Phillip Good
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View article: A Preliminary Prospective Study on the Association of Polymorphisms in <i>BDNF</i> , <i>ARRB2</i> and <i>KCNJ6</i> and Response to Fentanyl for Pain Management in Advanced Cancer
A Preliminary Prospective Study on the Association of Polymorphisms in <i>BDNF</i> , <i>ARRB2</i> and <i>KCNJ6</i> and Response to Fentanyl for Pain Management in Advanced Cancer Open
Introduction Pain is common in cancer patients, particularly in the advanced stage of the disease with more than 70% prevalence. Despite research regarding cancer pain management, clinicians’ ability to predict and manage patient pain rema…
View article: Palliative management of depression in advanced cancer
Palliative management of depression in advanced cancer Open
Throughout this article, the term depression is used loosely, and an approach to patients who might not strictly meet diagnostic criteria is included. The limits of the evidence are emphasised in the hope that general practitioners will fe…
View article: Management of constipation in people receiving palliative care
Management of constipation in people receiving palliative care Open
Management involves treatment of reversible causes, if appropriate, as well as both non-pharmacological and pharmacological interventions. Recommended laxatives for use in palliative care are osmotic laxatives and stimulant laxatives. Prop…
View article: Palliative management of breathlessness
Palliative management of breathlessness Open
Current management guidelines for the palliative management of breathlessness recommend treatment of reversible causes followed by non-pharmacological interventions such as breathing exercises, use of mobility aids, fans and focused psycho…
View article: Pharmaceutical pitfalls in treating patients with advanced cancer
Pharmaceutical pitfalls in treating patients with advanced cancer Open
Sublingual and transdermal fentanyl are contraindicated in patients who are opioid-naïve. Opioid-naïve has a strict definition. Buprenorphine does not reduce the efficacy of other analgesics. Equianalgesic tables should not be followed bli…
View article: Palliative management of type 2 diabetes mellitus in patients with advanced cancer
Palliative management of type 2 diabetes mellitus in patients with advanced cancer Open
T2DM often co-exists in patients with advanced cancer. Management is aimed at reducing the complications of hyperglycaemia and hypoglycaemia, and maximising quality of life. Interventions and treatments need to be balanced against quality …
View article: Medicinal cannabis for symptom control in advanced cancer: a double-blind, placebo-controlled, randomised clinical trial of 1:1 tetrahydrocannabinol and cannabidiol
Medicinal cannabis for symptom control in advanced cancer: a double-blind, placebo-controlled, randomised clinical trial of 1:1 tetrahydrocannabinol and cannabidiol Open
Purpose Patients with cancer commonly access cannabis hoping to relieve their symptoms. This study assessed whether a 1:1 10 mg/ml THC:CBD combination oil could improve total symptom burden in patients with advanced cancer over that provid…
View article: Experiments on leak rate and back diffusion characteristics of the fuel element. Project DRAGON
Experiments on leak rate and back diffusion characteristics of the fuel element. Project DRAGON Open
This report describes leak rate and back diffusion measurements on the joints at the lower end of the fhel element, viz. between fhel tube and end plug, end plug and end cap and between end cap and double cone assembly. The first two joint…
View article: Dying as a Collective Encounter: Relationality and Affect at the End of Life
Dying as a Collective Encounter: Relationality and Affect at the End of Life Open
The end of life is replete with relational complexities. Yet, despite the work of humanities and social science scholars in the field of death and dying, our final days and weeks are still often framed through a highly individualistic lens…
View article: Dying at home: a prospective comparative study of home death rates in a private health insured palliative care community programme
Dying at home: a prospective comparative study of home death rates in a private health insured palliative care community programme Open
Background Despite preferring end‐of‐life care at home, only a small percentage of deaths in Australia occur in private homes. Aim This study evaluates a private health insurance‐funded support programme (provided in addition to the standa…
View article: Tensions of time at the end (of life)
Tensions of time at the end (of life) Open
Perhaps the most valuable asset in our cultural imaginary is time. Yet, this notion of time-as-asset intensifies, is contested, and is often derailed at the end of life. When faced with death, time can become many things, including both pe…
View article: Correction: Medicinal Cannabis (MedCan 3): a randomised, multicentre, double-blind, placebo-controlled trial to assess THC/CBD (1:20) to relieve symptom burden in patients with cancer—a study protocol for a randomised controlled trial
Correction: Medicinal Cannabis (MedCan 3): a randomised, multicentre, double-blind, placebo-controlled trial to assess THC/CBD (1:20) to relieve symptom burden in patients with cancer—a study protocol for a randomised controlled trial Open
View article: Medicinal Cannabis (MedCan 3): a randomised, multicentre, double-blind, placebo-controlled trial to assess THC/CBD (1:20) to relieve symptom burden in patients with cancer—a study protocol for a randomised controlled trial
Medicinal Cannabis (MedCan 3): a randomised, multicentre, double-blind, placebo-controlled trial to assess THC/CBD (1:20) to relieve symptom burden in patients with cancer—a study protocol for a randomised controlled trial Open
View article: A community-embedded approach to increasing the health literacy of Aboriginal children in a regional area: processes of co-design and local implementation
A community-embedded approach to increasing the health literacy of Aboriginal children in a regional area: processes of co-design and local implementation Open
