Philipp Vick
YOU?
Author Swipe
View article: Enhancing Molecular Biology Content Knowledge and Teaching Self-Efficacy in Pre-Service Teachers Through Virtual and Hands-On Labs and Reflective Teaching
Enhancing Molecular Biology Content Knowledge and Teaching Self-Efficacy in Pre-Service Teachers Through Virtual and Hands-On Labs and Reflective Teaching Open
Teachers in lower secondary education often lack content knowledge and self-efficacy to teach molecular biology. The focus of this study was to develop and evaluate an innovative educational approach to prepare pre-service teachers for tea…
View article: Identification of novel genes including NAV2 associated with isolated tall stature
Identification of novel genes including NAV2 associated with isolated tall stature Open
Very tall people attract much attention and represent a clinically and genetically heterogenous group of individuals. Identifying the genetic etiology can provide important insights into the molecular mechanisms regulating linear growth. W…
View article: FGF-mediated establishment of left-right asymmetry requires Rab7 function in the dorsal mesoderm in Xenopus
FGF-mediated establishment of left-right asymmetry requires Rab7 function in the dorsal mesoderm in Xenopus Open
Gastrulation denotes a very important developmental process, which includes significant structural tissue rearrangements and patterning events that shape the emerging vertebrate organism. At the end of gastrulation, the three body axes are…
View article: Identification of ZBTB26 as a Novel Risk Factor for Congenital Hypothyroidism
Identification of ZBTB26 as a Novel Risk Factor for Congenital Hypothyroidism Open
Congenital primary hypothyroidism (CH; OMIM 218700) is characterized by an impaired thyroid development, or dyshormonogenesis, and can lead to intellectual disability and growth retardation if untreated. Most of the children with congenita…
View article: Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5
Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5 Open
Rotating cilia at the vertebrate left-right organizer (LRO) generate an asymmetric leftward flow, which is sensed by cells at the left LRO margin. Ciliary activity of the calcium channel Pkd2 is crucial for flow sensing. How this flow sign…
View article: Rab7 is required for mesoderm patterning and gastrulation in <i>Xenopus</i>
Rab7 is required for mesoderm patterning and gastrulation in <i>Xenopus</i> Open
Early embryogenesis requires tightly controlled temporal and spatial coordination of cellular behavior and signaling. Modulations are achieved at multiple levels, from cellular transcription to tissue-scale behavior. Intracellularly, the e…
View article: Expression of an endosome-excluded Cd63 prevents axis elongation in Xenopus
Expression of an endosome-excluded Cd63 prevents axis elongation in Xenopus Open
Cd63 is an adapter protein belonging to the tetraspanin family. As other members, it possesses four membrane-spanning domains, two extracellular loops, and the N- and C-terminus both face the cytoplasm. Cd63 is highly enriched in intralumi…
View article: The tetraspanin Cd63 is required for eye morphogenesis in Xenopus
The tetraspanin Cd63 is required for eye morphogenesis in Xenopus Open
Tetraspanins (TSPAN) are a family of (33 in humans) scaffold proteins consisting of the name-giving four membrane-spanning domains, two extracellular loops, and an intracellular N- and C-terminus. By forming ‘tetraspanin-enriched microdoma…
View article: Rab7 mediates Wnt-dependent mesoderm patterning and gastrulation in<i>Xenopus</i>
Rab7 mediates Wnt-dependent mesoderm patterning and gastrulation in<i>Xenopus</i> Open
Early embryogenesis requires tightly controlled temporal and spatial activity of growth factors. Modulation is achieved at multiple levels, from cellular transcription to tissue-scale propagation, concerning activation, maintenance, or ter…
View article: <i>Bicc1</i>and<i>dicer</i>regulate left-right patterning through post-transcriptional control of the Nodal-inhibitor<i>dand5</i>
