobin expression improves T-cell metabolism and antitumor effector function Open
Background The tumor microenvironment is frequently hypoxic and characterized by a scarcity of nutritional resources including a shortage of glucose. As effector T cells have high energy demands, tumor metabolism can contribute to T-cell d…
View article: Deep transfer learning approach for automated cell death classification reveals novel ferroptosis-inducing agents in subsets of B-ALL
Deep transfer learning approach for automated cell death classification reveals novel ferroptosis-inducing agents in subsets of B-ALL Open
Ferroptosis is a recently described type of regulated necrotic cell death whose induction has anti-cancer therapeutic potential, especially in hematological malignancies. However, efforts to uncover novel ferroptosis-inducing therapeutics …
View article: Effects of Anti-CD20 Antibody Therapy on Immune Cell Dynamics in Relapsing-Remitting Multiple Sclerosis
Effects of Anti-CD20 Antibody Therapy on Immune Cell Dynamics in Relapsing-Remitting Multiple Sclerosis Open
Introduction: The efficacy of anti-CD20 antibodies has significantly contributed to advancing our understanding of disease pathogenesis and improved treatment outcomes in relapsing-remitting multiple sclerosis (RRMS). A comprehensive analy…
View article: Immune training enhances anti-viral responses and improves outcomes in Pax5−/+ mice susceptible to chronic infection
Immune training enhances anti-viral responses and improves outcomes in Pax5−/+ mice susceptible to chronic infection Open
Viral infections pose a significant global burden. Host susceptibility to pathogens is determined by many factors including genetic variation that can lead to immunodeficient or dysregulated antiviral immune responses. Pax5 heterozygosity …
View article: Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease
Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease Open
Macrophages have important protective functions during infection with herpes simplex virus type 1 (HSV-1). However, molecular mechanisms that restrict viral propagation and protect from severe disease are unclear. Here we show that macroph…
View article: A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation
A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation Open
The intestinal tract generates significant reactive oxygen species (ROS), but the role of T cell antioxidant mechanisms in maintaining intestinal homeostasis is poorly understood. We used T cell-specific ablation of the catalytic subunit o…
View article: High-Affinity–Mediated Viral Entry Triggers Innate Affinity Escape Resulting in Type I IFN Resistance and Impaired T Cell Immunity
High-Affinity–Mediated Viral Entry Triggers Innate Affinity Escape Resulting in Type I IFN Resistance and Impaired T Cell Immunity Open
Increased receptor binding affinity may allow viruses to escape from Ab-mediated inhibition. However, how high-affinity receptor binding affects innate immune escape and T cell function is poorly understood. In this study, we used the lymp…
View article: A comparison of the <scp>McGrath</scp> videolaryngoscope with direct laryngoscopy for rapid sequence intubation in the operating theatre: a multicentre randomised controlled trial
A comparison of the <span>McGrath</span> videolaryngoscope with direct laryngoscopy for rapid sequence intubation in the operating theatre: a multicentre randomised controlled trial Open
Summary Aspiration of gastric contents is a recognised complication during all phases of anaesthesia. The risk of this event becomes more likely with repeated attempts at tracheal intubation. There is a lack of clinical data on the effecti…
View article: BATF controls IFN I production via DC-SCRIPT in plasmacytoid dendritic cells
BATF controls IFN I production via DC-SCRIPT in plasmacytoid dendritic cells Open
The basic leucine zipper ATF-like transcription factor (BATF) plays a pivotal role in coordinating various aspects of lymphoid cell biology, yet essential functions in dendritic cells (DCs) have not been reported. Here we demonstrate that …
View article: 1403-C 5-Nonyloxytryptamine reveals novel approach for MHC-I upregulation in tumors
1403-C 5-Nonyloxytryptamine reveals novel approach for MHC-I upregulation in tumors Open
Background Melanoma is categorized as an immunologically 'cold' tumor due to its unresponsiveness to immunotherapies. Efforts to enhance the immune response against tumor cells have focused on manipulating exhausted cytotoxic T lymphocyte …
View article: Regulation of STING activity in DNA sensing by ISG15 modification
Regulation of STING activity in DNA sensing by ISG15 modification Open
Sensing of human immunodeficiency virus type 1 (HIV-1) DNA is mediated by the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling axis. Signal transduction and regulation of this cascade is achieved by post-transl…
View article: Unleashing T cell anti-tumor immunity: new potential for 5-Nonloxytryptamine as an agent mediating MHC-I upregulation in tumors
Unleashing T cell anti-tumor immunity: new potential for 5-Nonloxytryptamine as an agent mediating MHC-I upregulation in tumors Open
Background New therapies are urgently needed in melanoma, particularly in late-stage patients not responsive to immunotherapies and kinase inhibitors. To uncover novel potentiators of T cell anti-tumor immunity, we carried out an ex vivo p…
View article: The role of glycosylation patterns of viral glycoproteins and cell entry receptors in arenavirus infection.
The role of glycosylation patterns of viral glycoproteins and cell entry receptors in arenavirus infection. Open
Mammarenaviruses are enveloped RNA viruses that can be associated with rodent-transmitted diseases in humans. Their virions are composed of a nucleocapsid surrounded by a lipid bilayer with glycoprotein (GP) spikes interacting with recepto…
View article: Differential Modulation of miR-122 Transcription by TGFβ1/BMP6: Implications for Nonresolving Inflammation and Hepatocarcinogenesis
Differential Modulation of miR-122 Transcription by TGFβ1/BMP6: Implications for Nonresolving Inflammation and Hepatocarcinogenesis Open
Chronic inflammation is widely recognized as a significant factor that promotes and worsens the development of malignancies, including hepatocellular carcinoma. This study aimed to explore the potential role of microRNAs in inflammation-as…
View article: A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation
A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation Open
Summary Although the intestinal tract is a major site of reactive oxygen species (ROS) generation, the mechanisms by which antioxidant defense in gut T cells contribute to intestinal homeostasis are currently unknown. Here we show, using T…
View article: Differential modulation of miR-122 transcription by TGFβ1/BMP6: implications for nonresolving inflammation and hepatocarcinogenesis
Differential modulation of miR-122 transcription by TGFβ1/BMP6: implications for nonresolving inflammation and hepatocarcinogenesis Open
Chronic inflammation is widely recognized as a significant factor that promotes and worsens the development of malignancies, including hepatocellular carcinoma. This study aimed to explore the potential role of microRNAs in inflammation-as…
View article: Supplementary Table 2 from BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment
Supplementary Table 2 from BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment Open
Supplementary Table 2 provides the clinical details of melanoma patients treated with immunotherapy
View article: Supplementary Figure7 from BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment
Supplementary Figure7 from BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment Open
Figure S7 shows the individual tumor growths comprising the main figures
View article: Supplementary Table 1 from BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment
Supplementary Table 1 from BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment Open
Supplementary Table 1 provides a list of significantly changed genes between monocytes harvested from BAFF and control tumors
View article: Supplementary Table 2 from BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment
Supplementary Table 2 from BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment Open
Supplementary Table 2 provides the clinical details of melanoma patients treated with immunotherapy
View article: Supplementary Figure 1 from BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment
Supplementary Figure 1 from BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment Open
Figure S1 shows the in vitro characterization of the BAFF-expressing melanoma cell line