Phong D. Nguyen
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View article: Oxidative phosphorylation is required for cardiomyocyte re-differentiation and long-term fish heart regeneration
Oxidative phosphorylation is required for cardiomyocyte re-differentiation and long-term fish heart regeneration Open
In contrast to humans, fish can fully regenerate their hearts after cardiac injury. However, not all fish have the same regenerative potential, allowing comparative inter-species and intra-species analysis to identify the mechanisms contro…
View article: Somites are a source of nephron progenitors in zebrafish
Somites are a source of nephron progenitors in zebrafish Open
Summary For over a century it has been believed that the vertebrate kidney arises exclusively from the intermediate mesoderm. Here, we overturn this paradigm by demonstrating that some nephrons, the functional units of the kidney, originat…
View article: Cross-species comparison reveals that Hmga1 reduces H3K27me3 levels to promote cardiomyocyte proliferation and cardiac regeneration
Cross-species comparison reveals that Hmga1 reduces H3K27me3 levels to promote cardiomyocyte proliferation and cardiac regeneration Open
In contrast to adult mammalian hearts, the adult zebrafish heart efficiently replaces cardiomyocytes lost after injury. Here we reveal shared and species-specific injury response pathways and a correlation between Hmga1, an architectural n…
View article: Interplay between calcium and sarcomeres directs cardiomyocyte maturation during regeneration
Interplay between calcium and sarcomeres directs cardiomyocyte maturation during regeneration Open
Zebrafish hearts can regenerate by replacing damaged tissue with new cardiomyocytes. Although the steps leading up to the proliferation of surviving cardiomyocytes have been extensively studied, little is known about the mechanisms that co…
View article: Redifferentiated cardiomyocytes retain residual dedifferentiation signatures and are protected against ischaemic injury
Redifferentiated cardiomyocytes retain residual dedifferentiation signatures and are protected against ischaemic injury Open
Cardiomyocyte renewal by dedifferentiation and proliferation has fueled the field of regenerative cardiology in recent years, while the reverse process of redifferentiation remains largely unexplored. Redifferentiation is characterised by …
View article: Single-cell profiling of transcriptome and histone modifications with EpiDamID
Single-cell profiling of transcriptome and histone modifications with EpiDamID Open
Recent advances in single-cell sequencing technologies have enabled simultaneous measurement of multiple cellular modalities, including various combinations of transcriptome, genome and epigenome. However, comprehensive profiling of the hi…
View article: Live imaging of adult zebrafish cardiomyocyte proliferation <i>ex vivo</i>
Live imaging of adult zebrafish cardiomyocyte proliferation <i>ex vivo</i> Open
Zebrafish are excellent at regenerating their heart by reinitiating proliferation in pre-existing cardiomyocytes. Studying how zebrafish achieve this holds great potential in developing new strategies to boost mammalian heart regeneration.…
View article: Cardiac regenerative capacity: an evolutionary afterthought?
Cardiac regenerative capacity: an evolutionary afterthought? Open
Cardiac regeneration is the outcome of the highly regulated interplay of multiple processes, including the inflammatory response, cardiomyocyte dedifferentiation and proliferation, neovascularization and extracellular matrix turnover. Spec…
View article: Is zebrafish heart regeneration “complete”? Lineage-restricted cardiomyocytes proliferate to pre-injury numbers but some fail to differentiate in fibrotic hearts
Is zebrafish heart regeneration “complete”? Lineage-restricted cardiomyocytes proliferate to pre-injury numbers but some fail to differentiate in fibrotic hearts Open
Adult zebrafish are frequently described to be able to “completely” regenerate the heart. Yet, the extent to which cardiomyocytes lost to injury are replaced is unknown, since only indirect or non-quantitative evidence for cardiomyocyte pr…
View article: Macrophages provide a transient muscle stem cell niche via NAMPT secretion
Macrophages provide a transient muscle stem cell niche via NAMPT secretion Open
Skeletal muscle is paradigmatic of a regenerative tissue that repairs itself via the activation of a resident stem cell 1 . Termed the satellite cell, these normally quiescent cells are induced to proliferate by ill-defined wound-derived s…
View article: Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart
Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart Open
While the heart regenerates poorly in mammals, efficient heart regeneration occurs in zebrafish. Studies in zebrafish have resulted in a model in which preexisting cardiomyocytes dedifferentiate and reinitiate proliferation to replace the …
View article: Author response: Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart
Author response: Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract While the heart regenerates p…
View article: A metabolic switch from OXPHOS to glycolysis is essential for cardiomyocyte proliferation in the regenerating heart
A metabolic switch from OXPHOS to glycolysis is essential for cardiomyocyte proliferation in the regenerating heart Open
The capacity to regenerate damaged tissues, such as the heart, various enormously amongst species. While heart regeneration is generally very low in mammals, it can regenerate efficiently in certain amphibian and fish species. Zebrafish ha…
View article: Different Fgfs have distinct roles in regulating neurogenesis after spinal cord injury in zebrafish
Different Fgfs have distinct roles in regulating neurogenesis after spinal cord injury in zebrafish Open
Background Despite conserved developmental processes and organization of the vertebrate central nervous system, only some vertebrates including zebrafish can efficiently regenerate neural damage including after spinal cord injury. The mamm…
View article: <i>In vivo</i> imaging: shining a light on stem cells in the living animal
<i>In vivo</i> imaging: shining a light on stem cells in the living animal Open
Stem cells are undifferentiated cells that play crucial roles during development, growth and regeneration. Traditionally, these cells have been primarily characterised by histology, cell sorting, cell culture and ex vivo methods. However, …
View article: Using Transgenic Zebrafish to Study Muscle Stem/Progenitor Cells
Using Transgenic Zebrafish to Study Muscle Stem/Progenitor Cells Open
Understanding muscle stem cell behaviors can potentially provide insights into how these cells act and respond during normal growth and diseased contexts. The zebrafish is an ideal model organism to examine these behaviors in vivo where it…
View article: Origins and genetic control of the external cell layer
Origins and genetic control of the external cell layer Open
The external cell layer (ECL) is a single cell layer located lateral to the myotome and directly underneath the skin of the zebrafish. It is considered to be the functional equivalent to the amniote dermomyotome due to its similar gene exp…