Explanipedia

Beyond Black and White: Cancer Disparities Within Racial Groups Open

Davidi Tawfiles, Mutlay Sayan, Brandon A. Mahal, Miriam Tawfiles, Erin Jay G. Feliciano , et al. · 2025

Randomized PROSTATE-IQ Trial to Reduce ADT Treatment Burden for Patients with Biochemical Recurrence after Prostatectomy Open

Richard M. Hoffman, Paul L. Nguyen, A. Zurita-Saavedra, Amee Morgans, Dana E. Rathkopf , et al. · 2025

Hallmark Interferon-Alpha Response Analysis in Localized Prostate Cancer: Analysis of the NRG Oncology/RTOG 9202, 9413, 9902, 0126, and 0521 Clinical Trials Open

Adam C. Olson, Haixia Wang, William A. Hall, P.T. Tran, P.F. Nguyen-Tan , et al. · 2025

Real World Utilization of Salvage Radiotherapy (SRT) in Biochemically Recurrent (BCR) Prostate Cancer Patients Open

Michelle Finkelstein, Alex S. Bart, J.A. Efstathiou, Paul L. Nguyen, E.D. Crawford , et al. · 2025

Clinical and Genetic Features of Autosomal Recessive Bestrophinopathy: A Case Series from a Vietnamese Cohort Open

Trang Nguyen, Văn Khanh Trần, Lan Ngoc-Nguyen, Nguyễn Văn Huy, Thinh Huy Tran , et al. · 2025

Objectives: This study aims to describe the clinical features and genetic findings of nine Vietnamese patients with autosomal recessive bestrophinopathy. Methods: This retrospective and cross-sectional study included individuals diagnosed …

Immune Spatial Organization Predicts Metastasis Risk in Aggressive Localized Prostate Cancer Open

David D. Yang, Anwar Abdelnaser, Jeremiah A. Wala, A. Haas, Alfred A. Barney , et al. · 2025

Risk stratification in localized prostate cancer (PCa) remains imprecise. Computational pathology has emerged as an attractive option for improving risk stratification, but current approaches either lack interpretability or focus solely on…

Impact of Cribriform Pattern on Progression-Free Survival After Radical Prostatectomy in Gleason Score 8-10 Prostate Cancer Open

Tyler Walburn, Yetkin Tuaç, Çağdaş Aktan, Ömer Burak Argun, Luke W. Chen , et al. · 2025

Background: Although extensive research highlights the detrimental effect of cribriform pattern 4 (CP4) on survival in non-high-risk prostate cancer (PC), its prognostic significance in high-risk PC is not well understood. Methods: The ind…

Health Care Contact Days and Outcomes in Clinical Trials vs Routine Care Among Patients With Non–Small Cell Lung Cancer Open

Arjun Gupta, Paul L. Nguyen, Brooke E. Wilson, Christopher M. Booth, Timothy P. Hanna · 2025

Importance Although patients enrolled in trials have superior survival outcomes compared with those in routine practice, it is unknown whether such differences extend to contact days, a measure of time toxicity. Objective To evaluate diffe…

Mitochondrial HMG-CoA Synthase Deficiency in Vietnamese Patients Open

Khanh Ngoc Nguyen, Trần Minh Điền, Thi Bich Ngoc Can, Bùi Phương Thảo, Ta Cong Son , et al. · 2025

Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency (HMGCS2D) is a rare metabolic disorder that impairs the body’s ability to produce ketone bodies and regulate energy metabolism. Diagnosing HMGCS2D is challenging because pati…

Prostate cancer screening in the Middle East and North Africa: a cross-sectional study on current practices Open

Özlem Aynaci, Yetkin Tuaç, Layth Mula‐Hussain, Lubna Hammoudeh, Salameh Obeidat , et al. · 2025

Background Prostate cancer is a substantial health concern in the Middle East and North Africa region, with many cases diagnosed at advanced stages, a high mortality to incidence ratio, and low prostate cancer awareness. This study aimed t…

