Philippe Arnoux
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View article: A Triple Threat Against Ovarian Cancer: Os(II)‐Pt(IV)‐Ceritinib Conjugates for Photodynamic Therapy, Chemotherapy, and Immunogenic Cell Death Induction
A Triple Threat Against Ovarian Cancer: Os(II)‐Pt(IV)‐Ceritinib Conjugates for Photodynamic Therapy, Chemotherapy, and Immunogenic Cell Death Induction Open
Metal‐based anticancer agents offer unique opportunities to integrate multiple therapeutic modalities within a single molecular framework. Herein, we present the first Osmium(II)‐Platinum(IV)‐Ceritinib conjugate ( Os‐Pt‐Cer ) that synergis…
View article: A Triple Threat Against Ovarian Cancer: Os(II)‐Pt(IV)‐Ceritinib Conjugates for Photodynamic Therapy, Chemotherapy, and Immunogenic Cell Death Induction
A Triple Threat Against Ovarian Cancer: Os(II)‐Pt(IV)‐Ceritinib Conjugates for Photodynamic Therapy, Chemotherapy, and Immunogenic Cell Death Induction Open
Metal‐based anticancer agents offer unique opportunities to integrate multiple therapeutic modalities within a single molecular framework. Herein, we present the first Osmium(II)‐Platinum(IV)‐Ceritinib conjugate ( Os‐Pt‐Cer ) that synergis…
View article: Hydrodynamics of a gas–liquid microreactor designed for the oxidation kinetics of organic compounds
Hydrodynamics of a gas–liquid microreactor designed for the oxidation kinetics of organic compounds Open
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View article: Gelatin from red tilapia (Oreochromis spp.) scales: Optimization of its extraction and detailed characterization of its chemical and viscoelastic properties
Gelatin from red tilapia (Oreochromis spp.) scales: Optimization of its extraction and detailed characterization of its chemical and viscoelastic properties Open
Gelatin is widely used in food and pharmaceutical industries for its functional and bioactive properties. When extracted from fish by-products, the environmental impacts of these former waste are reduced. This study aimed to optimize the g…
View article: Metal-Chelating Peptides Derived from Sunflower Meal Protein: Preparation, Isolation, Identification, and Antioxidant Properties
Metal-Chelating Peptides Derived from Sunflower Meal Protein: Preparation, Isolation, Identification, and Antioxidant Properties Open
International audience
View article: Lanthanides-Based Nanoparticles Conjugated with Rose Bengal for FRET-Mediated X-Ray-Induced PDT
Lanthanides-Based Nanoparticles Conjugated with Rose Bengal for FRET-Mediated X-Ray-Induced PDT Open
In order to find a good candidate for Förster Resonance Energy Transfer (FRET)-mediated X-ray-induced photodynamic therapy (X-PDT) for the treatment of cancer, lanthanide (Ln)-based AGuIX nanoparticles (NPs) conjugated with Rose Bengal (RB…
View article: Synthesis, Characterization, and Biological Evaluation of Red Light‐Activatable BODIPY‐Caged Ceritinib Compounds
Synthesis, Characterization, and Biological Evaluation of Red Light‐Activatable BODIPY‐Caged Ceritinib Compounds Open
In this work, we aimed at photocaging the well‐known anticancer agents dasatinib, ceritinib, gemcitabine, and combretastatin A4 with red‐light activatable 4,4‐difluoro‐4‐bora‐3a,4a‐diaza‐s‐indacene (BODIPY)‐based cages using a carbonate/ca…
View article: Synthesis, Physicochemical Properties and Anti-Fungal Activities of New Meso-Arylporphyrins
Synthesis, Physicochemical Properties and Anti-Fungal Activities of New Meso-Arylporphyrins Open
In this work, we describe the synthesis of three new meso-arylporphyrins, named meso-tetrakis [4-(nicotinoyloxy)phenyl] porphyrin (H2TNPP), meso-tetrakis [4-(picolinoyloxy)phenyl] porphyrin (H2TPPP), and meso-tetrakis [4-(isonicotinoyloxy)…
View article: Conformational fluxionality of long-chain alkene clusters in the gas phase evidenced from a combined experimental and theoretical approach
Conformational fluxionality of long-chain alkene clusters in the gas phase evidenced from a combined experimental and theoretical approach Open
Clusters bound by weak, non-covalent forces, such as van der Waals interactions and hydrogen bonds, are ubiquitous in dilute media ranging from aerosols to molecular fluids and biological structures, their interest being not only fundament…
View article: Photophysical studies of Zn(II) tetra, tert-butyl phthalocyanine
Photophysical studies of Zn(II) tetra, tert-butyl phthalocyanine Open
Phthalocyanine derivatives have attracted significant attention due to their unique chemical properties and applications in various fields, including photodynamic therapy. However, the synthesis and purification of phthalocyanines remain c…
View article: Conformational effects in the identification and quantification of ketohydroperoxides in the oxidation of <i>n</i>-pentane
Conformational effects in the identification and quantification of ketohydroperoxides in the oxidation of <i>n</i>-pentane Open
