Philippe Nizard
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View article: In Vivo Monitoring and Magnetically‐Enhanced Delivery of CAR T‐Cells to Solid Tumor
In Vivo Monitoring and Magnetically‐Enhanced Delivery of CAR T‐Cells to Solid Tumor Open
Chimeric antigen receptor (CAR) T‐cell therapy demonstrates efficacy for the treatment of hematologic cancers, but remains challenging in solid tumors because of the hostile tumor microenvironment and heterogeneity that restrict the infilt…
View article: Triphenylamine Sensitized 8‐Dimethylaminoquinoline: An Efficient Two‐Photon Caging Group for Intracellular Delivery
Triphenylamine Sensitized 8‐Dimethylaminoquinoline: An Efficient Two‐Photon Caging Group for Intracellular Delivery Open
Triphenylamine‐sensitized 8‐dimethylaminoquinoline (TAQ) probes showed fair two‐photon absorption and fragmentation cross sections in releasing kainate and GABA ligands. The water‐soluble PEG and TEG‐analogs allowed cell internalization an…
View article: Dual-Probe SERS Nanosensor: A Promising Approach for Sensitive and Ratiometric Detection of Glucose in Clinical Settings
Dual-Probe SERS Nanosensor: A Promising Approach for Sensitive and Ratiometric Detection of Glucose in Clinical Settings Open
Diabetes is a major global health concern, with millions of annual deaths. Monitoring glucose levels is vital for clinical management, and urine samples offer a noninvasive alternative to blood samples. Optical techniques for urine glucose…
View article: Dual‐Mode Nanoprobes Based on Lanthanide Doped Fluoride Nanoparticles Functionalized by Aryl Diazonium Salts for Fluorescence and SERS Bioimaging
Dual‐Mode Nanoprobes Based on Lanthanide Doped Fluoride Nanoparticles Functionalized by Aryl Diazonium Salts for Fluorescence and SERS Bioimaging Open
The design of dual‐mode fluorescence and Raman tags stimulates a growing interest in biomedical imaging and sensing applications as they offer the possibility to synergistically combine the versatility and velocity of fluorescence imaging …
View article: Supplemental Materials from Clinical Relevance of <i>KRAS</i>-Mutated Subclones Detected with Picodroplet Digital PCR in Advanced Colorectal Cancer Treated with Anti-EGFR Therapy
Supplemental Materials from Clinical Relevance of <i>KRAS</i>-Mutated Subclones Detected with Picodroplet Digital PCR in Advanced Colorectal Cancer Treated with Anti-EGFR Therapy Open
Supplemental Materials. Supplemental Table 1: Patient mutational status and agreement between qPCR, dPCR and sequencing results. Supplemental Table 2: Analysis of different tissue samples coming from the same patient. Supplemental Figure 1…
View article: Data from Clinical Relevance of <i>KRAS</i>-Mutated Subclones Detected with Picodroplet Digital PCR in Advanced Colorectal Cancer Treated with Anti-EGFR Therapy
Data from Clinical Relevance of <i>KRAS</i>-Mutated Subclones Detected with Picodroplet Digital PCR in Advanced Colorectal Cancer Treated with Anti-EGFR Therapy Open
Purpose:KRAS mutations are predictive of nonresponse to anti-EGFR therapies in metastatic colorectal cancer (mCRC). However, only 50% of nonmutated patients benefit from them. KRAS-mutated subclonal populations nondetectable by conventiona…
View article: Supplemental Materials from Clinical Relevance of <i>KRAS</i>-Mutated Subclones Detected with Picodroplet Digital PCR in Advanced Colorectal Cancer Treated with Anti-EGFR Therapy
Supplemental Materials from Clinical Relevance of <i>KRAS</i>-Mutated Subclones Detected with Picodroplet Digital PCR in Advanced Colorectal Cancer Treated with Anti-EGFR Therapy Open
Supplemental Materials. Supplemental Table 1: Patient mutational status and agreement between qPCR, dPCR and sequencing results. Supplemental Table 2: Analysis of different tissue samples coming from the same patient. Supplemental Figure 1…
