Philipp Novoszel
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View article: TYK2 Promotes Immunosurveillance of Colorectal Cancer Liver Metastasis
TYK2 Promotes Immunosurveillance of Colorectal Cancer Liver Metastasis Open
Colorectal cancer liver metastasis (CRLM) is a major clinical problem. The regulators of immunosurveillance of CRLM could hold potential for developing therapeutic strategies to prevent or treat metastasis. In this study, using a murine co…
View article: JAK-STAT1 as therapeutic target for EGFR deficiency-associated inflammation and scarring alopecia
JAK-STAT1 as therapeutic target for EGFR deficiency-associated inflammation and scarring alopecia Open
The hair follicle stem cell niche is an immune-privileged microenvironment, characterized by reduced antigen presentation, thus shielding against permanent immune-mediated tissue damage. In this study, we demonstrated the protective role o…
View article: The histone deacetylase HDAC1 controls dendritic cell development and anti-tumor immunity
The histone deacetylase HDAC1 controls dendritic cell development and anti-tumor immunity Open
Dendritic cell (DC) progenitors adapt their transcriptional program during development, generating different subsets. How chromatin modifications modulate these processes is unclear. Here, we investigate the impact of histone deacetylation…
View article: Scarring hair follicle destruction is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege
Scarring hair follicle destruction is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege Open
The hair follicle stem cell niche is an immune-privileged microenvironment, characterised by suppressed antigen presentation, thus shielding against permanent immune-mediated tissue damage. In this study, we demonstrate the protective role…
View article: <scp>FAM3C</scp> / <scp>ILEI</scp> protein is elevated in psoriatic lesions and triggers psoriasiform hyperproliferation in mice
<span>FAM3C</span> / <span>ILEI</span> protein is elevated in psoriatic lesions and triggers psoriasiform hyperproliferation in mice Open
FAM3C/ILEI is an important cytokine for tumor progression and metastasis. However, its involvement in inflammation remains elusive. Here, we show that ILEI protein is highly expressed in psoriatic lesions. Inducible keratinocyte‐specific I…
View article: Ex-Vivo Skin Explant Culture Is a Model for TSLP-Mediated Skin Barrier Immunity
Ex-Vivo Skin Explant Culture Is a Model for TSLP-Mediated Skin Barrier Immunity Open
The skin is the outermost barrier protecting the body from pathogenic invasion and environmental insults. Its breakdown initiates the start of skin inflammation. The epidermal growth factor (EGFR) on keratinocytes protects this barrier, an…
View article: EGFR is required for FOS‐dependent bone tumor development via RSK2/CREB signaling
EGFR is required for FOS‐dependent bone tumor development via RSK2/CREB signaling Open
Osteosarcoma (OS) is a rare tumor of the bone occurring mainly in young adults accounting for 5% of all childhood cancers. Because of the limited therapeutic options, there has been no survival improvement for OS patients in the past 40 ye…