Phillip R. Gordon‐Weeks
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View article: The drebrin/EB3 pathway regulates cytoskeletal dynamics to drive neuritogenesis in embryonic cortical neurons
The drebrin/EB3 pathway regulates cytoskeletal dynamics to drive neuritogenesis in embryonic cortical neurons Open
Co‐ordinating the dynamic behaviour of actin filaments (F‐actin) and microtubules in filopodia is an important underlying process in neuritogenesis, but the molecular pathways involved are ill‐defined. The drebrin/end‐binding protein 3 (EB…
View article: The drebrin/EB3 pathway drives invasive activity in prostate cancer
The drebrin/EB3 pathway drives invasive activity in prostate cancer Open
Prostate cancer is the most common cancer in men and the metastatic form of the disease is incurable. We show here that the drebrin/EB3 pathway, which co-ordinates dynamic microtubule/actin filament interactions underlying cell shape chang…
View article: The role of the drebrin/EB3/Cdk5 pathway in dendritic spine plasticity, implications for Alzheimer’s disease
The role of the drebrin/EB3/Cdk5 pathway in dendritic spine plasticity, implications for Alzheimer’s disease Open
The drebrin/EB3/Cdk5 intracellular signalling pathway couples actin filaments to dynamic microtubules in cellular settings where cells are changing shape. The pathway has been most intensively studied in neuronal development, particularly …
View article: The Actin-Binding Protein Drebrin Inhibits Neointimal Hyperplasia
The Actin-Binding Protein Drebrin Inhibits Neointimal Hyperplasia Open
Objective— Vascular smooth muscle cell (SMC) migration is regulated by cytoskeletal remodeling as well as by certain transient receptor potential (TRP) channels, nonselective cation channels that modulate calcium influx. Proper function of…
View article: Drebrin Regulates Neuroblast Migration in the Postnatal Mammalian Brain
Drebrin Regulates Neuroblast Migration in the Postnatal Mammalian Brain Open
After birth, stem cells in the subventricular zone (SVZ) generate neuroblasts that migrate along the rostral migratory stream (RMS) to become interneurons in the olfactory bulb (OB). This migration is crucial for the proper integration of …