Philippe Robin
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View article: Proximal pulmonary artery wall shear stress derived from computational fluid dynamics: A noninvasive biomarker for <scp>CTEPH</scp> and perfusion mismatch
Proximal pulmonary artery wall shear stress derived from computational fluid dynamics: A noninvasive biomarker for <span>CTEPH</span> and perfusion mismatch Open
Chronic thromboembolic pulmonary hypertension (CTEPH) is a severe complication of pulmonary embolism (PE), often diagnosed late due to nonspecific symptoms and limitations of current screening tools like V/Q scintigraphy. This study invest…
View article: Residual pulmonary vascular obstruction computed with ventilation/perfusion single photon emission computed tomography/computed tomography to predict the risk of venous thromboembolism recurrence in patients with pulmonary embolism: protocol for a cohort study (PRONOSPECT)
Residual pulmonary vascular obstruction computed with ventilation/perfusion single photon emission computed tomography/computed tomography to predict the risk of venous thromboembolism recurrence in patients with pulmonary embolism: protocol for a cohort study (PRONOSPECT) Open
View article: Rattlesnake Crotalphine Analgesic Active on Tetrodotoxin-Sensitive Na+ Current in Mouse Dorsal Root Ganglion Neurons
Rattlesnake Crotalphine Analgesic Active on Tetrodotoxin-Sensitive Na+ Current in Mouse Dorsal Root Ganglion Neurons Open
Crotalphine is an analgesic peptide identified from the venom of the South American rattlesnake Crotalus durissus terrificus. Although its antinociceptive effect is well documented, its direct mechanisms of action are still unclear. The ai…
View article: Comparison of three diagnostic strategies for suspicion of pulmonary embolism: planar ventilation-perfusion scan (V/Q), CT pulmonary angiography (CTPA) and single photon emission CT ventilation-perfusion scan (SPECT V/Q): a protocol of a randomised controlled trial
Comparison of three diagnostic strategies for suspicion of pulmonary embolism: planar ventilation-perfusion scan (V/Q), CT pulmonary angiography (CTPA) and single photon emission CT ventilation-perfusion scan (SPECT V/Q): a protocol of a randomised controlled trial Open
Introduction Pulmonary embolism (PE) is a challenge to diagnose and when missed, exposes patients to potentially fatal recurrent events. Beyond CT pulmonary angiography (CTPA) and planar ventilation/perfusion (V/Q) scan, single photon emis…
View article: Dosimetry for targeted radionuclide therapy in routine clinical practice: experts advice vs. clinical evidence
Dosimetry for targeted radionuclide therapy in routine clinical practice: experts advice vs. clinical evidence Open
International audience
View article: Recommandations pour la réalisation d’un examen de tomographie par émission de positons aux ligands de l’antigène membranaire spécifique de la prostate
Recommandations pour la réalisation d’un examen de tomographie par émission de positons aux ligands de l’antigène membranaire spécifique de la prostate Open
View article: [18F]DCFPyL PET/CT versus [18F]fluoromethylcholine PET/CT in Biochemical Recurrence of Prostate Cancer (PYTHON): a prospective, open label, cross-over, comparative study
[18F]DCFPyL PET/CT versus [18F]fluoromethylcholine PET/CT in Biochemical Recurrence of Prostate Cancer (PYTHON): a prospective, open label, cross-over, comparative study Open
View article: Residual pulmonary vascular obstruction and recurrence after acute pulmonary embolism: a systematic review and meta-analysis of individual participant data
Residual pulmonary vascular obstruction and recurrence after acute pulmonary embolism: a systematic review and meta-analysis of individual participant data Open
View article: Characterization of the First Animal Toxin Acting as an Antagonist on AT1 Receptor
Characterization of the First Animal Toxin Acting as an Antagonist on AT1 Receptor Open
The renin-angiotensin system (RAS) is one of the main regulatory systems of cardiovascular homeostasis. It is mainly composed of angiotensin-converting enzyme (ACE) and angiotensin II receptors AT1 and AT2. ACE and AT1 are targets of choic…
View article: Radiation exposure to nuclear medicine technologists performing a V/Q PET: Comparison with conventional V/Q scintigraphy, [18F]FDG PET and [68Ga]Ga DOTATOC PET procedures
Radiation exposure to nuclear medicine technologists performing a V/Q PET: Comparison with conventional V/Q scintigraphy, [18F]FDG PET and [68Ga]Ga DOTATOC PET procedures Open
