Phillip B. Storm
YOU?
Author Swipe
View article: Germline pathogenic variation impacts somatic alterations and patient outcomes in pediatric central nervous system tumors
Germline pathogenic variation impacts somatic alterations and patient outcomes in pediatric central nervous system tumors Open
The contribution of rare pathogenic/likely pathogenic (P/LP) germline variants to pediatric central nervous system (CNS) tumor development remains understudied. Here, we characterize the prevalence and biological significance of germline P…
View article: Claudin 6 is a suitable target for CAR T-cell therapy in atypical teratoid/rhabdoid brain tumors and other pediatric solid tumors
Claudin 6 is a suitable target for CAR T-cell therapy in atypical teratoid/rhabdoid brain tumors and other pediatric solid tumors Open
Background Solid tumors comprise approximately 60% of all pediatric cancers. Relapsed or refractory tumors of the central nervous system (CNS), such as atypical teratoid/rhabdoid tumors (AT/RTs), are the leading cause of death in children …
View article: Targeted tumor resection to reestablish cerebrospinal fluid flow in the setting of a pediatric third ventricular glioma with obstructive hydrocephalus
Targeted tumor resection to reestablish cerebrospinal fluid flow in the setting of a pediatric third ventricular glioma with obstructive hydrocephalus Open
Background: Pediatric third ventricular gliomas may obstruct the flow of cerebrospinal fluid (CSF) requiring surgical intervention, typically involving ventriculoperitoneal shunt placement. We present an alternative surgical strategy invol…
View article: The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science
The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science Open
View article: AI-Powered Segmentation and Prognosis with Missing MRI in Pediatric Brain Tumors
AI-Powered Segmentation and Prognosis with Missing MRI in Pediatric Brain Tumors Open
Importance Brain MRI is the main imaging modality for pediatric brain tumors (PBTs); however, incomplete MRI exams are common in pediatric neuro-oncology settings and pose a barrier to the development and application of deep learning (DL) …
View article: BraTS-PEDs: Results of the Multi-Consortium International Pediatric Brain Tumor Segmentation Challenge 2023
BraTS-PEDs: Results of the Multi-Consortium International Pediatric Brain Tumor Segmentation Challenge 2023 Open
Pediatric central nervous system tumors are the leading cause of cancer-related deaths in children. The five-year survival rate for high-grade glioma in children is less than 20%. The development of new treatments is dependent upon multi-i…
View article: Transient mRNA CAR T cells targeting GD2 provide dose-adjusted efficacy against diffuse midline glioma and high-grade glioma models
Transient mRNA CAR T cells targeting GD2 provide dose-adjusted efficacy against diffuse midline glioma and high-grade glioma models Open
Background Diffuse midline glioma (DMG) and high-grade glioma are devastating pediatric central nervous system tumors that remain incurable. Recent chimeric antigen receptor (CAR) T cell studies have shown proof of concept and early signs …
View article: Evaluating the Potential of PSMA Targeting in CNS Tumors: Insights from Large-Scale Transcriptome Profiling
Evaluating the Potential of PSMA Targeting in CNS Tumors: Insights from Large-Scale Transcriptome Profiling Open
Background/Objectives: Prostate-specific membrane antigen (PSMA) is a well-established target in prostate cancer therapy that has shown potential as a theranostic target across non-central nervous system (CNS) and CNS tumor types. We aimed…
View article: 120 Imaging and CSF biomarkers to optimize neurosurgical intervention for post-hemorrhagic hydrocephalus of prematurity
120 Imaging and CSF biomarkers to optimize neurosurgical intervention for post-hemorrhagic hydrocephalus of prematurity Open
Objectives/Goals: The timing of neurosurgery is highly variable for post-hemorrhagic hydrocephalus (PHH) of prematurity. We sought to utilize microvascular imaging (MVI) in ultrasound (US) to identify biomarkers to discern the opportune ti…
View article: Germline pathogenic variation impacts somatic alterations and patient outcomes in pediatric CNS tumors
Germline pathogenic variation impacts somatic alterations and patient outcomes in pediatric CNS tumors Open
The contribution of rare pathogenic/likely pathogenic (P/LP) germline variants to pediatric central nervous system (CNS) tumor development remains understudied. Here, we characterized the prevalence and clinical significance of germline P/…
View article: Medical management of cerebellar mutism syndrome at a quaternary children’s hospital
Medical management of cerebellar mutism syndrome at a quaternary children’s hospital Open
