Philippe Codron
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View article: Prevalence of <scp><i>SOD1</i></scp> and <scp><i>C9orf72</i></scp> Variants Among French <scp>ALS</scp> Population: The <scp>GENIALS</scp> Study
Prevalence of <span><i>SOD1</i></span> and <span><i>C9orf72</i></span> Variants Among French <span>ALS</span> Population: The <span>GENIALS</span> Study Open
Rationale Amyotrophic Lateral Sclerosis (ALS) is a fatal motoneuron disease in which genetics plays a central role for both familial and sporadic ALS cases. Systematic genetic analysis for all ALS patients is recommended at the time of dia…
View article: English Workshops with Simulated Patients and Peers Reduce Medical Students’ Apprehension About Speaking in English
English Workshops with Simulated Patients and Peers Reduce Medical Students’ Apprehension About Speaking in English Open
View article: From suspicion to diagnosis: exploration strategy for suspected amyotrophic lateral sclerosis
From suspicion to diagnosis: exploration strategy for suspected amyotrophic lateral sclerosis Open
The diagnosis of amyotrophic lateral sclerosis (ALS) is based on evidence of upper and lower motor neuron degeneration in the bulbar, cervical, thoracic, and lumbar regions in a patient with progressive motor weakness, in the absence of di…
View article: EVolution in ALS diagnosis: molecular markers in extracellular vesicles
EVolution in ALS diagnosis: molecular markers in extracellular vesicles Open
The identification of biomarkers for amyotrophic lateral sclerosis (ALS) is a central issue in disease research. In a recent article, Chatterjee et al. show that blood extracellular vesicles (EVs) with high levels of transactive response D…
View article: Mitochondrial F0F1-ATP synthase governs the induction of mitochondrial fission
Mitochondrial F0F1-ATP synthase governs the induction of mitochondrial fission Open
View article: <scp>Stochastic Optical Reconstruction Microscopy</scp> Imaging of Multiple System Atrophy Inclusions Suggests Stepwise α‐Synuclein Aggregation
<span>Stochastic Optical Reconstruction Microscopy</span> Imaging of Multiple System Atrophy Inclusions Suggests Stepwise α‐Synuclein Aggregation Open
Background The architecture and composition of glial (GCI) and neuronal (NCI) α‐synuclein inclusions observed in multiple system atrophy (MSA) remain to be precisely defined to better understand the disease. Methods Here, we used stochasti…
View article: Opa1 and MT-Nd6 mutations induce early mitochondrial changes in the retina and prelaminar optic nerve of hereditary optic neuropathy mouse models
Opa1 and MT-Nd6 mutations induce early mitochondrial changes in the retina and prelaminar optic nerve of hereditary optic neuropathy mouse models Open
Hereditary optic neuropathies, including dominant optic atrophy and Leber’s hereditary optic neuropathy, are genetic disorders characterized by retinal ganglion cell degeneration leading to vision loss, mainly associated with mitochondrial…
View article: Transactive response DNA-binding protein 43 is enriched at the centrosome in human cells
Transactive response DNA-binding protein 43 is enriched at the centrosome in human cells Open
The centrosome, as the main microtubule organizing centre, plays key roles in cell polarity, genome stability and ciliogenesis. The recent identification of ribosomes, RNA-binding proteins and transcripts at the centrosome suggests local p…
View article: Dedifferentiated cells obtained from glioblastoma cell lines are an easy and robust model for mesenchymal glioblastoma stem cells studies.