Introduction Ventilation/Perfusion (V/Q) PET/CT is an emerging imaging modality for regional lung function evaluation. The same carrier molecules as conventional V/Q scintigraphy are used but they are radiolabelled with gallium-68 ( 68 Ga)…
View article: Quantification of the pulmonary vascular obstruction index on ventilation/perfusion lung scintigraphy: Comparison of a segmental visual scoring to the Meyer score
Quantification of the pulmonary vascular obstruction index on ventilation/perfusion lung scintigraphy: Comparison of a segmental visual scoring to the Meyer score Open
Introduction Quantifying the pulmonary vascular obstruction index (PVOI) is essential for the management of patients with pulmonary embolism or chronic thromboembolic pulmonary hypertension (CTEPH). The reference method for quantifying the…
View article: Frequency and predictors for chronic thromboembolic pulmonary hypertension after a first unprovoked pulmonary embolism: Results from PADIS studies
Frequency and predictors for chronic thromboembolic pulmonary hypertension after a first unprovoked pulmonary embolism: Results from PADIS studies Open
View article: Radiopharmaceutical Labelling for Lung Ventilation/Perfusion PET/CT Imaging: A Review of Production and Optimization Processes for Clinical Use
Radiopharmaceutical Labelling for Lung Ventilation/Perfusion PET/CT Imaging: A Review of Production and Optimization Processes for Clinical Use Open
Lung ventilation/perfusion (V/Q) positron emission tomography-computed tomography (PET/CT) is a promising imaging modality for regional lung function assessment. The same carrier molecules as a conventional V/Q scan (i.e., carbon nanoparti…
View article: Lung Ventilation/Perfusion Scintigraphy for the Screening of Chronic Thromboembolic Pulmonary Hypertension (CTEPH): Which Criteria to Use?
Lung Ventilation/Perfusion Scintigraphy for the Screening of Chronic Thromboembolic Pulmonary Hypertension (CTEPH): Which Criteria to Use? Open
Objective The diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) is a major challenge as it is a curable cause of pulmonary hypertension (PH). Ventilation/Perfusion (V/Q) lung scintigraphy is the imaging modality of choice …
View article: L’apéline, un nouvel espoir thérapeutique dans les maladies cardiovasculaires
L’apéline, un nouvel espoir thérapeutique dans les maladies cardiovasculaires Open
View article: Risk stratification for predicting recurrent venous thromboembolism after discontinuation of anticoagulation: a<i>post hoc</i>analysis of a French prospective multicentre study
Risk stratification for predicting recurrent venous thromboembolism after discontinuation of anticoagulation: a<i>post hoc</i>analysis of a French prospective multicentre study Open
Background We aimed to validate and to refine current recurrent venous thromboembolism (VTE) risk classification. Methods We performed a post hoc analysis of a multicentre cohort including 1881 patients with a first symptomatic VTE prospec…
View article: Structural and Functional Diversity of Animal Toxins Interacting With GPCRs
Structural and Functional Diversity of Animal Toxins Interacting With GPCRs Open
Peptide toxins from venoms have undergone a long evolutionary process allowing host defense or prey capture and making them highly selective and potent for their target. This has resulted in the emergence of a large panel of toxins from a …
View article: Fully Automated 68Ga-Labeling and Purification of Macroaggregated Albumin Particles for Lung Perfusion PET Imaging
Fully Automated 68Ga-Labeling and Purification of Macroaggregated Albumin Particles for Lung Perfusion PET Imaging Open
Lung PET/CT is a promising imaging modality for regional lung function assessment. Our aim was to develop and validate a fast, simple, and fully automated GMP compliant [ 68 Ga]Ga-MAA labeling procedure, using a commercially available [ 99…
View article: Comparison of radiomic pre-processing steps in the reproducible prediction of disease free survival across multi-scanners/centers
Comparison of radiomic pre-processing steps in the reproducible prediction of disease free survival across multi-scanners/centers Open
Background Features reproducibility and the generalizability of the models are currently among the most important limitations when integrating radiomics into the clinics. Radiomic features are sensitive to imaging acquisition protocols, re…
View article: Automatic delineation and quantification of pulmonary vascular obstruction index in patients with pulmonary embolism using Perfusion SPECT-CT: a simulation study
