Philipp Reinhardt
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View article: Oncological value of MRI in brain metastasis: exploring the potential of combining post-contrast T1 TSE (SPACE) and T1 GRE (MPRAGE) for stereotactic radiosurgery planning and surveillance
Oncological value of MRI in brain metastasis: exploring the potential of combining post-contrast T1 TSE (SPACE) and T1 GRE (MPRAGE) for stereotactic radiosurgery planning and surveillance Open
Purpose Accurate MRI-based detection of brain metastases (BM) is essential for planning stereotactic radiosurgery (SRS). Although spin-echo (SE) sequences such as T1-SPACE have shown superior lesion detectability compared with gradient-rec…
View article: Evaluation of compartmentalized automatic segmentation for definition of the GTV in glioblastoma radiotherapy
Evaluation of compartmentalized automatic segmentation for definition of the GTV in glioblastoma radiotherapy Open
The Neosoma Glioma model generates clinically useful postoperative GTV segmentations, with geometric performance comparable to expert variability and dosimetric equivalence to consensus contours. It reduces contouring time by over 50%, ena…
View article: Does omitting the clinical target volume in stereotactic radiotherapy for NSCLC affect oncologic outcomes? A retrospective analysis
Does omitting the clinical target volume in stereotactic radiotherapy for NSCLC affect oncologic outcomes? A retrospective analysis Open
Omitting CTV margins in lung-SBRT may compromise LC when rCTV coverage with BED ≥100 Gy is insufficient, warranting further investigation into the clinical benefit of adding CTV margins.
View article: Predictive biomarkers of radiotherapy- related dermatitis, xerostomia, mucositis and dysphagia in head and neck cancer: A systematic review
Predictive biomarkers of radiotherapy- related dermatitis, xerostomia, mucositis and dysphagia in head and neck cancer: A systematic review Open
This review provides an overview of the research landscape, highlights research gaps and provides recommendations for future research directions. We identified several potential biomarkers, particularly in DNA repair pathways, that align w…
View article: Treatment and related morbidity of nasal cavity and paranasal sinus cancers
Treatment and related morbidity of nasal cavity and paranasal sinus cancers Open
Introduction Sinonasal malignancies are rare and histologically heterogeneous cancers of the nasal cavity and sinuses. The treatment of choice is usually surgery and, if necessary, adjuvant radiotherapy. In this study, we aimed to investig…
View article: Single versus multiple fraction stereotactic radiosurgery for medium-sized brain metastases (4-14 cc in volume): reducing or fractionating the radiosurgery dose?
Single versus multiple fraction stereotactic radiosurgery for medium-sized brain metastases (4-14 cc in volume): reducing or fractionating the radiosurgery dose? Open
Background and purpose Stereotactic radiosurgery (SRS) of brain metastases (BM) and resection cavities is a widely used and effective treatment modality. Based on target lesion size and anatomical location, single fraction SRS (SF-SRS) or …
View article: Accurate prediction of isocitrate dehydrogenase -mutation status of gliomas using SLOW-editing magnetic resonance spectroscopic imaging at 7 T MR
Accurate prediction of isocitrate dehydrogenase -mutation status of gliomas using SLOW-editing magnetic resonance spectroscopic imaging at 7 T MR Open
Background 2-hydroxy-glutarate (2HG) is a metabolite that accumulates in isocitrate dehydrogenase (IDH)-mutated gliomas and can be detected noninvasively using MR spectroscopy. However, due to the low concentration of 2HG, established magn…
View article: VoiceS: voice quality after transoral CO2 laser surgery versus single vocal cord irradiation for unilateral stage 0 and I glottic larynx cancer—a randomized phase III trial
VoiceS: voice quality after transoral CO2 laser surgery versus single vocal cord irradiation for unilateral stage 0 and I glottic larynx cancer—a randomized phase III trial Open
Background Surgery and radiotherapy are well-established standards of care for unilateral stage 0 and I early-stage glottic cancer (ESGC). Based on comparative studies and meta-analyses, functional and oncological outcomes after both treat…