Explanipedia

Evolution of human leptospirosis in French Guiana, 2016–2022 Open

Mathilde Zenou, Pascale Bourhy, Philippe Abboud, Mona Saout, Félix Djossou , et al. · 2025

Background Leptospirosis is a re-emerging zoonotic disease. In French Guiana (FG), updating its epidemiology is essential to guide prevention strategies. This study aimed to describe human leptospirosis cases from 2016 to 2022 and compare …

Comparing diagnostic methods for historical arbovirus outbreaks: Insights from 19th century “dengue” epidemics Open

Timothée Bonifay, Mathieu Nacher, C. Bonnefoy, Benjamín Rossi, Edouard Hallet , et al. · 2025

This study reexamines historical “dengue” epidemics of the 18th and 19th centuries, suggesting that chikungunya virus (CHIKV), rather than dengue virus (DENV), may have been responsible for many of these outbreaks. While “dengue” was ident…

Fracture related infection complicating civilian ballistic wounds in the amasonian zone Open

Karamba Sylla, Xiu-e Lu, Antoine Mons, V. Sainte-Rose, Paul Le Turnier , et al. · 2025

Introduction Fracture-Related Infections (FRI) are one of the most common complications of ballistic wounds sustained in military operations. There is very little data on ballistic wounds in civilians, especially FRIs. There is no data at …

Initial HIV-1 viral load in French Guiana: Factors associated with viral load set point differences Open

A. Lucarelli, Sébastien Rabier, Fanja Vergeade, M. El Guedj, Tânia Vaz , et al. · 2024

We show some significant differences in the viral load set point of different groups. For nationalities, we are inclined to attribute this to differences in the frequency of infecting subtypes. This suggests that models of incidence or dat…

Prise en charge du paludisme en Guyane : quels enjeux dans ce dernier territoire endémique français en 2024 ? Open

Laureen Dahuron, L. Musset, Hélène Tréhard, Alice Sanna, Aïssata Dia , et al. · 2024

Malaria control in French Guiana: What are the challenges in this last endemic French territory in 2024? French Guiana, the last malaria-endemic region of France, is facing an epidemic resurgence of malaria since the end of 2023. This epid…

Forty Years of HIV Research in French Guiana: Comprehend to Combat Open

Mathieu Nacher, A. Lucarelli, Astrid Van-Melle, Célia Basurko, Sébastien Rabier , et al. · 2024

The drivers of the HIV epidemic, the viruses, the opportunistic infections, the attitudes and the resources allocated to the fight against HIV/AIDS, vary substantially across countries. French Guiana, at the crossroads between Amazonian So…

Correction to: Human Q Fever on the Guiana Shield and Brazil: Recent Findings and Remaining Questions Open

Loïc Epelboin, Carole Eldin, P. Thill, Vincent Pommier de Santi, Philippe Abboud , et al. · 2023

International audience

Antimicrobial Susceptibility of Community-Acquired Urine Bacterial Isolates in French Amazonia Open

Flaubert Nkontcho, Vincent Sainte-Rose, Philippe Abboud, Patrick Portecop, Jean Marc Pujo , et al. · 2023

Bacterial resistance in community-acquired urinary tract infections (UTIs) is increasing worldwide. Our study aimed to assess the microbiological epidemiology and antimicrobial susceptibility patterns of community-acquired urine bacterial …

Primary or secondary prevention of HIV-associated histoplasmosis during the early antiretrovirals for all era Open

Mathieu Nacher, Paul Le Turnier, Philippe Abboud, Ugo Françoise, A. Lucarelli , et al. · 2023

Thinking anew about prophylaxis in the "treat all" eraAU : PleaseconfirmthataAlthough most studies actually concern symptomatic patients, the natural history of HIV-associated progressive disseminated histoplasmosis is presumably often gra…

Panorama des pathologies infectieuses et non infectieuses de Guyane en 2022 Open

Loïc Epelboin, Philippe Abboud, Karim Abdelmoumen, Frédégonde About, Antoine Adenis , et al. · 2023

Overview of infectious and non-infectious diseases in French Guiana in 2022 Source of many myths, French Guiana represents an exceptional territory due to the richness of its biodiversity and the variety of its communities. The only Europe…

Symptomatic Chikungunya Virus Infection and Pregnancy Outcomes: A Nested Case-Control Study in French Guiana Open

Célia Basurko, Najeh Hcini, Magalie Demar, Philippe Abboud, Mathieu Nacher , et al. · 2022

During the Chikungunya epidemic in the Caribbean and Latin America, pregnant women were affected by the virus in French Guiana. The question of the impact of the virus on pregnancy was raised because of the lack of scientific consensus and…

