Explanipedia

EP03.02 IMAGING-BASED PREDICTION OF 5-ALA FLUORESCENCE IN GLIOMAS USING PREOPERATIVE 7T MRSI COMPARED TO T1W MRI AND PET Open

Sara Huskić, Philipp Lazen, Cornelius Cadrien, Thomas Roetzer-Pejrimovsky, Barbara Kiesel , et al. · 2025

BACKGROUND Maximizing the extent of safe tumor resection is a critical factor influencing survival outcomes in glioma patients. The use of 5-aminolevulinic acid (5-ALA) fluorescence has proven effective in enhancing resection, particularly…

Glutamine Metabolism and Metabolic Profiling Using <span>7 T CRT</span>‐<span>FID MRSI</span> in Focal Epilepsy Open

Stuart M. Chambers, Philipp Lazen, Matej Hoťka, Haniye Shayeste, Matthias Tomschik , et al. · 2025

Background Approximately one‐third of people with epilepsy (PWE) remain drug‐resistant. In these cases, surgical resection of the epileptogenic zone may significantly reduce or eliminate seizures. Surgery necessitates precise delineation o…

High-Resolution Mapping of Tumor and Peritumoral Glutamate and Glutamine in Gliomas Using 7-T MRSI Open

Gilbert Hangel, Philipp Lazen, Cornelius Cadrien, Stefanie Chambers, Julia Furtner , et al. · 2025

The 7-T MR spectroscopic imaging revealed increased glutamate and glutamine metabolic ratios within the peritumoral region compared with normal-appearing white matter in patients with glioma distinct from intratumoral changes, suggesting i…

The relationship of glutamate and glutamine and metabolic profiling in focal epilepsy using 7T CRT-FID-MRSI Open

Stuart M. Chambers, Philipp Lazen, Haniye Shayeste, Matthias Tomschik, Jonathan Wais , et al. · 2025

Approximately one-third of people with epilepsy (PWE) remain drug-resistant. In these cases, surgical resection of the epileptogenic zone may significantly reduce or eliminate seizures. Surgery necessitates precise delineation of the epile…

Exploring in vivo human brain metabolism at 10.5 T: Initial insights from MR spectroscopic imaging Open

Lukas Hingerl, Bernhard Strasser, Simon Schmidt, Korbinian Eckstein, Guglielmo Genovese , et al. · 2025

These preliminary findings highlight the potential of 10.5 T MRSI as a powerful imaging tool for probing cerebral metabolism. By providing unprecedented spatial and spectral resolution, this technology could offer a unique view into the me…

Imaging of increased peritumoral glutamate and glutamine in gliomas using 7T MRSI Open

Gilbert Hangel, Philipp Lazen, Cornelius Cadrien, Stefanie Chambers, Julia Furtner , et al. · 2024

Objectives Diffuse gliomas, due to their infiltrative properties, still lack effective treatment options. Recent research indicates that infiltration, malignancy, and symptoms such as epilepsy are related to synaptic connections between in…

7 Tesla magnetic resonance spectroscopic imaging predicting IDH status and glioma grading Open

Cornelius Cadrien, Sukrit Sharma, Philipp Lazen, Roxane Licandro, Julia Furtner , et al. · 2024

Introduction With the application of high-resolution 3D 7 Tesla Magnetic Resonance Spectroscopy Imaging (MRSI) in high-grade gliomas, we previously identified intratumoral metabolic heterogeneities. In this study, we evaluated the potentia…

Correction to: Implementation of a 7T Epilepsy Task Force consensus imaging protocol for routine presurgical epilepsy work-up: effect on diagnostic yield and lesion delineation Open

Gilbert Hangel, Gregor Kasprian, Stefanie Chambers, Lukas Haider, Philipp Lazen , et al. · 2024

A guide to advanced MRI processing for clinical glioma research Open

Patricia Clement, Soetkin Beun, Fatemehsadat Arzanforoosh, Marco Castellaro, Giulia Debiasi , et al. · 2024

BackgroundTo date, multiple advanced magnetic resonance imaging (MRI) methods beyond conventional qualitative structural imaging for the diagnosis, prognosis, and treatment follow-up of glioma have demonstrated their utility for clinical s…

Advanced MRI processing for clinical glioma research (PubMed). Open

Patricia Clement, Soetkin Beun, Fatemehsadat Arzanforoosh, Marco Castellaro, Giulia Debiasi , et al. · 2024

This guide summarizes the state-of-the-art processing software solutions and the repositories/communities for the following advanced MRI methods: DSC; DCE; ASL; diffusion MRI; relaxometry; MRF; MRS; CEST; SWI; QSM; MRE; and task-based and …

A Comparison of 7 Tesla MR Spectroscopic Imaging and 3 Tesla MR Fingerprinting for Tumor Localization in Glioma Patients Open