Mitochondrial HMG-CoA Synthase Deficiency in Vietnamese Patients Open

Khanh Ngoc Nguyen, Trần Minh Điền, Thi Bich Ngoc Can, Bùi Phương Thảo, Thi Viet Phuong Dang , et al. · 2025

Background: Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency (HMGCS2D) is a rare metabolic disorder that impairs the body's ability to produce ketone bodies and regulate energy metabolism. Diagnosing HMGCS2D is challen…

Synthesis of methoxystilbenoid derivatives and evaluation of cytotoxicity against breast cancer cell line Open

Paul L. Nguyen, Tu Hoai Tran, Nhan Trung Nguyen, Phu Hoang Dang · 2025

Breast cancer is currently the most common cancer in women. According to the Global Cancer Observatory (Globocan 2020), there are over 2 million new cases of breast cancer diagnosed each year, accounting for 11.7% of all cancers, with an a…

Exercise to Enhance Cardiovascular Health Among Black Men with Prostate Cancer with Androgen Deprivation Therapy (The POWER Trial): A Study Protocol Open

Dong‐Woo Kang, Salvatore Ficarra, Rebekah L. Wilson, Alicia K. Morgans, Paul L. Nguyen , et al. · 2025

Transdisciplinary Collaboration of Healthcare Professionals and the Emotional Connectedness with Working with Patients Coping with Death and Dying Open

Paul L. Nguyen, Lindsay Gietzen · 2024

\nPurpose: This study explores how an integrated approach to care for patients and families by transdisciplinary healthcare teams provides opportunities for a patient-centered care approach to support quality of life throughout one's chron…

Practice patterns of Ontario physicians working in 'boutique' medical clinics Open

Eliot Frymire, Richard H. Glazier, Paul L. Nguyen, Emma McIlveen-Brown, Danielle Martin , et al. · 2024

CONTEXT: In Ontario, multiple organizations operate under a ‘boutique’ medicine model where patients pay a block or annual fee to access primary care services. Little is known about the characteristics of physicians and patients participat…

The Top 5 Minor Ailments and Pharmacist Management in Ontario: Attachment and Primary Care Open

Eliot Frymire, Mina Tadrous, Kamila Premji, Richard H. Glazier, Lisa Dolovich , et al. · 2024

CONTEXT: Pharmacists represent the 3rd largest healthcare profession in Canada, after nurses and physicians, with 46,699 licensed to practice in 2022. Minor ailments (MAs) are health conditions that can be managed with low prescribed treat…

Comprehensive and Focus Practice changes in the Family Physician Workforce in Ontario:1993-2022 Open

Eliot Frymire, Richard H. Glazier, Paul L. Nguyen, Michael Green, Lynn Roberts , et al. · 2024

CONTEXT: Comprehensive primary care is the foundation of an effective healthcare system but has been on the decline as more family physicians pursue careers in focused practice. OBJECTIVE: The objective is to explore the changes in compreh…

Mechanistic Interrogation of Photochemical Nickel-Catalyzed Tetrahydrofuran Arylation Leveraging Enantioinduction Data Open

Brennan D. McManus, Lang Hung, Olivia R. Taylor, Paul L. Nguyen, Alfredo Cedeno , et al. · 2024

This manuscript details the development of an asymmetric variant for the Ni-photoredox α-arylation of tetrahydrofuran (THF), which was originally reported in a racemic fashion by Doyle and Molander. Leveraging the enantioselectivity data t…

Management of Patients with Advanced Prostate Cancer. Report from the 2024 Advanced Prostate Cancer Consensus Conference (APCCC) Open

Silke Gillessen, Fabio Turco, Ian D. Davis, Jason A. Efstathiou, Karim Fizazi , et al. · 2024

Minor Ailments and Pharmacist Management in Ontario, Canada: Attachment and Primary Care Open

Lisa Dolovich, Paul L. Nguyen, Yasmin Abdul Aziz, Mina Tadrous, Ernie Avilla , et al. · 2024

