Philippe A. Tessier
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View article: Acquired Neutrophil Dysregulation in Systemic Lupus Erythematosus: A Central Role for Fc gamma Receptor Engagement
Acquired Neutrophil Dysregulation in Systemic Lupus Erythematosus: A Central Role for Fc gamma Receptor Engagement Open
Purpose Systemic lupus erythematosus is an autoimmune disease hallmarked by a plethora of autoantibodies, interferon-signature, auto-immune complexes, dysregulation of soluble factors in circulation, and abnormal neutrophils. We hypothesiz…
View article: The impact of the herbicide glyphosate and its metabolites AMPA and MPA on the metabolism and functions of human blood neutrophils and their sex-dependent effects on reactive oxygen species and CXCL8/IL-8 production
The impact of the herbicide glyphosate and its metabolites AMPA and MPA on the metabolism and functions of human blood neutrophils and their sex-dependent effects on reactive oxygen species and CXCL8/IL-8 production Open
Significant levels of glyphosate, the world's most widely used herbicide, and its primary metabolites, AMPA and MPA, are detected in various human organs and body fluids, including blood. Several studies have associated the presence of gly…
View article: Metabolic regulation of neutrophil functions in homeostasis and diseases
Metabolic regulation of neutrophil functions in homeostasis and diseases Open
Neutrophils are the most abundant leukocytes in humans and play a role in the innate immune response by being the first cells attracted to the site of infection. While early studies presented neutrophils as almost exclusively glycolytic ce…
View article: The Herbicide Glyphosate and its Two Primary Metabolites, Ampa and Mpa, Modulate Human Blood Neutrophil Function in a Sex-Specific Manner
The Herbicide Glyphosate and its Two Primary Metabolites, Ampa and Mpa, Modulate Human Blood Neutrophil Function in a Sex-Specific Manner Open
View article: Immune Cells Release MicroRNA-155 Enriched Extracellular Vesicles That Promote HIV-1 Infection
Immune Cells Release MicroRNA-155 Enriched Extracellular Vesicles That Promote HIV-1 Infection Open
The hallmark of HIV-1 infection is the rapid dysregulation of immune functions. Recent investigations for biomarkers of such dysregulation in people living with HIV (PLWH) reveal a strong correlation between viral rebound and immune activa…
View article: Acute inflammatory response via neutrophil activation protects against the development of chronic pain
Acute inflammatory response via neutrophil activation protects against the development of chronic pain Open
The transition from acute to chronic pain is critically important but not well understood. Here, we investigated the pathophysiological mechanisms underlying the transition from acute to chronic low back pain (LBP) and performed transcript…
View article: Colchicine for community-treated patients with COVID-19 (COLCORONA): a phase 3, randomised, double-blinded, adaptive, placebo-controlled, multicentre trial
Colchicine for community-treated patients with COVID-19 (COLCORONA): a phase 3, randomised, double-blinded, adaptive, placebo-controlled, multicentre trial Open
View article: Expression of the myeloid inhibitory receptor CLEC12A correlates with disease activity and cytokines in early rheumatoid arthritis
Expression of the myeloid inhibitory receptor CLEC12A correlates with disease activity and cytokines in early rheumatoid arthritis Open
View article: Velocity Gradient Separation Reveals a New Extracellular Vesicle Population Enriched in miR-155 and Mitochondrial DNA
Velocity Gradient Separation Reveals a New Extracellular Vesicle Population Enriched in miR-155 and Mitochondrial DNA Open
Extracellular vesicles (EVs) and their contents (proteins, lipids, messenger RNA, microRNA, and DNA) are viewed as intercellular signals, cell-transforming agents, and shelters for viruses that allow both diagnostic and therapeutic interve…
View article: Efficacy of Colchicine in Non-Hospitalized Patients with COVID-19
Efficacy of Colchicine in Non-Hospitalized Patients with COVID-19 Open
Background Evidence suggests the role of an inflammatory storm in COVID-19 complications. Colchicine is an orally administered, anti-inflammatory medication beneficial in gout, pericarditis and coronary disease. Methods We performed a rand…
View article: Optogenetic control of excitatory post-synaptic differentiation through neuroligin-1 tyrosine phosphorylation