Automatic delineation and quantification of pulmonary vascular obstruction index in patients with pulmonary embolism using Perfusion SPECT-CT: a simulation study Open
Background In patients with pulmonary embolism (PE), there is a growing interest in quantifying the pulmonary vascular obtruction index (PVOI), which may be an independent risk factor for PE recurrence. Perfusion SPECT/CT is a very attract…
View article: Correction to: [18F]FDG PET radiomics to predict disease-free survival in cervical cancer: a multi-scanner/center study with external validation
Correction to: [18F]FDG PET radiomics to predict disease-free survival in cervical cancer: a multi-scanner/center study with external validation Open
View article: Impact of the Age-Adjusted D-Dimer Cutoff to Exclude Pulmonary Embolism
Impact of the Age-Adjusted D-Dimer Cutoff to Exclude Pulmonary Embolism Open
Diagnosis of pulmonary embolism (PE) relies on the sequential use of pretest probability (PTP), plasma D-dimer, and computed tomography pulmonary angiography. D-dimer <500 µg/L safely excludes PE in association with a low or intermediate (…
View article: Convolutional neural networks for PET functional volume fully automatic segmentation: development and validation in a multi-center setting
Convolutional neural networks for PET functional volume fully automatic segmentation: development and validation in a multi-center setting Open
Purpose In this work, we addressed fully automatic determination of tumor functional uptake from positron emission tomography (PET) images without relying on other image modalities or additional prior constraints, in the context of multice…
View article: [18F]FDG PET radiomics to predict disease-free survival in cervical cancer: a multi-scanner/center study with external validation
[18F]FDG PET radiomics to predict disease-free survival in cervical cancer: a multi-scanner/center study with external validation Open
View article: Assessment of Image Quality and Lesion Detectability With Digital PET/CT System
Assessment of Image Quality and Lesion Detectability With Digital PET/CT System Open
Purpose: The aim of this study was to assess image quality and lesion detectability acquired with a digital Positron Emission Tomography/Computed Tomography (PET/CT) Siemens Biograph Vision 600 system. Material and Methods: Consecutive pat…
View article: Survey by the French Medicine Agency (ANSM) of the imaging protocol, detection rate, and safety of 68Ga-PSMA-11 PET/CT in the biochemical recurrence of prostate cancer in case of negative or equivocal 18F-fluorocholine PET/CT: 1084 examinations
Survey by the French Medicine Agency (ANSM) of the imaging protocol, detection rate, and safety of 68Ga-PSMA-11 PET/CT in the biochemical recurrence of prostate cancer in case of negative or equivocal 18F-fluorocholine PET/CT: 1084 examinations Open
View article: A snake toxin as a theranostic agent for the type 2 vasopressin receptor
A snake toxin as a theranostic agent for the type 2 vasopressin receptor Open
International audience
View article: Normal Dual Isotope V/Q SPECT Model for Monte-Carlo Studies
Normal Dual Isotope V/Q SPECT Model for Monte-Carlo Studies Open
Background: There is currently no reliable or validated tool to delineate and quantify functional lung volumes with ventilation/perfusion (V/Q) SPECT/CT. The main challenges encountered include the physiological non-uniformity of lu…
View article: Risk scores for occult cancer in patients with unprovoked venous thromboembolism: Results from an individual patient data meta‐analysis
Risk scores for occult cancer in patients with unprovoked venous thromboembolism: Results from an individual patient data meta‐analysis Open
The predictive discriminatory performance of both scores is poor. When used dichotomously, the RIETE score is able to discriminate between low- and high-risk patients. Because this is largely driven by advanced age, these results do not su…
View article: Integration of 18-FDG PET/CT in the Initial Work-Up to Stage Head and Neck Cancer: Prognostic Significance and Impact on Therapeutic Decision Making
Integration of 18-FDG PET/CT in the Initial Work-Up to Stage Head and Neck Cancer: Prognostic Significance and Impact on Therapeutic Decision Making Open
Background: The objective of this study was to assess the therapeutic and prognostic impact of integrating18F-fluorodeoxyglucose (18-FDG) positron emission tomography (PET)/computed tomography (CT) into work-up (WU) at initial stagi…