Explanipedia

Crystal structure and nanobodies against domain 3 of the malaria parasite fusogen Plasmodium falciparum HAP2 Open

Frankie M. T. Lyons, Jill Chmielewski, Li‐Jin Chan, Mikha Gabriela, Rosita Suk-Yi Chan , et al. · 2025

Malaria parasites are transmitted to humans through a bite from an infected female Anopheles mosquito. Within the mosquito midgut, malaria parasite gametes are activated and undergo fertilisation. If parasite fertilisation is perturbed, th…

Prediction of KIR3DL1 and human leukocyte antigen binding Open

Martin Maiers, Yoram Louzoun, Phillip Pymm, J.P. Vivian, Jamie Rossjohn , et al. · 2025

KIR3DL1 is a polymorphic inhibitory receptor on natural killer (NK) cells that recognizes HLA class I allotypes. While the Bw4 motif spanning residues 77 to 83 is central to this interaction, structural studies have shown that polymorphism…

Potent neutralising monoclonal antibodies targeting the spike of NL63 coronavirus Open

Wen Shi Lee, George Taiaroa, Robyn Esterbauer, Meghan Conlan, Jessica A. Neil , et al. · 2025

Stabilized designs of the malaria adhesin protein PvRBP2b for use as a potential diagnostic for Plasmodium vivax Open

D Jaison, Lucas Krauss, Lauren M. Smith, Laura D’Andrea, Li‐Jin Chan , et al. · 2025

Plasmodium vivax is emerging as the most prevalent species causing malaria outside Africa. Most P. vivax infections are relapses due to the reactivation of the dormant liver stage parasites (hypnozoites). Hypnozoites are a major reservoir …

Human coronavirus OC43 nanobody neutralizes virus and protects mice from infection Open

Amy Adair, Li Lynn Tan, Jackson Feng, Jason Girkin, Nathan Bryant , et al. · 2024

Human coronavirus (hCoV) OC43 is endemic to global populations and usually causes asymptomatic or mild upper respiratory tract illness. Here, we demonstrate the neutralization efficacy of isolated nanobodies from alpacas immunized with the…

Author Correction: A placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility and differentiation impairment in syncytiotrophoblasts Open

Joseph Chen, Jessica A. Neil, Jianping Tan, Rajeev Rudraraju, Monika Mohenska , et al. · 2023

Antibody Fc-binding profiles and ACE2 affinity to SARS-CoV-2 RBD variants Open

Ebene R. Haycroft, Samantha K. Davis, Pradhipa Ramanathan, Ester López, Ruth A Purcell , et al. · 2023

A placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility and differentiation impairment in syncytiotrophoblasts Open

Joseph Chen, Jessica A. Neil, Jianping Tan, Rajeev Rudraraju, Monika Mohenska , et al. · 2023

SARS-CoV-2 infection causes COVID-19. Several clinical reports have linked COVID-19 during pregnancy to negative birth outcomes and placentitis. However, the pathophysiological mechanisms underpinning SARS-CoV-2 infection during placentati…

Corrigendum: Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2 Open

Bruce D. Wines, Liriye Kurtovic, Halina M. Trist, Sandra Esparon, Ester López , et al. · 2023

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Biparatopic nanobodies targeting the receptor binding domain efficiently neutralize SARS-CoV-2 Open

Phillip Pymm, Samuel J. Redmond, Olan Dolezal, Francesca L. Mordant, Ester López , et al. · 2022

The development of therapeutics to prevent or treat COVID-19 remains an area of intense focus. Protein biologics, including monoclonal antibodies and nanobodies that neutralize virus, have potential for the treatment of active disease. Her…

Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2 Open

Bruce D. Wines, Liriye Kurtovic, Halina M. Trist, Sandra Esparon, Ester López , et al. · 2022

Joining a function-enhanced Fc-portion of human IgG to the SARS-CoV-2 entry receptor ACE2 produces an antiviral decoy with strain transcending virus neutralizing activity. SARS-CoV-2 neutralization and Fc-effector functions of ACE2-Fc deco…

Altered affinity to ACE2 and reduced Fc functional antibodies to SARS-CoV-2 RBD variants Open

Ebene R. Haycroft, Samantha K. Davis, Pradhipa Ramanathan, Ester López, Ruth A Purcell , et al. · 2022

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants remains a formidable challenge to worldwide public health. The receptor binding domain (RBD) of the SARS-CoV-2 spike protein is a hotspot for mutations,…

Epitope length variants balance protective immune responses and viral escape in HIV-1 infection Open

Phillip Pymm, Stefan Tenzer, Edmund G. Wee, Mirjana Weimershaus, Anne Burgevin , et al. · 2022

Heterologous SARS-CoV-2 IgA neutralising antibody responses in convalescent plasma Open

Samantha K. Davis, Kevin J. Selva, Ester López, Ebene R. Haycroft, Wen Shi Lee , et al. · 2022

Following infection with SARS-CoV-2, virus-specific antibodies are generated which can both neutralise virions and clear infection via Fc effector functions. The importance of IgG antibodies for protection and control of SARS-CoV-2 has bee…

Heterologous SARS‐CoV ‐2 IgA neutralising antibody responses in convalescent plasma Open

Samantha K. Davis, Kevin J. Selva, Ester López, Ebene R. Haycroft, Wen Shi Lee , et al. · 2022

Objectives Following infection with SARS‐CoV‐2, virus‐specific antibodies are generated, which can both neutralise virions and clear infection via Fc effector functions. The importance of IgG antibodies for protection and control of SARS‐C…

