Philippe Bégin
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View article: Dupilumab in Eosinophilic Gastrointestinal Disorders With Extraesophageal Involvement: A Pediatric Case Series and Systematic Review
Dupilumab in Eosinophilic Gastrointestinal Disorders With Extraesophageal Involvement: A Pediatric Case Series and Systematic Review Open
Dupilumab has proven effective in the treatment of eosinophilic esophagitis (EoE) in randomized controlled trials. Its efficacy in other, less common and generally more severe eosinophilic gastrointestinal disorders (EGIDs) is scientifical…
View article: Food allergy severity across the world: A World Allergy Organization international survey
Food allergy severity across the world: A World Allergy Organization international survey Open
Background: Data on severity of food allergy across nations are lacking. Building on the World Allergy Organization (WAO) DEFASE (Definition of Food Allergy Severity) score, we aim to explore its global applicability as a grading system fo…
View article: Genomic analysis of Canadian children with food allergies points to the immunoglobulin heavy chain gene locus
Genomic analysis of Canadian children with food allergies points to the immunoglobulin heavy chain gene locus Open
View article: Impact of oral immunotherapy on diversity of gut microbiota in food‐allergic children
Impact of oral immunotherapy on diversity of gut microbiota in food‐allergic children Open
Background Food allergies (FAs) are an increasing public health concern, particularly in children. Oral immunotherapy (OIT) is an emerging treatment strategy under clinical investigation for desensitization of children with FA to food alle…
View article: Publisher Correction: Immunoglobulin E (IgE)-mediated food allergy
Publisher Correction: Immunoglobulin E (IgE)-mediated food allergy Open
View article: Fear, facts, and the future: An update on coronavirus disease 2019 vaccine–induced anaphylaxis and vaccine hesitancy among those living with allergy
Fear, facts, and the future: An update on coronavirus disease 2019 vaccine–induced anaphylaxis and vaccine hesitancy among those living with allergy Open
To prepare for future pandemics, it is evident that more efforts are needed to address concerns regarding the potential for allergic reactions following vaccination. As part of this process, it is important to ensure medical professionals …
View article: HLH-like Hypersensitivity Reaction Secondary to Prolonged Piperacillin/Tazobactam: A Case Series
HLH-like Hypersensitivity Reaction Secondary to Prolonged Piperacillin/Tazobactam: A Case Series Open
Background Prolonged (>10 days) use of intravenous (IV) piperacillin/tazobactam has been associated with a risk of developing hemophagocytic lymphohistiocytosis (HLH) syndrome. However, clinical and biological descriptions of this rare …
View article: Respiratory Related Hospitalization in Children With Exposure to Meconium Aspiration or Staining
Respiratory Related Hospitalization in Children With Exposure to Meconium Aspiration or Staining Open
Background We investigated whether neonates exposed to meconium had a higher risk of respiratory hospitalization in childhood. Methods We analyzed a longitudinal cohort of 1,271,563 children with 6,334,857 person‐years of follow‐up between…
View article: Predicting Cow’s Milk Challenge Outcomes in Children: Multivariate Analysis of Clinical Predictors
Predicting Cow’s Milk Challenge Outcomes in Children: Multivariate Analysis of Clinical Predictors Open
Introduction: Oral food challenges are the gold standard for diagnosis and reactivity thresholds but are resource intensive and high risk for reactions. Limited data on factors associated with increased risk of positive oral food challenge…
View article: Use of a 24-Hour Hotline vs Voicemail for Off-Hour Support During Oral Immunotherapy for Food Allergy
Use of a 24-Hour Hotline vs Voicemail for Off-Hour Support During Oral Immunotherapy for Food Allergy Open
View article: Efficacy and Safety of Epicutaneous Immunotherapy in Peanut-Allergic Toddlers: Open-Label Extension to EPITOPE
Efficacy and Safety of Epicutaneous Immunotherapy in Peanut-Allergic Toddlers: Open-Label Extension to EPITOPE Open
View article: Food oral immunotherapy
Food oral immunotherapy Open
Food oral immunotherapy (OIT) is an option for the treatment of immunoglobin E (IgE)‐mediated food allergy that involves administering gradually increasing doses of an allergenic food over time (under medical supervision) with the goal of …
View article: Immunoglobulin E (IgE)-mediated food allergy
Immunoglobulin E (IgE)-mediated food allergy Open
Food allergy is defined as an adverse immunologic response to a food. Immunoglobulin E (IgE)-mediated reactions to foods are associated with a broad range of signs and symptoms that may involve any of the following body systems: the skin, …
View article: Food Allergy Genetics and Epigenetics: A Review of Genome‐Wide Association Studies
Food Allergy Genetics and Epigenetics: A Review of Genome‐Wide Association Studies Open
In this review, we provide an overview of food allergy genetics and epigenetics aimed at clinicians and researchers. This includes a brief review of the current understanding of genetic and epigenetic mechanisms, inheritance of food allerg…
View article: Efficacy and Safety of Dupilumab in Children With Peanut Allergy: A Multicenter, Open‐Label, Phase <scp>II</scp> Study
Efficacy and Safety of Dupilumab in Children With Peanut Allergy: A Multicenter, Open‐Label, Phase <span>II</span> Study Open
Background Peanut allergy is a potentially life‐threatening food allergy in children. This study explored whether dupilumab, a human monoclonal immunoglobulin (Ig)G4 antibody that blocks the activity of interleukin (IL)‐4/IL‐13, improved s…
View article: Patient-centred composite scores as tools for assessment of response to biological therapy for paediatric and adult severe asthma
Patient-centred composite scores as tools for assessment of response to biological therapy for paediatric and adult severe asthma Open
Background We have previously developed Core Outcome Measures sets for Severe Asthma (COMSA) by multi-stakeholder consensus. There are no patient-centred tools to quantify response to biological therapies for severe asthma. We aimed to dev…
View article: Zéro allergie research clinic: a clinical and research initiative in oral immunotherapy for managing IgE-mediated food allergy
Zéro allergie research clinic: a clinical and research initiative in oral immunotherapy for managing IgE-mediated food allergy Open
Background and methods The Zéro allergie research clinic (Saguenay, Canada) is a clinical and research initiative in oral immunotherapy (OIT) for managing IgE-mediated food allergy (FA). A total of 183 children with FA and 27 non-allergic …
View article: GA<sup>2</sup>LEN ANACARE consensus statement: Potential of omalizumab in food allergy management
GA<sup>2</sup>LEN ANACARE consensus statement: Potential of omalizumab in food allergy management Open
Immunoglobulin E (IgE)‐mediated food allergies are the most common type of food allergy, often causing rapid symptoms after exposure to allergens posing a serious health risk and a high impact on patient's and caregiver's quality of life. …
View article: Long-term outcomes of patients with toxic shock syndrome: A matched cohort study
Long-term outcomes of patients with toxic shock syndrome: A matched cohort study Open
Toxic shock syndrome is associated with rehospitalization up to 15 years later, especially in men. These patients may benefit from continued follow-up to prevent long-term morbidity.
