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View article: The Ethanol Extract of <i>Polyscias scutellaria</i> (EEPS) Shows Anti-Inflammatory Signaling Pathway Against LPS-Induced Inflammation in RAW 264.7 Macrophages
The Ethanol Extract of <i>Polyscias scutellaria</i> (EEPS) Shows Anti-Inflammatory Signaling Pathway Against LPS-Induced Inflammation in RAW 264.7 Macrophages Open
Aim of the Study This study investigates the anti-inflammatory effects of Polyscias scutellaria root ethanol extract (EEPS). The anti-inflammatory effects of the root samples, along with the molecular mechanisms behind these effects, are e…
View article: TÁC DỤNG CHỐNG LÃO HÓA DA CỦA MỸ PHẨM ĐẮP MẶT CHỨA CAO DƯƠNG XỈ VÀ ASTAXANTHIN TRÊN MÔ HÌNH THỰC NGHIỆM
TÁC DỤNG CHỐNG LÃO HÓA DA CỦA MỸ PHẨM ĐẮP MẶT CHỨA CAO DƯƠNG XỈ VÀ ASTAXANTHIN TRÊN MÔ HÌNH THỰC NGHIỆM Open
This study evaluated the anti-aging effect of a mask containing Dryopteris crassirhizoma extract (mask DC) and astaxanthin on the skin anti-aging model in mice induced by D-galactose at a subcutaneously injected dose of 1000 mg/kg. The ant…
View article: Resveratrol protects against Rankl-induced mineralized bone damage in a transgenic medaka fish model of osteoporosis
Resveratrol protects against Rankl-induced mineralized bone damage in a transgenic medaka fish model of osteoporosis Open
Natural substances with bone protective potential always greatly attract researchers for the development of safer and more effective drugs for osteopenia and osteoporosis. Resveratrol (RES), a plant polyphenol found in red grapes and berri…
View article: Neuroprotective Effects of Ethanol Extract Polyscias guilfoylei (EEPG) Against Glutamate Induced Neurotoxicity in HT22 Cells
Neuroprotective Effects of Ethanol Extract Polyscias guilfoylei (EEPG) Against Glutamate Induced Neurotoxicity in HT22 Cells Open
Oxidative stress induced by glutamate is a significant contributor to neuronal cell damage and can lead to neurodegenerative diseases such as Alzheimer’s, Huntington’s, and ischemic brain injury. At the cellular level, oxidative stress inc…
View article: Nghiên cứu độc tính bán trường diễn của cao dây thìa canh (Gymnema sylvestre) trên thực nghiệm
Nghiên cứu độc tính bán trường diễn của cao dây thìa canh (Gymnema sylvestre) trên thực nghiệm Open
Nghiên cứu được tiến hành nhằm đánh giá độc tính bán trường diễn của cao Dây thìa canh (Gymnema sylvestre) theo đường uống trên động vật thực nghiệm. Nghiên cứu độc tính bán trường diễn được tiến hành theo hướng dẫn của WHO, chuột cống trắ…
View article: Evaluation of subchronic toxicity of diabetna capsules in experimental animals
Evaluation of subchronic toxicity of diabetna capsules in experimental animals Open
This research aimed to evaluate the subchronic toxicity of Diabetna capsules through oral administration in experimental animals. The subchronic toxicity was studied in Wistar rats with oral doses of 0.72 g/kg/day (equal to recommended hum…
View article: Chemical Constituents and Neuroprotective Activity of <i>Hypericum hookerianum</i>
Chemical Constituents and Neuroprotective Activity of <i>Hypericum hookerianum</i> Open
Objective/Background The Hypericum hookerianum is widely distributed in Asian countries and prevalently used in traditional herbal medicines for its significant antioxidant, antipyretic, and anticancer properties. To date, very limited rep…
View article: Neuroprotective Effects of Ethanol Extract of Polyscias fruticosa (EEPF) against Glutamate-Mediated Neuronal Toxicity in HT22 Cells
Neuroprotective Effects of Ethanol Extract of Polyscias fruticosa (EEPF) against Glutamate-Mediated Neuronal Toxicity in HT22 Cells Open
In traditional herbal medicine, the Polyscias fruticosa has been frequently used for the treatment of ischemia and inflammation. Oxidative stress mediated by elevated glutamate levels cause neuronal cell death in ischemia and various neuro…
View article: Hesperidin Extracted from Citrus reticulata Blanco Protects Cardiac Mitochondria Against Hypoxia/Reoxygenation Injury
Hesperidin Extracted from Citrus reticulata Blanco Protects Cardiac Mitochondria Against Hypoxia/Reoxygenation Injury Open
This study was conducted to evaluate the protective effect of Hesperdin (Hes) extracted from Citrus reticulata Blanco on cardiac mitochondria in hypoxia/reoxygenation (HR) injury in vitro. Methods: H9C2 cardiomyocytes were cultured under n…
View article: Antidiabetic Activity of Gomphogyne bonii Gagnep. Extract against High-Fat Diet and Alloxan-Induced Type 2 Diabetes in Mice
Antidiabetic Activity of Gomphogyne bonii Gagnep. Extract against High-Fat Diet and Alloxan-Induced Type 2 Diabetes in Mice Open
So far, diabetes mellitus has become a health threat to society all over the world. Especially, people with diabetes have always coped with complications related to this disease and unexpected side effects of synthetic drugs. Thus, there h…