Philipp Lazen, Pedro Lima Cardoso, Sukrit Sharma, Cornelius Cadrien, Thomas Roetzer-Pejrimovsky , et al. · 2024

This paper investigated the correlation between magnetic resonance spectroscopic imaging (MRSI) and magnetic resonance fingerprinting (MRF) in glioma patients by comparing neuro-oncological markers obtained from MRSI to T1/T2 maps from MRF…

Intraoperative Precision Sampling of Tumor Microenvironments based on 7T MRSI: A pipeline development Open

Sagar Acharya, Cornelius Cadrien, Sara Huskić, Philipp Lazen, Claus Brenner , et al. · 2024

Segmentation of 7 Tesla Magnetic Resonance Images of Epileptic Patients using SynthSeg Open

Haniye Shayeste, Stefanie Chambers, Philipp Lazen, Matthias Tomschik, Jonathan Wais , et al. · 2024

Implementation of a 7T Epilepsy Task Force consensus imaging protocol for routine presurgical epilepsy work-up: effect on diagnostic yield and lesion delineation Open

Gilbert Hangel, Gregor Kasprian, Stefanie Chambers, Lukas Haider, Philipp Lazen , et al. · 2023

Objective Recently, the 7 Tesla (7 T) Epilepsy Task Force published recommendations for 7 T magnetic resonance imaging (MRI) in patients with pharmaco-resistant focal epilepsy in pre-surgical evaluation. The objective of this study was to …

A comparison of 7 Tesla MR spectroscopic imaging and 3 Tesla MR fingerprinting for tumor localization in glioma patients Open

Philipp Lazen, Pedro Lima Cardoso, Sukrit Sharma, Cornelius Cadrien, Thomas Roetzer-Pejrimovsky , et al. · 2023

This paper investigates the correlation between magnetic resonance spectroscopic imaging (MRSI) and magnetic resonance fingerprinting (MRF) in glioma patients by comparing neuro-oncological markers obtained from MRSI to T1/T2 maps from MRF…

7T HR FID-MRSI Compared to Amino Acid PET: Glutamine and Glycine as Promising Biomarkers in Brain Tumors Open

Gilbert Hangel, Philipp Lazen, Sukrit Sharma, Barbara Hristoska, Cornelius Cadrien , et al. · 2022

(1) Background: Recent developments in 7T magnetic resonance spectroscopic imaging (MRSI) made the acquisition of high-resolution metabolic images in clinically feasible measurement times possible. The amino acids glutamine (Gln) and glyci…

High-resolution 7 Tesla magnetic resonance metabolic imaging in epilepsy patients Open

Fabian Winter, Gilbert Hangel, Philipp Lazen, Matthias Tomschik, Jonathan Wais , et al. · 2022

Emerging methods and applications of ultra-high field MR spectroscopic imaging in the human brain Open

Gilbert Hangel, Eva Niess, Philipp Lazen, Petr Bednařík, Wolfgang Bogner , et al. · 2021

Magnetic Resonance Spectroscopic Imaging (MRSI) of the brain enables insights into the metabolic changes and fluxes in diseases such as tumors, multiple sclerosis, epilepsy, or hepatic encephalopathy, as well as insights into general brain…

Inter‐subject stability and regional concentration estimates of 3D‐FID‐MRSI in the human brain at 7 T Open

Gilbert Hangel, Benjamin Spurny‐Dworak, Philipp Lazen, Cornelius Cadrien, Sukrit Sharma , et al. · 2021

Purpose Recently, a 3D‐concentric ring trajectory (CRT)‐based free induction decay (FID)‐MRSI sequence was introduced for fast high‐resolution metabolic imaging at 7 T. This technique provides metabolic ratio maps of almost the entire brai…

BIMG-04. MAPPING HETEROGENEITY OF HIGH-GRADE GLIOMA METABOLISM USING HIGH RESOLUTION 7T MRSI Open

Gilbert Hangel, Cornelius Cadrien, Philipp Lazen, Sukrit Sharma, Julia Furtner , et al. · 2021

OBJECTIVES Neurosurgical resection in gliomas depends on the precise preoperative definition of the tumor and its margins to realize a safe maximum resection that translates into a better patient outcome. New metabolic imaging techniques c…

Creating an RF Pulse Simulation Model for Whole-Brain MRSI at 7T Open

Philipp Lazen · 2020

Diese Diplomarbeit befasst sich damit, wie man Magnetresonanzspektroskopie-Bildgebung (MRSI) durch optimierte Radio-Frequenz-Anregungspulse (RF Pulse) verbessern kann. Im Rahmen der Arbeit wurde ein Simulationsmodell programmiert und verwe…

High-resolution metabolic imaging of high-grade gliomas using 7T-CRT-FID-MRSI Open

Gilbert Hangel, Cornelius Cadrien, Philipp Lazen, Julia Furtner, Alexandra Lipka , et al. · 2020

Philipp Lazen YOU? Author Swipe