Philippe Bonniaud
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View article: Continuous Positive Airway Pressure Improves Marital Relationship and Sexual Satisfaction in Obstructive Sleep Apnea Patients and Partners
Continuous Positive Airway Pressure Improves Marital Relationship and Sexual Satisfaction in Obstructive Sleep Apnea Patients and Partners Open
Symptoms of obstructive sleep apnea and hypopnea can interfere with sleep and quality of life for the patient's partner and affect marital relationships. Our primary objective was to assess how continuous positive airway pressure (CPAP) tr…
View article: Accuracy of Measured Venous Bicarbonate to Detect Nocturnal Hypoventilation in Neuromuscular Adults
Accuracy of Measured Venous Bicarbonate to Detect Nocturnal Hypoventilation in Neuromuscular Adults Open
International audience
View article: POS1036 LONGITUDINAL ANTISYNTHETASE SYNDROME-ASSOCIATED INTERSTITIAL LUNG DISEASE EVOLUTION TRAJECTORIES
POS1036 LONGITUDINAL ANTISYNTHETASE SYNDROME-ASSOCIATED INTERSTITIAL LUNG DISEASE EVOLUTION TRAJECTORIES Open
View article: POS1037 SEVERITY OF ANTISYNTHETASE SYNDROME-ASSOCIATED INTERSTITIAL LUNG DISEASE AND ANTI-AMINOACYL-tRNA-SYNTHETASE ANTIBODY PROFILE
POS1037 SEVERITY OF ANTISYNTHETASE SYNDROME-ASSOCIATED INTERSTITIAL LUNG DISEASE AND ANTI-AMINOACYL-tRNA-SYNTHETASE ANTIBODY PROFILE Open
View article: Impact of A Multidisciplinary Team Discussion for Genetic Lung Fibrosis
Impact of A Multidisciplinary Team Discussion for Genetic Lung Fibrosis Open
Background and Objective Approximately 30% of individuals diagnosed with familial pulmonary fibrosis (FPF) exhibit a pathogenic variant upon genetic analysis. We established a genetic Multidisciplinary Discussion (geneMDD) aimed to enhance…
View article: Association of Pulmonary Hypertension With Trastuzumab Emtansine
Association of Pulmonary Hypertension With Trastuzumab Emtansine Open
View article: Protocol and research program of the European registry and biobank for interstitial lung diseases (eurILDreg)
Protocol and research program of the European registry and biobank for interstitial lung diseases (eurILDreg) Open
Background and Aims Interstitial lung diseases (ILDs), encompassing both pediatric and adult cases, present a diverse spectrum of chronic conditions with variable prognosis. Despite limited therapeutic options beyond antifibrotic drugs and…
View article: CD206<sup>+</sup>macrophages are relevant non-invasive imaging biomarkers and therapeutic targets in experimental lung fibrosis
CD206<sup>+</sup>macrophages are relevant non-invasive imaging biomarkers and therapeutic targets in experimental lung fibrosis Open
Background Interstitial lung diseases (ILDs) include a large number of diseases associated with progressive pulmonary fibrosis (PPF), including idiopathic pulmonary fibrosis (IPF). Despite the rarity of each of the fibrotic ILDs individual…
View article: Real-world comparison of chemo-immunotherapy and chemotherapy alone in the treatment of extensive-stage small-cell lung cancer
Real-world comparison of chemo-immunotherapy and chemotherapy alone in the treatment of extensive-stage small-cell lung cancer Open
In this real-world study, chemo-immunotherapy was associated with slightly better OS compared to chemotherapy alone as a first-line treatment in ES-SCLC patients in multivariate analysis, which is not explained by a benefit in PFS. However…
View article: High risk of lung cancer in surfactant-related gene variant carriers
High risk of lung cancer in surfactant-related gene variant carriers Open
Background Several rare surfactant-related gene (SRG) variants associated with interstitial lung disease are suspected to be associated with lung cancer, but data are missing. We aimed to study the epidemiology and phenotype of lung cancer…
View article: Severe asthma care trajectories: the French RAMSES cohort
Severe asthma care trajectories: the French RAMSES cohort Open
Background The French RAMSES study is an observational prospective multicentre real-life cohort including severe asthmatic subjects. The objective of the study was to compare the characteristics of patients, in terms of phenotype and asthm…
View article: Articular manifestations related to anti-interleukin-5 therapies in severe asthma: a case series
Articular manifestations related to anti-interleukin-5 therapies in severe asthma: a case series Open
Articular manifestations should be screened before and during anti-IL-5/5R biologic treatment in severe asthma. Rigorous multidisciplinary team discussion should be carried out to assess the risk-benefit balance of withholding effective…
View article: Reduction of daily maintenance inhaled corticosteroids in patients with severe eosinophilic asthma treated with benralizumab (SHAMAL): a randomised, multicentre, open-label, phase 4 study
Reduction of daily maintenance inhaled corticosteroids in patients with severe eosinophilic asthma treated with benralizumab (SHAMAL): a randomised, multicentre, open-label, phase 4 study Open
AstraZeneca.
View article: Infections in autoimmune pulmonary alveolar proteinosis: a large retrospective cohort
Infections in autoimmune pulmonary alveolar proteinosis: a large retrospective cohort Open
Background Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare disease, predisposing to an increased risk of infection. A complete picture of these infections is lacking. Research question Describe the characteristics and clinical o…
View article: <i>Aspergillus</i>colonisation in severe community-acquired pneumonia: not just a mere colonisation
<i>Aspergillus</i>colonisation in severe community-acquired pneumonia: not just a mere colonisation Open
In patients with severe community-acquired pneumonia, detection of Aspergillus is associated with a mortality rate surpassing 50%, irrespective of whether it is defined as invasion or colonisation https://bit.ly/46PMk1f.
