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View article: Characterization of the intraspecies chimeric mouse brain at embryonic day 12.5
Characterization of the intraspecies chimeric mouse brain at embryonic day 12.5 Open
Incidence of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis have increased dramatically as life expectancy has risen year-over-year, and can lead to neurologic changes. Neurolog…
View article: Pulmonary and Immune Dysfunction in Pediatric Long COVID: A Case Study Evaluating the Utility of ChatGPT-4 for Analyzing Scientific Articles
Pulmonary and Immune Dysfunction in Pediatric Long COVID: A Case Study Evaluating the Utility of ChatGPT-4 for Analyzing Scientific Articles Open
Coronavirus disease 2019 (COVID-19) in adults is well characterized and associated with multisystem dysfunction. A subset of patients develop post-acute sequelae of SARS-CoV-2 infection (PASC, or long COVID), marked by persistent and fluct…
View article: Functional Neural Connectivity of the Mouse Brain using Photoacoustic Ultrasound Imaging
Functional Neural Connectivity of the Mouse Brain using Photoacoustic Ultrasound Imaging Open
Brain connectomes are insightful models that describe the connectivity of different regions throughout the brain. These connectomes are traditionally generated through temporal correlation of blood oxygen level dependent (BOLD) signals det…
View article: Characterization of the intraspecies chimeric mouse brain at embryonic day 12.5
Characterization of the intraspecies chimeric mouse brain at embryonic day 12.5 Open
Incidence of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis have increased dramatically as life expectancy at birth has risen year-over-year and the population ages. Neurologica…
View article: Research Guideline Recommendations for Research on Stem Cells, Human Embryos, and Gene Editing
Research Guideline Recommendations for Research on Stem Cells, Human Embryos, and Gene Editing Open
Recent advances in biomedical technologies have extended the boundaries of previously established regulatory guidelines pertaining to stem cell research. These guidelines constrained the study of human pluripotent stem cells (hPSCs) and th…
View article: Transplanting Microglia for Treating CNS Injuries and Neurological Diseases and Disorders, and Prospects for Generating Exogenic Microglia
Transplanting Microglia for Treating CNS Injuries and Neurological Diseases and Disorders, and Prospects for Generating Exogenic Microglia Open
Microglia are associated with a wide range of both neuroprotective and neuroinflammatory functions in the central nervous system (CNS) during development and throughout lifespan. Chronically activated and dysfunctional microglia are found …
View article: <i>In Silico</i> Stage-Matching of Human, Marmoset, Mouse, and Pig Embryos to Enhance Organ Development Through Interspecies Chimerism
<i>In Silico</i> Stage-Matching of Human, Marmoset, Mouse, and Pig Embryos to Enhance Organ Development Through Interspecies Chimerism Open
Currently, there is a significant shortage of transplantable organs for patients in need. Interspecies chimerism and blastocyst complementation are alternatives for generating transplantable human organs in host animals such as pigs to mee…
View article: Neuronal Transplantation for Alzheimer’s Disease and Prospects for Generating Exogenic Neurons as a Source of Cells for Implantation
Neuronal Transplantation for Alzheimer’s Disease and Prospects for Generating Exogenic Neurons as a Source of Cells for Implantation Open
Alzheimer’s disease (AD) is a devastating neurodegenerative disease with limited therapeutic options. Cellular transplantation of healthy exogenic neurons to replace and restore neuronal cell function has previously been explored in AD ani…
View article: Cell Reprogramming for Regeneration and Repair of the Nervous System
Cell Reprogramming for Regeneration and Repair of the Nervous System Open
A persistent barrier to the cure and treatment of neurological diseases is the limited ability of the central and peripheral nervous systems to undergo neuroregeneration and repair. Recent efforts have turned to regeneration of various cel…
View article: Interspecies Chimeric Barriers for Generating Exogenic Organs and Cells for Transplantation
Interspecies Chimeric Barriers for Generating Exogenic Organs and Cells for Transplantation Open
A growing need for organs and novel cell-based therapies has provided a niche for approaches like interspecies chimeras. To generate organs from one donor species in another host species requires techniques such as blastocyst complementati…