Pia Jokela
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View article: Performance of the cobas EBV and cobas BKV assays: multi-site comparison of standardized quantitation
Performance of the cobas EBV and cobas BKV assays: multi-site comparison of standardized quantitation Open
Guidelines recommend monitoring of Epstein-Barr virus (EBV) and BK virus (BKV) in solid organ and hematopoietic stem cell transplant patients. The majority of quantitative DNA testing for EBV and BKV employs unstandardized individual labor…
View article: Real-life clinical sensitivity of SARS-CoV-2 RT-PCR test in symptomatic patients
Real-life clinical sensitivity of SARS-CoV-2 RT-PCR test in symptomatic patients Open
Background Understanding the false negative rates of SARS-CoV-2 RT-PCR testing is pivotal for the management of the COVID-19 pandemic and it has implications for patient management. Our aim was to determine the real-life clinical sensitivi…
View article: Evaluation of three rapid lateral flow antigen detection tests for the diagnosis of SARS-CoV-2 infection
Evaluation of three rapid lateral flow antigen detection tests for the diagnosis of SARS-CoV-2 infection Open
View article: Comparison of Two Commercial Platforms and a Laboratory-Developed Test for Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) RNA
Comparison of Two Commercial Platforms and a Laboratory-Developed Test for Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) RNA Open
Mitigation of the ongoing coronavirus disease 2019 (COVID-19) pandemic requires reliable and accessible laboratory diagnostic services. In this study, the performance of one laboratory-developed test (LDT) and two commercial tests, cobas S…
View article: Evaluation of three rapid lateral flow antigen detection tests for the diagnosis of SARS-CoV-2 infection
Evaluation of three rapid lateral flow antigen detection tests for the diagnosis of SARS-CoV-2 infection Open
Introduction The COVID-19 pandemic has led to high demand of diagnostic tools. Rapid antigen detection tests have been developed and many have received regulatory acceptance such as CE IVD or FDA markings. Their performance needs to be car…
View article: Laboratory-based surveillance of COVID-19 in the Greater Helsinki area, Finland, February–June 2020
Laboratory-based surveillance of COVID-19 in the Greater Helsinki area, Finland, February–June 2020 Open
View article: Real-life clinical sensitivity of SARS-CoV-2 RT-PCR test in symptomatic patients
Real-life clinical sensitivity of SARS-CoV-2 RT-PCR test in symptomatic patients Open
Importance Understanding the false negative rates of SARS-CoV-2 RT-PCR testing is pivotal for the management of the COVID-19 pandemic and it has practical implications for patient management in healthcare facilities. Objective To determine…
View article: SARS-CoV-2 sample-to-answer nucleic acid testing in a tertiary care emergency department: evaluation and utility
SARS-CoV-2 sample-to-answer nucleic acid testing in a tertiary care emergency department: evaluation and utility Open
View article: SARS-CoV-2 sample-to-answer nucleic acid testing in a tertiary care emergency department: evaluation and utility
SARS-CoV-2 sample-to-answer nucleic acid testing in a tertiary care emergency department: evaluation and utility Open
Rapid sample-to-answer tests for detection of SARS-CoV-2 are emerging and data on their relative performance is urgently needed. We evaluated the analytical performance of two rapid nucleic acid tests, Cepheid Xpert ® Xpress SARS-CoV-2 and…
View article: Comparison of two commercial platforms and a laboratory developed test for detection of SARS-CoV-2 RNA
Comparison of two commercial platforms and a laboratory developed test for detection of SARS-CoV-2 RNA Open
Mitigation of the ongoing COVID-19 pandemic requires reliable and accessible laboratory diagnostic services. We evaluated the performance of one LDT and two commercial tests, cobas® SARS-CoV-2 (Roche) and Amplidiag® COVID-19 (Mobidiag), fo…
View article: Laboratory-based surveillance of COVID-19 in the Greater Helsinki area, Finland, February-June 2020
Laboratory-based surveillance of COVID-19 in the Greater Helsinki area, Finland, February-June 2020 Open
Laboratory registry data (80,791 specimens, 70,517 individuals) was used to characterise age- and sex-specific SARS-CoV-2 RT-PCR sampling frequency and positivity rate, and laboratory capacity building in Greater Helsinki, Finland during F…
View article: The Finnish New Variant of Chlamydia trachomatis with a Single Nucleotide Polymorphism in the 23S rRNA Target Escapes Detection by the Aptima Combo 2 Test
The Finnish New Variant of Chlamydia trachomatis with a Single Nucleotide Polymorphism in the 23S rRNA Target Escapes Detection by the Aptima Combo 2 Test Open
In 2019, more than 200 cases of Chlamydia trachomatis negative/equivocal by the Aptima Combo 2 assay (AC2, target: 23S rRNA) with slightly elevated relative light units (RLUs), but positive by the Aptima Chlamydia trachomatis assay (ACT, t…
View article: Chlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019
Chlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019 Open
Since February 2019, over 160 Chlamydia trachomatis (CT) cases testing negative or equivocal by Aptima Combo 2 (AC2) but positive by Aptima CT test run with Panther instruments occurred in Finland. The AC2 test targets chlamydial 23S rRNA …