View article: Genetic ancestry superpopulations show distinct prevalence and outcomes across pediatric central nervous system tumors from the Pediatric Brain Tumor Atlas and Pediatric Neuro-Oncology Consortium
Genetic ancestry superpopulations show distinct prevalence and outcomes across pediatric central nervous system tumors from the Pediatric Brain Tumor Atlas and Pediatric Neuro-Oncology Consortium Open
Background Central nervous system (CNS) tumors lead to cancer-related mortality in children. Genetic ancestry-associated cancer prevalence and outcomes have been studied but are limited. Methods We performed genetic ancestry prediction in …
View article: Unilateral Versus Bilateral Endoscopic Resection of Olfactory Neuroblastoma: Pooled Analysis From Prospective and Retrospective Multicenter Data
Unilateral Versus Bilateral Endoscopic Resection of Olfactory Neuroblastoma: Pooled Analysis From Prospective and Retrospective Multicenter Data Open
Background Olfactory neuroblastoma (ONB) is a rare sinonasal malignancy primarily treated with surgery. For tumors arising from the olfactory area, traditional treatment involves transcribriform resection of the anterior cranial fossa. Sur…
View article: Multiparametric MRI along with machine learning predicts prognosis and treatment response in pediatric low-grade glioma
Multiparametric MRI along with machine learning predicts prognosis and treatment response in pediatric low-grade glioma Open
Pediatric low-grade gliomas (pLGGs) exhibit heterogeneous prognoses and variable responses to treatment, leading to tumor progression and adverse outcomes in cases where complete resection is unachievable. Early prediction of treatment res…
View article: Imaging Clusters of Pediatric Low-Grade Glioma are Associated with Distinct Molecular Characteristics
Imaging Clusters of Pediatric Low-Grade Glioma are Associated with Distinct Molecular Characteristics Open
Background Cancers show heterogeneity at various levels, from genome to radiological imaging. This study aimed to explore the interplay between genomic, transcriptomic, and radiophenotypic data in pediatric low-grade glioma (pLGG), the mos…
View article: Empowering Data Sharing in Neuroscience: A Deep Learning Deidentification Method for Pediatric Brain MRIs
Empowering Data Sharing in Neuroscience: A Deep Learning Deidentification Method for Pediatric Brain MRIs Open
The defacing model demonstrates efficacy in removing facial regions across multiple MRI types and exhibits minimal impact on downstream research usage. A software package with the trained model is freely provided for wider use and further …
View article: Endoscopic endonasal resection of olfactory tract hamartoma for pediatric epilepsy
Endoscopic endonasal resection of olfactory tract hamartoma for pediatric epilepsy Open
Background Non-hypothalamic glioneural hamartomas are rare entities known to cause medically refractory epilepsy. Olfactory bulb hamartomas, in particular, are exceptionally rare. Methods We describe a case of an olfactory bulb hamartoma t…
View article: Characterization of aberrant splicing in pediatric central nervous system tumors reveals <i>CLK1</i> as a candidate oncogenic dependency
Characterization of aberrant splicing in pediatric central nervous system tumors reveals <i>CLK1</i> as a candidate oncogenic dependency Open
Background Pediatric brain cancer is the leading cause of disease-related mortality in children, yet many aggressive tumors lack effective therapies. Aberrant RNA splicing is a hallmark of cancer, but its role in pediatric central nervous …
View article: Automated Pediatric Brain Tumor Imaging Assessment Tool from CBTN: Enhancing Suprasellar Region Inclusion and Managing Limited Data with Deep Learning
Automated Pediatric Brain Tumor Imaging Assessment Tool from CBTN: Enhancing Suprasellar Region Inclusion and Managing Limited Data with Deep Learning Open
Background Fully-automatic skull-stripping and tumor segmentation are crucial for monitoring pediatric brain tumors (PBT). Current methods, however, often lack generalizability, particularly for rare tumors in the sellar/suprasellar region…
View article: BraTS-PEDs: Results of the Multi-Consortium International Pediatric Brain Tumor Segmentation Challenge 2023
BraTS-PEDs: Results of the Multi-Consortium International Pediatric Brain Tumor Segmentation Challenge 2023 Open
Pediatric central nervous system tumors are the leading cause of cancer-related deaths in children. The five-year survival rate for high-grade glioma in children is less than 20%. The development of new treatments is dependent upon multi-i…
View article: IMG-08. SYNTHESIZING MISSING MRI SEQUENCES IN PEDIATRIC BRAIN TUMORS USING GENERATIVE ADVERSARIAL NETWORKS; TOWARDS IMPROVED VOLUMETRIC TUMOR ASSESSMENT
