Philippe Allain
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View article: Comparison of tetrabenazine, tiapride and olanzapine in Huntington's disease: a one-year French randomized multicenter study (Neuro-HD)
Comparison of tetrabenazine, tiapride and olanzapine in Huntington's disease: a one-year French randomized multicenter study (Neuro-HD) Open
Olanzapine improved chorea, behavior, and irritability, although with a slight increase in rigidity. Tetrabenazine confirmed efficacy for chorea but was associated with mood disorders and drowsiness, while tiapride reduced irritability. Th…
View article: Recommendations of the jury of the consensus conference on the interpretation and communication of neuropsychology scores (Paris, November 22, 2024)
Recommendations of the jury of the consensus conference on the interpretation and communication of neuropsychology scores (Paris, November 22, 2024) Open
International audience
View article: Comparison of Two Exergame-based Motor-Cognitive Trainings:
Comparison of Two Exergame-based Motor-Cognitive Trainings: Open
View article: Assessment of social cognition in patients with amyotrophic lateral sclerosis: protocol for a cross-sectional comparative study at Angers University Hospital
Assessment of social cognition in patients with amyotrophic lateral sclerosis: protocol for a cross-sectional comparative study at Angers University Hospital Open
Introduction Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder primarily affecting motor neurons. In addition to motor impairments, ALS frequently involves cognitive and behavioural disturbances, including def…
View article: Combinations of physical and cognitive training for subcortical neurodegenerative diseases with physical, cognitive and behavioral symptoms: a systematic review
Combinations of physical and cognitive training for subcortical neurodegenerative diseases with physical, cognitive and behavioral symptoms: a systematic review Open
Background The onset of the symptoms of subcortical NDs is due to a unique part of the brain which strengthens the idea of reciprocal influence of physical activity and cognitive training in improving clinical symptoms. Consequently, proto…
View article: The 20-item dysexecutive questionnaire after severe traumatic brain injury: Distribution of the total score and its significance
The 20-item dysexecutive questionnaire after severe traumatic brain injury: Distribution of the total score and its significance Open
ClinicalTrials.gov identifier: NCT01437683..
View article: Social cognition in adult survivors of brain tumors: studying the relationship between theory of mind and quality of life
Social cognition in adult survivors of brain tumors: studying the relationship between theory of mind and quality of life Open
Adult survivors of primary brain tumors may exhibit ToM deficits several years after treatment and report more problems on social/emotional HRQoL components. Our findings highlight the need to consider these late effects in survivors' long…
View article: Psychological Care Through Mindfulness Meditation in Virtual Reality for Individuals with Amyotrophic Lateral Sclerosis: Effects on Cognition, Behavior, Quality of Life, and Psychological Well-Being: Protocol for a Randomized Control Trial
Psychological Care Through Mindfulness Meditation in Virtual Reality for Individuals with Amyotrophic Lateral Sclerosis: Effects on Cognition, Behavior, Quality of Life, and Psychological Well-Being: Protocol for a Randomized Control Trial Open
View article: Memory in Social Interactions: The Effects of Introspection on Destination Memory in Traumatic Brain Injury
Memory in Social Interactions: The Effects of Introspection on Destination Memory in Traumatic Brain Injury Open
Destination memory, which is the ability to remember to whom one has sent information, is intimately associated with social cognition. We assessed whether processing attributes of destinations would improve destination memory in patients w…
View article: Associations between Adult Primary Brain Tumor Survivors’ Behavioral Executive Functions, Health Related Quality of Life and their Caregivers’ Health Related Quality : A cross-sectional study
Associations between Adult Primary Brain Tumor Survivors’ Behavioral Executive Functions, Health Related Quality of Life and their Caregivers’ Health Related Quality : A cross-sectional study Open
The present study focused on adult primary brain tumor (PBT) survivors' caregivers. The main objective was to study associations between PBT survivors' health-related quality of life (HRQOL), their behavioral executive functions (EF) and t…
View article: “What Did I Tell This Sad Person?”: Memory for Emotional Destinations in Korsakoff’s Syndrome
“What Did I Tell This Sad Person?”: Memory for Emotional Destinations in Korsakoff’s Syndrome Open
We investigated destination memory, defined as the ability to remember to whom a piece of information was previously transmitted, for emotional destinations (i.e., a happy or sad person) in Korsakoff’s syndrome (KS). We asked patients with…
View article: The "Sickness" Memory: Can Patients With Alzheimer Disease Remember the Diagnosis Announcement?
