Phoebe Hodges
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View article: Associations of 13C-Sucrose Breath Test Dynamics with Anthropometry and Demographics: A Comparison of Studies in the United Kingdom and Zambia
Associations of 13C-Sucrose Breath Test Dynamics with Anthropometry and Demographics: A Comparison of Studies in the United Kingdom and Zambia Open
The associations we identified between weight and the rate-limiting parameter (πρ) should be further investigated and better understood mechanistically. These anthropometric associations identified for adults should be further confirmed in…
View article: Future of research on inflammatory bowel disease in Nigeria: Gaps and opportunities
Future of research on inflammatory bowel disease in Nigeria: Gaps and opportunities Open
Inflammatory bowel disease (IBD) is an increasing global health issue that poses specific challenges in Nigeria. Although awareness of IBD is growing in the country, research and resources remain limited. This review aims to address this s…
View article: Association of Intestinal Amino Acid Absorption with the Uptake of Lactulose and Rhamnose in Adults with Environmental Enteropathy
Association of Intestinal Amino Acid Absorption with the Uptake of Lactulose and Rhamnose in Adults with Environmental Enteropathy Open
It is not clear whether impaired amino acid (AA) absorption occurs in adults with environmental enteropathy (EE). Therefore, we set out to determine the association between intestinal 13 C 6 15 N-allo-isoleucine absorption (reflecting neut…
View article: Clinical Utility and Cost‐Effectiveness of Pretreatment <i>NUDT15</i> Pharmacogenetic Testing to Prevent Thiopurine‐Induced Myelosuppression: A Genotype‐First Reverse Phenotyping Cohort Study Within the <scp>UK NIHR</scp> Inflammatory Bowel Disease Bioresource
Clinical Utility and Cost‐Effectiveness of Pretreatment <i>NUDT15</i> Pharmacogenetic Testing to Prevent Thiopurine‐Induced Myelosuppression: A Genotype‐First Reverse Phenotyping Cohort Study Within the <span>UK NIHR</span> Inflammatory Bowel Disease Bioresource Open
Background The clinical utility and cost‐effectiveness of pre‐thiopurine NUDT15 pharmacogenetic testing in European and admixed populations are unknown. Aims To report the prevalence, penetrance, expressivity, and pathogenicity of NUDT15 v…
View article: Environmental enteropathy and inflammatory bowel disease are not mutually exclusive
Environmental enteropathy and inflammatory bowel disease are not mutually exclusive Open
The co-existence of IBD and EE within the same individuals may prove to be a confounding factor when assessing patients presenting with symptoms suggestive of IBD in this setting and could be interpreted as evidence that improved environme…
View article: Emerging Patterns of Inflammatory Bowel Disease in Sub-Saharan Africa: 175 Cases From an Inflammatory Bowel Disease Network
Emerging Patterns of Inflammatory Bowel Disease in Sub-Saharan Africa: 175 Cases From an Inflammatory Bowel Disease Network Open
There is a knowledge gap on the epidemiology of inflammatory bowel disease in Africa. To begin to address this issue, we formed a case reporting network of practitioners with an interest in inflammatory bowel disease across sub-Saharan Afr…
View article: The Global Evolution of Inflammatory Bowel Disease across Four Epidemiologic Stages
The Global Evolution of Inflammatory Bowel Disease across Four Epidemiologic Stages Open
During the 20th century, inflammatory bowel disease (IBD) was considered a disease of early-industrialized regions in North America, Europe, and Oceania. At the turn of the 21st century, incidence of IBD increased in newly-industrialized a…
View article: ECCO Global Grant Genetic risk factors for IBD in its emergent phase in sub-Saharan Africa
ECCO Global Grant Genetic risk factors for IBD in its emergent phase in sub-Saharan Africa Open
Background and Aims Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), is an idiopathic, chronic, and frequently disabling inflammatory disorder of the intestines characterized by a dysregulated m…
View article: Challenges in the diagnosis and management of IBD: a sub-Saharan African perspective
Challenges in the diagnosis and management of IBD: a sub-Saharan African perspective Open
With the exception of South Africa, inflammatory bowel disease (IBD) has long been considered uncommon in sub-Saharan Africa (SSA) with a dearth of peer-reviewed publications from the subcontinent. This most likely reflects underreporting …
View article: 13C-sucrose breath test for the non-invasive assessment of environmental enteropathy in Zambian adults
13C-sucrose breath test for the non-invasive assessment of environmental enteropathy in Zambian adults Open
Objectives Environmental enteropathy (EE) is a subclinical disorder highly prevalent in tropical and disadvantaged populations and is thought to play a role in growth faltering in children, poor responses to oral vaccines, and micronutrien…
View article: Global Hospitalization Trends for Crohn’s Disease and Ulcerative Colitis in the 21st Century: A Systematic Review With Temporal Analyses
Global Hospitalization Trends for Crohn’s Disease and Ulcerative Colitis in the 21st Century: A Systematic Review With Temporal Analyses Open
Hospitalization rates for IBD are stabilizing in countries in stage 3, whereas newly industrialized countries in stage 2 have rapidly increasing hospitalization rates, contributing to an increasing burden on global health care systems.
View article: Association between oesophageal cancer and biomass smoke exposure: a case-control study
Association between oesophageal cancer and biomass smoke exposure: a case-control study Open
Most African populations are regularly exposed to biomass smoke, but knowledge of associated health implications is limited. This study aimed to investigate the association between oesophageal cancer (OC) and exposure to biomass smoke. Thi…
View article: P026 Inflammatory bowel disease does not preclude the presence of environmental enteropathy in Zambian adults
P026 Inflammatory bowel disease does not preclude the presence of environmental enteropathy in Zambian adults Open
Background Although data is scarce, inflammatory bowel disease (IBD) seems to be increasing in incidence in newly industrialised countries.(1) The environmental factors driving this change are not entirely clear, although it seems likely t…
View article: Helicobacter pylori infection and hypochlorhydria in Zambian adults and children: A secondary data analysis
Helicobacter pylori infection and hypochlorhydria in Zambian adults and children: A secondary data analysis Open
Background Hypochlorhydria (gastric pH >4) increases susceptibility to diarrhoea, iron deficiency, and gastric cancer. We sought to clarify the prevalence of this condition and its predisposing factors in Zambia by pooling data from previo…
View article: Intestinal Biopsies for the Evaluation of Environmental Enteropathy and Environmental Enteric Dysfunction
Intestinal Biopsies for the Evaluation of Environmental Enteropathy and Environmental Enteric Dysfunction Open
Environmental enteric dysfunction (EED) is a syndrome characterized by impairments of digestion and absorption and intestinal barrier failure in people living in insanitary or tropical environments. There is substantial evidence that it co…
View article: Inflammatory bowel disease in Africa: what is the current state of knowledge?
Inflammatory bowel disease in Africa: what is the current state of knowledge? Open
Inflammatory bowel disease (IBD) is increasingly recognized as a global disease in the twenty-first century; however, little is known about its epidemiology in Africa. We conducted a literature review in order to assess what is currently k…
View article: P589 Longer-term outcomes in patients with Crohn’s disease who are primary non-responders to anti-TNF in a single UK centre
P589 Longer-term outcomes in patients with Crohn’s disease who are primary non-responders to anti-TNF in a single UK centre Open
Background Primary non-response (PNR) is reported to occur in up to 24% patients with inflammatory bowel disease treated with anti-TNF drugs. The longer-term outcomes of these patients are less well documented however it is recognised that…