Minor ailments (MA) are health conditions that can be managed with minimal prescribed treatment and/or self-care strategies. In Ontario, Canada, pharmacists were given authority to deliver service for thirteen MAs on January 1, 2023, with …

Molecular Alterations Associated with Histologically Overt Stromal Response in Patients with Prostate Cancer Open

Mutlay Sayan, Yetkin Tuaç, Mahmut Akgül, Samet Kucukcolak, Elza Tjio , et al. · 2024

Prostate cancer has substantial heterogeneity in clinical outcomes and therapeutic responses, posing challenges in predicting disease progression and tailoring treatment strategies. Recent studies have highlighted the potential prognostic …

Leveraging Asymmetric Catalysis Data for Mechanistic Interrogation of Nickel-Photoredox THF Arylation Open

Brennan D. McManus, Lang Hung, Olivia R. Taylor, Paul L. Nguyen, Alfredo Cedeno , et al. · 2024

This manuscript details the development of an asymmetric variant for the Ni-photoredox α-arylation of tetrahydrofuran (THF), which was originally reported in a racemic fashion by Doyle and Molander. Leveraging the enantioselectivity data t…

Leveraging Asymmetric Catalysis Data for Mechanistic Interrogation of Nickel-Photoredox THF Arylation Open

Brennan D. McManus, Lang Hung, Olivia R. Taylor, Paul L. Nguyen, Alfredo Cedeno , et al. · 2024

This manuscript details the development of an asymmetric variant for the Ni-photoredox α-arylation of tetrahydrofuran (THF), which was originally reported in a racemic fashion by Doyle and Molander. Leveraging the enantioselectivity data t…

Artemisinin-induced cholestatic liver injury and intrahepatic ductopenia Open

Joel Thio, Adam Haig, Ei Phyu Phyu Swe, Paul L. Nguyen, Kayla Tran , et al. · 2024

Artemisinin, an ancient Chinese herbal remedy known colloquially as “Qinghao”, is now used as treatment for malaria as recommended by the World Health Organisation. There have been few reports of artemisinin-induced liver injury. Most of t…

Ergonomics assessment of loading and unloading bagged cargoes: Case study at Sai Gon Port Open

Paul L. Nguyen · 2024

Musculoskeletal disorders (MSDs) are a prevalent global health issue, affecting workers in various industries, including port workers. The 28 labor postures are divided into independent manual loading and unloading, coordinated manual load…

Dying with dignity: how can we deliver values-concordant end-of-life care for immigrant patients in the United States? Open

Khushi Kohli, Erin Jay G. Feliciano, Nishwant Swami, Aditya Narayan, Tej A. Patel , et al. · 2024

Long-Term Analysis of NRG Oncology RTOG 0415: A Randomized Phase III Noninferiority Study Comparing Two Fractionation Schedules in Patients With Low-Risk Prostate Cancer Open

W. Robert Lee, James J. Dignam, Mahul B. Amin, Deborah Watkins Bruner, Daniel A. Low , et al. · 2024

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. …

Histologically Overt Stromal Response and the Risk of Progression after Radical Prostatectomy for Prostate Cancer Open

Mutlay Sayan, Yetkin Tuaç, Samet Kucukcolak, Mary D. Rowan, Grace K. Pratt , et al. · 2024

Purpose: Given the variable clinical course of prostate cancer and the limitations of current prognostic factors, this study was conducted to investigate the impact of a histologically overt stromal response (HOST-response) to prostate can…

Remote operation of the DIII-D National Fusion Facility Open

D. P. Schissel, Eunjung Cho, S. Flanagan, F. García, C. Liu , et al. · 2024

Full remote scientific operation of the DIII-D National Fusion Facility is now possible through significant advances in the computer science hardware and software infrastructure made over the last decade. Capabilities around information vi…

The Lancet Commission on prostate cancer: planning for the surge in cases Open

Nicholas D. James, Ian F. Tannock, James N’Dow, Felix Y. Feng, Silke Gillessen , et al. · 2024

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