Pia Kuss
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View article: 641 ABT-863 is a first-in-class inverse agonistic anti-CCR8 antibody that blocks suppressive Treg activity without cell depletion to more safely promote an anti-tumor immune response
641 ABT-863 is a first-in-class inverse agonistic anti-CCR8 antibody that blocks suppressive Treg activity without cell depletion to more safely promote an anti-tumor immune response Open
View article: “3D, human renal proximal tubule (RPTEC-TERT1) organoids ‘tubuloids’ for translatable evaluation of nephrotoxins in high-throughput”
“3D, human renal proximal tubule (RPTEC-TERT1) organoids ‘tubuloids’ for translatable evaluation of nephrotoxins in high-throughput” Open
The importance of human cell-based in vitro tools to drug development that are robust, accurate, and predictive cannot be understated. There has been significant effort in recent years to develop such platforms, with increased interest in …
View article: Skeletal muscle in MuRF1 null mice is not spared in low-gravity conditions, indicating atrophy proceeds by unique mechanisms in space
Skeletal muscle in MuRF1 null mice is not spared in low-gravity conditions, indicating atrophy proceeds by unique mechanisms in space Open
View article: PAR2 regulates regeneration, transdifferentiation, and death
PAR2 regulates regeneration, transdifferentiation, and death Open
View article: Conditional <i>Alpl</i> Ablation Phenocopies Dental Defects of Hypophosphatasia
Conditional <i>Alpl</i> Ablation Phenocopies Dental Defects of Hypophosphatasia Open
Loss-of-function mutations in ALPL result in hypophosphatasia (HPP), an inborn error of metabolism that causes defective skeletal and dental mineralization. ALPL encodes tissue-nonspecific alkaline phosphatase, an enzyme expressed in bone,…
View article: Role of PHOSPHO1 in Periodontal Development and Function
Role of PHOSPHO1 in Periodontal Development and Function Open
The tooth root and periodontal apparatus, including the acellular and cellular cementum, periodontal ligament (PDL), and alveolar bone, are critical for tooth function. Cementum and bone mineralization is regulated by factors including enz…
View article: Skeletal Mineralization Deficits and Impaired Biogenesis and Function of Chondrocyte-Derived Matrix Vesicles in <i>Phospho1</i>–/– and <i>Phospho1/Pit1</i> Double-Knockout Mice
Skeletal Mineralization Deficits and Impaired Biogenesis and Function of Chondrocyte-Derived Matrix Vesicles in <i>Phospho1</i>–/– and <i>Phospho1/Pit1</i> Double-Knockout Mice Open
We have previously shown that ablation of either the Phospho1 or Alpl gene, encoding PHOSPHO1 and tissue-nonspecific alkaline phosphatase (TNAP) respectively, lead to hyperosteoidosis, but that their chondrocyte-derived and osteoblast-deri…
View article: Erratum: Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs
Erratum: Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs Open
View article: Erratum: Corrigendum: Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs
Erratum: Corrigendum: Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs Open