View article: POS1230 ASSOCIATION OF CANCER AND ANTISYNTHETASE SYNDROME: A RETROSPECTIVE MULTICENTER STUDY
POS1230 ASSOCIATION OF CANCER AND ANTISYNTHETASE SYNDROME: A RETROSPECTIVE MULTICENTER STUDY Open
Background Idiopathic inflammatory myopathies (IIM) are rare and heterogeneous conditions, associated with cancer in 10 to 30% of cases. While some features have been associated with cancer (age, male sex, dermatomyositis, anti-TIF1-γ anti…
View article: Severe Asthma Standard-of-Care Background Medication Reduction With Benralizumab: ANDHI in Practice Substudy
Severe Asthma Standard-of-Care Background Medication Reduction With Benralizumab: ANDHI in Practice Substudy Open
These findings demonstrate benralizumab's ability to improve asthma control, thereby allowing background medication reduction.
View article: HSPB5 Inhibition by NCI-41356 Reduces Experimental Lung Fibrosis by Blocking TGF-β1 Signaling
HSPB5 Inhibition by NCI-41356 Reduces Experimental Lung Fibrosis by Blocking TGF-β1 Signaling Open
Idiopathic pulmonary fibrosis is a chronic, progressive and lethal disease of unknown etiology that ranks among the most frequent interstitial lung diseases. Idiopathic pulmonary fibrosis is characterized by dysregulated healing mechanisms…
View article: Real-life evaluation of NIV to CPAP switch in patients with chronic respiratory failure. A case control study.
Real-life evaluation of NIV to CPAP switch in patients with chronic respiratory failure. A case control study. Open
Background Non-invasive ventilation (NIV) is a standard of care for hypercapnic chronic respiratory failure (CRF). Obstructive sleep apnea (OSA) frequently contribute to hypoventilation in CRF. CPAP improves hypercapnia in selected COPD an…
View article: Improvement in severe asthma patients receiving biologics and factors associated with persistent insufficient control: a real-life national study
Improvement in severe asthma patients receiving biologics and factors associated with persistent insufficient control: a real-life national study Open
Background: Biological therapies have revolutionized the treatment of severe asthma with type 2 inflammation. Although such treatments are very effective in reducing exacerbation and the dose of oral steroids, little is known about the per…
View article: French practical guidelines for the diagnosis and management of idiopathic pulmonary fibrosis – 2021 update. Full-length version
French practical guidelines for the diagnosis and management of idiopathic pulmonary fibrosis – 2021 update. Full-length version Open
View article: Recommandations pratiques pour le diagnostic et la prise en charge de la fibrose pulmonaire idiopathique – Actualisation 2021. Version intégrale
Recommandations pratiques pour le diagnostic et la prise en charge de la fibrose pulmonaire idiopathique – Actualisation 2021. Version intégrale Open
View article: Uncommon EGFR mutations in lung carcinoma: features and treatment outcomes in a retrospective French cohort
Uncommon EGFR mutations in lung carcinoma: features and treatment outcomes in a retrospective French cohort Open
There were variations in treatment outcomes among subgroups in our cohort. Exon 20 insertions showed better ORR and PFS with 1st line chemotherapy compared to TKI. Conversely, other rare EGFR mutations including ECM had better ORR and PFS …
View article: The burden of mild asthma: Clinical burden and healthcare resource utilisation in the NOVELTY study
The burden of mild asthma: Clinical burden and healthcare resource utilisation in the NOVELTY study Open
View article: Targeting the nasty nestin to shoot lung fibrosis
Targeting the nasty nestin to shoot lung fibrosis Open
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal lung disease [1]. Therapeutic options are limited to pirfenidone and nintedanib, which can slow down but not halt or reverse disease progression. The biology of IPF is…
View article: Extracellular Lipids in the Lung and Their Role in Pulmonary Fibrosis
Extracellular Lipids in the Lung and Their Role in Pulmonary Fibrosis Open
Lipids are major actors and regulators of physiological processes within the lung. Initial research has described their critical role in tissue homeostasis and in orchestrating cellular communication to allow respiration. Over the past dec…
View article: COVID-19 Lockdown in Patients with Chronic Diseases: A Cross-Sectional Study
COVID-19 Lockdown in Patients with Chronic Diseases: A Cross-Sectional Study Open
Background: We aimed to investigate the impact of the first COVID-19 lockdown on medication adherence, physician access, lifestyle behaviours, and mental health in patients with chronic conditions. Methods: A cross-sectional phone survey w…
View article: Drug-induced interstitial lung disease
Drug-induced interstitial lung disease Open
Interstitial lung disease (ILD) secondary to drug-induced lung injury is an increasingly common cause of morbidity and mortality. The number of drugs associated with the development of ILD continues to rise, mainly due to the use of novel …
View article: Recommandations pratiques pour le diagnostic et la prise en charge de la fibrose pulmonaire idiopathique – Actualisation 2021. Version courte
Recommandations pratiques pour le diagnostic et la prise en charge de la fibrose pulmonaire idiopathique – Actualisation 2021. Version courte Open
View article: RESPIRenT : RESeau de Pneumologie en Innovation et Recherche translaTionnelle, un nouveau souffle pour les J2R
RESPIRenT : RESeau de Pneumologie en Innovation et Recherche translaTionnelle, un nouveau souffle pour les J2R Open