Jan Pícha
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View article: The final walk with preptin
The final walk with preptin Open
Preptin, a 34-amino acid peptide derived from pro-IGF2, is believed to influence various physiological processes, including insulin secretion and the regulation of bone metabolism. Despite its recognized involvement, the precise physiologi…
View article: Combinatorial Libraries of Bipodal Binders of the Insulin Receptor
Combinatorial Libraries of Bipodal Binders of the Insulin Receptor Open
The binding process of insulin to its transmembrane receptor entails a sophisticated interplay between two proteins, each possessing two binding sites. Given the difficulties associated with the use of insulin in the treatment of diabetes,…
View article: Modulation of the antagonistic properties of an insulin mimetic peptide by disulfide bridge modifications
Modulation of the antagonistic properties of an insulin mimetic peptide by disulfide bridge modifications Open
Insulin is a peptide responsible for regulating the metabolic homeostasis of the organism; it elicits its effects through binding to the transmembrane insulin receptor (IR). Insulin mimetics with agonistic or antagonistic effects toward th…
View article: Effect of different immobilization strategies on chiral recognition properties of <i>Cinchona</i>‐based anion exchangers
Effect of different immobilization strategies on chiral recognition properties of <i>Cinchona</i>‐based anion exchangers Open
In the enantiomeric separation of highly polar compounds, a traditionally challenging task for high‐performance liquid chromatography, ion‐exchange chiral stationary phases have found the main field of application. In this contribution, we…
View article: Insulin-like Growth Factor 1 Analogs Clicked in the C Domain: Chemical Synthesis and Biological Activities
Insulin-like Growth Factor 1 Analogs Clicked in the C Domain: Chemical Synthesis and Biological Activities Open
Human insulin-like growth factor 1 (IGF-1) is a 70 amino acid protein hormone, with key impact on growth, development, and lifespan. The physiological and clinical importance of IGF-1 prompted challenging chemical and biological trials tow…
View article: Optimized syntheses of Fmoc azido amino acids for the preparation of azidopeptides
Optimized syntheses of Fmoc azido amino acids for the preparation of azidopeptides Open
The rise of CuI‐catalyzed click chemistry has initiated an increased demand for azido and alkyne derivatives of amino acid as precursors for the synthesis of clicked peptides. However, the use of azido and alkyne amino acids in peptide che…
View article: Key Aspects of Corporate Strategy in International Construction
Key Aspects of Corporate Strategy in International Construction Open
In view of increasing market competition, construction and engineering firms are forced to seek new business activities in foreign countries since their domestic markets disable their further growth. Many construction firms have already en…
View article: Success Factors of Export Financing under the Buyer's Credit Scheme
Success Factors of Export Financing under the Buyer's Credit Scheme Open
Buyer's credit is a very useful mode of exporting in international construction especially in relation to extensive infrastructure projects. Large projects usually require substantial amounts of liquidity provided by banks. Importers seldo…