IMG-08. SYNTHESIZING MISSING MRI SEQUENCES IN PEDIATRIC BRAIN TUMORS USING GENERATIVE ADVERSARIAL NETWORKS; TOWARDS IMPROVED VOLUMETRIC TUMOR ASSESSMENT Open
BACKGROUND Standard MRI sequences, such as pre- and post-contrast T1w, T2w, and FLAIR images, are essential for optimizing segmentation of tumor subregions and evaluating treatment responses in pediatric brain tumors (PBTs). However, MRI s…
View article: CP-17. NKX3.1 AS A PROGNOSTIC MARKER IN PEDIATRIC CRANIOPHARYNGIOMA
CP-17. NKX3.1 AS A PROGNOSTIC MARKER IN PEDIATRIC CRANIOPHARYNGIOMA Open
BACKGROUND Craniopharyngiomas are rare, low histologic grade neoplasms of the suprasellar region. Despite their benign histology, these tumors can be challenging to manage due to the morbidities associated with surgery or radiation and the…
View article: IMG-11. RADIOGENOMIC ANALYSIS INFORMS ON IMMUNOLOGICAL PROFILES, PROGNOSIS, AND TREATMENT RESPONSE IN PEDIATRIC LOW-GRADE GLIOMA
IMG-11. RADIOGENOMIC ANALYSIS INFORMS ON IMMUNOLOGICAL PROFILES, PROGNOSIS, AND TREATMENT RESPONSE IN PEDIATRIC LOW-GRADE GLIOMA Open
BACKGROUND Pediatric low-grade gliomas (pLGGs) have variable prognosis and treatment responses. Complete resection cannot be achieved for all tumors, especially for highly infiltrative or deep-seated tumors, necessitating additional therap…
View article: MODL-11. LOW-GRADE GLIOMA 3D PATIENT-DERIVED ORGANOID PLATFORM AS TRANSFORMATIVE TOOL FOR TUMOR BIOLOGY AND TRANSLATIONAL RESEARCH
MODL-11. LOW-GRADE GLIOMA 3D PATIENT-DERIVED ORGANOID PLATFORM AS TRANSFORMATIVE TOOL FOR TUMOR BIOLOGY AND TRANSLATIONAL RESEARCH Open
Unlike many high-grade tumors, low-grade glioma (LGG) has faced challenges in advancing scientific and clinical breakthroughs, affected by the limited capacity to develop representative preclinical tumor models. Major barriers to establish…
View article: MDB-96. CEREBROSPINAL FLUID LEVELS OF THE MIR216B-5P AS A MINIMALLY INVASIVE MONITORING TOOL FOR MEDULLOBLASTOMA
MDB-96. CEREBROSPINAL FLUID LEVELS OF THE MIR216B-5P AS A MINIMALLY INVASIVE MONITORING TOOL FOR MEDULLOBLASTOMA Open
BACKGROUND Current management of pediatric brain tumor patients relies on imaging as the only non-invasive tool available for monitoring therapeutic response and tumor progression. Results are often inconclusive and unable to capture biolo…
View article: IMG-10. IMAGING SUBTYPES OF PEDIATRIC LOW-GRADE GLIOMA ARE ASSOCIATED WITH DISTINCT MOLECULAR CHARACTERISTICS
IMG-10. IMAGING SUBTYPES OF PEDIATRIC LOW-GRADE GLIOMA ARE ASSOCIATED WITH DISTINCT MOLECULAR CHARACTERISTICS Open
BACKGROUND Pediatric low-grade gliomas (pLGGs) have diverse molecular subtypes with distinct prognoses, necessitating personalized treatments. We aimed to determine whether radiomic features of pLGGs co-segregate with molecular subtypes, e…
View article: METB-12. GIFT FROM A CHILD POSTMORTEM SPECIMEN DATASET EXTENSION OF THE PEDIATRIC BRAIN TUMOR ATLAS EMPOWERS PEDIATRIC BRAIN TUMOR RESEARCH
METB-12. GIFT FROM A CHILD POSTMORTEM SPECIMEN DATASET EXTENSION OF THE PEDIATRIC BRAIN TUMOR ATLAS EMPOWERS PEDIATRIC BRAIN TUMOR RESEARCH Open
BACKGROUND Pediatric brain and spinal cord tumors are the leading cause of cancer-related mortality in children. An incomplete understanding of brain tumor biology and associated limited access to high-quality biological samples for resear…
View article: IMG-13. PREDICTION OF PEDIATRIC MEDULLOBLASTOMA SUBGROUPS USING CLINICO-RADIOMIC ANALYSIS
IMG-13. PREDICTION OF PEDIATRIC MEDULLOBLASTOMA SUBGROUPS USING CLINICO-RADIOMIC ANALYSIS Open
BACKGROUND Pediatric medulloblastoma is an aggressive brain tumor and tailored treatment has the potential to lead to better patient outcomes. The WHO 2021 classification of medulloblastoma involves an integrated diagnosis that incorporate…
View article: METB-14. INTEGRATED GERMLINE AND SOMATIC PROFILING OF PEDIATRIC BRAIN TUMORS REVEALS INCIDENTAL FINDINGS AND NOVEL TUMOR BIOLOGY
METB-14. INTEGRATED GERMLINE AND SOMATIC PROFILING OF PEDIATRIC BRAIN TUMORS REVEALS INCIDENTAL FINDINGS AND NOVEL TUMOR BIOLOGY Open
BACKGROUND The contribution of rare pathogenic germline variation to central nervous system (CNS) tumor formation in pediatric patients without a family history of cancer remains unclear. METHODS We characterized the prevalence of pathogen…
View article: IMG-09. A DEEP LEARNING-BASED APPROACH FOR BRAIN TISSUE EXTRACTION USING MULTI- AND SINGLE-PARAMETRIC MRI IN PEDIATRICS
IMG-09. A DEEP LEARNING-BASED APPROACH FOR BRAIN TISSUE EXTRACTION USING MULTI- AND SINGLE-PARAMETRIC MRI IN PEDIATRICS Open
BACKGROUND Skull-stripping, the process of extracting brain tissue from MR images, is an important step for tumor segmentation and downstream imaging-based analytics such as AI-powered radiomic feature extraction. Existing skull-stripping …