Philipp T. Meyer
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View article: O-(2-[18F]fluoroethyl)-L-tyrosine-PET-guided versus contrast-enhanced T1-weighted MRI-guided re-irradiation in patients with recurrent glioblastoma (GLIAA/NOA-10 ARO2013-01): a multicentre, open-label, randomised trial
O-(2-[18F]fluoroethyl)-L-tyrosine-PET-guided versus contrast-enhanced T1-weighted MRI-guided re-irradiation in patients with recurrent glioblastoma (GLIAA/NOA-10 ARO2013-01): a multicentre, open-label, randomised trial Open
View article: Salvage Lymph Node Dissection for Nodal Recurrent Prostate Cancer—Oncological Outcome from Long-term Follow-up
Salvage Lymph Node Dissection for Nodal Recurrent Prostate Cancer—Oncological Outcome from Long-term Follow-up Open
View article: The German Cancer Consortium (DKTK) multi-center prospective phase 1/2 68Ga-PSMA-11 PET-imaging trial in newly-diagnosed high-risk prostate cancer: Safety and diagnostic accuracy compared to histopathology and their impact on patient management
The German Cancer Consortium (DKTK) multi-center prospective phase 1/2 68Ga-PSMA-11 PET-imaging trial in newly-diagnosed high-risk prostate cancer: Safety and diagnostic accuracy compared to histopathology and their impact on patient management Open
Purpose Clinically accurate detection of prostate cancer (PCa) metastases is crucial for management of high-risk PCa patients scheduled for radical prostatectomy. We determine the safety and diagnostic accuracy of pre-operative 68 Ga-PSMA-…
View article: Neuronal mechanisms underlying binaural performance with cochlear implant in single-sided deafness: a [15O]water PET study
Neuronal mechanisms underlying binaural performance with cochlear implant in single-sided deafness: a [15O]water PET study Open
Purpose We examined neuronal activation patterns in single-sided deaf (SSD) cochlear implant (CI) recipients and normal-hearing (NH) controls to unravel neuronal mechanisms underlying binaural integration in SSD-CI. Methods 20 SSD-CI (CI l…
View article: Associations of lifestyle factors with amyloid pathology in persons without dementia
Associations of lifestyle factors with amyloid pathology in persons without dementia Open
Background The association between lifestyle factors and Alzheimer's disease (AD) pathophysiology remains incompletely understood. Objective The aim of this study was to assess the association of alcohol consumption, smoking behavior, slee…
View article: [18F]FDG-PET reveals early postoperative cortical dysfunction after subthalamic nucleus deep brain stimulation in Parkinson’s disease
[18F]FDG-PET reveals early postoperative cortical dysfunction after subthalamic nucleus deep brain stimulation in Parkinson’s disease Open
Purpose Motor improvement and neuropsychiatric symptoms may immediately follow implantation of subthalamic nucleus deep brain stimulation (STN-DBS) electrodes in Parkinson’s disease (PD). We investigated the impact of electrode implantatio…
View article: Acetyl-DL-leucine (Tanganil™) in three patients with advanced multiple system atrophy
Acetyl-DL-leucine (Tanganil™) in three patients with advanced multiple system atrophy Open
View article: Divergent effects of age on imaging‐based ATN biomarkers and cognition in Alzheimer's disease
Divergent effects of age on imaging‐based ATN biomarkers and cognition in Alzheimer's disease Open
INTRODUCTION We investigated whether age of patients with Alzheimer‘s disease (AD) at first visit to a memory clinic predicts biomarker findings along the amyloid beta deposition, pathologic tau, and neurodegeneration (ATN) scheme and mode…
View article: Building Automotive Security on Internet Standards: An Integration of DNSSEC, DANE, and DANCE to Authenticate and Authorize In-Car Services
Building Automotive Security on Internet Standards: An Integration of DNSSEC, DANE, and DANCE to Authenticate and Authorize In-Car Services Open
The automotive industry is undergoing a software-as-a-service transformation that enables software-defined functions and post-sale updates via cloud and vehicle-to-everything communication. Connectivity in cars introduces significant secur…
View article: Stemless total shoulder arthroplasty with nonspherical polyethylene humeral head
Stemless total shoulder arthroplasty with nonspherical polyethylene humeral head Open
The early clinical and radiographic results of this novel implant are promising and support the concept of inverted bearing materials in stemless aTSA, demonstrating improvements that outreach the relative substantial clinical benefit for …