An iTSC-derived placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility in syncytiotrophoblasts Open

Jinxin Chen, JA Neil, JP Tan, Rajeev Rudraraju, Monika Mohenska , et al. · 2021

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causing coronavirus disease 2019 (COVID-19) has caused a global health crisis. The primary site of infection is in the respiratory tract but the virus has been associat…

Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain Open

Adam K. Wheatley, Phillip Pymm, Robyn Esterbauer, Melanie H. Dietrich, Wen Shi Lee , et al. · 2021

Potent neutralizing monoclonal antibodies are one of the few agents currently available to treat COVID-19. SARS-CoV-2 variants of concern (VOCs) that carry multiple mutations in the viral spike protein can exhibit neutralization resistance…

Simultaneous evaluation of antibodies that inhibit SARS-CoV-2 variants via multiplex assay Open

Ester López, Ebene R. Haycroft, Amy Adair, Francesca L. Mordant, Matthew T. O’Neill , et al. · 2021

The SARS-CoV-2 receptor binding domain (RBD) is both the principal target of neutralizing antibodies and one of the most rapidly evolving domains, which can result in the emergence of immune escape mutations, limiting the effectiveness of …

Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice Open

Phillip Pymm, Amy Adair, Li‐Jin Chan, James P. Cooney, Francesca L. Mordant , et al. · 2021

Significance Neutralizing antibodies are important for immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and as therapeutics for the prevention and treatment of COVID-19. We identified high-affinity nanobodies a…

Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C Open

Shoeib Moradi, Sanda Stankovic, Geraldine M. O’Connor, Phillip Pymm, Bruce J. MacLachlan , et al. · 2021

Simultaneous evaluation of antibodies that inhibit SARS-CoV-2 RBD variants with a novel competitive multiplex assay Open

Ester López, Ebene R. Haycroft, Amy Adair, Francesca L. Mordant, Matthew T. O’Neill , et al. · 2021

The SARS-CoV-2 Receptor Binding Domain (RBD) is both the principal target of neutralizing antibodies, and one of the most rapidly evolving domains, which can result in the emergence of immune escape mutations limiting the effectiveness of …

Nanobody generation and structural characterization of Plasmodium falciparum 6-cysteine protein Pf12p Open

Melanie H. Dietrich, Li‐Jin Chan, Amy Adair, Sravya Keremane, Phillip Pymm , et al. · 2021

Surface-associated proteins play critical roles in the Plasmodium parasite life cycle and are major targets for vaccine development. The 6-cysteine (6-cys) protein family is expressed in a stage-specific manner throughout Plasmodium falcip…

Nanobody generation and structural characterization ofPlasmodium falciparum6-cysteine protein Pf12p Open

Melanie H. Dietrich, Li‐Jin Chan, Amy Adair, Sravya Keremane, Phillip Pymm , et al. · 2020

Surface-associated proteins play critical roles in the Plasmodium parasite life cycle and are major targets for vaccine development. The 6-cysteine (6-cys) protein family is expressed in a stage-specific manner throughout Plasmodium falcip…

Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19 Open

Jennifer A. Juno, Hyon‐Xhi Tan, Wen Shi Lee, Arnold Reynaldi, Hannah G. Kelly , et al. · 2020

Immunogenic profile of SARS-CoV-2 spike in individuals recovered from COVID-19 Open

Jennifer A. Juno, Hyon‐Xhi Tan, Wen Shi Lee, Arnold Reynaldi, Hannah G. Kelly , et al. · 2020

The rapid global spread of SARS-CoV-2 and resultant mortality and social disruption have highlighted the need to better understand coronavirus immunity to expedite vaccine development efforts. Multiple candidate vaccines, designed to elici…

The molecular basis of how buried human leukocyte antigen polymorphism modulates natural killer cell function Open

Philippa M. Saunders, Bruce J. MacLachlan, Phillip Pymm, Patricia T. Illing, Yuanchen Deng , et al. · 2020

Micropolymorphisms within human leukocyte antigen (HLA) class I molecules can change the architecture of the peptide-binding cleft, leading to differences in peptide presentation and T cell recognition. The impact of such HLA variation on …

HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome Open

Patricia T. Illing, Phillip Pymm, Nathan P. Croft, Hugo G. Hilton, Vladimir Jojic , et al. · 2018

Killer cell immunoglobulin–like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1 Open

Maureen P. Martin, Vivek Naranbhai, Patrick R. Shea, Qi Ying, Veron Ramsuran , et al. · 2018

HLA-B*57 control of HIV involves enhanced CD8+ T cell responses against infected cells, but extensive heterogeneity exists in the level of HIV control among B*57+ individuals. Using whole-genome sequencing of untreated B*57+ HIV-1-infected…

MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape Open

Phillip Pymm, Patricia T. Illing, Sri H. Ramarathinam, Geraldine M. O’Connor, Victoria A. Hughes , et al. · 2017

Killer cell immunoglobulin-like receptor 3DL1 polymorphism defines distinct hierarchies of HLA class I recognition Open

Philippa M. Saunders, Phillip Pymm, Gabriella Pietra, Victoria A. Hughes, Corinne Hitchen , et al. · 2016

Natural killer (NK) cells play a key role in immunity, but how HLA class I (HLA-I) and killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1) polymorphism impacts disease outcome remains unclear. KIR3DL1 (*001/*005/*015) tetramers were sc…

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