Pier Paolo Mattogno
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View article: Repeated radiosurgery for recurrent or refractory trigeminal neuralgia: a systematic review and meta-analysis
Repeated radiosurgery for recurrent or refractory trigeminal neuralgia: a systematic review and meta-analysis Open
Stereotactic Radiosurgery (SRS) is a well-established component of the multimodal approach to treating trigeminal neuralgia (TN), a condition marked by frequent and recurrent episodes despite treatments. As a result, an increasing number o…
View article: The clinicopathological PANOMEN-3 classification predicts pituitary adenoma prognosis: a real-world retrospective single center study of a surgically treated cohort
The clinicopathological PANOMEN-3 classification predicts pituitary adenoma prognosis: a real-world retrospective single center study of a surgically treated cohort Open
Introduction Pituitary adenomas (PAs) are generally benign neoplasms, though in rare cases may exhibit aggressive behavior. In 2024, the PANOMEN-3 workshop released a new clinical-pathological classification. The objective of this study wa…
View article: Tumor‐infiltrating immune cells predict the response to somatostatin receptor ligands only in somatotropinomas naïve to medical therapy
Tumor‐infiltrating immune cells predict the response to somatostatin receptor ligands only in somatotropinomas naïve to medical therapy Open
Tumor‐infiltrating immune cells (TICs) are important components of the tumor microenvironment (TME). They regulate somatotroph adenoma treatment responses to therapy with somatostatin receptor ligands (SRLs), mediated by soluble factors an…
View article: A white matter-centered approach to investigate recurrence pathways in high-grade gliomas: a single-center retrospective study
A white matter-centered approach to investigate recurrence pathways in high-grade gliomas: a single-center retrospective study Open
View article: Genes of the “regulation of lymphocyte activation” pathway may influence immune cells infiltration in growth hormone secreting pituitary tumors
Genes of the “regulation of lymphocyte activation” pathway may influence immune cells infiltration in growth hormone secreting pituitary tumors Open
Purpose The tumor microenvironment (TME) may provide a useful framework for understanding the heterogeneous behavior of growth hormone (GH) secreting pituitary adenomas. Although the interest in TME in somatotropinomas has increased expone…
View article: Simulation tools in neuro-oncological surgery: a scoping review of perioperative and training applications
Simulation tools in neuro-oncological surgery: a scoping review of perioperative and training applications Open
Background Neuro-oncological surgery has lagged other neurosurgical subspecialties in integrating simulation technologies for training and surgical planning. This study provides a comprehensive scoping review of the current landscape of si…
View article: Cytokines and chemokines modulate the growth of pituitary adenoma/neuroendocrine tumors: preliminary results of a monocenter prospective pilot study
Cytokines and chemokines modulate the growth of pituitary adenoma/neuroendocrine tumors: preliminary results of a monocenter prospective pilot study Open
View article: Temporoparietal Fascia Flap (TPFF) in Extended Endoscopic Transnasal Skull Base Surgery: Clinical Experience and Systematic Literature Review
Temporoparietal Fascia Flap (TPFF) in Extended Endoscopic Transnasal Skull Base Surgery: Clinical Experience and Systematic Literature Review Open
Background and Objectives: The temporoparietal fascia flap (TPFF) has recently emerged as an option for skull base reconstruction in endoscopic transnasal surgery when vascularized nasal flaps are not available. This study provides a syste…
View article: Late meningitis and a nonabsorbable stent in recurrent Rathke’s cleft cyst: illustrative case
Late meningitis and a nonabsorbable stent in recurrent Rathke’s cleft cyst: illustrative case Open
BACKGROUND The management of recurrent Rathke’s cleft cysts (RCCs) remains challenging. The off-label application of steroid-eluting bioabsorbable or nonabsorbable intracystic stents has been recently described. Early outcomes and complica…
View article: GH receptor polymorphisms guide second-line therapies to prevent acromegaly skeletal fragility: preliminary results of a pilot study
GH receptor polymorphisms guide second-line therapies to prevent acromegaly skeletal fragility: preliminary results of a pilot study Open
Background Skeletal fragility is characterized by increased frequency of vertebral fractures (VFs) in acromegaly. Several trials were conducted to identify modifiable risk factors and predictors of VFs, with limited data on the prognostic …