View article: Measuring cerebrovascular reactivity with breath-hold fMRI in patients with Moyamoya angiopathy: MR perfusion based delay correction significantly improves agreement to [15O]water PET
Measuring cerebrovascular reactivity with breath-hold fMRI in patients with Moyamoya angiopathy: MR perfusion based delay correction significantly improves agreement to [15O]water PET Open
View article: Use of 68Ga-labeled Macroaggregated Albumin Particles for Selective Internal Radiation Therapy (SIRT) Dosimetry and Treatment Planning
Use of 68Ga-labeled Macroaggregated Albumin Particles for Selective Internal Radiation Therapy (SIRT) Dosimetry and Treatment Planning Open
In October 2024, Europe again experienced a period of shortage of technetium-labeled tracers. In order not to delay time-critical treatments of liver tumors, we turned to 68 Ga-labeled macroaggregated albumin particles ([ 68 Ga]Ga-MAA) as …
View article: [<sup>18</sup>F]Florzolotau PET for the Differential Diagnosis of Parkinsonism in Patients with Suspected 4-Repeat Tauopathies
[<sup>18</sup>F]Florzolotau PET for the Differential Diagnosis of Parkinsonism in Patients with Suspected 4-Repeat Tauopathies Open
The second-generation tau radioligand [18F]florzolotau is a promising biomarker for 4-repeat (4R) tauopathies such as progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), which are difficult to disentangle c…
View article: The Status of Neuroimaging with SPECT and PET in Germany: Results from the 1st Survey on Nuclear Neuroimaging in Germany in 2023
The Status of Neuroimaging with SPECT and PET in Germany: Results from the 1st Survey on Nuclear Neuroimaging in Germany in 2023 Open
Summary The advent of disease-modifying therapies for neurodegenerative diseases may result in a growing demand for nuclear neuroimaging procedures presenting opportunities but also challenges to the nuclear medicine community. Whether cap…
View article: Neuroimaging in multiple system atrophy: clinical implications and novel developments
Neuroimaging in multiple system atrophy: clinical implications and novel developments Open
Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by cerebellar dysfunction, a Parkinsonian syndrome with poor response to levodopa and autonomic failure. The diagnosis of MSA is particularly challenging in its ea…
View article: Capacity for brain amyloid PET in Germany: Results from the 1st survey on nuclear brain imaging in Germany
Capacity for brain amyloid PET in Germany: Results from the 1st survey on nuclear brain imaging in Germany Open
View article: The Neuropsychiatric Checklist for Autoimmune Psychosis: A Narrative Review
The Neuropsychiatric Checklist for Autoimmune Psychosis: A Narrative Review Open
Autoimmune encephalitis (AE) is a rapidly evolving topic in both neurology and psychiatry. A recent international consensus article defined criteria for possible, probable, and definite autoimmune psychosis (AP) inspired by the principles …
View article: First Lessons Learned of an Artificial Intelligence Robotic System for Autonomous Coarse Waste Recycling Using Multispectral Imaging-Based Methods
First Lessons Learned of an Artificial Intelligence Robotic System for Autonomous Coarse Waste Recycling Using Multispectral Imaging-Based Methods Open
Current disposal facilities for coarse-grained waste perform manual sorting of materials with heavy machinery. Large quantities of recyclable materials are lost to coarse waste, so more effective sorting processes must be developed to reco…
View article: Depressive Symptoms and Amyloid Pathology
Depressive Symptoms and Amyloid Pathology Open
Importance Depressive symptoms are associated with cognitive decline in older individuals. Uncertainty about underlying mechanisms hampers diagnostic and therapeutic efforts. This large-scale study aimed to elucidate the association betwee…
View article: IR spectra of the CH3 stretching region of methylamine monomer, dimer and trimer in helium nanodroplets
IR spectra of the CH3 stretching region of methylamine monomer, dimer and trimer in helium nanodroplets Open
View article: Voxel‐wise Florzolotau (APN‐1607) Tau PET Covariance Patterns in Alzheimer’s Disease and Progressive Supranuclear Palsy
Voxel‐wise Florzolotau (APN‐1607) Tau PET Covariance Patterns in Alzheimer’s Disease and Progressive Supranuclear Palsy Open