Dedifferentiated cells obtained from glioblastoma cell lines are an easy and robust model for mesenchymal glioblastoma stem cells studies. Open
Glioblastoma is an aggressive brain tumor with a poor prognosis. Glioblastoma Stem Cells (GSC) are involved in glioblastoma resistance and relapse. Effective glioblastoma treatment must include GSC targeting strategy. Robust and well defin…
View article: Design and application of a customizable relational <scp>DataBase</scp> to assess clinicopathological correlations and concomitant pathology in neurodegenerative diseases
Design and application of a customizable relational <span>DataBase</span> to assess clinicopathological correlations and concomitant pathology in neurodegenerative diseases Open
The diagnosis of neurodegenerative diseases is made complex by the heterogenous phenotype of the patients and the regular occurrence of concomitant pathology. Studying clinicopathological correlations in autopsy series is a central approac…
View article: Correction to: A chasing dead-end case report: a fatal lead intoxication following an attempted homicide
Correction to: A chasing dead-end case report: a fatal lead intoxication following an attempted homicide Open
View article: 63rd Meeting of the French Society of Neuropathology - Meeting Abstracts , December 3rd. 2021
63rd Meeting of the French Society of Neuropathology - Meeting Abstracts , December 3rd. 2021 Open
International audience
View article: Hydroxychloroquine in mild-to-moderate coronavirus disease 2019: a placebo-controlled double blind trial
Hydroxychloroquine in mild-to-moderate coronavirus disease 2019: a placebo-controlled double blind trial Open
View article: COvid-19 and high-dose VITamin D supplementation TRIAL in high-risk older patients (COVIT-TRIAL): study protocol for a randomized controlled trial
COvid-19 and high-dose VITamin D supplementation TRIAL in high-risk older patients (COVIT-TRIAL): study protocol for a randomized controlled trial Open
Background With the lack of effective therapy, chemoprevention, and vaccination against SARS-CoV-2, focusing on the immediate repurposing of existing drugs gives hope of curbing the COVID-19 pandemic. A recent unbiased genomics-guided trac…
View article: Monoclonal full-length antibody against TAR DNA binding protein 43 reduces related proteinopathy in neurons
Monoclonal full-length antibody against TAR DNA binding protein 43 reduces related proteinopathy in neurons Open
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), 2 incurable neurodegenerative disorders, share the same pathological hallmark named TDP43 (TAR DNA binding protein 43) proteinopathy. This event is character…
View article: Une OACR révélant un pseudoxanthome élastique
Une OACR révélant un pseudoxanthome élastique Open
View article: STochastic Optical Reconstruction Microscopy (STORM) reveals the nanoscale organization of pathological aggregates in human brain
STochastic Optical Reconstruction Microscopy (STORM) reveals the nanoscale organization of pathological aggregates in human brain Open
Aims Histological analysis of brain tissue samples provides valuable information about the pathological processes leading to common neurodegenerative disorders. In this context, the development of novel high‐resolution imaging approaches i…
View article: STochastic Optical Reconstruction Microscopy (STORM) reveals the nanoscale organization of pathological aggregates in human brain
STochastic Optical Reconstruction Microscopy (STORM) reveals the nanoscale organization of pathological aggregates in human brain Open
Background Histological analysis of brain tissue samples provide valuable information about the pathological processes leading to common neurodegenerative disorders such as Alzheimer’s or Parkinson’s diseases. In particular, high resolutio…
View article: Oxidative stress contributes differentially to the pathophysiology of Charcot-Marie-Tooth disease type 2K
Oxidative stress contributes differentially to the pathophysiology of Charcot-Marie-Tooth disease type 2K Open
View article: Marqueurs pathologiques et pistes thérapeutiques dans la Sclérose Latérale Amyotrophique Sporadique
Marqueurs pathologiques et pistes thérapeutiques dans la Sclérose Latérale Amyotrophique Sporadique Open
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder affecting both upper and lower motor neurons.The disease is responsible for a progressive paralysis leading to death within 5 years after the symptom onset, with no curati…
View article: Key role of UBQLN2 in pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia
Key role of UBQLN2 in pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia Open
Ubiquilin-2 (UBQLN2) is a member of the ubiquilin family, actively implicated in the degradation of misfolded and redundant proteins through the ubiquitin-proteasome system and macroautophagy. UBQLN2 received much attention after the disco…
View article: Virus-mediated delivery of antibody targeting TAR DNA-binding protein-43 mitigates associated neuropathology
Virus-mediated delivery of antibody targeting TAR DNA-binding protein-43 mitigates associated neuropathology Open
The cytoplasmic aggregation of TAR DNA-binding protein-43 (TDP-43) is a hallmark of degenerating neurons in amyotrophic lateral sclerosis (ALS) and subsets of frontotemporal dementia (FTD). In order to reduce TDP-43 pathology, we generated…
View article: Characterization of Cells Interactions with Patterned Azopolymer-Based Materials using SEM, AFM and Video Microscopy
Characterization of Cells Interactions with Patterned Azopolymer-Based Materials using SEM, AFM and Video Microscopy Open
Introduction: Artificial Extracellular Matrices (ECMs) are promising tools for the study of cell behaviors. Methods: Here, we report a protocol for the use of a reconfigurable biocompatible azopolymer thin film through a photoinduced recon…
View article: Neuronal Intermediate Filaments in Amyotrophic Lateral Sclerosis
Neuronal Intermediate Filaments in Amyotrophic Lateral Sclerosis Open
Neuronal intermediate filaments (NIFs) are the most abundant cytoskeletal element in mature neurons. They are composed of different protein subunits encoded by separate genes such as neurofilament light chain (NFL), neurofilament medium ch…