Philippe Büchler
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View article: Biomechanical Comparison of PRK, LASIK, and KLEx Using Personalized Finite Element Simulations
Biomechanical Comparison of PRK, LASIK, and KLEx Using Personalized Finite Element Simulations Open
Purpose: To investigate the biomechanical effects of photorefractive keratectomy (PRK), laser in situ keratomileusis (LASIK), and keratorefractive lenticule extraction (KLEx) on postoperative corneal biomechanics and visual outcomes using …
View article: Bimodal ex vivo biomechanical characterization of corneal UVA-crosslinking via optical coherence elastography and nanoindentation under physiological conditions
Bimodal ex vivo biomechanical characterization of corneal UVA-crosslinking via optical coherence elastography and nanoindentation under physiological conditions Open
Riboflavin-mediated UVA corneal crosslinking (CXL) stabilizes corneal ectasia, but its biomechanical effects remain difficult to quantify. This study combines Optical Coherence Elastography (OCE), an imaging technique which provides spatia…
View article: Predicting the Effects of Customized Corneal Cross-Linking on Corneal Geometry
Predicting the Effects of Customized Corneal Cross-Linking on Corneal Geometry Open
Customized CXL induces a flattening of about 2 diopters in the cone region six months after surgery. The model adequately captured the curvature corrections induced by the treatment in the keratoconus cone region, but showed reduced accura…
View article: Integration of mechanical testing, <i>in vivo</i> optical coherence elastography and personalized finite element modeling to predict geometrical outcomes of corneal cross-linking
Integration of mechanical testing, <i>in vivo</i> optical coherence elastography and personalized finite element modeling to predict geometrical outcomes of corneal cross-linking Open
Purpose Corneal cross-linking (CXL) induces both mechanical and geometrical changes in the cornea, which are typically overlooked in pre-operative planning. We propose a patient-specific finite element model (FEM) to predict the topographi…
View article: Regional corneal biomechanics assessment as a function of age using Strain–Stress Index maps
Regional corneal biomechanics assessment as a function of age using Strain–Stress Index maps Open
Purpose To gain a better understanding of corneal Stress–Strain Index (SSI) maps in healthy eyes and to determine their changes with age. Method The eyes of 72 participants (age 43.1 ± 20.9 years, 69.5% female) were included in the analysi…
View article: ULTRASHORT TIME ECHO MRI SEQUENCE TO QUANTIFY VERTEBRAL BONE MORPHOLOGY IN YOUNG ADULTS
ULTRASHORT TIME ECHO MRI SEQUENCE TO QUANTIFY VERTEBRAL BONE MORPHOLOGY IN YOUNG ADULTS Open
While MRI is the modality of choice for soft tissue imaging, its ability to visualize bone structures remains limited. In contrast, CT provides superior bone imaging but involves ionizing radiation, making it suboptimal for longitudinal st…
View article: Patient-Specific Finite Element Modeling of Refractive Surgery Biomechanics: Technical Assessment of PRK, LASIK, and KLEx
Patient-Specific Finite Element Modeling of Refractive Surgery Biomechanics: Technical Assessment of PRK, LASIK, and KLEx Open
This study evaluates the biomechanical and optical consequences of three corneal refractive surgeries-PRK, LASIK, and KLEx-using patient-specific finite element simulations. Personalized corneal geometries were derived from preoperative to…
View article: A causal Bayesian model to evaluate shoulder pathology effect on glenoid bone mineral density
A causal Bayesian model to evaluate shoulder pathology effect on glenoid bone mineral density Open
Background: The effect of shoulder pathologies on glenoid bone mineral density (BMD) remains unclear and can be critical in surgical treatments. It is thus useful to predict this effect and understand how it is influenced by sex, age, and …
View article: Evaluation of design parameters on the outcome of intrastromal ring surgery using biomechanical simulations
Evaluation of design parameters on the outcome of intrastromal ring surgery using biomechanical simulations Open
Background The cornea plays a role in the refractive power of the eye, and when its natural curvature and thickness are compromised by diseases such as keratoconus or high myopia, this results in loss of visual acuity. Intracorneal rings (…
View article: A Multidisciplinary Hyper-Modeling Scheme in Personalized In Silico Oncology: Coupling Cell Kinetics with Metabolism, Signaling Networks, and Biomechanics as Plug-In Component Models of a Cancer Digital Twin