Using synchrotron-based VUV spectroscopy and theoretical quantum calculations, this work identifies distinct conformers in ketohydroperoxides and their impact on dissociative ionization, advancing molecular-level insights into oxidation pr…
View article: An innovative microfluidic reactor for testing the oxidation stability of fuels: application to a saf surrogate and comparison with the petrooxy test
An innovative microfluidic reactor for testing the oxidation stability of fuels: application to a saf surrogate and comparison with the petrooxy test Open
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View article: Experimental study of hydroperoxide content in surrogate jet-fuels using HPLC
Experimental study of hydroperoxide content in surrogate jet-fuels using HPLC Open
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View article: Energy Transfer between AGuIX Nanoparticles and Photofrin under Light or X-ray Excitation for PDT Applications
Energy Transfer between AGuIX Nanoparticles and Photofrin under Light or X-ray Excitation for PDT Applications Open
Photodynamic therapy is an accepted therapy cancer treatment. Its advantages encourage researchers to delve deeper. The use of nanoparticles in PDT has several advantages including the passive targeting of cancer cells. The aim of this art…
View article: 1-Hexene Ozonolysis across Atmospheric and Combustion Temperatures via Synchrotron-Based Photoelectron Spectroscopy and Chemical Ionization Mass Spectrometry
1-Hexene Ozonolysis across Atmospheric and Combustion Temperatures via Synchrotron-Based Photoelectron Spectroscopy and Chemical Ionization Mass Spectrometry Open
This study investigates the complex interaction between ozone and the autoxidation of 1-hexene over a wide temperature range (300-800 K), overlapping atmospheric and combustion regimes. It is found that atmospheric molecular mechanisms ini…
View article: The use of folic acid as targeting agent in PDT: what about the stability?
The use of folic acid as targeting agent in PDT: what about the stability? Open
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View article: Synthesis and preliminary anticancer evaluation of photo-responsive prodrugs of hydroxymethylene bisphosphonate alendronate
Synthesis and preliminary anticancer evaluation of photo-responsive prodrugs of hydroxymethylene bisphosphonate alendronate Open
The antitumoral activity of hydroxymethylene bisphosphonates (HMBP) such as alendronate or zoledronate is hampered by their exceptional bone-binding properties and their short plasmatic half-life which preclude their accumulation in non-sk…
View article: Density Functional Theory calculations of Photosensitizers used in Photodynamic Therapy
Density Functional Theory calculations of Photosensitizers used in Photodynamic Therapy Open
The quantum-chemical method is a crucial area of innovation for photodynamic therapy. Density Functional Theory can be used to investigate the electronic structures, excited states, and other photochemical properties of a photosensitizer. …
View article: Oligomeric fragments distribution, structure and functionalities upon ruthenium-catalyzed technical lignin depolymerization
Oligomeric fragments distribution, structure and functionalities upon ruthenium-catalyzed technical lignin depolymerization Open
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View article: Thiochromenocarbazole imide-based photosensitizers decorated with carbonic anhydrase inhibitors for the targeted treatment of hypoxic tumours
Thiochromenocarbazole imide-based photosensitizers decorated with carbonic anhydrase inhibitors for the targeted treatment of hypoxic tumours Open
A series of thiochromenocarbazole imide (TCI) photosensitizers featuring carbonic anhydrase inhibitors (CAi) was designed to alleviate the consequences of PDT-induced hypoxia by merging the advantages of hCA IX knockdowns with PDT.
View article: Ru(II)‐Cyanine Complexes as Promising Photodynamic Photosensitizers for the Treatment of Hypoxic Tumours with Highly Penetrating 770 nm Near‐Infrared Light
Ru(II)‐Cyanine Complexes as Promising Photodynamic Photosensitizers for the Treatment of Hypoxic Tumours with Highly Penetrating 770 nm Near‐Infrared Light Open
Light‐activated treatments, such as photodynamic therapy (PDT), provide temporal and spatial control over a specific cytotoxic response by exploiting toxicity differences between irradiated and dark conditions. In this work, a novel strate…
View article: A Novel Near‐IR Absorbing Ruthenium(II) Complex as Photosensitizer for Photodynamic Therapy and its Cetuximab Bioconjugates
A Novel Near‐IR Absorbing Ruthenium(II) Complex as Photosensitizer for Photodynamic Therapy and its Cetuximab Bioconjugates Open
A novel Ru(II) cyclometalated photosensitizer (PS), Ru‐NH 2 , for photodynamic therapy (PDT) of formula [Ru(appy)(bphen) 2 ]PF 6 (where appy=4‐amino‐2‐phenylpyridine and bphen=bathophenanthroline) and its cetuximab (CTX) bioconjugates, Ru‐…