Phillip Trefz
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View article: Effects of Contagious Respiratory Pathogens on Breath Biomarkers
Effects of Contagious Respiratory Pathogens on Breath Biomarkers Open
Due to their immediate exhalation after generation at the cellular/microbiome levels, exhaled volatile organic compounds (VOCs) may provide real-time information on pathophysiological mechanisms and the host response to infection. In recen…
View article: Effects of contagious respiratory infections on breath biomarkers
Effects of contagious respiratory infections on breath biomarkers Open
Background Due to their immediate exhalation after generation at the cellular/microbiome levels, exhaled volatile organic compounds (VOCs) may provide real-time information on pathophysiological mechanisms and host response to infections. …
View article: Profiling of exhaled volatile organics in the screening scenario of a COVID-19 test center
Profiling of exhaled volatile organics in the screening scenario of a COVID-19 test center Open
Breath volatile organics (VOCs) may provide immediate information on infection mechanisms and host response. We conducted real-time mass spectrometry-based breath profiling in 708 non-preselected consecutive subjects in the screening scena…
View article: Real-time metabolic monitoring under exhaustive exercise and evaluation of ventilatory threshold by breathomics: Independent validation of evidence and advances
Real-time metabolic monitoring under exhaustive exercise and evaluation of ventilatory threshold by breathomics: Independent validation of evidence and advances Open
Breath analysis was coupled with ergo-spirometry for non-invasive profiling of physio-metabolic status under exhaustive exercise. Real-time mass-spectrometry based continuous analysis of exhaled metabolites along with breath-resolved spiro…
View article: Advanced setup for safe breath sampling and patient monitoring under highly infectious conditions in the clinical environment
Advanced setup for safe breath sampling and patient monitoring under highly infectious conditions in the clinical environment Open
Being the proximal matrix, breath offers immediate metabolic outlook of respiratory infections. However, high viral load in exhalations imposes higher transmission risk that needs improved methods for safe and repeatable analysis. Here, we…
View article: Non-Invasive O-Toluidine Monitoring during Regional Anaesthesia with Prilocaine and Detection of Accidental Intravenous Injection in an Animal Model
Non-Invasive O-Toluidine Monitoring during Regional Anaesthesia with Prilocaine and Detection of Accidental Intravenous Injection in an Animal Model Open
Regional anaesthesia is well established as a standard method in clinical practice. Currently, the local anaesthetics of amino-amide types such as prilocaine are frequently used. Despite routine use, complications due to overdose or accide…
View article: Effects of COVID-19 protective face masks and wearing durations on respiratory haemodynamic physiology and exhaled breath constituents
Effects of COVID-19 protective face masks and wearing durations on respiratory haemodynamic physiology and exhaled breath constituents Open
Background While assumed to protect against coronavirus transmission, face masks may have effects on respiratory–haemodynamic parameters. Within this pilot study, we investigated immediate and progressive effects of FFP2 and surgical masks…
View article: Physiological and metabolic effects of healthy female aging on exhaled breath biomarkers
Physiological and metabolic effects of healthy female aging on exhaled breath biomarkers Open
Healthy aging driven physio-metabolic events in females hold the key to complex in vivo mechanistic links and systemic cross talks. Effects from basic changes at genome, proteome, metabolome, and lipidome levels are often reflected at the …
View article: Adverse effects of COVID-protective face-masks and wearing durations onto respiratory-haemodynamic physiology and exhaled breath constituents
Adverse effects of COVID-protective face-masks and wearing durations onto respiratory-haemodynamic physiology and exhaled breath constituents Open
While protecting against the coronavirus transmission, face-masks may have adverse effects on respiratory-haemodynamic parameters. We investigated immediate and progressive effects of FFP2 and surgical masks on exhaled breath constituents …
View article: Detection of Mycobacterium avium ssp. paratuberculosis in Cultures From Fecal and Tissue Samples Using VOC Analysis and Machine Learning Tools
Detection of Mycobacterium avium ssp. paratuberculosis in Cultures From Fecal and Tissue Samples Using VOC Analysis and Machine Learning Tools Open
Analysis of volatile organic compounds (VOCs) is a novel approach to accelerate bacterial culture diagnostics of Mycobacterium avium subsp. paratuberculosis (MAP). In the present study, cultures of fecal and tissue samples from MAP-infecte…
View article: Exhaled breath compositions under varying respiratory rhythms reflects ventilatory variations: translating breathomics towards respiratory medicine
Exhaled breath compositions under varying respiratory rhythms reflects ventilatory variations: translating breathomics towards respiratory medicine Open
Control of breathing is automatic and its regulation is keen to autonomic functions. Therefore, involuntary and voluntary nervous regulation of breathing affects ventilatory variations, which has profound potential to address expanding cha…
View article: Effects of modular ion-funnel technology onto analysis of breath VOCs by means of real-time mass spectrometry
Effects of modular ion-funnel technology onto analysis of breath VOCs by means of real-time mass spectrometry Open