View article: Effects of glucocorticoid replacement therapy in patients with pituitary disease: A new perspective for personalized replacement therapy
Effects of glucocorticoid replacement therapy in patients with pituitary disease: A new perspective for personalized replacement therapy Open
View article: 3D Printing for Customized Bone Reconstruction in Spheno-Orbital Meningiomas: A Systematic Literature Review and Institutional Experience
3D Printing for Customized Bone Reconstruction in Spheno-Orbital Meningiomas: A Systematic Literature Review and Institutional Experience Open
Background: The treatment of spheno-orbital meningiomas (SOMs) requires extensive bone resections, creating significant defects in a complex geometrical space. Bone reconstruction represents a fundamental step that optimizes long-term aest…
View article: Retroperitoneal schwannoma during pregnancy: A case report and practice-based overview
Retroperitoneal schwannoma during pregnancy: A case report and practice-based overview Open
View article: Trouillas’s Grading and Post-Surgical Tumor Residue Assessment in Pituitary Adenomas: The Importance of the Multidisciplinary Approach
Trouillas’s Grading and Post-Surgical Tumor Residue Assessment in Pituitary Adenomas: The Importance of the Multidisciplinary Approach Open
Background: We aim to assess the role of a multidisciplinary approach in pituitary adenomas (PitNETs) classification, evaluate criteria concordance, and compare intraoperative assessments with post-operative MRIs for tumor remnants. Method…
View article: Aggressive PitNETs and Potential Target Therapies: A Systematic Review of Molecular and Genetic Pathways
Aggressive PitNETs and Potential Target Therapies: A Systematic Review of Molecular and Genetic Pathways Open
Recently, advances in molecular biology and bioinformatics have allowed a more thorough understanding of tumorigenesis in aggressive PitNETs (pituitary neuroendocrine tumors) through the identification of specific essential genes, crucial …
View article: THU055 The Acro-TIME Score: A New Clinical, Pathological And Immune Integrative Approach To Early Identify Acromegaly Patients Resistant To Treatment With First Generation Somatostatin Ligands
THU055 The Acro-TIME Score: A New Clinical, Pathological And Immune Integrative Approach To Early Identify Acromegaly Patients Resistant To Treatment With First Generation Somatostatin Ligands Open
Disclosure: S. Chiloiro: None. A. Giampietro: None. M. Gessi: None. L. Lauretti: None. M. Pier Paolo: None. A. Carlino: None. A. Olivi: None. G. RIndi: None. A. Pontecorvi: None. L. De Marinis: None. F. Doglietto: None. A. Bianchi: None. I…
View article: THU050 The Role Of The GH Receptor Polymorphism As Prognostic Factor Of Vertebral Fractures In Acromegaly Patients Resistant To First Generation SSAs And Treated With GH Receptor Antagonist Or Second Generation Somatostatin Ligand
THU050 The Role Of The GH Receptor Polymorphism As Prognostic Factor Of Vertebral Fractures In Acromegaly Patients Resistant To First Generation SSAs And Treated With GH Receptor Antagonist Or Second Generation Somatostatin Ligand Open
Disclosure: F. Costanza: None. S. Chiloiro: None. A. Giampietro: None. P. Mattogno: None. A. Infante: None. F. Angelini: None. L. Lauretti: None. A. Olivi: None. A. Pontecorvi: None. F. Doglietto: None. L. De Marinis: None. A. Bianchi: Non…
View article: Reliability of intraoperative visual evoked potentials (iVEPs) in monitoring visual function during endoscopic transsphenoidal surgery
Reliability of intraoperative visual evoked potentials (iVEPs) in monitoring visual function during endoscopic transsphenoidal surgery Open
Objective To refine a reliable and reproducible intraoperative visual evoked potentials (iVEPs) monitoring protocol during endoscopic transsphenoidal surgery. To assess the reliability of baseline iVEPs in predicting preoperative visual st…
View article: Training models and simulators for endoscopic transsphenoidal surgery: a systematic review
Training models and simulators for endoscopic transsphenoidal surgery: a systematic review Open
View article: Treatment of Clival Chordomas: A 20-Year Experience and Systematic Literature Review
Treatment of Clival Chordomas: A 20-Year Experience and Systematic Literature Review Open
Clival chordomas are rare but aggressive skull base tumors that pose significant treatment challenges and portend dismal prognosis. The aim of this study was to highlight the advantages and limitations of available treatments, to furnish p…
View article: #759 Comprehensive cancer genomic profiling in matched primary tumor and brain metastasis samples of ovarian cancer patients: a single-institution case series