Establishing the proportion of severe/moderately severe vs mild cases of progressive disseminated histoplasmosis in patients with HIV Open

Mathieu Nacher, Antoine Adenis, Romain Blaizot, Philippe Abboud, Paul Le Turnier , et al. · 2022

Background Progressive disseminated histoplasmosis remains a major but neglected cause of death among patients with advanced HIV. Recently, aiming to reduce avoidable deaths, the Pan American Health Organization issued the first diagnosis …

Q Fever as a Cause of Community-Acquired Pneumonia in French Guiana Open

Loïc Epelboin, Aba Mahamat, Timothée Bonifay, Magalie Demar, Philippe Abboud , et al. · 2022

In French Guiana, community-acquired pneumonia (CAP) represents over 90% of Coxiella burnetii acute infections. Between 2004 and 2007, we reported that C. burnetii was responsible for 24.4% of the 131 CAP hospitalized in Cayenne. The main …

Sacro-iliite à Erysipelothrix rhusiopathiae révélant une endocardite tricuspide, premier cas rapporté sur le Bouclier des Guyanes : cas clinique et revue de la littérature Open

Mathilde Kheng, Jean Francky Alexis, Gaëlle Walter, Émilie Mosnier, Thomas Malmontet , et al. · 2022

Nous rapportons le cas d’une patiente de 53 ans, sans antécédent, dont le bilan étiologique d’une douleur de hanche fébrile, réalisé à l’hôpital de Cayenne, a révélé une sacro-iliite droite associée à une endocardite infectieuse tricuspide…

Active Surveillance Program to Increase Awareness on Invasive Fungal Diseases: the French RESSIF Network (2012 to 2018) Open

Stéphane Bretagne, Karine Sitbon, Marie Desnos‐Ollivier, Dea Garcia‐Hermoso, Valérie Letscher‐Bru , et al. · 2022

The epidemiology of invasive fungal diseases (IFDs) is hard to delineate given the difficulties in ascertaining the diagnosis that is often based on the confrontation of clinical and microbiological criteria. The present report underlines …

Case Report: Invasive Cryptococcosis in French Guiana: Immune and Genetic Investigation in Six Non-HIV Patients Open

Jeanne Goupil de Bouillé, Loïc Epelboin, Fanny Hénaff, Mélanie Migaud, Philippe Abboud , et al. · 2022

Objectives We describe the clinical, mycological, immunological, and genetic characteristics of six HIV-negative patients presenting with invasive cryptococcosis. Methods Patients with cryptococcosis without any of the classical risk facto…

A Simple Predictive Score to Distinguish between Disseminated Histoplasmosis and Tuberculosis in Patients with HIV Open

Mathieu Nacher, Kinan Drak Alsibai, Loïc Epelboin, Philippe Abboud, Frédégonde About , et al. · 2021

Disseminated histoplasmosis is a common differential diagnosis of tuberculosis in disease-endemic areas. We aimed to find a predictive score to orient clinicians towards disseminated histoplasmosis or tuberculosis when facing a non-specifi…

Levers and Barriers to Vaccinate against COVID-19 in the Multicultural Context of French Guiana: A Qualitative Cross-Sectional Survey among Health Care Workers Open

Maylis Douine, Sibylle Granier, Kepha Brureau, Jacques Breton, Céline Michaud , et al. · 2021

In French Guiana, a French overseas territory in South America facing a fourth wave of COVID-19, vaccination coverage is very low, both in the population and among health care workers (HCWs). Vaccine hesitancy concerned 35.7% of the latter…

Outbreak of Oropouche Virus in French Guiana Open

Mélanie Gaillet, Clara Pichard, Johana Restrepo, Anne Lavergne, Lucas Perez , et al. · 2021

Oropouche fever is a zoonotic dengue-like syndrome caused by Oropouche virus. In August-September 2020, dengue-like syndrome developed in 41 patients in a remote rainforest village in French Guiana. By PCR or microneutralization, 23 (82.1%…

Review of diagnostic methods and results for HIV‐associated disseminated histoplasmosis: Pathologists are not sufficiently involved Open

Mathieu Nacher, Audrey Valdes, Antoine Adenis, Romain Blaizot, Ugo Françoise , et al. · 2021

Objectives Disseminated histoplasmosis is a major killer of HIV‐infected persons in Latin America. Antigen detection, fungal culture and Polymerase Chain Reaction are often not available, but cytology and histology are present in most hosp…

Attitudes towards the COVID-19 Vaccine and Willingness to Get Vaccinated among Healthcare Workers in French Guiana: The Influence of Geographical Origin Open