The "Sickness" Memory: Can Patients With Alzheimer Disease Remember the Diagnosis Announcement? Open
Retrieval of the diagnosis announcement can activate a strong emotional and personally important experience in patients with AD. When remembering the diagnosis announcement, patients with AD may re-experience some features of that turning …
View article: Does Sex Matter? High Semantic Autobiographical Retrieval in Women and Men With Alzheimer’s Disease
Does Sex Matter? High Semantic Autobiographical Retrieval in Women and Men With Alzheimer’s Disease Open
The decline of autobiographical memory in Alzheimer’s disease (AD) is mainly characterized by overgenerality. While there is a large body of research on autobiographical overgenerality in AD, this research has mainly assessed retrieval wit…
View article: “Who will I be?”: The future of the self as described by Alzheimer's disease (AD) patients
“Who will I be?”: The future of the self as described by Alzheimer's disease (AD) patients Open
View article: On Covid-19 and mental health
On Covid-19 and mental health Open
While visiting and socialization restrictions during lockdowns were instituted to cope with the Covid-19 spread and to prolong the life of residents of retirement homes, these measures could have been expected to decrease the quality of li…
View article: Empathy of individuals with Alzheimer’s disease (AD) toward other AD patients
Empathy of individuals with Alzheimer’s disease (AD) toward other AD patients Open
International audience
View article: The “Sickness” Memory
The “Sickness” Memory Open
Background: Diagnosis of Alzheimer disease (AD) can cause substantial psychological distress in patients. We thus assessed how patients with AD remember the announcement of diagnosis. Methods: We recruited 47 participants with mild AD (26 …
View article: Relationships between Theory of Mind and Attachment Styles in Emerging Adulthood
Relationships between Theory of Mind and Attachment Styles in Emerging Adulthood Open
View article: “My sympathetic clinician”: perception of sympathy by patients with Alzheimer’s disease increases when asked to provide autobiographical memories
“My sympathetic clinician”: perception of sympathy by patients with Alzheimer’s disease increases when asked to provide autobiographical memories Open
View article: Neuropsychological assessment of patients with alzheimer’s Disease in the presence or absence of spouses
Neuropsychological assessment of patients with alzheimer’s Disease in the presence or absence of spouses Open
A common question in the neuropsychological testing of patients with Alzheimer's Disease is whether or not patients should be tested in the presence of their spouses. We addressed this issue by assessing the neuropsychological performances…
View article: High Destination Memory for Emotionally Incongruent Information
High Destination Memory for Emotionally Incongruent Information Open
This article investigates the effect of emotion on destination memory. Participants were asked to tell neutral, positive, and negative information to neutral, positive, and negative faces. Afterward, participants were asked to remember to …
View article: Relationships between executive functioning and health-related quality of life in adult survivors of brain tumor and matched healthy controls
Relationships between executive functioning and health-related quality of life in adult survivors of brain tumor and matched healthy controls Open
From a clinical point of view, this study demonstrates that even several years after end of treatment, adult PBT survivors experience substantial problems across different HRQOL domains. HRQOL assessment should therefore be part of the lon…
View article: High Exhaustion in Geriatric Healthcare Professionals During the COVID-19 Second Lockdown
High Exhaustion in Geriatric Healthcare Professionals During the COVID-19 Second Lockdown Open
Background: In a previous study, we assessed burnout in geriatric healthcare workers during the first lockdown that lasted from March to May 2020 in France, in response to the COVID-19 crisis. Objective: We carried out a follow-up study to…
View article: The use of the French Dimensional Apathy Scale (f-DAS) to assess apathy in schizophrenia: Properties and profiles
The use of the French Dimensional Apathy Scale (f-DAS) to assess apathy in schizophrenia: Properties and profiles Open
View article: How to deal with the consent of adults with cognitive impairment involved in European geriatric living labs?
How to deal with the consent of adults with cognitive impairment involved in European geriatric living labs? Open
Background Living labs are realistic environments designed to create links between technology developers and end-users (i.e. mostly older adults). Research in LLH (Living labs in health) covers a wide range of studies from non-intervention…
View article: High exhaustion in geriatric healthcare professionals during the Covid-19 second lockdown (Preprint)
High exhaustion in geriatric healthcare professionals during the Covid-19 second lockdown (Preprint) Open
BACKGROUND In a previous study, we assessed burnout in geriatric healthcare workers during the first lockdown that lasted from March to May 2020 in France, in response to the Covid-19 crisis. OBJECTIVE We carried out a follow-up study t…
View article: Patient-reported functional executive challenges and caregiver confirmation in adult brain tumor survivors
Patient-reported functional executive challenges and caregiver confirmation in adult brain tumor survivors Open
View article: Burnout of Healthcare Workers in Acute Care Geriatric Facilities During the COVID-19 Crisis: An Online-Based Study
Burnout of Healthcare Workers in Acute Care Geriatric Facilities During the COVID-19 Crisis: An Online-Based Study Open
Background/Objective: The COVID-19 crisis has been increasing the burden of healthcare workers in acute care geriatric facilities. These workers have been dealing with drastic changes in the care they provide to their residents including c…
View article: Psychometric validation of an Assessment Questionnaire on the Perception of and Adaptation to Visual Handicap in Adults (QUEPAHVA)
Psychometric validation of an Assessment Questionnaire on the Perception of and Adaptation to Visual Handicap in Adults (QUEPAHVA) Open
View article: Better Destination Memory in Females
Better Destination Memory in Females Open
Destination memory refers to the ability to remember to whom one has sent information. The current study investigated gender differences in destination memory. Female and male participants were asked to tell proverbs to pictures depicting …