<i>Bicc1</i>and<i>dicer</i>regulate left-right patterning through post-transcriptional control of the Nodal-inhibitor<i>dand5</i> Open
Rotating cilia at the vertebrate left-right organizer (LRO) generate an asymmetric leftward flow, which is sensed by cells at the left LRO margin. How the flow signal is processed and relayed to the laterality-determining Nodal cascade in …
View article: Supplementary Material for: Identification of <b><i>Transient Receptor Potential Channel 4-Associated Protein</i></b> as a Novel Candidate Gene Causing Congenital Primary Hypothyroidism
Supplementary Material for: Identification of <b><i>Transient Receptor Potential Channel 4-Associated Protein</i></b> as a Novel Candidate Gene Causing Congenital Primary Hypothyroidism Open
Background: Congenital primary hypothyroidism (CH) is the most common endocrine disorder in neonates. Methods: To identify novel genes, we performed whole exome sequencing (WES) in 6 patients with CH due to thyroid dysgenesis (TD). The pot…
View article: A dual function of FGF signaling in <i>Xenopus</i> left-right axis formation
A dual function of FGF signaling in <i>Xenopus</i> left-right axis formation Open
Organ left-right (LR) asymmetry is a conserved vertebrate feature, which is regulated by left-sided activation of Nodal signaling. Nodal asymmetry is established by a leftward fluid-flow generated at the ciliated LR organizer (LRO). Althou…
View article: A dual function of FGF signaling in<i>Xenopus</i>left-right axis formation
A dual function of FGF signaling in<i>Xenopus</i>left-right axis formation Open
Organ left-right (LR) asymmetry is a conserved vertebrate feature, which is regulated by left-sided activation of Nodal signaling. Nodal asymmetry is established by a leftward fluid-flow generated at the ciliated LR organizer (LRO). While …
View article: Size of the core genome and dispensable genome and number of strain unique CDS in 21 <i>Mannheimia haemolytica</i> genomes.
Size of the core genome and dispensable genome and number of strain unique CDS in 21 <i>Mannheimia haemolytica</i> genomes. Open
Petals contain number of unique CDS per strain. Petals a-h represent the serotype 1 strains M. haemolytica L024A, M. haemolytica 157-4-1, M. haemolytica L044A, M. haemolytica 535A, M. haemolytica D153, M. haemolytica MhBrain2012, M. haemol…
View article: Metadata for prophage identified within the genomes of 11 strains of <i>Mannheimia haemolytica</i>.
Metadata for prophage identified within the genomes of 11 strains of <i>Mannheimia haemolytica</i>. Open
Metadata for prophage identified within the genomes of 11 strains of Mannheimia haemolytica.
View article: Pan-genome and core genome of 21 <i>M</i>. <i>haemolytica</i> isolates.
Pan-genome and core genome of 21 <i>M</i>. <i>haemolytica</i> isolates. Open
For both the pan-genome and the core genome, the number of genes is plotted as a function of the number n of strains sequential added. The curve for the pan-genome represents the least-squares fit for the function y = AxB + C with the best…
View article: Schematic of CRISPR-Cas systems identified in whole genome sequence analysis of 11 <i>Mannheimia haemolytica genomes</i>.
Schematic of CRISPR-Cas systems identified in whole genome sequence analysis of 11 <i>Mannheimia haemolytica genomes</i>. Open
Panel A: Cas loci present in serotype 1, 6 and 2 genomes. Panel B: consensus sequence for leader and trailer regions of CRISPR arrays. Underlined regions are complementary to psi-tag. Panel C: Sequences of the 6 unique direct repeats detec…
View article: Additional file 1: Figure S1. of Cilia are required for asymmetric nodal induction in the sea urchin embryo
Additional file 1: Figure S1. of Cilia are required for asymmetric nodal induction in the sea urchin embryo Open
mRNA expression of bicc1 (aâ d) and overall normal development of Paracentrotus lividus embryos upon high salt induced deciliation (eâ j) or upon early MAPK/p38 inhibition (kâ n). (PDF 877 kb)