Nicolas Vignier, Kepha Brureau, Sybille Granier, Jacques Breton, Céline Michaud , et al. · 2021

Background: In the context of the global COVID-19 pandemic and the expansion of the more transmissible 20J/501Y.V3 (Gamma) variant of concern (VOC), mRNA vaccines have been made available in French Guiana, an overseas French territory in S…

Human Q Fever on the Guiana Shield and Brazil: Recent Findings and Remaining Questions Open

Loïc Epelboin, Carole Eldin, P. Thill, Vincent Pommier de Santi, Philippe Abboud , et al. · 2021

Purpose of Review In this review, we report on the state of knowledge about human Q fever in Brazil and on the Guiana Shield, an Amazonian region located in northeastern South America. There is a contrast between French Guiana, where the i…

Invasive Fungal Infections in Persons Living with HIV in an Amazonian Context: French Guiana, 2009–2019 Open

Laurène Cachera, Antoine Adenis, Basma Guarmit, Sébastien Rabier, Pierre Couppié , et al. · 2021

Although the burden of histoplasmosis in patients with advanced HIV has been the focus of detailed estimations, knowledge about invasive fungal infections in patients living with HIV in an Amazonian context is somewhat scattered. Our goal …

Histoplasmosis of the Central Nervous System: A Case Series between 1990 and 2019 in French Guiana Open

Loïc Epelboin, Aïda Dione, Alexandra Serris, Denis Blanchet, Bastien Bidaud , et al. · 2021

Disseminated histoplasmosis is the most frequent acquired immunodeficiency syndrome–defining illness in French Guiana. Paradoxically, central nervous system (CNS) involvement has been scarcely described. We aimed to identify CNS histoplasm…

HIV-Associated Disseminated Histoplasmosis and Rare Adrenal Involvement: Evidence of Absence or Absence of Evidence Open

Mathieu Nacher, Kinan Drak Alsibai, Audrey Valdes, Philippe Abboud, Antoine Adenis , et al. · 2021

Adrenal histoplasmosis and primary adrenal insufficiency are mostly described in immunocompetent patients. This particular tropism is attributed to the presence of cortisol within the adrenal gland, a privileged niche for Histoplasma growt…

The Epidemiology of COVID 19 in the Amazon and the Guianas: Similarities, Differences, and International Comparisons Open

Mathieu Nacher, Cyril Rousseau, Tiphanie Succo, Audrey Andrieu, Mélanie Gaillet , et al. · 2021

Background: The COVID 19 epidemic submerged many health systems in the Amazon. The objective of the present study was to focus on the epidemic curves of the COVID 19 epidemic in different centers, and to look at testing and mortality data.…

Reduced Severity in Patients With HIV-Associated Disseminated Histoplasmosis With Deep Lymphadenopathies: A Trench War Remains Within the Lymph Nodes? Open

Mathieu Nacher, Kinan Drak Alsibai, Antoine Adenis, Romain Blaizot, Philippe Abboud , et al. · 2021

Background Disseminated histoplasmosis is a major killer of patients with advanced HIV. It is proteiform and often hard to diagnose in the absence of diagnostic tests. We aimed to describe disseminated histoplasmosis with lymphadenopathies…

Gastrointestinal disseminated histoplasmosis in HIV-infected patients: A descriptive and comparative study Open

Mathieu Nacher, Audrey Valdes, Antoine Adenis, Romain Blaizot, Philippe Abboud , et al. · 2021

Disseminated histoplasmosis is one the main AIDS-defining opportunistic infections in HIV-infected patients, notably in Latin America. The non-specific and proteiform clinical presentation leads to diagnostic delays that may lead to fatal …

Relationship between Influenza and Dengue Outbreaks, and Subsequent Bacterial Sepsis in French Guiana: A Time Series Analysis Open

Claire Cropet, Philippe Abboud, Émilie Mosnier, Loïc Epelboin, Félix Djossou , et al. · 2021

Background Influenza has been shown to increase the risk for severe bacterial infection, in the tropics the seasonality of influenza epidemics is less marked, and this may not be the case. Dengue is often followed by prolonged asthenia and…

Risk Factors for Mortality among HIV-Infected Patients with Disseminated Histoplasmosis Open

Mathieu Nacher, Kinan Drak Alsibai, Audrey Valdes, Romain Blaizot, Philippe Abboud , et al. · 2020

Identifying prognostic factors is important in order to guide the choice of first-line therapy for disseminated histoplasmosis. Our objective was to identify factors associated with death among a cohort of 330 patients compiled over 34 yea…

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