Ping Wang
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View article: Targeting Mitochondrial Calcium Homeostasis via novel S100A9 Inhibitor B2 as a Promising Agent Against AML
Targeting Mitochondrial Calcium Homeostasis via novel S100A9 Inhibitor B2 as a Promising Agent Against AML Open
Acute myeloid leukemia (AML) remains difficult to treat in the relapsed or refractory (R/R) setting due to limited therapeutic targets and the emergence of drug resistance. Through integrative analysis of BeatAML, TCGA, and GEO datasets, w…
View article: WITHDRAWN: Symptom Network and Latent Profile Analysis in Patients After Glioma Surgery: A Cross-sectional Study
WITHDRAWN: Symptom Network and Latent Profile Analysis in Patients After Glioma Surgery: A Cross-sectional Study Open
The full text of this preprint has been withdrawn by the authors as it was submitted and made public without the full consent of all the authors. Therefore, the authors do not wish this work to be cited as a reference. Questions should be …
View article: WITHDRAWN: Symptom Network and Latent Profile Analysis in Patients After Glioma Surgery: A Cross-sectional Study
WITHDRAWN: Symptom Network and Latent Profile Analysis in Patients After Glioma Surgery: A Cross-sectional Study Open
Background Glioma is characterized by a high rate of disability and recurrence. Postoperative patients often experience three or more concurrent symptoms. Exploring the interrelationships among these symptoms from both group and individual…
View article: A protocol for developing, disseminating and implementing a core outcome set for clinical trials of integrative Chinese and Western medicine for ulcerative colitis
A protocol for developing, disseminating and implementing a core outcome set for clinical trials of integrative Chinese and Western medicine for ulcerative colitis Open
To improve the consistency of outcome documentation and address the potential for outcome reporting bias in clinical trials involving integrative Chinese and Western medicine (ICWM) for ulcerative colitis (UC), we aim to develop a customiz…
View article: Amino acids shape the metabolic and immunologic landscape in the tumor immune microenvironment: from molecular mechanisms to therapeutic strategies
Amino acids shape the metabolic and immunologic landscape in the tumor immune microenvironment: from molecular mechanisms to therapeutic strategies Open
The tumor immune microenvironment (TIME) represents a complex battlefield where metabolic competition and immune evasion mechanisms converge to drive cancer progression. Amino acids, with their multifaceted biological roles, have emerged a…
View article: MONKI: a three-dimensional Monte Carlo simulator of total and polarised radiation reflected by planetary atmospheres
MONKI: a three-dimensional Monte Carlo simulator of total and polarised radiation reflected by planetary atmospheres Open
Spectropolarimetry is a powerful tool for characterising planetary atmospheres and surfaces. For the design and operation of spectro(polari)metric instrumentation, numerically simulated signals of the measured radiation are essential. Here…
View article: Eosinophilic Fasciitis with Isolated Hand Involvement: A Diagnostic Challenge
Eosinophilic Fasciitis with Isolated Hand Involvement: A Diagnostic Challenge Open
Dear Editor, We present this case to highlight an atypical clinical manifestation of eosinophilic fasciitis (EF), which predominantly involved the hands without systemic features—a scenario rarely reported in the literature. This case unde…
View article: The Molecular Basis of Amino Acids Sensing
The Molecular Basis of Amino Acids Sensing Open
Amino acids are organic compounds that serve as the building blocks of proteins and peptides. Additionally, they function as bioactive molecules that play important roles in metabolic regulation and signal transduction. The ability of cell…
View article: Branched-chain amino acid metabolic disorder promotes osteoporosis by inhibiting HIF1-α-mediated glycolytic reprogramming in osteoblasts
Branched-chain amino acid metabolic disorder promotes osteoporosis by inhibiting HIF1-α-mediated glycolytic reprogramming in osteoblasts Open
Osteoporosis is the leading cause of fractures in the elderly, and metabolic changes, including elevated levels of branched-chain amino acids (BCAAs), have been implicated in its pathogenesis. This study explores the impact of high BCAAs l…
View article: Successful Treatment of Cutaneous Foreign Body Granuloma with JAK Inhibitor Abrocitinib and Prednisone: A Case Report
Successful Treatment of Cutaneous Foreign Body Granuloma with JAK Inhibitor Abrocitinib and Prednisone: A Case Report Open
This report provides preliminary evidence for JAK inhibitors' efficacy in managing refractory filler-induced FBG. Large-scale controlled trials are warranted to validate long-term safety and therapeutic benefits.
