Phyo W. Win
YOU?
Author Swipe
View article: Mitochondrial DNA copy number reduction via<i>in vitro TFAM</i>knockout remodels the nuclear epigenome and transcriptome
Mitochondrial DNA copy number reduction via<i>in vitro TFAM</i>knockout remodels the nuclear epigenome and transcriptome Open
Mitochondrial DNA copy number (mtDNA-CN) is associated with several age-related chronic diseases and is a predictor of all-cause mortality. Here, we examine site-specific differential nuclear DNA (nDNA) methylation and differential gene ex…
View article: Simultaneous assessment of mitochondrial DNA copy number and nuclear epigenetic age towards predictive models of development and aging
Simultaneous assessment of mitochondrial DNA copy number and nuclear epigenetic age towards predictive models of development and aging Open
Objective Mitochondrial dysfunction and nuclear epigenetic alterations, two hallmarks of aging, are associated with aberrant development and complex disease risk. Here, we report a method for the simultaneous assessment of mitochondrial DN…
View article: Mitochondrial DNA Copy Number and Heteroplasmy in Monozygotic Twins Discordant for Schizophrenia
Mitochondrial DNA Copy Number and Heteroplasmy in Monozygotic Twins Discordant for Schizophrenia Open
Schizophrenia (SZ) is a severe, complex, and common mental disorder with high heritability (80%), an adult age of onset, and high discordance (∼50%) in monozygotic twins (MZ). Extensive studies on familial and non-familial cases have impli…
View article: Mitochondrial genomic integrity and the nuclear epigenome in health and disease
Mitochondrial genomic integrity and the nuclear epigenome in health and disease Open
Bidirectional crosstalk between the nuclear and mitochondrial genomes is essential for proper cell functioning. Mitochondrial DNA copy number (mtDNA-CN) and heteroplasmy influence mitochondrial function, which can influence the nuclear gen…