View article: Data from Clinical Relevance of <i>KRAS</i>-Mutated Subclones Detected with Picodroplet Digital PCR in Advanced Colorectal Cancer Treated with Anti-EGFR Therapy
Data from Clinical Relevance of <i>KRAS</i>-Mutated Subclones Detected with Picodroplet Digital PCR in Advanced Colorectal Cancer Treated with Anti-EGFR Therapy Open
Purpose:KRAS mutations are predictive of nonresponse to anti-EGFR therapies in metastatic colorectal cancer (mCRC). However, only 50% of nonmutated patients benefit from them. KRAS-mutated subclonal populations nondetectable by conventiona…
View article: Synergic Thermo- and pH-Sensitive Hybrid Microgels Loaded with Fluorescent Dyes and Ultrasmall Gold Nanoparticles for Photoacoustic Imaging and Photothermal Therapy
Synergic Thermo- and pH-Sensitive Hybrid Microgels Loaded with Fluorescent Dyes and Ultrasmall Gold Nanoparticles for Photoacoustic Imaging and Photothermal Therapy Open
Smart microgels (μGels) made of polymeric particles doped with inorganic nanoparticles have emerged recently as promising multifunctional materials for nanomedicine applications. However, the synthesis of these hybrid materials is still a …
View article: SERS tags derived from silver nanoparticles and aryl diazonium salts for cell Raman imaging
SERS tags derived from silver nanoparticles and aryl diazonium salts for cell Raman imaging Open
Surface functionalization of silver nanoparticles by Raman reporters derived from aryl diazonium salts offers new opportunities for the design of Surface-Enhanced Raman Spectroscopy (SERS) labels for Cell Raman Imaging
View article: Anti-counterfeiting SERS security labels derived from silver nanoparticles and aryl diazonium salts
Anti-counterfeiting SERS security labels derived from silver nanoparticles and aryl diazonium salts Open
The development of anti-counterfeiting inks based on surface-enhanced Raman scattering (SERS) labels have attracted great interest in recent years for their use as security labels in anti-counterfeiting applications.
View article: Characterization of Plasma Cell-Free DNA Integrity Using Droplet-Based Digital PCR: Toward the Development of Circulating Tumor DNA-Dedicated Assays
Characterization of Plasma Cell-Free DNA Integrity Using Droplet-Based Digital PCR: Toward the Development of Circulating Tumor DNA-Dedicated Assays Open
Background: Cellular-cell free-DNA (ccfDNA) is being explored as a diagnostic and prognostic tool for various diseases including cancer. Beyond the evaluation of the ccfDNA mutational status, its fragmentation has been investigated as a po…
View article: Author Correction: High throughput single cell counting in droplet-based microfluidics
Author Correction: High throughput single cell counting in droplet-based microfluidics Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Circulating cell‐free <i>BRAF</i><sup>V600E</sup> as a biomarker in children with Langerhans cell histiocytosis
Circulating cell‐free <i>BRAF</i><sup>V600E</sup> as a biomarker in children with Langerhans cell histiocytosis Open
Summary The BRAF V600E mutation is reported in half of patients with Langerhans cell histiocytosis ( LCH ). This study investigated the detection of the BRAF V600E allele in circulating cell‐free (ccf) DNA in a paediatric LCH cohort. Child…
View article: A Study of Hypermethylated Circulating Tumor DNA as a Universal Colorectal Cancer Biomarker
A Study of Hypermethylated Circulating Tumor DNA as a Universal Colorectal Cancer Biomarker Open
BACKGROUND Circulating tumor DNA (ctDNA) has emerged as a good candidate for tracking tumor dynamics in different cancer types, potentially avoiding repeated tumor biopsies. Many different genes can be mutated within a tumor, complicating …