Mindie H. Nguyen
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View article: Linkage disequilibrium score regression identifies genetic correlations between hepatocellular carcinoma and clinically relevant traits
Linkage disequilibrium score regression identifies genetic correlations between hepatocellular carcinoma and clinically relevant traits Open
Hepatocellular carcinoma (HCC) mortality is increasing globally, partly due to the growing prevalence of nonviral liver diseases. Genome‐wide association studies (GWAS) have identified genetic variants associated with HCC development. Leve…
View article: Delayed Diagnosis of Hepatitis C Infection: Results of a Nationwide US Study
Delayed Diagnosis of Hepatitis C Infection: Results of a Nationwide US Study Open
Introduction: Universal screening of hepatitis C virus (HCV) was encouraged for individuals born 1945–65 in the USA in 2012. In 2014, efficacious treatments, namely, direct-acting antivirals (DAAs), were introduced. To examine their impact…
View article: Virulence factors and outcomes in bacteremia caused by extended-spectrum β-lactamase-producing uropathogenic Escherichia coli ST131-H30Rx in a Swedish county
Virulence factors and outcomes in bacteremia caused by extended-spectrum β-lactamase-producing uropathogenic Escherichia coli ST131-H30Rx in a Swedish county Open
Background Escherichia coli ST131 and clade H30Rx are the most prevalent extended-spectrum β-lactamase-producing E. coli (ESBL-EC) causing bacteremia and urinary tract infections globally and in Sweden. Previous studies have linked ST131-H…
View article: Reply: Methodological Concerns Regarding GLP-1RA Effects on MASLD Outcomes
Reply: Methodological Concerns Regarding GLP-1RA Effects on MASLD Outcomes Open
View article: Impact of metabolic dysfunction on treatment responses to nucleos(t)ide analogues in chronic hepatitis B: a retrospective multi-center REAL-B cohort study
Impact of metabolic dysfunction on treatment responses to nucleos(t)ide analogues in chronic hepatitis B: a retrospective multi-center REAL-B cohort study Open
View article: Peri-Complication Diagnosis of Nonalcoholic Fatty Liver Disease: A US Population-Based Retrospective Analysis
Peri-Complication Diagnosis of Nonalcoholic Fatty Liver Disease: A US Population-Based Retrospective Analysis Open
Introduction: Screening guidelines for nonalcoholic fatty liver disease, now called metabolic dysfunction‐associated steatotic liver disease (MASLD), remain controversial, though early diagnosis can faciliate intervention and prevention. M…
View article: Correspondence to editorial on “GLP-1RA may open a new era for MASLD treatment”
Correspondence to editorial on “GLP-1RA may open a new era for MASLD treatment” Open
View article: Letter: Advancing Serologic Classification in Indeterminate Chronic Hepatitis B Through Dynamic and Integrated Frameworks—Authors' Reply
Letter: Advancing Serologic Classification in Indeterminate Chronic Hepatitis B Through Dynamic and Integrated Frameworks—Authors' Reply Open
View article: Projected Trends in Metabolic Dysfunction–Associated Steatotic Liver Disease Mortality Through 2040
Projected Trends in Metabolic Dysfunction–Associated Steatotic Liver Disease Mortality Through 2040 Open
Importance Population-based data for metabolic dysfunction–associated steatotic liver disease (MASLD)–related mortality trends and forecasts in the United States are limited. Objective To examine MASLD-related mortality trends in the Unite…
View article: Superior Diagnostic Efficacy of N‐Terminal Propeptide of Type III Collagen and Golgi Protein 73 for Detection of Fibrosis in Chronic Hepatitis B Patients
Superior Diagnostic Efficacy of N‐Terminal Propeptide of Type III Collagen and Golgi Protein 73 for Detection of Fibrosis in Chronic Hepatitis B Patients Open
Significant liver fibrosis is an indication for antiviral therapy in chronic hepatitis B (CHB). Using liver histology assessed by Scheuer system, we evaluated the diagnostic performance of PRO‐C3, GP73, and their combination for the presen…
View article: Projected Tumor Characteristics and Survival of Patients with Nonviral Hepatocellular Carcinoma in the USA
Projected Tumor Characteristics and Survival of Patients with Nonviral Hepatocellular Carcinoma in the USA Open
Introduction: Nonviral liver diseases, including alcohol-associated liver disease (ALD) and metabolic dysfunction-associated steatotic liver disease (MASLD), are increasing the burden of nonviral hepatocellular carcinoma (HCC) in the USA. …
View article: Late Diagnosis of Chronic Hepatitis B in the United States: A Population‐Based, Retrospective Cohort Study From 2007 to 2021
Late Diagnosis of Chronic Hepatitis B in the United States: A Population‐Based, Retrospective Cohort Study From 2007 to 2021 Open
Background Underdiagnosis of chronic hepatitis B (CHB) remains a major problem in the United States (USA), with > 80% of CHB patients remaining undiagnosed. Aims To determine the prevalence of late diagnosis of CHB and resultant liver comp…
View article: Glucagon-like peptide 1 receptor agonist and reduced liver and non-liver complications in adults with type 2 diabetes and metabolic dysfunction-associated steatotic liver disease: a target trial emulation study
Glucagon-like peptide 1 receptor agonist and reduced liver and non-liver complications in adults with type 2 diabetes and metabolic dysfunction-associated steatotic liver disease: a target trial emulation study Open
Background/Aims: Information about the association of glucagon-like peptide-1 receptor (GLP-1RA) with liver and non-liver complications is insufficient in patients with type 2 diabetes (T2D) and metabolic dysfunction-associated steatotic l…
View article: Impacts of metabolic syndrome diseases on long-term outcomes of chronic hepatitis B patients treated with nucleos(t)ide analogues
Impacts of metabolic syndrome diseases on long-term outcomes of chronic hepatitis B patients treated with nucleos(t)ide analogues Open