#759 Comprehensive cancer genomic profiling in matched primary tumor and brain metastasis samples of ovarian cancer patients: a single-institution case series Open
Introduction/Background Brain metastases (BMs) are rare sites of ovarian cancer (OC) recurrence, associated with poor prognosis. While the genomic landscape of primary OC has been well described, genomic alterations characterizing BM are u…
View article: Quantitative Anatomical Studies in Neurosurgery: A Systematic and Critical Review of Research Methods
Quantitative Anatomical Studies in Neurosurgery: A Systematic and Critical Review of Research Methods Open
Background: The anatomy laboratory can provide the ideal setting for the preclinical phase of neurosurgical research. Our purpose is to comprehensively and critically review the preclinical anatomical quantification methods used in cranial…
View article: Ultra-Early Treatment of Neurosurgical Emergencies with Endoscopic Endonasal Approach: Experience from Three Italian Referral Centers
Ultra-Early Treatment of Neurosurgical Emergencies with Endoscopic Endonasal Approach: Experience from Three Italian Referral Centers Open
Purpose: the aim of this multicenter study is to preliminarily assess the role of the Endoscopic Endonasal Approach (EEA) in ultra-early (i.e., within 12 h) management of selected neurosurgical emergencies in terms of clinical and radiolog…
View article: Integrated Neurosurgical Management of Retroperitoneal Benign Nerve Sheath Tumors
Integrated Neurosurgical Management of Retroperitoneal Benign Nerve Sheath Tumors Open
Peripheral nerve sheath tumors (PNST) of the retroperitoneum are rare and are often treated by general surgeons dealing with retroperitoneal cancers. However, resection without the correct microsurgical technique can cause permanent neurol…
View article: The Extracellular Matrix in Glioblastomas: A Glance at Its Structural Modifications in Shaping the Tumoral Microenvironment—A Systematic Review
The Extracellular Matrix in Glioblastomas: A Glance at Its Structural Modifications in Shaping the Tumoral Microenvironment—A Systematic Review Open
Background and aim: While many components of the ECM have been isolated and characterized, its modifications in the specific setting of GBMs have only been recently explored in the literature. The aim of this paper is to provide a systemat…
View article: Colon Cancer Presenting as Pituitary Mass and Hypopituitarism: Recognition and Multidisciplinary Approach of a Rare Case
Colon Cancer Presenting as Pituitary Mass and Hypopituitarism: Recognition and Multidisciplinary Approach of a Rare Case Open
Pituitary metastases are rare. Until now, few cases have been reported; about 50% of pituitary metastases originate from breast or lung cancers. We describe the clinical case of a primary colon carcinoma first presenting with a pituitary m…
View article: 2022-RA-1356-ESGO Epithelial ovarian cancer and brain metastases: survival analysis according to the BRCA status
2022-RA-1356-ESGO Epithelial ovarian cancer and brain metastases: survival analysis according to the BRCA status Open
View article: Neurosurgical Defeats: Critically Ill Patients and the Role of Palliative Care Service
Neurosurgical Defeats: Critically Ill Patients and the Role of Palliative Care Service Open
The onco-functional balance in neuro-oncology requires maximizing tumor removal while rigorously preserving patients’ neurological status. When postoperative worsening prevents the implementation of oncologic treatments, palliative care se…
View article: Glioma-Associated Microglia Characterization in the Glioblastoma Microenvironment through a ‘Seed-and Soil’ Approach: A Systematic Review
Glioma-Associated Microglia Characterization in the Glioblastoma Microenvironment through a ‘Seed-and Soil’ Approach: A Systematic Review Open
Background and aim: Ever since the discovery of tumor-associated immune cells, there has been growing interest in the understanding of the mechanisms underlying the crosstalk between these cells and tumor cells. A “seed and soil” approach …
View article: Interpretable Machine Learning–Based Prediction of Intraoperative Cerebrospinal Fluid Leakage in Endoscopic Transsphenoidal Pituitary Surgery: A Pilot Study
Interpretable Machine Learning–Based Prediction of Intraoperative Cerebrospinal Fluid Leakage in Endoscopic Transsphenoidal Pituitary Surgery: A Pilot Study Open
Purpose Transsphenoidal surgery (TSS) for pituitary adenomas can be complicated by the occurrence of intraoperative cerebrospinal fluid (CSF) leakage (IOL). IOL significantly affects the course of surgery predisposing to the development of…