Explanipedia

Can Low Cortisol Predict Long COVID? A Controversial Issue Open

Tom Quach, A Wilson, Oliver Sum‐Ping, Sara Lomba, Linda N. Geng , et al. · 2025

Cortisol dysregulation has been proposed as a biomarker of long COVID (LC), but findings remain inconsistent. Prior reports suggested low cortisol levels in LC, yet collection times and study designs varied substantially. To evaluate morni…

Molecular Mechanisms of Exosomes From Human iPSC‐Cardiomyocytes and Mesenchymal Stem Cells in Restoring the Injured Myocardium Open

Eileen Tzng, Nathan Bayardo, Gentaro Ikeda, Nirmal Vadgama, Hiroyuki Takashima , et al. · 2025

Background Exosomes are extracellular vesicles 30 to 150 nm in size, mediating the paracrine effects of mesenchymal stem cells (MSCs) and induced pluripotent stem cell–derived cardiomyocytes (iCMs) when used to restore the injured myocardi…

Digital Biometric Measures in Long COVID: A Secondary Analysis of the STOP-PASC Randomized Clinical Trial. Open

Fatma Gunturkun, Haley Hedlin, Bren Botzheim, Yaowei Deng, Hector Bonilla , et al. · 2025

ClinicalTrials.gov Identifier: NCT05576662.

Rapid manufacturing of angiogenic cellular collagen patches for ischemic cardiomyopathy Open

Eric M. Pfrender, Sung Woo Kim, John A Farag, Shin Yajima, Yujiro Kawai , et al. · 2025

Background One in ten Americans carry a lifetime risk of ischemic heart failure, the most severe form of ischemic heart disease. Carrying a nearly 50% five‑year mortality rate, no interventional therapy exists to treat the underlying cause…

Associations between adverse childhood experiences and medical students’ interest in careers: a single-setting study Open

Phillip C. Yang, Barbara Robles-Ramamurthy, Kristen Plastino · 2025

Background Adverse childhood experiences (ACEs) are pervasive across communities, including medical students and physicians. Exposure to childhood trauma influences career decisions, such as social workers and nurses. However, the impact o…

P-1974. Surface Protein Profiling of Extracellular Vesicles: A Novel Biomarker Approach for Long COVID Diagnosis? Open

Gentaro Ikeda, Prasanna Jagannathan, Mario Leki, H. Inoue, Vanessa El Kamari , et al. · 2025

Background Extracellular vehicles (EVs) are lipid bilayer vesicles secreted by all cell types into the circulation. EVs carry an array of biomolecules indicative of their origin cells and act as cargo vesicles capable of delivering protein…

Correction: Cloud-Based Machine Learning Platform to Predict Clinical Outcomes at Home for Patients With Cardiovascular Conditions Discharged From Hospital: Clinical Trial Open

Phillip C. Yang, Alokkumar Jha, William Xu, Zitao Song, Patrick Jamp , et al. · 2024

[This corrects the article DOI: .].

Evaluating Long-Term Autonomic Dysfunction and Functional Impacts of Long COVID: A Follow-Up Study Open

Ella F. Eastin, Jannika Machnik, Nicholas Larsen, Jordan Seliger, Linda N. Geng , et al. · 2024

Background The longitudinal prevalence and autonomic symptom burden in Long COVID patients is not well-established. Objective Assess the duration and severity of autonomic dysfunction in adults with Long COVID and evaluate its impact on fu…

Wideband radiofrequency pulse sequence for evaluation of myocardial scar in patients with cardiac implantable devices Open

Neil Shah, Mayil S. Krishnam, Bharat Ambale Venkatesh, Fouzia Khan, Michele Smith , et al. · 2024

Background Cardiac magnetic resonance is a useful clinical tool to identify late gadolinium enhancement in heart failure patients with implantable electronic devices. Identification of LGE in patients with CIED is limited by artifact, whic…

Nirmatrelvir-Ritonavir and Symptoms in Adults With Postacute Sequelae of SARS-CoV-2 Infection Open

Linda N. Geng, Hector Bonilla, Haley Hedlin, Karen B. Jacobson, Lü Tian , et al. · 2024