Optogenetic control of excitatory post-synaptic differentiation through neuroligin-1 tyrosine phosphorylation Open
View article: P98 Neutrophils in lupus: a new phenotype
P98 Neutrophils in lupus: a new phenotype Open
Background Polymorphonuclear neutrophils (PMNs) with irregular properties have been reported in patients with lupus and compelling evidence implicates them as a source of self-antigens. PMNs are the most abundant circulating leukocytes in …
View article: Optogenetic control of excitatory post-synaptic differentiation through neuroligin-1 tyrosine phosphorylation
Optogenetic control of excitatory post-synaptic differentiation through neuroligin-1 tyrosine phosphorylation Open
Neuroligins (Nlgs) are adhesion proteins mediating trans-synaptic contacts in neurons. However, conflicting results around their role in synaptic differentiation arise from the various techniques used to manipulate Nlg expression. Orthogon…
View article: Enhanced myelopoiesis and aggravated arthritis in S100a8-deficient mice
Enhanced myelopoiesis and aggravated arthritis in S100a8-deficient mice Open
Expressed strongly by myeloid cells, damage-associated molecular pattern (DAMP) proteins S100A8 and S100A9 are found in the serum of patients with infectious and autoimmune diseases. Compared to S100A9, the role of S100A8 is controversial.…
View article: The use of leukocytes’ secretome to individually target biological therapy in autoimmune arthritis: a case report
The use of leukocytes’ secretome to individually target biological therapy in autoimmune arthritis: a case report Open
Background Biological agents have allowed remarkable improvement in controlling autoimmune arthropathies, although none of the numerous biologics readily available represent a universal treatment standard. Moreover, classical and genetic p…
View article: Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis
Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis Open
View article: Quinoline-3-carboxamides such as tasquinimod are not specific inhibitors of S100A9
Quinoline-3-carboxamides such as tasquinimod are not specific inhibitors of S100A9 Open
Comment on
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\n Neutrophils and the S100A9 protein critically regulate granuloma formation.
View article: S100A8/A9 and sRAGE kinetic after polytrauma; an explorative observational study
S100A8/A9 and sRAGE kinetic after polytrauma; an explorative observational study Open
View article: S100A9 induces differentiation of acute myeloid leukemia cells through TLR4
S100A9 induces differentiation of acute myeloid leukemia cells through TLR4 Open
Key Points S100A9 induces differentiation and growth arrest of AML cells via TLR4. S100A8 regulates S100A9 activity and sustains AML immature phenotype.
View article: IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization
IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization Open
Atopic dermatitis (AD) is a Th2-dominated inflammatory skin disease characterized by epidermal thickening. Serum levels of IL-22, a cytokine known to induce keratinocyte proliferation, are elevated in AD, and Th22 cells infiltrate AD skin …
View article: Discoidin domain receptor 1 promotes Th17 cell migration by activating the RhoA/ROCK/MAPK/ERK signaling pathway
Discoidin domain receptor 1 promotes Th17 cell migration by activating the RhoA/ROCK/MAPK/ERK signaling pathway Open
Effector T cell migration through the tissue extracellular matrix (ECM) is an important step of the adaptive immune response and in the development of inflammatory diseases. However, the mechanisms involved in this process are still poorly…
View article: Regulation of TLR3 Activation by S100A9
Regulation of TLR3 Activation by S100A9 Open
Recognition of viral dsRNA by endosomal TLR3 activates innate immune response during virus infection. Trafficking of TLR3 to the endolysosomal compartment arising from fusion of late endosome (LE) with lysosome is required for recognition …
View article: Secretion of S100A8, S100A9, and S100A12 by Neutrophils Involves Reactive Oxygen Species and Potassium Efflux
Secretion of S100A8, S100A9, and S100A12 by Neutrophils Involves Reactive Oxygen Species and Potassium Efflux Open
S100A8/A9 (calprotectin) and S100A12 proinflammatory mediators are found at inflammatory sites and in the serum of patients with inflammatory or autoimmune diseases. These cytoplasmic proteins are secreted by neutrophils at sites of inflam…