Purpose This research explores the implementation of a child-centred, co-designed, community-embedded program called ‘Young Doctors for Life’ (YDFL). YDFL is designed to improve health and wellbeing outcomes for Aboriginal children in the …
View article: The effects of OPRM1 118A>G on methadone response in pain management in advanced cancer at end of life
The effects of OPRM1 118A>G on methadone response in pain management in advanced cancer at end of life Open
Cancer pain is the most feared symptom at end of life. Methadone has advantages over other opioids but is associated with significant variability in clinical response, making dosing challenging in practice. OPRM1 is the most studied pharma…
View article: Exploring potential anti-inflammatory effects of medicinal cannabis
Exploring potential anti-inflammatory effects of medicinal cannabis Open
View article: Medically assisted hydration for adults receiving palliative care
Medically assisted hydration for adults receiving palliative care Open
Three review authors independently reviewed titles and abstracts for relevance, and two review authors extracted data and performed risk of bias assessment. The primary outcome was QoL using validated scales; secondary outcomes were surviv…
View article: Defining research priorities and needs in cancer symptoms for adults diagnosed with cancer: an Australian/New Zealand modified Delphi study
Defining research priorities and needs in cancer symptoms for adults diagnosed with cancer: an Australian/New Zealand modified Delphi study Open
Purpose This study asked consumers (patients, carers) and healthcare professionals (HCPs) to identify the most important symptoms for adults with cancer and potential treatment interventions. Methods A modified Delphi study was conducted i…
View article: Corticosteroids for the management of cancer-related fatigue in adults with advanced cancer
Corticosteroids for the management of cancer-related fatigue in adults with advanced cancer Open
There is insufficient evidence to support or refute the use of systemic corticosteroids in adults with cancer and CRF. We included four small studies that provided very low-certainty of evidence for the efficacy of corticosteroids in the m…
View article: ‘What price do you put on your health?’: Medical cannabis, financial toxicity and patient perspectives on medication access in advanced cancer
‘What price do you put on your health?’: Medical cannabis, financial toxicity and patient perspectives on medication access in advanced cancer Open
Introduction Following 2016 legislation permitting limited access to cannabis for research and medicinal purposes, the number of randomized clinical trials (RCTs) investigating the effectiveness of medicinal cannabis (MC) on symptom burden…
View article: Association of KCNJ6 rs2070995 and methadone response for pain management in advanced cancer at end-of-life
Association of KCNJ6 rs2070995 and methadone response for pain management in advanced cancer at end-of-life Open
View article: Pain management in advanced cancer: physical activity as an outcome – accelerometer feasibility study
Pain management in advanced cancer: physical activity as an outcome – accelerometer feasibility study Open
Objective Cancer pain is a common distressing symptom. Numerical Pain Scales (NPS) assess pain but lack information about function and quality of life. This feasibility study assesses the use of triaxial accelerometers to measure function …
View article: Using a qualitative sub-study to inform the design and delivery of randomised controlled trials on medicinal cannabis for symptom relief in patients with advanced cancer
Using a qualitative sub-study to inform the design and delivery of randomised controlled trials on medicinal cannabis for symptom relief in patients with advanced cancer Open
View article: The lived experience of end-stage cardiac failure
The lived experience of end-stage cardiac failure Open
Psychological and spiritual distress are common in ESHF. Patients with ESHF often feel socially isolated. Inadequate communication from clinical staff is a common negative experience for patients to which they frequently resign themselves.…
View article: Research agenda for medical cannabis in palliative care
Research agenda for medical cannabis in palliative care Open
View article: Does Cannabidiol Have a Benefit as a Supportive Care Drug in Cancer?
Does Cannabidiol Have a Benefit as a Supportive Care Drug in Cancer? Open
View article: Personalising pain management in advanced cancer: is KCNJ6 A1032G associated with methadone response?
Personalising pain management in advanced cancer: is KCNJ6 A1032G associated with methadone response? Open
Opioids are the therapeutic agents of choice to manage moderate to severe pain in patients with advanced cancer, however the unpredictable inter-individual response to opioid therapy remains a challenge for clinicians. While studies are fe…
View article: Association of Polymorphisms in <i>ARRB2</i> and Clinical Response to Methadone for Pain in Advanced Cancer
Association of Polymorphisms in <i>ARRB2</i> and Clinical Response to Methadone for Pain in Advanced Cancer Open
Background: The prescription of methadone in advanced cancer poses multiple challenges due to the considerable interpatient variation seen in effective dose and toxicity. Previous reports have suggested that ARRB2 influences the res…
View article: Care of older people and people requiring palliative care with COVID‐19: guidance from the Australian National COVID‐19 Clinical Evidence Taskforce
Care of older people and people requiring palliative care with COVID‐19: guidance from the Australian National COVID‐19 Clinical Evidence Taskforce Open
The practice points in the flow charts emphasise quality clinical care, with a focus on addressing the most important challenges when caring for older individuals and people with COVID-19 requiring palliative care. The adult recommendation…
View article: Corticosteroids for the management of cancer-related fatigue in adults with advanced cancer
Corticosteroids for the management of cancer-related fatigue in adults with advanced cancer Open
Objectives:\nThis is a protocol for a Cochrane Review (intervention). The objectives are as follows:\n\nTo determine the benefits and harms of corticosteroids compared with placebo, no intervention, or any active comparator (including supp…