Proton transfer reaction time-of-flight mass spectrometry (PTR-ToF-MS) is a powerful tool for real-time monitoring of trace concentrations of volatile organic compounds (VOCs). The sensitivity of PTR-ToF-MS also depends on the ability to e…
View article: Changes of Exhaled Volatile Organic Compounds in Postoperative Patients Undergoing Analgesic Treatment: A Prospective Observational Study
Changes of Exhaled Volatile Organic Compounds in Postoperative Patients Undergoing Analgesic Treatment: A Prospective Observational Study Open
Assessment and treatment of postoperative pain can be challenging as objective examination techniques to detect and quantify pain are lacking. We aimed to investigate changes of exhaled volatile organic compounds (VOCs) in patients with po…
View article: Author Correction: Exhaled volatile substances in children suffering from type 1 diabetes mellitus: results from a cross-sectional study
Author Correction: Exhaled volatile substances in children suffering from type 1 diabetes mellitus: results from a cross-sectional study Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Non-Invasive Assessment of Metabolic Adaptation in Paediatric Patients Suffering from Type 1 Diabetes Mellitus
Non-Invasive Assessment of Metabolic Adaptation in Paediatric Patients Suffering from Type 1 Diabetes Mellitus Open
An analysis of exhaled volatile organic compounds (VOC) may deliver systemic information quicker than available invasive techniques. Metabolic aberrations in pediatric type 1 diabetes (T1DM) are of high clinical importance and could be add…
View article: Core profile of volatile organic compounds related to growth of Mycobacterium avium subspecies paratuberculosis – A comparative extract of three independent studies
Core profile of volatile organic compounds related to growth of Mycobacterium avium subspecies paratuberculosis – A comparative extract of three independent studies Open
Analysis of volatile organic compounds (VOC) derived from bacterial metabolism during cultivation is considered an innovative approach to accelerate in vitro detection of slowly growing bacteria. This applies also to Mycobacterium avium su…
View article: VOC breath profile in spontaneously breathing awake swine during Influenza A infection
VOC breath profile in spontaneously breathing awake swine during Influenza A infection Open
Influenza is one of the most common causes of virus diseases worldwide. Virus detection requires determination of Influenza RNA in the upper respiratory tract. Efficient screening is not possible in this way. Analysis of volatile organic c…
View article: Natural menstrual rhythm and oral contraception diversely affect exhaled breath compositions
Natural menstrual rhythm and oral contraception diversely affect exhaled breath compositions Open
Natural menstrual cycle and/or oral contraception diversely affect women metabolites. Longitudinal metabolic profiling under constant experimental conditions is thereby realistic to understand such effects. Thus, we investigated volatile o…
View article: Comparative analysis of volatile organic compounds for the classification and identification of mycobacterial species
Comparative analysis of volatile organic compounds for the classification and identification of mycobacterial species Open
This study revealed species-specific VOC profiles for eleven species of mycobacteria that showed visually apparent bacterial growth at the time point of analysis.
View article: Applied upper-airway resistance instantly affects breath components: a unique insight into pulmonary medicine
Applied upper-airway resistance instantly affects breath components: a unique insight into pulmonary medicine Open
Respiratory parameters such as flow or rate have complex effects on the exhalation of volatile substances and can hamper clinical interpretation of breath biomarkers. We have investigated the effects of progressively applied upper-airway r…
View article: Strategies for the identification of disease-related patterns of volatile organic compounds: prediction of paratuberculosis in an animal model using random forests
Strategies for the identification of disease-related patterns of volatile organic compounds: prediction of paratuberculosis in an animal model using random forests Open
Modern statistical methods which were developed for pattern recognition are increasingly being used for data analysis in studies on emissions of volatile organic compounds (VOCs). With the detection of disease-related VOC profiles, novel n…
View article: Exhaled volatile substances mirror clinical conditions in pediatric chronic kidney disease
Exhaled volatile substances mirror clinical conditions in pediatric chronic kidney disease Open
Monitoring metabolic adaptation to chronic kidney disease (CKD) early in the time course of the disease is challenging. As a non-invasive technique, analysis of exhaled breath profiles is especially attractive in children. Up to now, no re…
View article: O-Toluidine in Breath-Non-Invasive Prilocaine Monitoring
O-Toluidine in Breath-Non-Invasive Prilocaine Monitoring Open
The generation of methaemoglobin is a rare but potential life-threatening side effect in the use of the local anaesthetic prilocaine.It is currently only possible to ensure the diagnosis by means of blood tests.Rapid noninvasive diagnosis …
View article: Effects of biological and methodological factors on volatile organic compound patterns during cultural growth of <i>Mycobacterium avium</i> ssp <i>. paratuberculosis</i>
Effects of biological and methodological factors on volatile organic compound patterns during cultural growth of <i>Mycobacterium avium</i> ssp <i>. paratuberculosis</i> Open
Mycobacterium avium ssp. paratuberculosis (MAP) causes chronic granulomatous enteritis in ruminants. Bacterial growth is still the diagnostic 'gold standard', but is very time consuming. MAP-specific volatile organic compounds (VOCs) above…