Background Florzolotau (APN‐1607) tau‐PET has shown distinct patterns of binding in patients with AD and 4‐repeat tauopathies. We aimed to establish disease‐specific tau covariance patterns in AD and PSP/CBS and validate them as user‐indep…
View article: Voxel‐wise Florzolotau (APN‐1607) Tau PET Covariance Patterns in Alzheimer’s Disease and Progressive Supranuclear Palsy
Voxel‐wise Florzolotau (APN‐1607) Tau PET Covariance Patterns in Alzheimer’s Disease and Progressive Supranuclear Palsy Open
Background Florzolotau (APN‐1607) tau‐PET has shown distinct patterns of binding in patients with AD and 4‐repeat tauopathies. We aimed to establish disease‐specific tau covariance patterns in AD and PSP/CBS and validate them as user‐indep…
View article: Reliable diagnosis of nigrostriatal degeneration by dopamine transporter SPECT despite drug interaction with venlafaxine or bupropion
Reliable diagnosis of nigrostriatal degeneration by dopamine transporter SPECT despite drug interaction with venlafaxine or bupropion Open
Purpose This study examined the impact of venlafaxine and bupropion on the detection of nigrostriatal degeneration by dopamine transporter (DAT)-SPECT. Methods 43 patients (70.7 ± 8.6y, 44% female) with [ 123 I]FP-CIT-SPECT under venlafaxi…
View article: Effect of cerebral sinus venous thrombosis and its location on cerebral blood flow: a [15O]water PET study in acute stroke patients compared to healthy volunteers
Effect of cerebral sinus venous thrombosis and its location on cerebral blood flow: a [15O]water PET study in acute stroke patients compared to healthy volunteers Open
View article: Alternative lengthening of telomere-based immortalization renders H3G34R-mutant diffuse hemispheric glioma hypersensitive to PARP inhibitor combination regimens
Alternative lengthening of telomere-based immortalization renders H3G34R-mutant diffuse hemispheric glioma hypersensitive to PARP inhibitor combination regimens Open
Background Diffuse hemispheric glioma, H3 G34R/V-mutant (DHG-H3G34) is characterized by poor prognosis and lack of effective treatment options. DHG-H3G34R further harbor deactivation of alpha-thalassemia/mental retardation syndrome X-linke…
View article: O07 PSMA-PET and PROMISE re-define stage and risk in patients with prostate cancer: A multicentre retrospective study
O07 PSMA-PET and PROMISE re-define stage and risk in patients with prostate cancer: A multicentre retrospective study Open
View article: Aphthous lesions turned out to be neonatal very early-onset inflammatory bowel disease: a case report
Aphthous lesions turned out to be neonatal very early-onset inflammatory bowel disease: a case report Open
Neonatal diagnosis of inflammatory bowel disease (IBD) proves challenging due to its non-specific symptoms. A term-born neonate showing states of inflammation and aphthae was treated for sepsis and candidiasis before being diagnosed with i…
View article: SPECT/CT Accurately Predicts Postoperative Lung Function in Patients with Limited Pulmonary Reserve Undergoing Resection for Lung Cancer
SPECT/CT Accurately Predicts Postoperative Lung Function in Patients with Limited Pulmonary Reserve Undergoing Resection for Lung Cancer Open
Background: Preoperative prediction of postoperative pulmonary function after anatomical resection for lung cancer is essential to prevent long-term morbidity and mortality. Here, we compared the accuracy of hybrid single-photon emission c…
View article: Effect of cerebral sinus venous thrombosis and its location on cerebral blood flow: a [15O]water PET study in acute stroke patients compared to healthy volunteers
Effect of cerebral sinus venous thrombosis and its location on cerebral blood flow: a [15O]water PET study in acute stroke patients compared to healthy volunteers Open
Background: Symptoms in acute cerebral sinus venous thrombosis (CSVT) are highly variable, ranging from headaches to fatal stroke, and the basis for this high inter-individual variability is poorly understood. We assessed whether acute CSV…
View article: Brain perfusion SPECT in the presurgical evaluation of epilepsy: is additional ictal SPECT required in case of high-confidence lateralization of the seizure onset zone by interictal SPECT and vice versa?
Brain perfusion SPECT in the presurgical evaluation of epilepsy: is additional ictal SPECT required in case of high-confidence lateralization of the seizure onset zone by interictal SPECT and vice versa? Open