Background/Aims: Given the increase in prevalence of metabolic diseases, we investigated their long-term impacts on the outcomes of chronic hepatitis B (CHB) patients receiving nucleos(t)ide analogue (NA) treatment.Methods: We analyzed dat…
View article: Correspondence to editorial on “Bariatric surgery reduces long-term mortality in patients with metabolic dysfunction-associated steatotic liver disease and cirrhosis”
Correspondence to editorial on “Bariatric surgery reduces long-term mortality in patients with metabolic dysfunction-associated steatotic liver disease and cirrhosis” Open
View article: Antiviral Therapies are Associated with Reduced Mortality but Under-Utilized in Patients with Viral Hepatocellular Carcinoma: A Multinational REAL-HCC Study
Antiviral Therapies are Associated with Reduced Mortality but Under-Utilized in Patients with Viral Hepatocellular Carcinoma: A Multinational REAL-HCC Study Open
View article: Prevalence, Clinical Presentation, and Outcome of Hepatitis B Patients with Indeterminate Phase: A Systematic Review and Meta-Analysis
Prevalence, Clinical Presentation, and Outcome of Hepatitis B Patients with Indeterminate Phase: A Systematic Review and Meta-Analysis Open
View article: Comparative Efficacy of Promising Targets in the Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease And Steatohepatitis: A Systematic Review and Network Meta-Analysis
Comparative Efficacy of Promising Targets in the Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease And Steatohepatitis: A Systematic Review and Network Meta-Analysis Open
View article: Underperforming Student Perceptions of Small Group Discussion: Experiences from a Preclinical Medical Course in Vietnam
Underperforming Student Perceptions of Small Group Discussion: Experiences from a Preclinical Medical Course in Vietnam Open
View article: Bariatric surgery reduces long-term mortality in patients with metabolic dysfunction-associated steatotic liver disease and cirrhosis
Bariatric surgery reduces long-term mortality in patients with metabolic dysfunction-associated steatotic liver disease and cirrhosis Open
Background/Aims: With the obesity pandemic, metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common liver disease and a leading cause of end-stage liver disease and liver-related deaths in the USA. Therefore, we…
View article: Modified FIB-4 Index in Type 2 Diabetes Mellitus with Steatosis: A Non-Linear Predictive Model for Advanced Hepatic Fibrosis
Modified FIB-4 Index in Type 2 Diabetes Mellitus with Steatosis: A Non-Linear Predictive Model for Advanced Hepatic Fibrosis Open
Background: The Fibrosis-4 (FIB-4) index is widely recommended as a first-tier method for screening advanced hepatic fibrosis; however, its diagnostic performance is known to be suboptimal in patients with Type 2 diabetes mellitus (T2DM). …
View article: Phase 3 Validation of PAaM for Hepatocellular Carcinoma Risk Stratification in Cirrhosis
Phase 3 Validation of PAaM for Hepatocellular Carcinoma Risk Stratification in Cirrhosis Open
View article: Incidence rates of hepatocellular carcinoma based on risk stratification in steatotic liver disease for precision medicine: A real-world longitudinal nationwide study
Incidence rates of hepatocellular carcinoma based on risk stratification in steatotic liver disease for precision medicine: A real-world longitudinal nationwide study Open
Background Detailed subgroup incidence rates for steatotic liver disease (SLD)-related hepatocellular carcinoma (HCC) are critical to inform practice and public health interventions but remain sparse. We aimed to fill in this gap. Methods …
View article: Disease Progression for Histologic Diagnosis of Metabolic Dysfunction-Associated Steatotic Liver Disease in the Real-World: A Nationwide US Study
Disease Progression for Histologic Diagnosis of Metabolic Dysfunction-Associated Steatotic Liver Disease in the Real-World: A Nationwide US Study Open
Introduction: We compared clinical characteristics and outcomes in real-world metabolic dysfunction-associated steatotic liver disease (MASLD) patients with or without liver biopsy using a nationwide cohort in United States (USA) to fill i…
View article: Correspondence to editorial on “Differences in liver and mortality outcomes of non-alcoholic fatty liver disease by race and ethnicity: A longitudinal real-world study”
Correspondence to editorial on “Differences in liver and mortality outcomes of non-alcoholic fatty liver disease by race and ethnicity: A longitudinal real-world study” Open
View article: Global epidemiology, natural history, maternal-to-child transmission, and treatment with DAA of pregnant women with HCV: a systematic review and meta-analysis
Global epidemiology, natural history, maternal-to-child transmission, and treatment with DAA of pregnant women with HCV: a systematic review and meta-analysis Open
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View article: Impact of Income-to-Poverty Ratio on Long-Term Mortality of Persons with Chronic Liver Disease in the USA, 1999–2018
Impact of Income-to-Poverty Ratio on Long-Term Mortality of Persons with Chronic Liver Disease in the USA, 1999–2018 Open
Introduction: Chronic liver disease (CLD) is associated with increased morbidity and mortality. Understanding health disparities can inform appropriate interventions. We aimed to study mortality outcomes of those with CLD by the income lev…
View article: Issue Information
Issue Information Open
View article: In response to: Steatotic liver disease-know your enemies
In response to: Steatotic liver disease-know your enemies Open
View article: Global incidence of adverse clinical events in non-alcoholic fatty liver disease: A systematic review and meta-analysis
Global incidence of adverse clinical events in non-alcoholic fatty liver disease: A systematic review and meta-analysis Open
Background/Aims: Nonalcoholic fatty liver disease (NAFLD) is associated with a multitude of adverse outcomes. We aimed to estimate the pooled incidence of NAFLD-related adverse events.Methods: We performed a systematic review and meta-anal…