A Multidisciplinary Hyper-Modeling Scheme in Personalized In Silico Oncology: Coupling Cell Kinetics with Metabolism, Signaling Networks, and Biomechanics as Plug-In Component Models of a Cancer Digital Twin Open
The massive amount of human biological, imaging, and clinical data produced by multiple and diverse sources necessitates integrative modeling approaches able to summarize all this information into answers to specific clinical questions. In…
View article: A Multidisciplinary Hyper-Modeling Scheme in Personalized In Silico Oncology: Coupling Cell Kinetics With Metabolism, Signaling Networks and Biomechanics As Plug-In Component Models of a Cancer Digital Twin
A Multidisciplinary Hyper-Modeling Scheme in Personalized In Silico Oncology: Coupling Cell Kinetics With Metabolism, Signaling Networks and Biomechanics As Plug-In Component Models of a Cancer Digital Twin Open
The massive amount of human biological, imaging and clinical data produced by multiple and diverse sources, necessitates integrative modeling approaches able to summarize all this information into answers to specific clinical questions. In…
View article: Predicted vs. measured paraspinal muscle activity in adolescent idiopathic scoliosis patients: EMG validation of optimization-based musculoskeletal simulations
Predicted vs. measured paraspinal muscle activity in adolescent idiopathic scoliosis patients: EMG validation of optimization-based musculoskeletal simulations Open
Musculoskeletal (MSK) models offer great potential for predicting the muscle forces required to inform more detailed simulations of vertebral endplate loading in adolescent idiopathic scoliosis (AIS). In this work, simulations based on sta…
View article: Optomechanical assessment of photorefractive corneal cross-linking via optical coherence elastography
Optomechanical assessment of photorefractive corneal cross-linking via optical coherence elastography Open
Purpose: Corneal cross-linking (CXL) has recently been used with promising results to positively affect corneal refractive power in the treatment of hyperopia and mild myopia. However, understanding and predicting the optomechanical change…
View article: Depth-dependent mechanical properties of the human cornea by uniaxial extension
Depth-dependent mechanical properties of the human cornea by uniaxial extension Open
The purpose of this study was to investigate the depth-dependent biomechanical properties of the human corneal stroma under uniaxial tensile loading. Human stroma samples were obtained after the removal of Descemet's membrane in the course…
View article: Patient-specific finite element analysis of human corneal lenticules: An experimental and numerical study
Patient-specific finite element analysis of human corneal lenticules: An experimental and numerical study Open
The number of elective refractive surgeries is constantly increasing due to the drastic increase in myopia prevalence. Since corneal biomechanics are critical to human vision, accurate modeling is essential to improve surgical planning and…
View article: Analysis of Biomechanical Response After Corneal Crosslinking with Different Fluence Levels in Porcine Corneas
Analysis of Biomechanical Response After Corneal Crosslinking with Different Fluence Levels in Porcine Corneas Open
Additional mechanical stiffening can be achieved by increasing the fluence of the CXL. There was no threshold detected up to 20 J/cm2. A higher fluence could compensate the weaker effect of accelerated or epi-on CXL procedures.
View article: Traditional T1-S1 Measurement of the Spinal Length on X-ray Images Does Not Correlate With the True Length of the Spine
Traditional T1-S1 Measurement of the Spinal Length on X-ray Images Does Not Correlate With the True Length of the Spine Open
BACKGROUND: The T1-S1 distance to evaluate spinal length is traditionally measured as a straight line on an anteroposterior radiograph. However, this method may not reflect the true 3-dimensional (3D) spinal length. The objective of the st…
View article: Orientation and depth dependent mechanical properties of the porcine cornea: Experiments and parameter identification
Orientation and depth dependent mechanical properties of the porcine cornea: Experiments and parameter identification Open
The porcine cornea is a standard animal model in ophthalmic research, making its biomechanical characterization and modeling important to develop novel treatments such as crosslinking and refractive surgeries. In this study, we present a n…