Importance There is an urgent need to identify treatments for postacute sequelae of SARS-CoV-2 infection (PASC). Objective To assess the efficacy of a 15-day course of nirmatrelvir-ritonavir in reducing the severity of select PASC symptoms…

Dual Mechanism of Action: Exosomes from Human iPSC-Cardiomyocytes and Mesenchymal Stem Cells Restore Injured Myocardium Open

Eileen Tzng, Nathan Bayardo, Gentaro Ikeda, Hiroyuki Takashima, Jennifer Lyons , et al. · 2024

Background Transplantation of mesenchymal stem cells or induced pluripotent stem cell derived cardiomyocytes improve heart function after myocardial infarction in pre-clinical models. Exosomes are extracellular vesicles, 30-150nm in size, …

Sex Influences the Safety and Therapeutic Efficacy of Cardiac Nanomedicine Technologies Open

Zijin Lin, Zahra Jiwani, Vahid Serpooshan, Haniyeh Aghaverdi, Phillip C. Yang , et al. · 2023

Nanomedicine technologies are being developed for the prevention, diagnosis, and treatment of cardiovascular disease (CVD), which is the leading cause of death worldwide. Before delving into the nuances of cardiac nanomedicine, it is essen…

Cloud-Based Machine Learning Platform to Predict Clinical Outcomes at Home for Patients With Cardiovascular Conditions Discharged From Hospital: Clinical Trial Open

Phillip C. Yang, Alokkumar Jha, William Xu, Zitao Song, Patrick Jamp , et al. · 2023

Background Hospitalizations account for almost one-third of the US $4.1 trillion health care cost in the United States. A substantial portion of these hospitalizations are attributed to readmissions, which led to the establishment of the H…

Anti-breast cancer-induced cardiomyopathy: Mechanisms and future directions Open

Chunping Liu, Huiqi Chen, Sien Guo, Qiaojing Liu, Zhijun Chen , et al. · 2023

With the progression of tumor treatment, the 5-year survival rate of breast cancer is close to 90%. Cardiovascular toxicity caused by chemotherapy has become a vital factor affecting the survival of patients with breast cancer. Anthracycli…

Current challenges surrounding exosome treatments Open

Eileen Tzng, Nathan Bayardo, Phillip C. Yang · 2023

Cardiovascular disease is the leading cause of death worldwide today and numerous studies are demonstrating that exosomes improve cardiac function after myocardial injury through various mechanisms. Exosome therapy has great potential as a…

Extracellular vesicle-derived circCEBPZOS attenuates postmyocardial infarction remodeling by promoting angiogenesis via the miR-1178-3p/PDPK1 axis Open

Ling Yu, Yubin Liang, Minzhou Zhang, Phillip C. Yang, Aleksander Hinek , et al. · 2023

Current challenges and future directions for engineering extracellular vesicles for heart, lung, blood and sleep diseases Open

Guoping Li, Tianji Chen, James E. Dahlman, Lola Eniola‐Adefeso, Ionita Ghiran , et al. · 2023

Extracellular vesicles (EVs) carry diverse bioactive components including nucleic acids, proteins, lipids and metabolites that play versatile roles in intercellular and interorgan communication. The capability to modulate their stability, …

The Use of Nirmatrelvir-ritonavir in a Case of Breakthrough Long COVID Open

Linda N. Geng, Hector Bonilla, Robert W. Shafer, Mitchell G. Miglis, Phillip C. Yang · 2023

Post-acute sequelae of SARS-CoV-2 (PASC) or long COVID is a major public health problem. The underlying mechanism(s) of this disease remains unclear, and there is a lack of effective therapies. We report a case of a 47-year-old patient who…

High-resolution, respiratory-resolved coronary MRA using a Phyllotaxis-reordered variable-density 3D cones trajectory Open

Srivathsan Koundinyan, Corey A. Baron, Mario O. Malavé, Frank Ong, Nii Okai Addy , et al. · 2023

Cloud-Based Machine Learning Platform to Predict Clinical Outcomes at Home for Patients With Cardiovascular Conditions Discharged From Hospital: Clinical Trial (Preprint) Open

Phillip C. Yang, Alokkumar Jha, William Xu, Zitao Song, Patrick Jamp , et al. · 2022