View article: N-deglycosylation targeting chimera (DGlyTAC): a strategy for immune checkpoint proteins inactivation by specifically removing N-glycan
N-deglycosylation targeting chimera (DGlyTAC): a strategy for immune checkpoint proteins inactivation by specifically removing N-glycan Open
Among the leading methods for triggering therapeutic anti-cancer immunity is the inhibition of immune checkpoint pathways. N-glycosylation is found to be essential for the function of various immune checkpoint proteins, playing a critical …
View article: Eosinophilic Granulomatous Polyangiitis with Autoimmune Hemolytic Anemia: A Case Report and Review of the Literature
Eosinophilic Granulomatous Polyangiitis with Autoimmune Hemolytic Anemia: A Case Report and Review of the Literature Open
EGPA can affect multiple organ systems, typically presenting with respiratory symptoms as the initial manifestation. The absence of specific diagnostic biomarkers makes it prone to misdiagnosis. This article describes a 40-year-old female …
View article: Predictive Inverse Dynamics Models are Scalable Learners for Robotic Manipulation
Predictive Inverse Dynamics Models are Scalable Learners for Robotic Manipulation Open
Current efforts to learn scalable policies in robotic manipulation primarily fall into two categories: one focuses on "action," which involves behavior cloning from extensive collections of robotic data, while the other emphasizes "vision,…
View article: The analysis of molten salt energy storage mode with multiple steam sources heating in thermal power unit peaking operation
The analysis of molten salt energy storage mode with multiple steam sources heating in thermal power unit peaking operation Open
A 350MW cogeneration unit is used as research object in molten salt energy storage which is characterized by energy mobility, combined with steam grade, steam split ratio, the evaluation indicators such as peaking load, thermal efficiency,…
View article: Enhancing creep rupture life prediction of high‐temperature titanium alloys using convolutional neural networks
Enhancing creep rupture life prediction of high‐temperature titanium alloys using convolutional neural networks Open
Prediction of creep rupture life of high‐temperature titanium alloys is crucial for their practical applications. The efficient representations (features) of the information encoded in the data are essential to achieve an accurate predicti…
View article: A motion compensation method for the single transmitter and multiple receivers mobile radar system
A motion compensation method for the single transmitter and multiple receivers mobile radar system Open
The single transmitter and multiple receivers (STMR) mobile radar system is a special distributed radar system, which has stronger detection and survival capabilities. However, the high‐speed movement of the radar platforms easily produce …
View article: Non-linear Association between Composite Dietary Antioxidant Index and Pulmonary Function: A Cross-Sectional Study Based on NHANES 2007-2012
Non-linear Association between Composite Dietary Antioxidant Index and Pulmonary Function: A Cross-Sectional Study Based on NHANES 2007-2012 Open
Background The relationship between pulmonary function and various diseases was well established; however, limited research has been conducted to examine the association between diet and pulmonary function. Investigating the potential corr…
View article: Development and validation of a relatively accurate gastric cancer high-risk group screening scoring system in urban residents
Development and validation of a relatively accurate gastric cancer high-risk group screening scoring system in urban residents Open
Urban residents benefited from the effective and verified GC-risk scoring systems, which demonstrated excellent performance in identifying individuals with an elevated risk of GC.
View article: CDT1 is a Potential Therapeutic Target for the Progression of NAFLD to HCC and the Exacerbation of Cancer
CDT1 is a Potential Therapeutic Target for the Progression of NAFLD to HCC and the Exacerbation of Cancer Open
Aims: This study aimed to identify potential therapeutic targets in the progression from non-alcoholic fatty liver disease (NAFLD) to hepatocellular carcinoma (HCC), with a focus on genes that could influence disease development and progre…
View article: Causal Relationship Between Childhood Obesity and Sleep Apnea Syndrome: Bidirectional Two-Sample Mendelian Randomization Analysis
Causal Relationship Between Childhood Obesity and Sleep Apnea Syndrome: Bidirectional Two-Sample Mendelian Randomization Analysis Open
There is a causal relationship between genetic susceptibility to childhood obesity and increased risk of sleep apnea syndrome. People with a history of childhood obesity should pay more attention to physical examination to early prevention…