Philipp Ralfs
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View article: Soluble ORF2 protein enhances HEV replication and induces long-lasting antibody response and protective immunity in vivo
Soluble ORF2 protein enhances HEV replication and induces long-lasting antibody response and protective immunity in vivo Open
Background and Aims: The HEV is a small positive–sense RNA virus that encodes a cytoplasmic form of the capsid protein (ORF2c), essential for virion structure, and a secreted glycosylated form (ORF2s) that accumulates at high titer in seru…
View article: Plasmacytoid dendritic cells produce type I interferon and reduce viral replication in airway epithelial cells after SARS-CoV-2 infection
Plasmacytoid dendritic cells produce type I interferon and reduce viral replication in airway epithelial cells after SARS-CoV-2 infection Open
Infection with SARS-CoV-2 has caused a pandemic of unprecedented dimensions. SARS-CoV-2 infects airway and lung cells causing viral pneumonia. The importance of type I interferon (IFN) production for the control of SARS-CoV-2 infection is …
View article: Type I and Type III Interferons Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures
Type I and Type III Interferons Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures Open
The current pandemic of respiratory illness, COVID-19, is caused by a recently emerged coronavirus named SARS-CoV-2. This virus infects airway and lung cells causing fever, dry cough, and shortness of breath. Severe cases of COVID-19 can r…
View article: Generation of induced pluripotent stem cells (iPSCs) from human foreskin fibroblasts
Generation of induced pluripotent stem cells (iPSCs) from human foreskin fibroblasts Open
The human iPS cell line VUZUZLi001-A (hVH-1) was generated from human foreskin fibroblasts to be used as a control line. Reprogramming was performed by retroviral transduction of reprogramming factors OCT4, SOX2, KLF4 and c-MYC. Resource t…