BACKGROUND Hospitalizations account for almost one-third of the US $4.1 trillion health care cost in the United States. A substantial portion of these hospitalizations are attributed to readmissions, which led to the establishment of the …

Angiogenic stem cell delivery platform to augment post-infarction neovasculature and reverse ventricular remodeling Open

Hye Sook Shin, Akshara D. Thakore, Yuko Tada, Albert J. Pedroza, Gentaro Ikeda , et al. · 2022

1.22 “Bored, Lonely, Sad, Thankful, Tired”: A Qualitative Report of Adolescents’ Feelings at the End of the First COVID-19 School Year Open

Phillip C. Yang, Jolie Gomez, Jake A. Neill, Kristen Plastino · 2022

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is common in post-acute sequelae of SARS-CoV-2 infection (PASC): Results from a post-COVID-19 multidisciplinary clinic Open

H Bonilla, Thu-Hang Thi QUACH, Abhishek Tiwari, A García Bonilla, Mitchell G. Miglis , et al. · 2022

Summary Background The global prevalence of PASC is estimated to be present in 0·43 and based on the WHO estimation of 470 million worldwide COVID-19 infections, corresponds to around 200 million people experiencing long COVID symptoms. De…

Spinning-enabled wireless amphibious origami millirobot Open

Qiji Ze, S. M. Wu, Jize Dai, Sophie Leanza, Gentaro Ikeda , et al. · 2022

Case Report of Breakthrough Long COVID and the Use of Nirmatrelvir-Ritonavir Open

Linda N. Geng, Hector Bonilla, Robert W. Shafer, Mitchell G. Miglis, Phillip C. Yang · 2022

Post-Acute Sequelae of SARS-CoV-2 (PASC), or long COVID, is a major public health problem. Encouraging data suggest that vaccination can reduce the risk of PASC. We report a cautionary case of breakthrough PASC and its resolution following…

Auto-Gait: Automatic Ataxia Risk Assessment with Computer Vision on Gait Task Videos Open

Wasifur Rahman, Moaraj Hasan, Md Saiful Islam, Titilayo Olubajo, Jeet Thaker , et al. · 2022

In this paper, we investigated whether we can 1) detect participants with ataxia-specific gait characteristics (risk-prediction), and 2) assess severity of ataxia from gait (severity-assessment) using computer vision. We created a dataset …

Auto-Gait: Automatic Ataxia Risk Assessment with Computer Vision on Gait\n Task Videos Open

Wasifur Rahman, Masum Hasan, Md Saiful Islam, Titilayo Olubajo, Jeet Thaker , et al. · 2022

In this paper, we investigated whether we can 1) detect participants with\nataxia-specific gait characteristics (risk-prediction), and 2) assess severity\nof ataxia from gait (severity-assessment) using computer vision. We created a\ndatas…

Naturally aligned cell delivery platform to augment post-infarction neovasculature and ventricular remodeling Open

Hye Won Shin, Akshara D. Thakore, Yuko Tada, Albert J. Pedroza, Gentaro Ikeda , et al. · 2022

We demonstrated that joint delivery of human-derived endothelial progenitor cell (EPC) and smooth muscle cell (SMC) sheets mimics the native architecture of structurally mature blood vessels and contributes to limiting ventricular remodeli…

Stem Cell and Exosome Therapy in Pulmonary Hypertension Open

Seyeon Oh, Ji‐Hye Jung, Kyung Jin Ahn, Albert Youngwoo Jang, Kyunghee Byun , et al. · 2022

Pulmonary hypertension is a rare and progressive illness with a devastating prognosis. Promising research efforts have advanced the understanding and recognition of the pathobiology of pulmonary hypertension. Despite remarkable achievement…

Therapeutic Applications of Extracellular Vesicles for Myocardial Repair Open

Chunping Liu, Nathan Bayado, Dongyue He, Jie Li, Huiqi Chen , et al. · 2021

Cardiovascular disease is the leading cause of human death worldwide. Drug thrombolysis, percutaneous coronary intervention, coronary artery bypass grafting and other methods are used to restore blood perfusion for coronary artery stenosis…

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