View article: Configurational Assignment of a Flexible Benzo[<i>g</i>]isochromene Stereodiad from <i>Rubia philippinensis</i> and Inhibition of Soluble Epoxide Hydrolase Activity
Configurational Assignment of a Flexible Benzo[<i>g</i>]isochromene Stereodiad from <i>Rubia philippinensis</i> and Inhibition of Soluble Epoxide Hydrolase Activity Open
A new benzo[g]isochromene possessing a conformationally mobile moiety was identified from Rubia philippinensis. The 2D structure was established utilizing spectrometric and spectroscopic techniques with variable temperatures.…
View article: A New Ursane-Type Triterpene from the Roots of Salvia miltiorrhiza Bunge
A New Ursane-Type Triterpene from the Roots of Salvia miltiorrhiza Bunge Open
Danshen (Salvia miltiorrhiza) is a one of the most well-known medicinal herbs in the Oriental medicine for treatment of certain cardiovascular disoders.Our current research on triterpenoid component in danshen roots led to the isolation of…
View article: Chemical Constituents From the Vietnamese Medicinal Plant <i>Anemone chapaensis</i> and Their Cytotoxic Activity
Chemical Constituents From the Vietnamese Medicinal Plant <i>Anemone chapaensis</i> and Their Cytotoxic Activity Open
Our current research on phytochemical profile of the folk medicinal plant Anemone chapaensis Gagnep. led to the isolation of a new saponin, chapaenoside (1), along with 13 known compounds (2-14). Their structures were elucidated on the bas…
View article: NMR-Based Investigation of Hydrogen Bonding in a Dihydroanthracen-1(4<i>H</i>)one from <i>Rubia philippinensis</i> and Its Soluble Epoxide Hydrolase Inhibitory Potential
NMR-Based Investigation of Hydrogen Bonding in a Dihydroanthracen-1(4<i>H</i>)one from <i>Rubia philippinensis</i> and Its Soluble Epoxide Hydrolase Inhibitory Potential Open
Hydrogen bonding is a vital feature of a large ensemble of chemical structures. Soluble epoxide hydrolase (sEH) has been targeted for development of the treatment for inflammation-associated diseases. Compounds 1 and 2 were purified from R…
View article: A natural ent‑kaurane diterpenoid induces antiproliferation in ovarian cancer cells via ERK1/2 regulation and inhibition of cellular migration and invasion
A natural ent‑kaurane diterpenoid induces antiproliferation in ovarian cancer cells via ERK1/2 regulation and inhibition of cellular migration and invasion Open
Ovarian cancer is one of the most common causes of female mortalities from gynecological tumors. An ent‑kaurane diterpenoid compound CRT1 (ent‑18‑acetoxy‑7β‑hydroxy kaur‑15‑oxo‑16‑ene), mainly isolated from the Vietnamese herb Croton tonki…
View article: Xây dưng phương phap đinh tinh, đinh lương hoat chât ent-7-hydroxy-15-oxokaur-16-en-18-yl acetate trong dươc liêu khô sâm cho la (Croton tonkinensis Gagnep.)
Xây dưng phương phap đinh tinh, đinh lương hoat chât ent-7-hydroxy-15-oxokaur-16-en-18-yl acetate trong dươc liêu khô sâm cho la (Croton tonkinensis Gagnep.) Open
The compound ent-7β-hydroxy-15-oxo kaur-16-en-18-yl acetat (CT1) is the major constituent and found uniquely in the medicinal plant Croton tonkinensis Gagnep. This compound was also found to have numerous pharmaceutical activities, therefo…
View article: Xanthine oxidase inhibitors from Archidendron clypearia (Jack.) I.C. Nielsen: Results from systematic screening of Vietnamese medicinal plants
Xanthine oxidase inhibitors from Archidendron clypearia (Jack.) I.C. Nielsen: Results from systematic screening of Vietnamese medicinal plants Open
From this investigation, four Vietnamese medicinal plants were identified to have XO inhibitory effects with IC50 values of the methanol extracts below 30 μg/mL. Compound (-)-7-O- galloyltricetiflavan was identified as an XO inh…
View article: Anti-Hyperuricemic, Anti-Inflammatory and Analgesic Effects of Siegesbeckia orientalis L. Resulting from the Fraction with High Phenolic Content
Anti-Hyperuricemic, Anti-Inflammatory and Analgesic Effects of Siegesbeckia orientalis L. Resulting from the Fraction with High Phenolic Content Open
This study suggested that anti-hyperuricemic and anti-inflammatory mechanism of S. orientalis is related to XO inhibitory effect of the phenolic components. Our findings support the use of this plant as the treatment of gout and other infl…
View article: Tác dụng chống viêm cấp và mạn của hợp chất ent-7-hydroxy-15-oxokaur-16-en-18-yl acetate từ khổ sâm cho lá
Tác dụng chống viêm cấp và mạn của hợp chất ent-7-hydroxy-15-oxokaur-16-en-18-yl acetate từ khổ sâm cho lá Open
Tóm tắtNghiên cứu này được thực hiện nhằm đánh giá tác dụng chống viêm cấp và mạn của hợp chất ent-7β-hydroxy-15-oxokaur-16-en-18-yl acetate (CT1) phân lập từ cây khổ sâm cho lá bằng các mô hình thực nghiệm. Ở mô hình gây phù bàn chân chuộ…