View article: Skin‐centered strategies in food allergy prevention
Skin‐centered strategies in food allergy prevention Open
While the early introduction of food allergens in the infant diet has been shown to be effective at preventing the development of food allergy (FA), its implementation in real life has been associated with various challenges. Interventions…
View article: Preparing Patients for Oral Immunotherapy (PPOINT): International Delphi consensus for procedural preparation and consent
Preparing Patients for Oral Immunotherapy (PPOINT): International Delphi consensus for procedural preparation and consent Open
View article: Quality of life and <scp>cost‐effectiveness</scp> of convalescent plasma compared to standard care for hospitalized <scp>COVID</scp>‐19 patients in the <scp>CONCOR</scp>‐1 trial
Quality of life and <span>cost‐effectiveness</span> of convalescent plasma compared to standard care for hospitalized <span>COVID</span>‐19 patients in the <span>CONCOR</span>‐1 trial Open
Background The CONvalescent Plasma for Hospitalized Adults With COVID‐19 Respiratory Illness (CONCOR‐1) trial was a multicenter randomized controlled trial assessing convalescent plasma in hospitalized COVID‐19 patients. This study evaluat…
View article: Age-Related Food Aversion and Anxiety Represent Primary Patient Barriers to Food Oral Immunotherapy
Age-Related Food Aversion and Anxiety Represent Primary Patient Barriers to Food Oral Immunotherapy Open
View article: Impact of Exacerbation History on Dupilumab Efficacy in Children with Uncontrolled Moderate-to-Severe Asthma: LIBERTY ASTHMA VOYAGE Study
Impact of Exacerbation History on Dupilumab Efficacy in Children with Uncontrolled Moderate-to-Severe Asthma: LIBERTY ASTHMA VOYAGE Study Open
In children with uncontrolled, moderate-to-severe asthma with a type 2 phenotype, dupilumab consistently reduced the risk of asthma exacerbations, improved lung function, and reduced ACQ-7-IA scores, regardless of exacerbation history.
View article: Varying Doses of Epicutaneous Immunotherapy With Viaskin Milk vs Placebo in Children With Cow’s Milk Allergy
Varying Doses of Epicutaneous Immunotherapy With Viaskin Milk vs Placebo in Children With Cow’s Milk Allergy Open
Importance No approved allergen-specific treatment exists for immunoglobulin E (IgE)–mediated cow’s milk allergy (CMA), a common childhood food allergy. Objective To assess dose, efficacy, and safety of epicutaneous immunotherapy with Vias…
View article: Predictors of support line utilization by patients undergoing oral immunotherapy
Predictors of support line utilization by patients undergoing oral immunotherapy Open
View article: A comprehensive approach integrating epinephrine use into symptom-based scoring systems to improve severity grading of reactions at milk oral challenge
A comprehensive approach integrating epinephrine use into symptom-based scoring systems to improve severity grading of reactions at milk oral challenge Open
View article: Effect‐modifying impact of age on sex‐based differences during oral immunotherapy
Effect‐modifying impact of age on sex‐based differences during oral immunotherapy Open
International audience
View article: Plasma Human Immunodeficiency Virus 1 Soluble Glycoprotein 120 Association With Correlates of Immune Dysfunction and Inflammation in Antiretroviral Therapy–Treated Individuals With Undetectable Viremia
Plasma Human Immunodeficiency Virus 1 Soluble Glycoprotein 120 Association With Correlates of Immune Dysfunction and Inflammation in Antiretroviral Therapy–Treated Individuals With Undetectable Viremia Open
Background Chronic inflammation persists in some people living with human immunodeficiency virus (HIV) during antiretroviral therapy and is associated with premature aging. The glycoprotein 120 (gp120) subunit of HIV-1 envelope sheds and c…
View article: A qualitative investigation into vaccine hesitancy and confidence among people managing allergy
A qualitative investigation into vaccine hesitancy and confidence among people managing allergy Open
Vaccine hesitancy has a multifactorial etiology, and, among atopic individuals, is exacerbated by documented, but rare, cases of allergic reactions to COVID-19 vaccines.1–3 Furthermore, conflicting information regarding the safety of COVID…