Philipp Seppelt
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View article: Multimodality assessment of aortic valve area in aortic stenosis: a multicenter validation study
Multimodality assessment of aortic valve area in aortic stenosis: a multicenter validation study Open
Objectives Transthoracic echocardiography (TTE) is the standard modality for grading aortic stenosis (AS) severity. Transesophageal echocardiography (TOE) allows direct aortic valve area (AVA) planimetry (AVA TOE ), while computed tomograp…
View article: Multimodality assessment of aortic valve area in aortic stenosis: a multicenter validation study
Multimodality assessment of aortic valve area in aortic stenosis: a multicenter validation study Open
Objectives Transthoracic echocardiography (TTE) is the standard modality for grading aortic stenosis (AS) severity. Transesophageal echocardiography (TOE) allows direct aortic valve area (AVA) planimetry (AVA TOE ), while computed tomograp…
View article: Inferior Vena Cava Ultrasound to Guide Decongestion in Acute Decompensated Heart Failure
Inferior Vena Cava Ultrasound to Guide Decongestion in Acute Decompensated Heart Failure Open
Additional ultrasound evaluation of IVC diameters did not improve decongestion treatment compared with clinical assessment alone among patients admitted for ADHF. (Ultrasound Evaluation of the IVC in Addition to Clinical Assessment to Guid…
Mitral Valve Repair and SAVR After TAVR Complicated With Endocarditis and Mitral Valve Leaflet Perforation Open
Poor positioning of TAVR valves can result in severe structural and subsequent infectious complications. Early surgical treatment in high-risk older adult patients can be successfully performed, with favorable outcomes. Scrupulous asepsis …
Cerebral Embolic Protection in Patients Undergoing Left Atrial Appendage Closure Open
(1) Background: Cerebral magnetic resonance imaging has reported new cerebral ischemic lesions after left atrial appendage (LAA) closure in about one- third of patients. Stroke occurs predominantly periprocedurally. This study evaluated th…
View article: Comparison of two self-expanding transcatheter heart valves for degenerated surgical bioprostheses: the AVENGER multicentre registry
Comparison of two self-expanding transcatheter heart valves for degenerated surgical bioprostheses: the AVENGER multicentre registry Open
ViV TAVI using either ACURATE or Evolut THVs showed similar procedural outcomes. However, a true ID >19 mm was associated with higher device success among ACURATE recipients, whereas in patients with a true ID ≤19 mm, device success was hi…
Short- and long-term impact of nutrition in a large cohort of patients undergoing transcatheter aortic valve implantation: prognostic value of GNRI Open
Background Nutritional status, as measured by Geriatric Nutritional Risk Index (GNRI), an easy-to-use tool combining both clinical and laboratory parameters, was shown to predict short-term survival in patients with aortic stenosis undergo…
View article: Iatrogenic atrial septal defects after transseptal puncture for percutaneous left atrial appendage occlusion and their hemodynamic effects.
Iatrogenic atrial septal defects after transseptal puncture for percutaneous left atrial appendage occlusion and their hemodynamic effects. Open
Our study suggests that iASD after percutaneous LAAO does not result in significant shunts directly after the procedure, although a significant increase of mean right atrial pressure can be observed. Persistent iASDs after percutaneous LAA…
Personalized Preoperative Prediction of the Length of Hospital Stay after TAVI Using a Dedicated Decision Tree Algorithm Open
Background: The aim of this study was to identify pre-operative parameters able to predict length of stay (LoS) based on clinical data and patient-reported outcome measures (PROMs) from a scorecard database in patients with significant aor…
A Novel Method to Predict Mortality and Length of Stay after Transfemoral Transcatheter Aortic Valve Implantation Open
Background and Objectives: We tested if a novel combination of predictors could improve the accuracy of outcome prediction after transfemoral transcatheter aortic valve implantation (TAVI). Materials and Methods: This prospective study rec…
Potential Role and Prognostic Value of Erythropoietin Levels in Patients With Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement Open
Background: Both EPO levels and anemia have shown prognostic value in several cardiac disorders. An observational study with a prospective follow-up was performed to investigate their independent prognostic roles in severe aortic stenosis.…
Dynamics of cerebral oxygenation during rapid ventricular pacing and its impact on outcome in transfemoral transcatheter aortic valve implantation Open
Background Cerebral O 2 saturation (ScO 2 ) reflects cerebral perfusion and can be measured noninvasively by near‐infrared spectroscopy (NIRS). Objectives In this pilot study, we describe the dynamics of ScO 2 during TAVI in nonventilated …
View article: Inferior vena cava ultrasound in acute decompensated heart failure: design rationale of the <scp>CAVA‐ADHF‐DZHK10</scp> trial
Inferior vena cava ultrasound in acute decompensated heart failure: design rationale of the <span>CAVA‐ADHF‐DZHK10</span> trial Open
Aims Treating patients with acute decompensated heart failure (ADHF) presenting with volume overload is a common task. However, optimal guidance of decongesting therapy and treatment targets are not well defined. The inferior vena cava (IV…
Life beyond 5 Years after TAVI: Patients’ Perceived Health Status and Long-Term Outcome after Transcatheter Aortic Valve Implantation Open
Background . Transcatheter aortic valve implantation (TAVI) is currently recommended for patients with severe aortic stenosis at intermediate or high surgical risk. The decision process during TAVI evaluation includes a thorough benefit-ri…
Combination of Modified Bentall Procedure and Orthotopic Liver Transplantation Open
Indication for combined cardiac surgery and orthotopic liver transplantation is rare and patients are at high risks. Individual surgical strategy must be developed since a general standard of such procedure does not exist. We report the ca…
Extracorporeal life support with left ventricular decompression—improved survival in severe cardiogenic shock: results from a retrospective study Open
Objective Extracorporeal life support (ECLS) is a life-saving procedure used in the treatment of severe cardiogenic shock. Within this retrospective single centre study, we examined our experience in this critically ill patient cohort to a…
Removal of a giant left ventricular thrombus after myocardial infarction due to dissection of left anterior descending artery Open
Left ventricular thrombus is a frequent complication after myocardial infarction and is associated with high risk for arterial embolic complications. In addition to oral anticoagulation, surgical thrombectomy may be a promising treatment f…
View article: Loss of Endothelial Barrier in Marfan Mice (mgR/mgR) Results in Severe Inflammation after Adenoviral Gene Therapy
Loss of Endothelial Barrier in Marfan Mice (mgR/mgR) Results in Severe Inflammation after Adenoviral Gene Therapy Open
Murine Marfan aortic grafts developed severe inflammation after adenoviral contact. We demonstrated that fibrillin-1 deficiency is associated with relevant dysfunction of the endothelial barrier that enables adenovirus to induce vessel-har…